Research output per year
Research output per year
Personal profile
Research
In 2017, I acquired a PhD in Biomedicine (Experimental Diabetes Research) from Lund University. My thesis project was entitled “Salt-inducible kinases in adipose tissue” and focused on identifying and describing the expression, regulation, and function of the AMPK-related kinase SIK2 in human adipose tissue and adipocytes, in relation to obesity and insulin resistance.
Since 2018, I am a postdoctoral fellow in the "Diabetes and Epigenetics" research group at Lund University Diabetes Centre. My current research project focuses on profiling epigenetic modifications in human pancreatic islets on both bulk and single-cell level, and exploring the functional role of altered epigenetic modifications for the risk of developing type 2 diabetes. The identification of differentially regulated epigenetic networks will enable the development of novel strategies for the treatment, diagnosis and prevention of this disease in the future.
UKÄ subject classification
- Cell and Molecular Biology
- Endocrinology and Diabetes
Keywords
- Diabetes
- Diabetes Mellitus
- Adipose tissue
- Adipocyte
- Pancreas
- Islets of Langerhans
- Beta cell
- Epigenetics
- Histone Modification
- Chromatin
- Obesity
- DNA
- Gene-environment interaction
- Histone
- Metabolism
- Signalling
- Phosphorylation
- Western Blot
- Type 2 diabetes
- ChIP-sequencing
- Antibodies
- DNA methylation
- insulin resistance
- LUDC
- Lund University Diabetes Centre
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Salt-inducible kinase 2 and -3 are downregulated in adipose tissue from obese or insulin-resistant individuals: implications for insulin signalling and glucose uptake in human adipocytes
Säll, J., Pettersson, A. M. L., Björk, C., Henriksson, E., Wasserstrom, S., Linder, W., Zhou, Y., Hansson, O., Andersson, D. P., Ekelund, M., Degerman, E., Stenkula, K. G., Laurencikiene, J. & Göransson, O., 2017 Feb, In: Diabetologia. 60, 2, p. 314–323Research output: Contribution to journal › Article › peer-review
Open Access -
VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
Davegårdh, C., Säll, J., Benrick, A., Broholm, C., Volkov, P., Perfilyev, A., Henriksen, T. I., Wu, Y., Hjort, L., Brøns, C., Hansson, O., Pedersen, M., Würthner, J. U., Pfeffer, K., Nilsson, E., Vaag, A., Stener-Victorin, E., Pircs, K., Scheele, C. & Ling, C., 2021 Apr 23, In: Nature Communications. 12, 2431.Research output: Contribution to journal › Article › peer-review
Open Access -
Epigenetic epidemiology and alterations in type 2 diabetes and obesity
Ling, C., Ruhrmann, S., Säll, J., Bacos, K. & Rönn, T., 2022, Epigenetic epidemiology. Michels, K. B. (ed.). Cham: Springer, p. 445-474 30 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Differential DNA Methylation and Expression of miRNAs in Adipose Tissue From Twin Pairs Discordant for Type 2 Diabetes
Nilsson, E., Vavakova, M., Perfilyev, A., Säll, J., Jansson, P-A., Poulsen, P., Esguerra, J. L. S., Eliasson, L., Vaag, A., Göransson, O. & Ling, C., 2021, In: Diabetes. 70, 10, p. 2402-2418Research output: Contribution to journal › Article › peer-review
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Inhibition of AMPK activity in response to insulin in adipocytes: involvement of AMPK pS485, PDEs, and cellular energy levels
Kopietz, F., Rupar, K., Berggreen, C., Säll, J., Vertommen, D., Degerman, E., Rider, M. H. & Göransson, O., 2020, In: American Journal of Physiology - Endocrinology and Metabolism. 319, 3, p. E459-E471Research output: Contribution to journal › Article › peer-review
Projects
- 1 Finished
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Salt-inducible kinases in adipose tissue
Säll Sernevi, J., Göransson, O. & Holm Wallenberg, C.
2012/09/15 → 2017/09/05
Project: Dissertation
File
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Reviewer at PhD halfway seminar
Johanna Säll Sernevi (Commissioned member of Examining committee)
2021 Oct 5Activity: Examination and supervision › External Reviewer of PhD thesis/Opponent
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Press release: Muscle gene linked to type 2 diabetes
Johanna Säll Sernevi (Contributor)
2021 Apr 23Activity: Other › Media participation
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Press release: Sambandet mellan kroppsvikt och insulinresistens
Johanna Säll Sernevi (Contributor)
2016 Dec 21Activity: Other › Media participation