Hindrik Mulder

Search results

• 2022

  Elucidating the role of TFB1Mgenetic variants in diabetogenic mechanisms using genome-edited stem cell models

  Roberts, F., Hladkou, S., Singh, T., Prasad, R., Fex, M. & Mulder, H., 2022, In: Diabetologia. 65, Suppl 1, p. S93 178.

  Research output: Contribution to journal › Published meeting abstract › peer-review
• 2021

  CRISPR editing of the PPARGC1A Gly482ser (rs8192678) polymorphism in human white adipose cells shows differential effects on mitochondrial function and adipogenesis.

  Huang, M., Claussnitzer, M., Saadat, A., Mulder, H., Kalamajski, S. & Franks, P., 2021, In: Diabetologia. 64, Suppl 1, p. S159 306.

  Research output: Contribution to journal › Published meeting abstract › peer-review

  • CRISPR 100%
  • PPARGC1A 100%
  • Allele 75%
  • CRISPR/Cas9 25%
  • Luciferase 25%

• Novel miR-29 mitochondrial-associated gene pathways predicted to regulate beta cell insulin secretion

  Cowan, E., Sun, J., Ofori, J., Luan, C., Zhang, E., Ling, C., Mulder, H. & Eliasson, L., 2021, In: Diabetologia. 64 , Suppl 1, 323.

  Research output: Contribution to journal › Published meeting abstract › peer-review
• 2020

  Nudix Hydrolase 2 (NUDT2) is critical for physiological glucose stimulated insulin secretion from INS (832/13) beta cells

  Cowan, E., Kalamajski, S., Jain, R., Spégel, P., Mulder, H. & Fex, M., 2020 Aug 25, In: Diabetologia. 63, Suppl 1, 389.

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Lack of melatonin type 1 receptor results in dysregulated alpha cell function and metabolism

  Lyons, C., Hamilton, A., Grajales, D., Shcherbina, L., Lindqvist, A., Cowan, E., Wierup, N., Mulder, H. & Fex, M., 2020, In: Diabetologia. 63, Suppl 1, p. S231

  Research output: Contribution to journal › Published meeting abstract › peer-review
• 2019

  Lack of melatonin type 1A receptor results in dysregulated whole-body metabolism characterised by hyperglucagonaemia, glucose intolerance and enhanced insulin secretion

  Lyons, C. L., Grajales, D., Hamilton, A., Mulder, H. & Fex, M., 2019, In: Diabetologia. 62, Suppl 1, p. S267

  Research output: Contribution to journal › Published meeting abstract › peer-review
• 2018

  Loss of melatonin receptor 1 in mouse pancreatic islets results in dysregulated glucagon secretion in vitro

  Lyons, C. L., Cowan, E., Abellan, D. G., Nagorny, C. L. F., Mulder, H. & Fex, M., 2018, In: Diabetologia. 61, Suppl 1, p. S244 499.

  Research output: Contribution to journal › Published meeting abstract › peer-review
• 2010

  A lipotoxicity model in the INS-1 832/13 beta cell line and the epigenetic alterations induced by it

  Malmgren, S., Sharoyko, V., Nicholls, D., Nagorny, C., Spégel, P., Dekker Nitert, M., Mulder, H. & Ling, C., 2010, In: Diabetologia. 53, Suppl. 1, p. 348

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Growth arrest specific protein 6 (gas6) and its receptors expression and signalling in beta cells

  Sharoyko, V., Köck, T., Ekman, C., Wierup, N., Sundler, F., Dahlbäck, B. & Mulder, H., 2010, In: Diabetologia. 53, Suppl. 1, p. 530

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Melatonin effects on insulin secretion and clock genes expression

  Stamenkovic, J., Nagorny, C., Ling, C., Salehi, S. A., Sharoyko, V. & Mulder, H., 2010, In: Diabetologia. 53, Suppl. 1, p. 93

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Oxidative phosphorylation-dependent insulin secretion in pancreatic beta cells: new insights by disrupting TFB1M

  Köck, T., Spégel, P., Sharoyko, V., Ling, C. & Mulder, H., 2010, In: Diabetologia. 53, Suppl. 1, p. 491

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Pancreatic islets of melatonin receptor knock-out mice

  Nagorny, C., Voss, U., Bennet, H., Stamenkovic, J., Sathanoori, R., Fex, M., Wierup, N. & Mulder, H., 2010, In: Diabetologia. 53, Suppl. 1, p. 294

  Research output: Contribution to journal › Published meeting abstract › peer-review

• The membrane potential response is altered in pancreatic beta cells chronically exposed to high glucose

  Göhring, I., Köck, T., Mulder, H. & Nicholls, D., 2010, In: Diabetologia. 53, Suppl. 1, p. 554

  Research output: Contribution to journal › Published meeting abstract › peer-review
• 2009

  Differences in metabolic regulation between glucose responsive INS-1 832/13 and its glucose non-responsive INS-1 832/2 sister clonal rat beta cell line decides their beta cell functionality

  Malmgren, S., Sharoyko, V., Nicholls, D. & Mulder, H., 2009, In: Diabetologia. 52, Suppl 1, p. 454

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Disruption of TFB1M impairs insulin secretion in beta cells

  Köck, T., Dekker Nitert, M., Olsson, A., Kotova, O., Stamenkovic, J., Lyssenko, V., Groop, L., Luthman, H., Ling, C. & Mulder, H., 2009, In: Diabetologia. 52, Suppl 1, p. 116

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Hyperthyroidism decreases islet pyruvate dehydrogenase kinase 1 (PDHK1) expression and attenuates islet starvation adaptations

  Holness, M. J., Mulder, H., Kotova, O., Krus, U., Greenwood, G. K. & Sugden, M. C., 2009, In: Diabetologia. 52, Suppl 1, p. 453

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Melatonin receptor signalling is involved in insulin secretion in the INS-1 832/13 beta cell line

  Nagorny, C. & Mulder, H., 2009, In: Diabetologia. 52, Suppl. 1, p. 401

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Metabolite profiling of clonal (832/13) beta cells after glucose stimulation

  Spégel, P., Danielsson, A., Nagorny, C. & Mulder, H., 2009, In: Diabetologia. 52, Suppl 1, p. 117

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Protein GAS6 and its receptor Axl are expressed and operate in pancreatic beta cells

  Sharoyko, V., Ekman, C., Wierup, N., Sundler, F., Dahlbäck, B. & Mulder, H., 2009, In: Diabetologia. 52, Suppl 1, p. 448

  Research output: Contribution to journal › Published meeting abstract › peer-review
• 2008

  A metabolic comparison of glucose-responsive INS-1 832/13 and glucose-nonresponsive INS-1 832/2 cells

  Sharoyko, V., Bacos, K., Abhyankar, A., Nagorny, C., Mulder, H. & Luthman, H., 2008, In: Diabetologia. 51, S1, p. S203-S204

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Pyruvate dehydrogenase kinase I knock down in INS-1 832/13 Cells enhances insulin secretion and the cellular NADPH/NADP(+) ratio

  Kotova, O., Krus, U., Sugden, M. C. & Mulder, H., 2008, In: Diabetologia. 51, S1, p. S201-S201

  Research output: Contribution to journal › Published meeting abstract › peer-review