Ingrid Hedenfalk

Ingrid Hedenfalk

Professor, Associate professor

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Personal profile


Breast and ovarian cancers share many features, including genetic predisposition caused by mutations in BRCA1/2. Epithelial ovarian cancer is heterogeneous and associated with poor survival relative to breast cancer. Utilizing comprehensive biobanks, genomics methods and in vitro model systems we aim to improve our understanding of tumour evolution, heterogeneity and therapy response. Events underlying malignant transformation are poorly characterised in ovarian cancer, but accumulating evidence suggests that a majority of ovarian cancers arise in the Fallopian tube epithelium.

We aim to increase our understanding of the origin and early genomic events leading to the development of epithelial ovarian cancer. The heterogeneity of the disease requires improved knowledge of key processes involved in tumour initiation, development and maintenance for translation into truly personalised treatment. Identification of novel therapeutic targets, stratified by histological as well as mutational and transcriptional phenotypes, should transform survival prospects. Our goal is to elucidate the molecular context and mechanisms by which aberrantly regulated genes contribute to breast and ovarian tumorigenesis.

Improved knowledge ofthe molecular landscapes of these heterogeneous malignancies in the primary as well as metastatic setting may lead to the development of next generation biomarkers and biologically informed treatment strategies.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

UKÄ subject classification

  • Cancer and Oncology
  • Biomedical Laboratory Science/Technology
  • Cell and Molecular Biology

Free keywords

  • HRD
  • cancer stem cells
  • PARP
  • breast cancer
  • ovarian cancer
  • gene expression
  • sequencing
  • BRCA1/2


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Collaborations and top research areas from the last five years

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