Research output per year
Research output per year
Personal profile
Research
My research revolves around ADP-ribosyltransferases, which cleave NAD+ to link ADP-ribose to their targets - proteins or nucleic acids. This flags target proteins for specific activities in our cells. A number of human enzymes, the PARP enzymes, catalyze this reaction. PARP enzymes are drug targets: Drugs that inhibit PARP activity are already in use today in treatment of certain forms of cancer. We want to understand enzymatic mechanisms and improve the fit of PARP inhibitors to their enzymatic pockets. This will lead to more potent, more selective drugs in the future. Many bacterial toxins, produced by pathogenic bacteria, have the same activity. We strive to contribute to a better understanding of these toxins and to create inhibitors also for their activities, with the aim of creating new anti-infective drugs.
PhD students
Constantinos Chatzicharalampous
BSc/MSc students
Herman Sjölin
Ikechukwu Casmir
Ljubomir Grcic
Alumni
Archimede Torretta (postdoc)
Angelica Nash (BSc)
Anton Hansson (BSc)
Antonio Ginés Garcia Saura (postdoc)
Elin Olsson (BSc)
Hannah Olsson (BSc)
Mathieu Long (postdoc)
Moa Rundberg (BSc)
Noah Björklöf Dolan (BSc)
Virginia Cristobal Martin (BSc)
Teaching
KEMA03/KEMA13 - Biochemistry, basic course (course responsibility)
MOBA02 - Chemistry of the cell (course responsibility)
KEMC03 - Experimental protein chemistry (lecturer)
KEML10, KEMR30 - Project work on Bachelor and Masters level
Societal impact
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
UKÄ subject classification
- Biochemistry and Molecular Biology
- Structural Biology
- Biophysics
- Medicinal Chemistry
Free keywords
- ADP-ribosylation
- bacterial toxins
- drug development
- enzyme mechanism
- protein structure
- protein complexes
Fingerprint
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Symmetry of loop extrusion by dimeric SMC complexes is DNA-tension-dependent
Pradhan, B., Pinto, A., Kanno, T., Tetiker, D., Baaske, M. D., Cutt, E., Chatzicharlampous, C., Schüler, H., Deep, A., Corbett, K. D., Aragon, L., Virnau, P., Björkegren, C. & Kim, E., 2024 Sept 12, bioRxiv, 26 p. (bioRxiv : the preprint server for biology).Research output: Working paper/Preprint › Preprint (in preprint archive)
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A multidomain PARP14 construct suitable for bacterial expression
Chatzicharalampous, C. & Schüler, H., 2024 Aug 19, In: Protein Expression and Purification. 224, 8 p., 106580.Research output: Contribution to journal › Article › peer-review
Open Access -
PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype
Sturniolo, I., Váróczy, C., Regdon, Z., Mázló, A., Muzsai, S., Bácsi, A., Intili, G., Hegedűs, C., Boothby, M. R., Holechek, J., Ferraris, D., Schüler, H. & Virág, L., 2024 Apr, In: International Journal of Molecular Sciences. 25, 7, 3601.Research output: Contribution to journal › Article › peer-review
Open Access -
PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities
Đukić, N., Strømland, Ø., Elsborg, J. D., Munnur, D., Zhu, K., Schuller, M., Chatrin, C., Kar, P., Duma, L., Suyari, O., Rack, J. G. M., Baretić, D., Crudgington, D. R. K., Groslambert, J., Fowler, G., Wijngaarden, S., Prokhorova, E., Rehwinkel, J., Schüler, H. & Filippov, D. V. & 5 others, , 2023 Sept 15, In: Science Advances. 9, 37, 18 p.Research output: Contribution to journal › Article › peer-review
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PARP14 is a writer, reader, and eraser of mono-ADP-ribosylation
Torretta, A., Chatzicharalampous, C., Ebenwaldner, C. & Schüler, H., 2023 Jul 26, In: The Journal of biological chemistry. 299, 9, 105096.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 3 Active
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Decoding the regulation of PARP14, a signaling hub in cancer, inflammation, and infection
Schüler, H. (PI)
2024/01/01 → 2027/12/31
Project: Research
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Structure-function relationship in ADP-ribosyl transferases
Chatzicharalampous, C. (Researcher) & Schüler, H. (Supervisor)
2023/09/01 → …
Project: Dissertation
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Decoding bacterial toxin-antitoxin systems: from high-throughput discovery to molecular mechanism and biotechnology
Atkinson, G. (PI), Hauryliuk, V. (Researcher) & Schüler, H. (Researcher)
Knut and Alice Wallenberg Foundation
2021/07/01 → 2026/06/30
Project: Research