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Personal profile


The focus of my research is exploring neurodevelopmental disorders in human brain tissue models. My current focus is to develop an in vitro human brain model of Gauchers disease, the most common form of lysosomal storage disorder. Using organoid technologies I can develop specific brain regions from patient stem cells to investigate disease progression over time. Using expertise in CRISPR editing and functional imaging, we hope to identify abberant lysosomal flux and calcium activity in neuronal and glial cells that may lead to neurodegeneration. Our ultimate goal in the project is to identify novel therapeutic avenues.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

UKÄ subject classification

  • Cell Biology
  • Genetics
  • Neurosciences
  • Cell and Molecular Biology
  • Medical Genetics

Free keywords

  • Organoids
  • Gaucher disease
  • iPSC
  • Calcium imaging
  • CRISPR-Cas9


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Collaborations and top research areas from the last five years

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