Research output per year
Research output per year
Research output
- 1 - 50 out of 112 results
Search results
-
2024
MicroRNA 29 modulates β-cell mitochondrial metabolism and insulin secretion via underlying miR-29-OXPHOS complex pathways
Cowan, E., Sun, J., Hamilton, A., Ruhrmann, S., Karagiannopoulos, A., Westholm, E., Ofori, J. K., Luan, C., Zhang, E., Mulder, H. & Eliasson, L., 2024 Aug, In: Acta Physiologica. 240, 8, e14180.Research output: Contribution to journal › Article › peer-review
Open Access -
Human Genetic Variation at rs10071329 Correlates with Adiposity-related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function
Huang, M., Prasad, R. B., Coral, D. E., Hjort, L., Minja, D. T. R., Mulder, H., Franks, P. W. & Kalamajski, S., 2024, In: Diabetes. 73, 4, p. 637-645Research output: Contribution to journal › Article › peer-review
-
2023
Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes
Rönn, T., Ofori, J. K., Perfilyev, A., Hamilton, A., Pircs, K., Eichelmann, F., Garcia-Calzon, S., Karagiannopoulos, A., Stenlund, H., Wendt, A., Volkov, P., Schulze, M. B., Mulder, H., Eliasson, L., Ruhrmann, S., Bacos, K. & Ling, C., 2023 Dec, In: Nature Communications. 14, 1, 8040.Research output: Contribution to journal › Article › peer-review
Open Access -
EndoC-βH5 cells are storable and ready-to-use human pancreatic beta cells with physiological insulin secretion
Blanchi, B., Taurand, M., Colace, C., Thomaidou, S., Audeoud, C., Fantuzzi, F., Sawatani, T., Gheibi, S., Sabadell-Basallote, J., Boot, F. W. J., Chantier, T., Piet, A., Cavanihac, C., Pilette, M., Balguerie, A., Olleik, H., Carlotti, F., Ejarque, M., Fex, M. & Mulder, H. & 8 others, , 2023 Oct, In: Molecular Metabolism. 76, 101772.Research output: Contribution to journal › Article › peer-review
Open Access -
Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes
Gheibi, S., Cataldo, L. R., Hamilton, A., Huang, M., Kalamajski, S., Fex, M. & Mulder, H., 2023 Apr 1, In: Diabetes. 72, 4, p. 455-466 12 p.Research output: Contribution to journal › Article › peer-review
-
Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function
Huang, M., Coral, D., Ardalani, H., Spégel, P., Saadat, A., Claussnitzer, M., Mulder, H., Franks, P. W. & Kalamajski, S., 2023 Mar 6, In: eLife. 12:e84168.Research output: Contribution to journal › Article › peer-review
Open Access -
Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets
Bacos, K., Perfilyev, A., Karagiannopoulos, A., Cowan, E., Ofori, J. K., Bertonnier-Brouty, L., Rönn, T., Lindqvist, A., Luan, C., Ruhrmann, S., Ngara, M., Nilsson, Å., Gheibi, S., Lyons, C. L., Lagerstedt, J. O., Barghouth, M., Esguerra, J. L., Volkov, P., Fex, M. & Mulder, H. & 7 others, , 2023, In: The Journal of clinical investigation. 133, 4, e163612.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Genetic regulation of RNA splicing in human pancreatic islets
Atla, G., Bonàs-Guarch, S., Cuenca-Ardura, M., Beucher, A., Crouch, D. J. M., Garcia-Hurtado, J., Moran, I., Consortium, T. T., Irimia, M., Prasad, R. B., Gloyn, A. L., Marselli, L., Berney, T., de Koning, E. J. P., Kerr-Conte, J., Pattou, F., Todd, J. A., Piemonti, L., Ferrer, J. & Eliasson, L. (Contributor) & 3 others, , 2022, In: Genome Biology. 23, p. 1-28 196 .Research output: Contribution to journal › Article › peer-review
Open Access -
Genomic editing of metformin efficacy-associated genetic variants in SLC47A1 does not alter SLC47A1 expression
Kalamajski, S., Huang, M., Dalla-Riva, J., Keller, M., Dawed, A. Y., Hansson, O., Pearson, E. R., Mulder, H., Franks, P. W. & MetGen Plus Consortium, 2022, In: Human Molecular Genetics. 31, 4, p. 491-498Research output: Contribution to journal › Article › peer-review
Open Access -
Islet Gene View-a tool to facilitate islet research
Asplund, O., Storm, P., Chandra, V., Hatem, G., Ottosson-Laakso, E., Mansour-Aly, D., Krus, U., Ibrahim, H., Ahlqvist, E., Tuomi, T., Renström, E., Korsgren, O., Wierup, N., Ibberson, M., Solimena, M., Marchetti, P., Wollheim, C., Artner, I., Mulder, H. & Hansson, O. & 3 others, , 2022, In: Life Science Alliance. 5, 12, e202201376.Research output: Contribution to journal › Article › peer-review
Open Access -
Ribosomal biogenesis regulator DIMT1 controls β-cell protein synthesis, mitochondrial function, and insulin secretion
Verma, G., Bowen, A., Gheibi, S., Hamilton, A., Muthukumar, S., Cataldo, L. R., Asplund, O., Esguerra, J., Karagiannopoulos, A., Lyons, C., Cowan, E., Bellodi, C., Prasad, R., Fex, M. & Mulder, H., 2022, In: The Journal of biological chemistry. 298, 3, 101692.Research output: Contribution to journal › Article › peer-review
Open Access -
The human batokine EPDR1 regulates β-cell metabolism and function
Cataldo, L. R., Gao, Q., Argemi-Muntadas, L., Hodek, O., Cowan, E., Hladkou, S., Gheibi, S., Spégel, P., Prasad, R. B., Eliasson, L., Scheele, C., Fex, M., Mulder, H. & Moritz, T., 2022, In: Molecular Metabolism. 66, 101629.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion
Vishnu, N., Hamilton, A., Bagge, A., Wernersson, A., Cowan, E., Barnard, H., Sancak, Y., Kamer, K. J., Spégel, P., Fex, M., Tengholm, A., Mootha, V. K., Nicholls, D. G. & Mulder, H., 2021 Sept, In: Molecular Metabolism. 51, 101239.Research output: Contribution to journal › Article › peer-review
Open Access -
The MafA-target gene PPP1R1A regulates GLP1R-mediated amplification of glucose-stimulated insulin secretion in β-cells
Cataldo, L. R., Vishnu, N., Singh, T., Bertonnier-Brouty, L., Bsharat, S., Luan, C., Renström, E., Prasad, R. B., Fex, M., Mulder, H. & Artner, I., 2021 Feb 22, In: Metabolism: Clinical and Experimental. 154734.Research output: Contribution to journal › Article › peer-review
Open Access -
TIGER: The gene expression regulatory variation landscape of human pancreatic islets
Alonso, L., Piron, A., Morán, I., Guindo-Martínez, M., Bonàs-Guarch, S., Atla, G., Miguel-Escalada, I., Royo, R., Puiggròs, M., Garcia-Hurtado, X., Suleiman, M., Marselli, L., Esguerra, J. L. S., Turatsinze, J.-V., Torres, J. M., Nylander, V., Chen, J., Eliasson, L., Defrance, M. & Amela, R. & 10 others, , 2021, In: Cell Reports. 37, 2, 109807.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production
Knudsen, J. G., Hamilton, A., Ramracheya, R., Tarasov, A. I., Brereton, M., Haythorne, E., Chibalina, M. V., Spégel, P., Mulder, H., Zhang, Q., Ashcroft, F. M., Adam, J. & Rorsman, P., 2019, In: Cell Metabolism. 29, 2, p. 430-442.e4Research output: Contribution to journal › Article › peer-review
Open Access -
2018
The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization
Lindström, L., Li, T., Malycheva, D., Kancharla, A., Nilsson, H., Vishnu, N., Mulder, H., Johansson, M., Rosselló, C. A. & Alvarado-Kristensson, M., 2018 May 3, In: Communications Biology. 1, https://doi.org/10.1038/s42003-018-0037-3, 37.Research output: Contribution to journal › Article › peer-review
Open Access -
Novel subgroups of adult-onset diabetes and their association with outcomes: A data-driven cluster analysis of six variables
Ahlqvist, E., Storm, P., Käräjämäki, A., Martinell, M., Dorkhan, M., Carlsson, A., Vikman, P., Prasad, R. B., Aly, D. M., Almgren, P., Wessman, Y., Shaat, N., Spégel, P., Mulder, H., Lindholm, E., Melander, O., Hansson, O., Malmqvist, U., Lernmark, Å. & Lahti, K. & 4 others, , 2018 May, In: The Lancet Diabetes and Endocrinology. 6, 5, p. 361-369Research output: Contribution to journal › Article › peer-review
-
Glutamine-elicited secretion of glucagon-like peptide 1 is governed by an activated glutamate dehydrogenase
Andersson, L. E., Shcherbina, L., Al-Majdoub, M., Vishnu, N., Arroyo, C. B., Carrara, J. A., Wollheim, C. B., Fex, M., Mulder, H., Wierup, N. & Spégel, P., 2018 Mar 1, In: Diabetes. 67, 3, p. 372-384 13 p.Research output: Contribution to journal › Article › peer-review
-
The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets
Hall, E., Dekker Nitert, M., Volkov, P., Malmgren, S., Mulder, H., Bacos, K. & Ling, C., 2018, In: Molecular and Cellular Endocrinology. 472, p. 57-67Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes
Adam, J., Ramracheya, R., Chibalina, M. V., Ternette, N., Hamilton, A., Tarasov, A. I., Zhang, Q., Rebelato, E., Rorsman, N. J. G., Martín-del-Río, R., Lewis, A., Özkan, G., Do, H. W., Spégel, P., Saitoh, K., Kato, K., Igarashi, K., Kessler, B. M., Pugh, C. W. & Tamarit-Rodriguez, J. & 8 others, , 2017 Sept 26, In: Cell Reports. 20, 13, p. 3135-3148 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells
Nicholas, L. M., Valtat, B., Benavente, A. M., Andersson, L., Abels, M., Mollet, I., Jain, D., Eliasson, L., Wierup, N., Fex, M. & Mulder, H., 2017 Jul, In: Molecular Metabolism. 6, 7, p. 651-663 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes
Axelsson, A. S., Tubbs, E., Mecham, B., Chacko, S., Nenonen, H. A., Tang, Y., Fahey, J. W., Derry, J. M. J., Wollheim, C. B., Wierup, N., Haymond, M. W., Friend, S. H., Mulder, H. & Rosengren, A. H., 2017 Jun 14, In: Science Translational Medicine. 9, 394, 4477.Research output: Contribution to journal › Article › peer-review
-
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
Axelsson, A., Mahdi, T., Nenonen, H. A., Singh, T., Hänzelmann, S., Wendt, A., Bagge, A., Reinbothe, T. M., Millstein, J., Yang, X., Zhang, B., Gusmao, E. G., Shu, L., Szabat, M., Tang, Y., Wang, J., Salö, S., Eliasson, L., Artner, I. & Fex, M. & 9 others, , 2017 Jun 6, In: Nature Communications. 8, p. 15652Research output: Contribution to journal › Article › peer-review
Open Access -
NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells
Santos, L. R. B., Muller, C., de Souza, A. H., Takahashi, H. K., Spégel, P., Sweet, I. R., Chae, H., Mulder, H. & Jonas, J. C., 2017 Jun, In: Molecular Metabolism. 6, 6, p. 535-547 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Bioenergetic Impairment in Congenital Muscular Dystrophy Type 1A and Leigh Syndrome Muscle Cells
Fontes-Oliveira, C. C., Steinz, M., Schneiderat, P., Mulder, H. & Durbeej, M., 2017 Apr 3, In: Scientific Reports. 7, 45272.Research output: Contribution to journal › Article › peer-review
Open Access -
Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell
Ofori, J. K., Salunkhe, V. A., Bagge, A., Vishnu, N., Nagao, M., Mulder, H., Wollheim, C. B., Eliasson, L. & Esguerra, J. L. S., 2017 Mar 23, In: Scientific Reports. 7, 44986.Research output: Contribution to journal › Article › peer-review
Open Access -
HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells
Daneshpajooh, M., Bacos, K., Bysani, M., Bagge, A., Ottosson Laakso, E., Vikman, P., Eliasson, L., Mulder, H. & Ling, C., 2017 Jan, In: Diabetologia. 60, 1, p. 116–125Research output: Contribution to journal › Article › peer-review
Open Access -
Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss
Geidenstam, N., Magnusson, M., Danielsson, A. P. H., Gerszten, R. E., Wang, T. J., Reinius, L. E., Mulder, H., Melander, O. & Ridderstråle, M., 2017, In: International Journal of Endocrinology. 2017, 6490473.Research output: Contribution to journal › Article › peer-review
Open Access -
Cartilage oligomeric matrix protein promotes prostate cancer progression by enhancing invasion and disrupting intracellular calcium homeostasis
Englund, E., Canesin, G., Papadakos, K. S., Vishnu, N., Persson, E., Reitsma, B., Anand, A., Jacobsson, L., Helczynski, L., Mulder, H., Bjartell, A. & Blom, A. M., 2017, In: Oncotarget. 8, 58, p. 98298-98311 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2016
Metabolic coupling in pancreatic beta cells: lipolysis revisited
Mulder, H., 2016 Dec 1, In: Diabetologia. 59, 12, p. 2510–2513 4 p.Research output: Contribution to journal › Article › peer-review
-
Discriminative prediction of A-To-I RNA editing events from DNA sequence
Sun, J., De Marinis, Y., Osmark, P., Singh, P., Bagge, A., Valtat, B., Vikman, P., Spégel, P. & Mulder, H., 2016 Oct 1, In: PLoS ONE. 11, 10, e0164962.Research output: Contribution to journal › Article › peer-review
Open Access -
Precise expression of Fis1 is important for glucose responsiveness of beta cells
Schultz, J., Waterstradt, R., Kantowski, T., Rickmann, A., Reinhardt, F., Sharoyko, V., Mulder, H., Tiedge, M. & Baltrusch, S., 2016 Jul, In: Journal of Endocrinology. 230, 1, p. 81-91 11 p.Research output: Contribution to journal › Article › peer-review
-
Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes
Tuomi, T., Nagorny, C. L. F., Singh, P., Bennet, H., Yu, Q., Alenkvist, I., Isomaa, B., Östman, B., Söderström, J., Pesonen, A. K., Martikainen, S., Räikkönen, K., Forsén, T., Hakaste, L., Almgren, P., Storm, P., Asplund, O., Shcherbina, L., Fex, M. & Fadista, J. & 4 others, , 2016 Jun 14, In: Cell Metabolism. 23, 6, p. 1067-1077 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile359 Downloads (Pure) -
Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer
Englund, E., Bartoschek, M., Reitsma, B., Jacobsson, L., Escudero-Esparza, A., Orimo, A., Leandersson, K., Hagerling, C., Aspberg, A., Storm, P., Okroj, M., Mulder, H., Jirström, K., Pietras, K. & Blom, A. M., 2016, In: Oncogene. 35, 43, p. 5585-5596 12 p.Research output: Contribution to journal › Article › peer-review
-
2015
The Human Diabetes Proteome Project (HDPP): The 2014 update
Schvartz, D., Bergsten, P., Baek, K. H., De La Rosa, A. B., Cantley, J., Dayon, L., Finamore, F., Fontana, P., Gaudet, P., Goo, Y. A., Moulder, R., Goodlett, D. R., Johnson, J. D., Konvalinka, A., Mulder, H., Priego-Capote, F., Sechi, S., Snyder, K. M., Tiss, A. & Wiederkehr, A. & 3 others, , 2015 Dec 1, In: Translational Proteomics. 8-9, p. 1-7 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Calcium Modulation of Exocytosis-Linked Plasma Membrane Potential Oscillations in INS-1 832/13 Cells.
Gerencser, A. A., Mulder, H. & Nicholls, D. G., 2015, In: Biochemical Journal. 471, 1, p. 111-122Research output: Contribution to journal › Article › peer-review
-
Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line.
Andersson, L., Valtat, B., Bagge, A., Sharoyko, V., Nicholls, D., Ravassard, P., Scharfmann, R., Spégel, P. & Mulder, H., 2015, In: PLoS ONE. 10, 3, e0120879.Research output: Contribution to journal › Article › peer-review
Open AccessFile279 Downloads (Pure) -
Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion
Stamenkovic, J., Andersson, L., Adriaenssens, A. E., Bagge, A., Sharoyko, V., Gribble, F., Reimann, F., Wollheim, C., Mulder, H. & Spégel, P., 2015, In: Biochemical Journal. 468, p. 49-63Research output: Contribution to journal › Article › peer-review
-
Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate.
Nilsson, H., Lindgren, D., Mandahl Forsberg, A., Mulder, H., Axelson, H. & Johansson, M., 2015, In: Cell Death & Disease. 6, e1585.Research output: Contribution to journal › Article › peer-review
Open AccessFile448 Downloads (Pure) -
Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study.
Renström, F., Koivula, R., V Varga, T., Hallmans, G., Mulder, H., Florez, J. C., Hu, F. B. & Franks, P., 2015, In: Diabetologia. 58, 5, p. 997-1005Research output: Contribution to journal › Article › peer-review
-
Unique and Shared Metabolic Regulation in Clonal β-cells and Primary Islets Derived from Rat Revealed by Metabolomics Analysis.
Spégel, P., Andersson, L., Storm, P., Sharoyko, V., Göhring, I., Rosengren, A. & Mulder, H., 2015, In: Endocrinology. 156, 6, p. 1995-2005Research output: Contribution to journal › Article › peer-review
-
2014
Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells.
Göhring, I., Sharoyko, V., Malmgren, S., Andersson, L., Spégel, P., Nicholls, D. & Mulder, H., 2014, In: Journal of Biological Chemistry. 289, 6, p. 3786-3798Research output: Contribution to journal › Article › peer-review
-
Gastric bypass improves ss-cell function and increases β-cell mass in a porcine model.
Lindqvist, A., Spégel, P., Ekelund, M., Garcia Vaz, E., Pierzynowski, S., Gomez, M., Mulder, H., Hedenbro, J., Groop, L. & Wierup, N., 2014, In: Diabetes. 63, 5, p. 1665-1671Research output: Contribution to journal › Article › peer-review
File444 Downloads (Pure) -
Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist.
Tang, Y., Axelsson, A., Spégel, P., Andersson, L., Mulder, H., Groop, L., Renström, E. & Rosengren, A., 2014, In: Science Translational Medicine. 6, 257, p. 257ra139Research output: Contribution to journal › Article › peer-review
-
Glucagon-Like Peptide 1 Stimulates Insulin Secretion via Inhibiting RhoA/ROCK Signaling and Disassembling Glucotoxicity-Induced Stress Fibers
Kong, X., Yan, D., Sun, J., Wu, X., Mulder, H., Hua, X. & Ma, X., 2014, In: Endocrinology. 155, 12, p. 4676-4685Research output: Contribution to journal › Article › peer-review
File263 Downloads (Pure) -
Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.
Sharoyko, V., Abels, M., Sun, J., Nicholas, L., Mollet, I., Stamenkovic, J., Göhring, I., Malmgren, S., Storm, P., Fadista, J., Spégel, P., Metodiev, M. D., Larsson, N.-G., Eliasson, L., Wierup, N. & Mulder, H., 2014, In: Human Molecular Genetics. 23, 21, p. 5733-5749Research output: Contribution to journal › Article › peer-review
-
Metabolite profile deviations in an oral glucose tolerance test-A comparison between lean and obese individuals.
Geidenstam, N., Spégel, P., Mulder, H., Filipsson, K., Ridderstråle, M. & Danielsson, A., 2014, In: Obesity. 22, 11, p. 2388-2395Research output: Contribution to journal › Article › peer-review
-
2013
Coordinate changes in histone modifications, mRNA levels and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity.
Malmgren, S., Spégel, P., Danielsson, A., Nagorny, C., Andersson, L., Dekker Nitert, M., Ridderstråle, M., Mulder, H. & Ling, C., 2013, In: Journal of Biological Chemistry. 288, 17, p. 11973-11987Research output: Contribution to journal › Article › peer-review
-
Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans
Lindqvist, A., Ekelund, M., Mulder, H., Spégel, P., Groop, L., Hedenbro, J. & Wierup, N., 2013, In: Journal of Clinical Endocrinology and Metabolism. 98, 5, p. E856-E861Research output: Contribution to journal › Article
File214 Downloads (Pure)