Research output per year
Research output per year
- 30 results
Search results
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2023
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution
Rastegar, B., Andersson, N., Petersson, A., Karlsson, J., Chattopadhyay, S., Valind, A., Jansson, C., Durand, G., Romerius, P., Jirström, K., Holmquist Mengelbier, L. & Gisselsson, D., 2023 Jul 14, In: Clinical Cancer Research. 29, 14, p. 2668-2677Research output: Contribution to journal › Article › peer-review
Open Access -
Inactivation of RB1, CDKN2A and TP53 have distinct effects on genomic stability at side-by-side comparison in karyotypically normal cells
Andersson, N., Saba, K., Magnusson, L., Nilsson, J., Karlsson, J., Hansén Nord, K. & Gisselsson Nord, D., 2023, In: Genes, Chromosomes and Cancer. 62, 2 , p. 93-100Research output: Contribution to journal › Article › peer-review
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Macrophage infiltration promotes regrowth in MYCN-amplified neuroblastoma after chemotherapy
Valind, A., Verhoeven, B. M., Enoksson, J., Karlsson, J., Christensson, G., Mañas, A., Aaltonen, K., Jansson, C., Bexell, D., Baryawno, N., Gisselsson, D. & Hagerling, C., 2023, In: OncoImmunology. 12, 1, 2184130.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance
Mañas, A., Aaltonen, K., Andersson, N., Hansson, K., Adamska, A., Seger, A., Yasui, H., van den Bos, H., Radke, K., Esfandyari, J., Bhave, M. S., Karlsson, J., Spierings, D., Foijer, F., Gisselsson, D. & Bexell, D., 2022 Oct 28, In: Science Advances. 8, 43, eabq4617.Research output: Contribution to journal › Article › peer-review
Open Access -
Branching copy number evolution and parallel immune profiles across the regional tumor space of resected pancreatic cancer
Petersson, A., Andersson, N., Olsson Hau, S., Eberhard, J., Karlsson, J., Chattopadhyay, S., Valind, A., Elebro, J., Nodin, B., Leandersson, K., Gisselsson Nord, D. & Jirström, K., 2022 May 1, In: Molecular Cancer Research. 20, 5, p. 749-761Research output: Contribution to journal › Article › peer-review
Open Access -
Differential Activation of Immune Effector Processes in Mature Compared to Immature Sacrococcygeal Teratomas
Hambraeus, M., Karlsson, J., Kasselaki, I., Hagerling, C., Hagander, L. & Gisselsson, D., 2022, In: Fetal and Pediatric Pathology. 41, 3, p. 413-425Research output: Contribution to journal › Article › peer-review
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2021
DEVOLUTION—A method for phylogenetic reconstruction of aneuploid cancers based on multiregional genotyping data
Andersson, N., Chattopadhyay, S., Valind, A., Karlsson, J. & Gisselsson Nord, D., 2021 Sept 20, In: Communications Biology. 4, 1103.Research output: Contribution to journal › Article › peer-review
Open Access -
Anti-tumor effects of rigosertib in high-risk neuroblastoma
Radke, K., Hansson, K., Sjölund, J., Wolska, M., Karlsson, J., Esfandyari, J., Pietras, K., Aaltonen, K., Gisselsson, D. & Bexell, D., 2021 Aug, In: Translational Oncology. 14, 8, 101149.Research output: Contribution to journal › Article › peer-review
Open Access -
Tracing the evolution of aneuploid cancers by multiregional sequencing with CRUST
Chattopadhyay, S., Karlsson, J., Valind, A., Andersson, N. & Gisselsson, D., 2021, In: Briefings in Bioinformatics. 22, 6Research output: Contribution to journal › Article › peer-review
Open Access -
2020
A dynamic mutational landscape associated with an inter-regionally diverse immune response in malignant rhabdoid tumour
Yasui, H., Valind, A., Karlsson, J., Pietras, C., Jansson, C., Wille, J., Romerius, P., Backman, T. & Gisselsson, D., 2020 Sept, In: Journal of Pathology. 252, 1, p. 22-28 7 p., e5490.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis
Holmquist Mengelbier, L., Lindell-Munther, S., Yasui, H., Jansson, C., Esfandyari, J., Karlsson, J., Lau, K., Hui, C. C., Bexell, D., Hopyan, S. & Gisselsson, D., 2019 Jan, In: Journal of Pathology. 247, 1Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Convergent evolution of 11p allelic loss in multifocal Wilms tumors arising in WT1 mutation carriers
Valind, A., Wessman, S., Pal, N., Karlsson, J., Jonson, T., Sandstedt, B. & Gisselsson, D., 2018 Nov 1, In: Pediatric Blood & Cancer. 65, 11, e27301.Research output: Contribution to journal › Article › peer-review
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Four evolutionary trajectories underlie genetic intratumoral variation in childhood cancer
Karlsson, J., Valind, A., Holmquist Mengelbier, L., Bredin, S., Cornmark, L., Jansson, C., Wali, A., Staaf, J., Viklund, B., Øra, I., Börjesson, A., Backman, T., Braekeveldt, N., Sandstedt, B., Pal, N., Isaksson, A., Lackner, B. G., Jonson, T., Bexell, D. & Gisselsson, D., 2018 Jul, In: Nature Genetics. 50, 7, p. 944-950Research output: Contribution to journal › Article › peer-review
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Patient-derived xenograft models reveal intratumor heterogeneity and temporal stability in neuroblastoma
Braekeveldt, N., Von Stedingk, K., Fransson, S., Martinez-Monleon, A., Lindgren, D., Axelson, H., Levander, F., Willforss, J., Hansson, K., Øra, I., Backman, T., Börjesson, A., Beckman, S., Esfandyari, J., Berbegall, A. P., Noguera, R., Karlsson, J., Koster, J., Martinsson, T. & Gisselsson, D. & 2 others, , 2018, In: Cancer Research. 78, 20, p. 5958-5969 12 p.Research output: Contribution to journal › Article › peer-review
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2016
Aberrant epigenetic regulation in clear cell sarcoma of the kidney featuring distinct DNA hypermethylation and EZH2 overexpression.
Karlsson, J., Valind, A., Jansson, C., O'Sullivan, M. J., Holmquist Mengelbier, L. & Gisselsson Nord, D., 2016 Mar, In: Oncotarget. 7, 10, p. 11127-36Research output: Contribution to journal › Article › peer-review
Open Access -
BCOR internal tandem duplication and YWHAE-NUTM2B/E fusion are mutually exclusive events in clear cell sarcoma of the kidney.
Karlsson, J., Valind, A. & Gisselsson Nord, D., 2016, In: Genes, Chromosomes and Cancer. 55, 2, p. 120-123Research output: Contribution to journal › Article › peer-review
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2015
Activation of human telomerase reverse transcriptase through gene fusion in clear cell sarcoma of the kidney.
Karlsson, J., Lilljebjörn, H., Holmquist Mengelbier, L., Valind, A., Rissler, M., Øra, I., Fioretos, T. & Gisselsson Nord, D., 2015, In: Cancer Letters. 357, 2, p. 498-501Research output: Contribution to journal › Article › peer-review
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Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer.
Holmquist Mengelbier, L., Karlsson, J., Lindgren, D., Valind, A., Lilljebjörn, H., Jansson, C., Bexell, D., Braekeveldt, N., Ameur, A., Jonson, T., Kultima, H. G., Isaksson, A., Asmundsson, J., Versteeg, R., Rissler, M., Fioretos, T., Sandstedt, B., Börjesson, A., Backman, T. & Pal, N. & 3 others, , 2015, In: Nature Communications. 6, 6125.Research output: Contribution to journal › Article › peer-review
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2014
Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin.
Karlsson, J., Holmquist Mengelbier, L., Ciornei, C., Naranjo, A., O'Sullivan, M. J. & Gisselsson Nord, D., 2014, In: Genes, Chromosomes and Cancer. 53, 5, p. 381-391Research output: Contribution to journal › Article › peer-review
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2013
Absence of Epstein-Barr and Cytomegalovirus Infection in Neuroblastoma Cells by Standard Detection Methodologies.
Sehic, D., Forslund, O., Sandén, E., Holmquist Mengelbier, L., Karlsson, J., Bzhalava, D., Ekström, J., Warenholt, J., Darabi, A., Dillner, J., Øra, I. & Gisselsson Nord, D., 2013, In: Pediatric Blood & Cancer. 60, 9, p. E91-E93Research output: Contribution to journal › Article › peer-review
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2012
Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney
O'Meara, E., Stack, D., Lee, C.-H., Garvin, A. J., Morris, T., Argani, P., Han, J. S., Karlsson, J., Gisselsson Nord, D., Leuschner, I., Gessler, M., Graf, N., Fletcher, J. A. & O'Sullivan, M. J., 2012, In: Journal of Pathology. 227, 1, p. 72-80Research output: Contribution to journal › Article › peer-review
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SIX1 protein expression selectively identifies blastemal elements in Wilms tumor.
Sehic, D., Karlsson, J., Sandstedt, B. & Gisselsson Nord, D., 2012, In: Pediatric Blood & Cancer. 59, 1, p. 62-68Research output: Contribution to journal › Article › peer-review
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2011
High-resolution genomic profiling of an adult Wilms' tumor: evidence for a pathogenesis distinct from corresponding pediatric tumors.
Karlsson, J., Holmquist Mengelbier, L., Elfving, P. & Gisselsson Nord, D., 2011, In: Virchows Archiv: an international journal of pathology. 459, p. 547-553Research output: Contribution to journal › Article › peer-review
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2010
Deletions of 16q in Wilms Tumors Localize to Blastemal-Anaplastic Cells and Are Associated with Reduced Expression of the IRXB Renal Tubulogenesis Gene Cluster.
Holmquist Mengelbier, L., Karlsson, J., Lindgren, D., Øra, I., Isaksson, M., Frigyesi, I., Frigyesi, A., Bras, J., Sandstedt, B. & Gisselsson Nord, D., 2010, In: American Journal of Pathology. 177, 5, p. 2609-2621Research output: Contribution to journal › Article › peer-review
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2009
Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells.
Pettersson, H., Pietras, A., Thorén, M., Karlsson, J., Johansson, L., Shoshan, M. C. & Påhlman, S., 2009, In: Molecular Cancer Therapeutics. 8, 1, p. 160-170Research output: Contribution to journal › Article › peer-review
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2007
Arsenic trioxide-induced neuroblastoma cell death is accompanied by proteolytic activation of nuclear Bax.
Karlsson, J., Pietras, A., Beckman, S., Pettersson, H., Larsson, C. & Påhlman, S., 2007, In: Oncogene. 26, 42, p. 6150-6159Research output: Contribution to journal › Article › peer-review
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2005
Multidrug-resistant neuroblastoma cells are responsive to arsenic trioxide at both normoxia and hypoxia.
Karlsson, J., Edsjö, A., Påhlman, S. & Pettersson, H., 2005, In: Molecular Cancer Therapeutics. 4, 7, p. 1128-1135Research output: Contribution to journal › Article › peer-review
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2004
Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53.
Karlsson, J., Øra, I., Ares, I. & Påhlman, S., 2004, In: Clinical Cancer Research. 10, 9, p. 3179-3188Research output: Contribution to journal › Article › peer-review
Open Access -
Neuroblastoma cells with overexpressed MYCN retain their capacity to undergo neuronal differentiation.
Edsjö, A., Nilsson, H., Vandesompele, J., Karlsson, J., Pattyn, F., Culp, L. A., Speleman, F. & Påhlman, S., 2004, In: Laboratory Investigation. 84, 4, p. 406-417Research output: Contribution to journal › Article › peer-review
Open Access -
2003
The Lim-only protein LMO4 modulates the transcriptional activity of HEN1.
Manetopoulos, C., Hansson, A., Karlsson, J., Jönsson, J.-I. & Axelson, H., 2003, In: Biochemical and Biophysical Research Communications. 307, 4, p. 891-899Research output: Contribution to journal › Article › peer-review