Research output per year
Research output per year
Personal profile
Research
In 2017, I acquired a PhD in Biomedicine (Experimental Diabetes Research) from Lund University. My thesis project was entitled “Salt-inducible kinases in adipose tissue” and focused on identifying and describing the expression, regulation, and function of the AMPK-related kinase SIK2 in human adipose tissue and adipocytes, in relation to obesity and insulin resistance.
Since 2018, I am a postdoctoral fellow in the "Diabetes and Epigenetics" research group at Lund University Diabetes Centre. My current research project focuses on profiling epigenetic modifications in human pancreatic islets on both bulk and single-cell level, and exploring the functional role of altered epigenetic modifications for the risk of developing type 2 diabetes. The identification of differentially regulated epigenetic networks will enable the development of novel strategies for the treatment, diagnosis and prevention of this disease in the future.
Subject classification (UKÄ)
- Medical Epigenetics and Epigenomics
- Cell and Molecular Biology
- Endocrinology and Diabetes
Free keywords
- Diabetes
- Diabetes Mellitus
- Adipose tissue
- Adipocyte
- Pancreas
- Islets of Langerhans
- Beta cell
- Epigenetics
- Histone Modification
- Chromatin
- Obesity
- DNA
- Gene-environment interaction
- Histone
- Metabolism
- Signalling
- Phosphorylation
- Western Blot
- Type 2 diabetes
- ChIP-sequencing
- Antibodies
- DNA methylation
- insulin resistance
- LUDC
- Lund University Diabetes Centre
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Salt-inducible kinase 2 and -3 are downregulated in adipose tissue from obese or insulin-resistant individuals: implications for insulin signalling and glucose uptake in human adipocytes
Säll, J., Pettersson, A. M. L., Björk, C., Henriksson, E., Wasserstrom, S., Linder, W., Zhou, Y., Hansson, O., Andersson, D. P., Ekelund, M., Degerman, E., Stenkula, K. G., Laurencikiene, J. & Göransson, O., 2017 Feb, In: Diabetologia. 60, 2, p. 314–323Research output: Contribution to journal › Article › peer-review
Open Access -
VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
Davegårdh, C., Säll, J., Benrick, A., Broholm, C., Volkov, P., Perfilyev, A., Henriksen, T. I., Wu, Y., Hjort, L., Brøns, C., Hansson, O., Pedersen, M., Würthner, J. U., Pfeffer, K., Nilsson, E., Vaag, A., Stener-Victorin, E., Pircs, K., Scheele, C. & Ling, C., 2021 Apr 23, In: Nature Communications. 12, 2431.Research output: Contribution to journal › Article › peer-review
Open Access -
Multiomics profiling of DNA methylation, microRNA, and mRNA in skeletal muscle from monozygotic twin pairs discordant for type 2 diabetes identifies dysregulated genes controlling metabolism
Ling, C., Vavakova, M., Ahmad Mir, B., Säll, J., Perfilyev, A., Martin, M., Jansson, P.-A., Davegårdh, C., Asplund, O., Hansson, O., Vaag, A. & Nilsson, E., 2024 Dec 2, In: BMC Medicine. 22, 1, 572.Research output: Contribution to journal › Article › peer-review
Open Access -
Salt-inducible kinases are required for glucose uptake and insulin signaling in human adipocytes
Säll, J., Lindahl, M., Fritzen, A. M., Fryklund, C., Kopietz, F., Nyberg, E., Warvsten, A., Morén, B., Foretz, M., Kiens, B., Stenkula, K. G. & Göransson, O., 2023, In: Obesity. 31, 10, p. 2515-2529Research output: Contribution to journal › Article › peer-review
Open Access -
Epigenetic epidemiology and alterations in type 2 diabetes and obesity
Ling, C., Ruhrmann, S., Säll, J., Bacos, K. & Rönn, T., 2022, Epigenetic epidemiology. Michels, K. B. (ed.). Cham: Springer, p. 445-474 30 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
Projects
- 2 Finished
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An atlas of histone modifications in human pancreatic islets - finding novel targets for future epigenetic therapies for type 2 diabetes
Säll Sernevi, J. (PI)
Crafoord Foundation, O. E. och Edla Johanssons vetenskapliga stiftelse, The Royal Physiographic Society in Lund, Stiftelsen Sigurd och Elsa Goljes Minne, Uppsala University
2024/09/15 → 2025/09/17
Project: Research
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Salt-inducible kinases in adipose tissue
Säll Sernevi, J. (Researcher), Göransson, O. (Supervisor) & Holm Wallenberg, C. (Assistant supervisor)
The Royal Physiographic Society in Lund
2012/09/15 → 2017/09/05
Project: Dissertation
File
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Reviewer at PhD halfway seminar
Säll Sernevi, J. (Commissioned member of Examining committee)
2021 Oct 5Activity: Examination and supervision › External Reviewer of PhD thesis
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Press release: Muscle gene linked to type 2 diabetes
Säll Sernevi, J. (Contributor)
2021 Apr 23Activity: Other › Media participation
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Press release: Sambandet mellan kroppsvikt och insulinresistens
Säll Sernevi, J. (Contributor)
2016 Dec 21Activity: Other › Media participation