Research output per year
Research output per year
Personal profile
Research
Apolipoprotein A-I in HDL
Apolipoprotein A-I is the major protein of high-density lipoprotein (HDL) in the transportation of cholesterol and other lipids in vivo. Rare variants of apoA-I aggregate as amyloids, leading to organ dysfunction. The structure-function relationship of atheroprotective and amyloidogenic apoA-I variants are investigated.
HDL also correlates to improved glucose metabolism in the diabetic state. Learning more about HDL, will lead in the search for new innovative peptide drugs to prevent and treat diabetes and atherosclerosis.
Zinc transporter ZnT8 in diabetes
The ZnT8 transporter is localized to insulin granules in pancreatic beta cells were microcrystals of insulin-zinc are stored. ZnT8 polymorphism relates to type 1 and type 2 diabetes, and constitutes a potential target for prevention and treatment. Analyses of variant-specific protein structure and function, and cellular organization and functionality, are carried out to understand the role of ZnT8 in diabetes.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
UKÄ subject classification
- Medical and Health Sciences
- Cell and Molecular Biology
- Endocrinology and Diabetes
- Biochemistry and Molecular Biology
- Structural Biology
Free keywords
- Protein Structure
- Diabetes
- Cardiometabolic disease
- Amyloid
Fingerprint
Dive into the research topics where Jens Lagerstedt is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Apolipoprotein A-I priming via SR-BI and ABCA1 receptor binding upregulates mitochondrial metabolism to promote insulin secretion in INS-1E cells
Lyons, C. L., Cowan, E., Nilsson, O., Mohar, M., Peña-Martínez, P., Eliasson, L. & Lagerstedt, J. O., 2024 Nov, In: PLoS ONE. 19, 11 November, e0311039.Research output: Contribution to journal › Article › peer-review
Open Access -
Lipid exchange of apolipoprotein A-I amyloidogenic variants in reconstituted high-density lipoprotein with artificial membranes
Correa, Y., Ravel, M., Imbert, M., Waldie, S., Clifton, L., Terry, A., Roosen-Runge, F., Lagerstedt, J. O., Moir, M., Darwish, T., Cárdenas, M. & Del Giudice, R., 2024 May, In: Protein Science. 33, 5, 16 p., e4987.Research output: Contribution to journal › Article › peer-review
Open Access -
RNA sequencing unravels novel L cell constituents and mechanisms of GLP-1 secretion in human gastric bypass-operated intestine
Miskelly, M. G., Lindqvist, A., Piccinin, E., Hamilton, A., Cowan, E., Nergård, B. J., Del Giudice, R., Ngara, M., Cataldo, L. R., Kryvokhyzha, D., Volkov, P., Engelking, L., Artner, I., Lagerstedt, J. O., Eliasson, L., Ahlqvist, E., Moschetta, A., Hedenbro, J. & Wierup, N., 2024, In: Diabetologia. 67, 2, p. 356–370 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study
Cronjé, H. T., Karhunen, V., Hovingh, G. K., Coppieters, K., Lagerstedt, J. O., Nyberg, M. & Gill, D., 2023 Dec, In: BMC Medicine. 21, 1, 158.Research output: Contribution to journal › Article › peer-review
Open Access -
The Apparent Organ-Specificity of Amyloidogenic ApoA-I Variants Is Linked to Tissue-Specific Extracellular Matrix Components
Del Giudice, R., Lindvall, M., Nilsson, O., Monti, D. M. & Lagerstedt, J. O., 2023, In: International Journal of Molecular Sciences. 24, 1, 318.Research output: Contribution to journal › Article › peer-review
Open Access
-
Structure differences in HDL particles of human amyloidogenic apoA-I variants may explain their unique degenerative phenotypes
Lagerstedt, J. (PI)
2018/08/15 → 2019/06/30
Project: Other
-
Structure and Function of ZnT8 Zinc Transporters in Diabetes
Lagerstedt, J. (PI)
2017/08/15 → 2018/06/30
Project: Other
-
LINXS: LINXS Institute of advanced Neutron and X-ray Science
Hall, S. (Supervisor), Mokso, R. (Researcher), Ntinidou, A. (Project coordinator), Egan, N. (Project communication officer), Grunning, Å. (Administrator), Terry, A. (Researcher), Olmsted , P. (Researcher), Richter, D. (Researcher), Lund, M. (Researcher), Schurtenberger, P. (Researcher), Skepö, M. (Researcher), Stradner, A. (Researcher), Sparr, E. (Researcher), Jönsson, P. (Researcher), Nylander, T. (Researcher), Stankovski, M. (Researcher), Cárdenas, M. (Researcher), Dicko, C. (Researcher), Arleth, L. (Researcher), Kragelund, B. B. (Researcher), Lindorff-Larsen, K. (Researcher), Lenton, S. (Researcher), Sparr, E. (Researcher), Jacobsen, C. (Researcher), Poulsen, H.-F. (Researcher), Mokso, R. (Researcher), Thånell, K. (Researcher), Jacobsen, C. (Researcher), Bech, M. (Researcher), Paterson, D. (Researcher), Schwenke, J. (Researcher), Johansson, U. (Researcher), Nilsson, B. (Researcher), Dell'Unto, N. (Researcher), Dal, L. (Researcher), Calner, M. (Researcher), Hammer, E. (Researcher), Pucetaite, M. (Researcher), Tunlid, A. (Researcher), Floudas, D. (Researcher), Gentile, L. (Researcher), Op de Beeck, M. (Researcher), Persson, P. (Researcher), Lagerstedt, J. (Researcher), Horsefield, S. (Researcher), Ursby, T. (Researcher), Oksanen, E. (Researcher), Ryde, U. (Researcher), Nan, J. (Researcher), André, I. (Researcher) & Aits, S. (Researcher)
Crafoord Foundation, Swedish Agency for Economic and Regional Growth
2017/06/07 → 2020/06/06
Project: Network
Activities
-
Amyloid diseases and amyloid mechanisms, 2019
Paulsson, K. M. (Chair), Gouras, G. (Chair), Lagerstedt, J. (Chair) & Klementieva, O. (Chair)
2019 Aug 28 → 2019 Aug 30Activity: Participating in or organising an event › Organisation of conference
-
LINXS First symposium - Integrative Structural Biology
Lagerstedt, J. (Organiser)
2018 Nov 19 → 2018 Nov 21Activity: Participating in or organising an event › Participation in conference
-
Pfizer, Internal Medicine Research Unit
Lagerstedt, J. (Visiting researcher)
2018 OctActivity: Visiting an external institution › Research or teaching at external organisation
-
Pfizer, Internal Medicine Research Unit
Lagerstedt, J. (Visiting researcher)
2018 May → 2018 JulActivity: Visiting an external institution › Research or teaching at external organisation
-
Pfizer, Internal Medicine Research Unit
Lagerstedt, J. (Visiting researcher)
2017 May → 2017 AugActivity: Visiting an external institution › Research or teaching at external organisation