Research output per year
Research output per year
Personal profile
Research
We are interested in how aging and neurodegenerative diseases affect the brain, neural cells and neural stem cells. Using novel stem cell, reprogramming and genome editing technologies we are studying how genetic pathways involved in aging and neurodegenerative disease affect formation and function of neural cells. We also have a strong interest in basic stem cell biology with a clear focus on neural stem cells and neurogenesis in the adult and aging brain.
Therefore, our aims are to develop cellular models of human neuronal aging and degeneration, to investigate underlying mechanisms responsible for dysfunction in neurons and neural stem cells in the aging and diseased brain and to dissect the regulation of normal neurogenesis.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
UKÄ subject classification
- Medical and Health Sciences
Free keywords
- Stem Cells
- Aging
- Neurodegneration
- Reprogramming
- Neural Stem Cells
- Neurogenesis
- Dementia
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Aberrant neurodevelopment in human iPS cell-derived models of Alexander disease
Matusova, Z., Dykstra, W., de Pablo, Y., Zetterdahl, O. G., Canals, I., van Gelder, C. A. G. H., Vos, H. R., Pérez-Sala, D., Kubista, M., Abaffy, P., Ahlenius, H., Valihrach, L., Hol, E. M. & Pekny, M., 2024, (E-pub ahead of print) In: GLIA.Research output: Contribution to journal › Article › peer-review
Open Access -
Single-cell RNA sequencing of aging neural progenitors reveals loss of excitatory neuron potential and a population with transcriptional immune response
Fritze, J., Lang, S., Sommarin, M., Soneji, S. & Ahlenius, H., 2024, In: Frontiers in Neuroscience. 18, 1400963.Research output: Contribution to journal › Article › peer-review
Open Access -
Transcription Factor-Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth In Vitro and In Vivo
Trovato, F., Stefani, F. R., Li, J., Zetterdahl, O. G., Canals, I., Ahlenius, H. & Bengzon, J., 2023 Feb 1, In: Molecular Cancer Therapeutics. 22, 2, p. 274-286Research output: Contribution to journal › Article › peer-review
Open Access -
Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant fluoxetine
Gioia, R., Seri, T., Diamanti, T., Fimmanò, S., Vitale, M., Ahlenius, H., Kokaia, Z., Tirone, F., Micheli, L., Biagioni, S., Lupo, G., Rinaldi, A., De Jaco, A. & Cacci, E., 2023, In: Journal of Neurochemistry. 165, 3, p. 318-333Research output: Contribution to journal › Article › peer-review
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Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia
Canals, I., Comella-Bolla, A., Cepeda-Prado, E., Avaliani, N., Crowe, J. A., Oburoglu, L., Bruzelius, A., King, N., Pajares, M. A., Pérez-Sala, D., Heuer, A., Rylander Ottosson, D., Soriano, J. & Ahlenius, H., 2023, In: Brain Communications. 5, 3, p. 1-16 fcad158.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 6 Active
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Neural Cell Dysfunction in Aging and Neurodegeneration
Ahlenius, H. (Researcher)
2024/01/01 → 2027/12/31
Project: Research
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Modeller och behandling av cancer i hjärnan med hjälp av stamceller, omprogrammering och genteknik
Ahlenius, H. (Researcher)
2024/01/01 → 2027/12/31
Project: Research
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Cellular reprogramming: a novel treatment for glioblastoma
Ahlenius, H. (Researcher)
Familjen Erling-Perssons Stiftelse
2023/03/01 → 2025/12/31
Project: Research
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Direct Conversions of Alzheimer Patient Fibroblasts to Astrocytes and Neurons - Disease Mechanism, Drug Targets and Biomarkers
Ahlenius, H. (PI)
2022/12/01 → 2024/12/31
Project: Research
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Modelling early-onset neurological disorders using pluripotent stem cells and genome engineering
Zetterdahl, O. (Research student), Ahlenius, H. (Supervisor) & Canals, I. (Assistant supervisor)
2020/09/01 → …
Project: Dissertation
Activities
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UniStem Day 2024: Dissemination and outreach of stem cell science
Ottosson, D. (Organiser), Magnusson, M. (Organiser), Kidnapillai, S. (Organiser), Ahlenius, H. (Organiser), Luis, A. B. (Organiser), Martinez Curiel, R. (Organiser), Laurin, K. (Organiser), Martos Salvo, P. (Organiser), Das, M. (Contributor), Wendler, M. (Contributor), Sivani, B. M. (Contributor), Ramos Passarello, G. (Contributor), Sozzi, E. (Contributor), García Garrote, M. (Contributor), Harrison Umeano, C. (Contributor), Okeke, U. C. (Contributor), Horvath, V. (Contributor), Garza, R. (Contributor), Adami, A. (Contributor), Castilla-Vallmanya, L. (Contributor), Gerdes, P. (Contributor), Pandiloski, N. (Contributor), Jin, Q. (Contributor), de Guidi, C. (Contributor), Palma Tortosa, S. (Contributor), Fritze, J. (Contributor), Jansson, L. I. (Contributor), Robles Rodriguez, L. (Contributor), Pracucci, E. (Contributor), Shen, Y.-P. (Contributor), Trovato, F. (Contributor), Tampé, J. (Contributor), Thakore, R. (Contributor), Stamouli, C.-A. (Contributor), Pinto dos Santos Vaz, C. (Contributor), Aretio, C. (Contributor), Piochon, C. (Contributor), Cepeda-Prado, E. (Contributor), de Jongh, M.-M. (Contributor), Tsalkitzidou, M. (Contributor), Bonsberger, J. (Contributor), Douse, C. (Contributor), Dorazehi, F. (Contributor), Koutounidou, S. (Contributor), Jarl, U. (Contributor), Corsi, S. (Contributor), Bruzelius, A. (Contributor), Mattsson, B. (Contributor), Hammarberg, A. (Contributor), Habekost, M. (Contributor), Prabhala, P. (Contributor), Bremborg, T. (Contributor), Nair, M. S. (Contributor), Burdeyron, P. (Contributor), Mazariegos, M. (Contributor), Björklund, M. (Contributor), Hidalgo, I. (Contributor), Hägg, A. (Invited speaker), Hammarlund, E. (Invited speaker), Mohlin, S. (Invited speaker) & Oesterle, M. (Contributor)
2024 Mar 22Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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Unistem Day 2020
Karlsson, G. (Organiser), Karlsson, C. (Organiser), Pettersson, P. (Organiser), McKay, C. (Organiser), Ahlenius, H. (Organiser), Parmar, M. (Organiser), Magnusson, M. (Organiser), Warfvinge, R. (Organiser), Nolbrant, S. (Speaker), Johansson, P. (Contributor), Atacho, D. (Contributor), Shrigley, S. (Contributor), Jarl, U. (Contributor), Sparrenius, M. (Contributor), Mattsson, B. (Contributor), Hoban, D. (Contributor), Fiorenzano, A. (Contributor), Giacomoni, J. (Contributor), Nilsson, F. (Contributor), Sozzi, E. (Contributor), Hammarberg, A. (Contributor), Pircs, K. (Contributor), Bruzelius, A. (Contributor), Birtele, M. (Contributor), Kidnapillai, S. (Contributor), Cepeda-Prado, E. (Contributor), Mikulik, K. (Contributor), Garza, R. (Contributor) & Storm, P. (Contributor)
2020 Mar 6Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
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Segerfalk Minisymposium 2019:
Pettersson, P. (Organiser), Jakobsson, J. (Organiser), Ahlenius, H. (Organiser), Ottosson, D. (Chair), Pircs, K. (Presenter), Drouin-Ouellet, J. (Presenter) & Canals, I. (Presenter)
2019 May 8Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
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Supervision of PhD student: Fábio Fiúza Rosa
Pereira, C.-F. (First/primary/lead supervisor), Agace, W. (Second supervisor), Ramalho-Santos, J. (Second supervisor), Graf, T. (Commissioned member of Examining committee), Ahlenius, H. (Commissioned member of Examining committee), Järås, M. (Commissioned member of Examining committee), Almeida, L. (Commissioned member of Examining committee), Mano, M. (Commissioned member of Examining committee) & Roelsgaard Jakobsen, M. (Commissioned member of Examining committee)
2018 → 2021Activity: Examination and supervision › Supervision of PhD students
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Supervision of PhD student: Marcella Birtele
Parmar, M. (First/primary/lead supervisor), Ottosson, D. (Second supervisor), Jakobsson, J. (Joint second supervisor), Ahlenius, H. (Commissioned member of Examining committee) & Flygare, J. (Commissioned member of Examining committee)
2016 → 2020 Oct 2Activity: Examination and supervision › Supervision of PhD students
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