Research output per year
Research output per year
Professor
Solid tumors are consistently less well-oxygenated than the normal tissues from which they arise. Associations between tumor hypoxia and aggressively malignant phenotypes are observed across a range of cancers, focusing attention on molecular dissection of these pathways and how they contribute to tumorigenesis. Clear cell renal cell carcinoma (ccRCC) is characterized by a loss of the tumor suppressor gene VHL, and hence this tumor type is characterized by constitutive activation of the hypoxic response. As such, it represents a model system for tumor hypoxia in general. Our research is aimed at identifying and characterizing the different cell types from which kidney cancer is thought to develop, and to characterize how they respond to hypoxia and loss of VHL. We have also defined as a novel ccRCC specific biomarker, SLC6A3, and explore the diagnostic and therapeutic potential of this protein. We have previously shown that hyperactivated Notch signaling may complement loss of VHL in the formation of ccRCC. Based on these findings we are establishing a model system for ccRCC based on conditional deletion of VHL in conjunction with constitutive activation of the Notch signaling pathway.
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Pantaleo, J., Pietras, K. & Axelson, H.
2020/06/01 → …
Project: Dissertation
Brueffer, C., Saal, L., Höglund, M. & Axelson, H.
2014/06/01 → 2021/01/13
Project: Dissertation
Håkan Axelson (Organiser), Fredrik Liedberg (Organiser), Olof Ståhl (Invited speaker), Louise Gamming (Invited speaker), Anna Johnsson (Invited speaker), Patrik Göransson (Invited speaker), Victoria Reimers (Invited speaker), Marie Stenmark Askmalm (Invited speaker), Martin Sjöström (Invited speaker) & Francisco Gatto (Invited speaker)
Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
Håkan Axelson (Organiser), Fredrik Liedberg (Organiser), Björn Båtshake (Invited speaker), Arni Saemundsson (Invited speaker), Johan Abrahamsson (Speaker), Fredrik Liedberg (Speaker), Göran B Jönsson (Speaker), Sarah Schoch (Speaker), Pontus Eriksson (Speaker) & Viktor Sincic (Speaker)
Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
Håkan Axelson (Organiser), Fredrik Liedberg (Organiser), Mark A. Rubin (Invited speaker) & Eli Van Allen (Invited speaker)
Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
Håkan Axelson (Organiser), Fredrik Liedberg (Role not specified), Anders Edsjö (Invited speaker), Anders Bjartell (Speaker) & Fredrik Liedberg (Role not specified)
Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
Håkan Axelson (Organiser), Fredrik Liedberg (Organiser) & Guido Jenster (Invited speaker)
Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
Kristian Pietras (Manager) & Håkan Axelson (Manager)
Division of Translational Cancer ResearchInfrastructure