Research output per year
Research output per year
Personal profile
Research
The focus of my research is exploring neurodevelopmental disorders in human brain tissue models. My current focus is to develop an in vitro human brain model of Gauchers disease, the most common form of lysosomal storage disorder. Using organoid technologies I can develop specific brain regions from patient stem cells to investigate disease progression over time. Using expertise in CRISPR editing and functional imaging, we hope to identify abberant lysosomal flux and calcium activity in neuronal and glial cells that may lead to neurodegeneration. Our ultimate goal in the project is to identify novel therapeutic avenues.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
UKÄ subject classification
- Cell Biology
- Genetics
- Neurosciences
- Cell and Molecular Biology
- Medical Genetics
Free keywords
- Organoids
- Gaucher disease
- iPSC
- Calcium imaging
- CRISPR-Cas9
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Collaborations and top research areas from the last five years
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Research output
- 6 Article
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Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia
Canals, I., Comella-Bolla, A., Cepeda-Prado, E., Avaliani, N., Crowe, J. A., Oburoglu, L., Bruzelius, A., King, N., Pajares, M. A., Pérez-Sala, D., Heuer, A., Rylander Ottosson, D., Soriano, J. & Ahlenius, H., 2023, In: Brain Communications. 5, 3, p. 1-16 fcad158.Research output: Contribution to journal › Article › peer-review
Open Access -
The effect of citalopram treatment on amyloid-β precursor protein processing and oxidative stress in human hNSC-derived neurons
Elsworthy, R. J., Crowe, J. A., King, M. C., Dunleavy, C., Fisher, E., Ludlam, A., Parri, H. R., Hill, E. J. & Aldred, S., 2022 Dec, In: Translational Psychiatry. 12, 1, 285.Research output: Contribution to journal › Article › peer-review
Open Access -
Amyloid-β precursor protein processing and oxidative stress are altered in human iPSC-derived neuron and astrocyte co-cultures carrying presenillin-1 gene mutations following spontaneous differentiation
Elsworthy, R. J., King, M. C., Grainger, A., Fisher, E., Crowe, J. A., Alqattan, S., Ludlam, A., Hill, D. E. J. & Aldred, S., 2021 Jul, In: Molecular and Cellular Neuroscience. 114, 103631.Research output: Contribution to journal › Article › peer-review
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Application of Airy beam light sheet microscopy to examine early neurodevelopmental structures in 3D hiPSC-derived human cortical spheroids
Adhya, D., Chennell, G., Crowe, J. A., Valencia-Alarcón, E. P., Seyforth, J., Hosny, N. A., Yasvoina, M. V., Forster, R., Baron-Cohen, S., Vernon, A. C. & Srivastava, D. P., 2021 Jan 22, In: Molecular Autism. 12, 4.Research output: Contribution to journal › Article › peer-review
Open Access -
Development of two-photon polymerised scaffolds for optical interrogation and neurite guidance of human iPSC-derived cortical neuronal networks
Crowe, J. A., El-tamer, A., Nagel, D., Koroleva, A. V., Madrid-Wolff, J., Olarte, O. E., Sokolovsky, S., Estevez-priego, E., Ludl, A., Soriano, J., Loza-alvarez, P., Chichkov, B. N., Hill, E. J., Parri, H. R. & Rafailov, E. U., 2020, In: Lab on a Chip. 20, 10, p. 1792-1806Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 1 Active