Giuseppe Giordano

Search results

• 2023

  Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

  Allesøe, R. L., Ridderstråle, M., Giordano, G. N., Franks, P. W., Groop, L., Pasdar, N. A., Fitipaldi, H., Kurbasic, A., Mutie, P., Pomares-Millan, H., Klintenberg, M., Abdalla, M. & IMI DIRECT Consortium, 2023, In: Nature Biotechnology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deep Learning 100%
  • Medical problems 79%
  • Deep learning 64%
  • Type 2 Diabetes Mellitus 54%
  • Atorvastatin 53%

• Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women

  Mutie, P. M., Pomares-Milan, H., Atabaki-Pasdar, N., Coral, D., Fitipaldi, H., Tsereteli, N., Tajes, J. F., Franks, P. W. & Giordano, G. N., 2023, In: Diabetologia. 66, 2 , p. 321-335

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Men's Health 100%
  • Women's Health 79%
  • Adiposity 78%
  • Random Allocation 73%
  • LDL Cholesterol 67%
• 2022

  Can Bureaucrats Break Trust? Testing Cultural and Institutional Theories of Trust with Chinese Panel Data

  Fairbrother, M., Mewes, J., Wilkes, R., Wu, C. & Giordano, N., 2022, In: Socius: Sociological Research for a Dynamic World. 8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • cultural theory 100%
  • Public officials 97%
  • test theory 51%
  • public institution 44%
  • political institution 43%

• Estimating the Direct Effect between Dietary Macronutrients and Cardiometabolic Disease, Accounting for Mediation by Adiposity and Physical Activity

  Pomares-Millan, H., Atabaki-Pasdar, N., Coral, D., Johansson, I., Giordano, G. N. & Franks, P. W., 2022 Mar 1, In: Nutrients. 14, 6, 1218.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • adiposity 100%
  • noninsulin-dependent diabetes mellitus 97%
  • physical activity 90%
  • Adiposity 80%
  • Nutrients 65%

• Predicting Sensitivity to Adverse Lifestyle Risk Factors for Cardiometabolic Morbidity and Mortality

  Pomares-Millan, H., Poveda, A., Atabaki Pasdar, N., Johansson, I., Björk, J., Ohlsson, M., Giordano, N. & Franks, P., 2022, In: Nutrients. 14, 15, p. 1-13 3171.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • morbidity 100%
  • lifestyle 96%
  • risk factors 93%
  • Life Style 77%
  • Morbidity 56%
• 2021

  Chinese Citizen Satisfaction with Government Performance during COVID-19

  Wu, C., Shi, Z., Wilkes, R., Wu, J., Gong, Z., He, N., Xiao, Z., Zhang, X., Lai, W., Zhou, D., Zhao, F., Yin, X., Xiong, P., Zhou, H., Chu, Q., Cao, L., Tian, R., Tan, Y., Yang, L., He, Z., & 3 othersFairbrother, M., Mewes, J. & Giordano, G. N., 2021, In: Journal of Contemporary China. 30, 132, p. 930-944 15 p.

  Research output: Contribution to journal › Article › peer-review

  • citizen 100%
  • Government 60%
  • Political Culture 53%
  • performance 47%
  • Performance 39%

• Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMIRHAPSODY Study

  Slieker, R. C., Donnelly, L. A., Fitipaldi, H., Bouland, G. A., Giordano, G. N., Åkerlund, M., Gerl, M. J., Ahlqvist, E., Ali, A., Dragan, I., Elders, P., Festa, A., Hansen, M. K., van der Heijden, A. A., Aly, D. M., Kim, M., Kuznetsov, D., Mehl, F., Klose, C., Simons, K., & 15 othersPavo, I., Pullen, T. J., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Quigley, C. L., Groop, L., Thorens, B., Franks, P. W., Ibberson, M., Rutter, G. A., Beulens, J. W., 't Hart, L. M. & Pearson, E. R., 2021, In: Diabetes. 70, 11, p. 2683-2693

  Research output: Contribution to journal › Article › peer-review

  • Type 2 Diabetes Mellitus 100%
  • Lipidomics 60%
  • Insulin 60%
  • Metabolomics 48%
  • Islets of Langerhans 44%

• Experiences matter: A longitudinal study of individual-level sources of declining social trust in the United States

  Mewes, J., Fairbrother, M., Giordano, N., Wu, C. & Wilkes, R., 2021, In: Social Science Research. 95, 102537.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • longitudinal study 100%
  • confidence 95%
  • unemployment 76%
  • scenario 62%
  • income 57%

• Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study

  Bizzotto, R., Jennison, C., Jones, A. G., Kurbasic, A., Tura, A., Kennedy, G., Bell, J. D., Thomas, E. L., Frost, G., Eriksen, R., Koivula, R. W., Brage, S., Kaye, J., Hattersley, A. T., Heggie, A., McEvoy, D., 't Hart, L. M., Beulens, J. W., Elders, P., Musholt, P. B., & 28 othersRidderstråle, M., Hansen, T. H., Allin, K. H., Hansen, T., Vestergaard, H., Lundgaard, A. T., Thomsen, H. S., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T. J., Kokkola, T., Forgie, I. M., Giordano, G. N., Pavo, I., Ruetten, H., Dermitzakis, E., McCarthy, M. I., Pedersen, O., Schwenk, J. M., Adamski, J., Franks, P. W., Walker, M., Pearson, E. R., Mari, A. & IMI DIRECT Consortium, 2021, In: Diabetes Care. 44, 2, p. 511-518 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Insulin Resistance 100%
  • Type 2 Diabetes Mellitus 91%
  • Fats 91%
  • Intra-Abdominal Fat 68%
  • Glucose 57%

• Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

  Tura, A., Grespan, E., Göbl, C. S., Koivula, R. W., Franks, P. W., Pearson, E. R., Walker, M., Forgie, I. M., Giordano, G. N., Pavo, I., Ruetten, H., Dermitzakis, E. T., McCarthy, M. I., Pedersen, O., Schwenk, J. M., Adamski, J., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., & 17 othersMahajan, A., McDonald, T. J., Kokkola, T., Vangipurapu, J., Cederberg, H., Laakso, M., Rutters, F., Elders, P. J. M., Koopman, A. D. M., Beulens, J. W., Ridderstråle, M., Hansen, T. H., Allin, K. H., Hansen, T., Vestergaard, H., Mari, A. & IMI DIRECT Consortium, 2021 Sep 1, In: Diabetes. 70, 9, p. 2092-2106 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prediabetic State 100%
  • Glycated Hemoglobin A 81%
  • Glucose Tolerance Test 78%
  • Glucose Intolerance 65%
  • Fasting 62%

• Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study

  Slieker, R. C., Donnelly, L. A., Fitipaldi, H., Bouland, G. A., Giordano, G. N., Åkerlund, M., Gerl, M. J., Ahlqvist, E., Ali, A., Dragan, I., Festa, A., Hansen, M. K., Mansour Aly, D., Kim, M., Kuznetsov, D., Mehl, F., Klose, C., Simons, K., Pavo, I., Pullen, T. J., & 13 othersSuvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido-Quigley, C., Groop, L., Thorens, B., Franks, P. W., Ibberson, M., Rutter, G. A., Beulens, J. W. J., 't Hart, L. M. & Pearson, E. R., 2021, In: Diabetologia. 64, 9, p. 1982-1989 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Type 2 Diabetes Mellitus 100%
  • Insulin 90%
  • HDL Cholesterol 83%
  • C-Peptide 61%
  • Cluster Analysis 35%

• RHAPSODY, Biomarkers and Novel Clinical Trial design in type 2 diabetes (T2D) and prediabetes

  Adams, R., Daly, N., Robertson, E. & Giordano, G. N., 2021, In: Endocrinology, Diabetes and Metabolism. 4, 2

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prediabetic State 100%
  • Type 2 Diabetes Mellitus 58%
  • Clinical Trials 50%
  • Biomarkers 50%
  • Disease Progression 20%
• 2020

  An investigation of causal relationships between prediabetes and vascular complications

  Mutie, P. M., Pomares-Millan, H., Atabaki-Pasdar, N., Jordan, N., Adams, R., Daly, N. L., Tajes, J. F., Giordano, G. N. & Franks, P. W., 2020 Dec 1, In: Nature Communications. 11, 1, 4592.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycemic 100%
  • coronary artery disease 84%
  • Prediabetic State 82%
  • Blood Vessels 37%
  • Diabetes Complications 37%

• Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

  Eriksen, R., Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, L. E., Koivula, R. W., Bizzotto, R., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F., Tsirigos, K. D., Brunak, S., Viñuela, A., Mahajan, A., McDonald, T. J., Kokkola, T., & 17 othersRutter, F., Teare, H., Hansen, T. H., Fernandez, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, O., Ruetten, H., Forgie, I., Bell, J. D., Pearson, E. R., Franks, P. W., Adamski, J., Holmes, E. & Frost, G., 2020, In: EBioMedicine. 58, 102932.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycemic 100%
  • Metabolic 69%
  • Type 2 Diabetes Mellitus 64%
  • Metabolite 60%
  • Adiposity 59%

• Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study

  Obura, M., Beulens, J. W. J., Slieker, R., Koopman, A. D. M., Hoekstra, T., Nijpels, G., Elders, P., Koivula, R. W., Kurbasic, A., Laakso, M., Hansen, T. H., Ridderstråle, M., Hansen, T., Pavo, I., Forgie, I., Jablonka, B., Ruetten, H., Mari, A., McCarthy, M. I., Walker, M., & 19 othersHeggie, A., McDonald, T. J., Perry, M. H., De Masi, F., Brunak, S., Mahajan, A., Giordano, G. N., Kokkola, T., Dermitzakis, E., Viñuela, A., Pedersen, O., Schwenk, J. M., Adamski, J., Teare, H. J. A., Pearson, E. R., Franks, P. W., 't Hart, L. M., Rutters, F. & IMI DIRECT Consortium, 2020, In: PLoS ONE. 15, 11, e0242360.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Type 2 Diabetes Mellitus 100%
  • Glucose 83%
  • Meals 71%
  • Triglycerides 42%
  • Latent Class Analysis 29%

• Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

  et al., Atabaki Pasdar, N., Ohlsson, M., Pomares-Millan, H., Koivula, R., Kurbasic, A., Mutie, P., Fitipaldi, H., Fernandez Tajes, J., Giordano, N. & Franks, P., 2020, In: PLoS Medicine. 17, 6, p. e1003149

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Machine Learning 100%
  • Validation Studies 97%
  • Non-alcoholic Fatty Liver Disease 95%
  • Fatty Liver 94%
  • Liver Diseases 74%

• The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

  Koivula, R. W., Atabaki-Pasdar, N., Giordano, G. N., White, T., Adamski, J., Bell, J. D., Beulens, J., Brage, S., Brunak, S., De Masi, F., Dermitzakis, E. T., Forgie, I. M., Frost, G., Hansen, T., Hansen, T. H., Hattersley, A., Kokkola, T., Kurbasic, A., Laakso, M., Mari, A., & 15 othersMcDonald, T. J., Pedersen, O., Rutters, F., Schwenk, J. M., Teare, H. J. A., Thomas, E. L., Vinuela, A., Mahajan, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E., Pavo, I., Franks, P. W. & IMI DIRECT Consortium, 2020 Apr, In: Diabetologia. 63, 4, p. 744-756 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Twins 100%
  • Type 2 Diabetes Mellitus 71%
  • Homeostasis 69%
  • Exercise 61%
  • Abdominal Fat 36%

• Trust, happiness and mortality: Findings from a prospective US population-based survey

  Miething, A., Mewes, J. & Giordano, G. N., 2020 May, In: Social Science & Medicine . 252, 112809.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Happiness 100%
  • happiness 74%
  • Mortality 74%
  • mortality 66%
  • Population 30%

• Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

  et al., Gudmundsdottir, V., Giordano, N., Koivula, R., Ridderstråle, M., Franks, P. & Brunak, S., 2020, In: Genome Medicine. 12, 1, 109.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Type 2 Diabetes Mellitus 100%
  • Neutrophils 23%
  • Immune System Phenomena 23%
  • Gene Regulatory Networks 16%
  • Metabolic Diseases 15%
• 2019

  Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

  Wilman, H. R., Atabaki Pasdar, N., Franks, P., Giordano, G., Pomares-Millan, H., Fitipaldi, H., Mutie, P., Klintenberg, M., Yaghootkar, H. & IMI DIRECT Consortium, 2019, In: Journal of Hepatology. 71, 3, p. 594-602

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hepcidins 100%
  • Iron 62%
  • Liver 38%
  • Genes 30%
  • Abdominal Obesity 15%

• Motivations for data sharing—views of research participants from four European countries: A DIRECT study

  Shah, N., Coathup, V., Teare, H., Forgie, I., Giordano, G. N., Hansen, T. H., Groeneveld, L., Hudson, M., Pearson, E., Ruetten, H. & Kaye, J., 2019 Jan 30, In: European Journal of Human Genetics.

  Research output: Contribution to journal › Article › peer-review

  • Motivation 100%
  • Information Dissemination 72%
  • Privacy 49%
  • Biomedical Research 20%
  • Risk Assessment 17%

• Sharing data for future research—engaging participants’ views about data governance beyond the original project: a DIRECT Study

  Shah, N., Coathup, V., Teare, H., Forgie, I., Giordano, G. N., Hansen, T. H., Groeneveld, L., Hudson, M., Pearson, E., Ruetten, H. & Kaye, J., 2019, In: Genetics in Medicine. 21, 5, p. 1131-1138

  Research output: Contribution to journal › Article › peer-review

  • Information Dissemination 100%
  • Research Personnel 59%
  • Patient Advocacy 22%
  • Denmark 18%
  • Sweden 16%

• Trust and all-cause mortality: a multilevel study of US General Social Survey data (1978–2010)

  Giordano, G. N., Mewes, J. & Miething, A., 2019, In: Journal of Epidemiology and Community Health. 73, 1, p. 50-55

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • mortality 100%
  • cause 69%
  • Mortality 59%
  • death 34%
  • household income 25%
  195 Downloads (Pure)
• 2017

  Self-rated health, generalized trust, and the Affordable Care Act: A US panel study, 2006–2014

  Mewes, J. & Giordano, G. N., 2017 Oct 1, In: Social Science and Medicine. 190, p. 48-56 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Patient Protection and Affordable Care Act 100%
  • act 48%
  • Health 47%
  • health 33%
  • Social Policy 26%
• 2016

  Changes in social capital and cigarette smoking behavior over time: A population-based panel study of temporal relationships

  Lindström, M. & Giordano, G. N., 2016 Nov 1, In: Nicotine & Tobacco Research. 18, 11, p. 2106-2114 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Social Capital 100%
  • Cigarette Smoking 68%
  • smoking 65%
  • social capital 60%
  • Smoking 50%

• The 2005 London terror attacks: An investigation of changes in psychological wellbeing and social capital pre- and post-attacks (2003-07)-A UK panel study

  Giordano, G. N. & Lindström, M., 2016 Dec 1, In: SSM - Population Health. 2, p. 485-494 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Social Capital 100%
  • social capital 60%
  • Terrorism 60%
  • terrorism 56%
  • Psychology 47%

• The 2008 financial crisis: Changes in social capital and its association with psychological wellbeing in the United Kingdom - A panel study.

  Lindström, M. & Giordano, G. N., 2016, In: Social Science and Medicine. 153, p. 71-80

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Social Capital 100%
  • Psychological Well-being 89%
  • Financial Crisis 85%
  • financial crisis 66%
  • social capital 60%

• Trust and health: testing the reverse causality hypothesis.

  Giordano, G. N. & Lindström, M., 2016, In: Journal of Epidemiology and Community Health. 70, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • causality 100%
  • Causality 89%
  • knowledge gap 55%
  • Health 47%
  • health status 46%
• 2015

  The association between cannabis abuse and subsequent schizophrenia: a Swedish national co-relative control study.

  Giordano, G. N., Ohlsson, H., Sundquist, K., Sundquist, J. & Kendler, K., 2015, In: Psychological Medicine. 45, 2, p. 407-414

  Research output: Contribution to journal › Article › peer-review

  File

  • Marijuana Abuse 100%
  • schizophrenia 75%
  • drug abuse 70%
  • Schizophrenia 56%
  • interpretation 41%
  265 Downloads (Pure)
• 2014

  Age, period and cohort trends in drug abuse hospitalizations within the total Swedish population (1975-2010).

  Giordano, G. N., Ohlsson, H., Kendler, K., Winkleby, M., Sundquist, K. & Sundquist, J., 2014, In: Drug and Alcohol Dependence. 134, Jan 1, p. 355-361

  Research output: Contribution to journal › Article › peer-review

  • Substance-Related Disorders 100%
  • Hospitalization 83%
  • Drug 59%
  • Population 44%
  • Cohort Effect 37%

• Unexpected adverse childhood experiences and subsequent drug use disorder: a Swedish population study (1995-2011).

  Giordano, G. N., Ohlsson, H., Kendler, K., Sundquist, K. & Sundquist, J., 2014, In: Addiction. 109, 7, p. 1119-1127

  Research output: Contribution to journal › Article › peer-review

  • Adverse Childhood Experiences 100%
  • Substance-Related Disorders 60%
  • Young Adult 55%
  • Hand 51%
  • Pharmaceutical Preparations 28%
• 2013

  Testing the association between social capital and health over time: a family-based design.

  Giordano, G. N., Merlo, J., Ohlsson, H., Rosvall, M. & Lindström, M., 2013, In: BMC Public Health. 13, Jul,17, 665.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Social Capital 100%
  • social capital 60%
  • Health 33%
  • Social Participation 31%
  • health 31%
  164 Downloads (Pure)
• 2012

  Social capital and self-rated health – a study of temporal (causal) relationships

  Giordano, G. N., Björk, J. & Lindström, M., 2012, In: Social Science and Medicine. 75, 2, p. 340-348

  Research output: Contribution to journal › Article › peer-review

  File

  • Social Capital 100%
  • social capital 60%
  • Causal 54%
  • Health 44%
  • health 31%
  648 Downloads (Pure)

• Socialt kapital och självrapporterad hälsa: en undersökning av samband med longitudinella analyser och flernivåanalyser

  Giordano, G. N. & Lindström, M., 2012, In: Socialmedicinsk tidskrift. 89, 4-5, p. 367-377

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2011

  Social capital and change in psychological health over time.

  Giordano, G. N. & Lindström, M., 2011, In: Social Science and Medicine. 72, p. 1219-1227

  Research output: Contribution to journal › Article › peer-review

  File

  • Social Capital 100%
  • Psychological Health 99%
  • Social Change 84%
  • social capital 60%
  • social change 56%
  168 Downloads (Pure)

• Social capital and health-Purely a question of context?

  Giordano, G. N., Ohlsson, H. & Lindström, M., 2011, In: Health and Place. 17, p. 946-953

  Research output: Contribution to journal › Article › peer-review

  • Social Capital 100%
  • social capital 60%
  • Health 33%
  • health 31%
  • Multilevel Analysis 18%

• The impact of social capital on changes in smoking behaviour: a longitudinal cohort study.

  Giordano, G. N. & Lindström, M., 2011, In: European Journal of Public Health. jul 1, p. 347-354

  Research output: Contribution to journal › Article › peer-review

  • Social Capital 100%
  • smoking 65%
  • social capital 60%
  • Longitudinal Studies 57%
  • Smoking 50%
• 2010

  The impact of changes in different aspects of social capital and material conditions on self-rated health over time: A longitudinal cohort study.

  Giordano, G. N. & Lindström, M., 2010, In: Social Science and Medicine. 70, p. 700-710

  Research output: Contribution to journal › Article › peer-review

  • Social Capital 100%
  • Cohort 75%
  • social capital 60%
  • Longitudinal Studies 57%
  • Cohort Studies 47%