Research output per year
Research output per year
Personal profile
Research
We are interested in how aging and neurodegenerative diseases affect the brain, neural cells and neural stem cells. Using novel stem cell, reprogramming and genome editing technologies we are studying how genetic pathways involved in aging and neurodegenerative disease affect formation and function of neural cells. We also have a strong interest in basic stem cell biology with a clear focus on neural stem cells and neurogenesis in the adult and aging brain.
Therefore, our aims are to develop cellular models of human neuronal aging and degeneration, to investigate underlying mechanisms responsible for dysfunction in neurons and neural stem cells in the aging and diseased brain and to dissect the regulation of normal neurogenesis.
UKÄ subject classification
- Medical and Health Sciences
Free keywords
- Stem Cells
- Aging
- Neurodegneration
- Reprogramming
- Neural Stem Cells
- Neurogenesis
- Dementia
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia
Canals, I., Comella-Bolla, A., Cepeda-Prado, E., Avaliani, N., Crowe, J. A., Oburoglu, L., Bruzelius, A., King, N., Pajares, M. A., Pérez-Sala, D., Heuer, A., Rylander Ottosson, D., Soriano, J. & Ahlenius, H., 2023, In: Brain Communications. 5, 3, p. 1-16 fcad158.Research output: Contribution to journal › Article › peer-review
Open Access -
Transcription Factor-Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth In Vitro and In Vivo
Trovato, F., Stefani, F. R., Li, J., Zetterdahl, O. G., Canals, I., Ahlenius, H. & Bengzon, J., 2023 Feb 1, In: Molecular Cancer Therapeutics. 22, 2, p. 274-286Research output: Contribution to journal › Article › peer-review
Open Access -
Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant fluoxetine
Gioia, R., Seri, T., Diamanti, T., Fimmanò, S., Vitale, M., Ahlenius, H., Kokaia, Z., Tirone, F., Micheli, L., Biagioni, S., Lupo, G., Rinaldi, A., De Jaco, A. & Cacci, E., 2022, (E-pub ahead of print) In: Journal of Neurochemistry.Research output: Contribution to journal › Article › peer-review
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Past, Present, and Future of Direct Cell Reprogramming
Ahlenius, H., 2022 Oct 1, In: Cellular Reprogramming. 24, 5, p. 205-211 7 p.Research output: Contribution to journal › Article › peer-review
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Transcription factor-based direct conversion of human fibroblasts to functional astrocytes
Quist, E., Trovato, F., Avaliani, N., Zetterdahl, O. G., Gonzalez-Ramos, A., Hansen, M. G., Kokaia, M., Canals, I. & Ahlenius, H., 2022 Jul 12, In: Stem Cell Reports. 17, 7, p. 1620-1635 16 p.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 2 Active
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Modelling early-onset neurological disorders using pluripotent stem cells and genome engineering
Zetterdahl, O., Ahlenius, H. & Canals, I.
2020/09/01 → …
Project: Dissertation
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Dissecting the role of Astrocytes in Leukodystrophies using Stem Cells, Reprogramming and Genome Engineering
Quist, E. & Ahlenius, H.
2017/09/01 → …
Project: Dissertation
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Unistem Day 2020
Göran Karlsson (Organiser), Christine Karlsson (Organiser), Paulina Pettersson (Organiser), Claire McKay (Organiser), Henrik Ahlenius (Organiser), Malin Parmar (Organiser), Mattias Magnusson (Organiser), Rebecca Warfvinge (Organiser), Sara Nolbrant (Speaker), Pia Johansson (Contributor), Diahann Atacho (Contributor), Shelby Shrigley (Contributor), Ulla Jarl (Contributor), Michael Sparrenius (Contributor), Bengt Mattsson (Contributor), Deirdre Hoban (Contributor), Alessandro Fiorenzano (Contributor), Jessica Giacomoni (Contributor), Fredrik Nilsson (Contributor), Edoardo Sozzi (Contributor), Anna Hammarberg (Contributor), Karolina Pircs (Contributor), Andreas Bruzelius (Contributor), Marcella Birtele (Contributor), Shayini Kidnapillai (Contributor), Efrain Cepeda-Prado (Contributor), Katharina Mikulik (Contributor), Raquel Garza (Contributor) & Petter Storm (Contributor)
2020 Mar 6Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
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Segerfalk Minisymposium 2019:
Paulina Pettersson (Organiser), Johan Jakobsson (Organiser), Henrik Ahlenius (Organiser), Daniella Ottosson (Chair), Karolina Pircs (Presenter), Janelle Drouin-Ouellet (Presenter) & Isaac Canals (Presenter)
2019 May 8Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
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Supervision of PhD student: Fábio Fiúza Rosa
Carlos-Filipe Pereira (First/primary/lead supervisor), William Agace (Second supervisor), João Ramalho-Santos (Second supervisor), Thomas Graf (Commissioned member of Examining committee), Henrik Ahlenius (Commissioned member of Examining committee), Marcus Järås (Commissioned member of Examining committee), Luis Almeida (Commissioned member of Examining committee), Miguel Mano (Commissioned member of Examining committee) & Martin Roelsgaard Jakobsen (Commissioned member of Examining committee)
2018 → 2021Activity: Examination and supervision › Supervision of PhD students
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Supervision of PhD student: Marcella Birtele
Malin Parmar (First/primary/lead supervisor), Daniella Ottosson (Second supervisor), Johan Jakobsson (Joint second supervisor), Henrik Ahlenius (Commissioned member of Examining committee) & Johan Flygare (Commissioned member of Examining committee)
2016 → 2020 Oct 2Activity: Examination and supervision › Supervision of PhD students
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Exploring the miRNA profile of medium spiny neurons using retrograde transport in rats
Cecilia Lundberg (First/primary/lead supervisor), Johan Jakobsson (Second supervisor), Henrik Ahlenius (Commissioned member of Examining committee) & Ulrica Englund Johansson (Commissioned member of Examining committee)
2015 → 2021 Jun 4Activity: Examination and supervision › Supervision of PhD students
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Infrastructure
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The Human Embryonic Stem Cell / Induced Pluripotent Stem Cell and CRISPR Gene Editing Core Facility
Niels-Bjarne Woods (Manager) & Qianren Jin (Manager)
StemTherapy: National Initiative on Stem Cells for Regenerative TherapyInfrastructure