Jonas Erjefält

Search results

• 2024

  Airway hyperresponsiveness correlates with airway TSLP in asthma independent of eosinophilic inflammation

  Andreasson, L. M., Dyhre-Petersen, N., Hvidtfeldt, M., Jørgensen, G. Ø., Von Bülow, A., Klein, D. K., Uller, L., Erjefält, J., Porsbjerg, C. & Sverrild, A., 2024, In: Journal of Allergy and Clinical Immunology. 153, 4, p. 988-997.e11

  Research output: Contribution to journal › Article › peer-review

  • Asthma 100%
  • Inflammation 100%
  • Respiratory Tract Allergy 100%
  • Eosinophilic 100%
  • Serum 41%

• The challenges of recruiting never-smokers with chronic obstructive pulmonary disease from the large population-based Swedish CArdiopulmonary bioImage study (SCAPIS) cohort

  Sönnerfors, P., Jacobson, P. K., Andersson, A., Behndig, A., Bjermer, L., Blomberg, A., Blomqvist, H., Erjefält, J., Friberg, M., Lamberg Lundström, K., Lundborg, A., Malinovschi, A., Persson, H. L., Tufvesson, E., Wheelock, Å., Janson, C. & Sköld, C. M., 2024, In: European clinical respiratory journal. 11, 1, 2372903.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2023

  Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model

  Tanner, L., Single, A. B., Bhongir, R. K. V., Heusel, M., Mohanty, T., Karlsson, C. A. Q., Pan, L., Clausson, C. M., Bergwik, J., Wang, K., Andersson, C. K., Oommen, R. M., Erjefält, J. S., Malmström, J., Wallner, O., Boldogh, I., Helleday, T., Kalderén, C. & Egesten, A., 2023 Dec, In: Nature Communications. 14, 1, 643.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pneumonia 100%
  • Lung Fibrosis 100%
  • 8 Hydroxyguanine 100%
  • DNA Glycosyltransferase 100%
  • Fibrosing Alveolitis 83%

• Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex

  Strickson, S., Houslay, K. F., Negri, V. A., Ohne, Y., Ottosson, T., Dodd, R. B., Huntington, C. C., Baker, T., Li, J., Stephenson, K. E., O’Connor, A. J., Sagawe, J. S., Killick, H., Moore, T., Rees, D. G., Koch, S., Sanden, C., Wang, Y., Gubbins, E. & Ghaedi, M. & 8 others, Kolbeck, R., Saumyaa, S., Erjefält, J. S., Sims, G. P., Humbles, A. A., Scott, I. C., Ros, X. R. & Cohen, E. S., 2023 Sept 1, In: European Respiratory Journal. 62, 3, 2202210.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stimulation 100%
  • Cytokine 100%
  • Chronic Obstructive Pulmonary Disease 100%
  • Eicosanoid Receptor 100%
  • Advanced Glycation End-Product 100%

• Anatomical and histopathological approaches to asthma phenotyping

  Erjefält, J. S., 2023 Apr 1, In: Respiratory Medicine. 210, 107168.

  Research output: Contribution to journal › Article › peer-review

  • Patient 100%
  • Therapeutic Procedure 100%
  • Symptom 66%
  • Inflammation 66%
  • Parenchyma 66%

• Alkaline sphingomyelinase (NPP7) impacts the homeostasis of intestinal T lymphocyte populations

  Alyamani, M., Kadivar, M., Erjefält, J., Johansson-Lindbom, B., Duan, R. D., Nilsson, Å. & Marsal, J., 2023 Jan 19, In: Frontiers in Immunology. 13, 1050625.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • T Lymphocyte 100%
  • Large Intestine 60%
  • Mesenteric Lymph Nodes 60%
  • Mouse 60%
  • Neutrophil 40%

• Airway hyperresponsiveness reflects corticosteroid-sensitive mast cell involvement across asthma phenotypes

  Hvidtfeldt, M., Sverrild, A., Pulga, A., Frøssing, L., Silberbrandt, A., Hostrup, M., Thomassen, M., Sanden, C., Clausson, C. M., Siddhuraj, P., Bornesund, D., Nieto-Fontarigo, J. J., Uller, L., Erjefält, J. & Porsbjerg, C., 2023, In: Journal of Allergy and Clinical Immunology. 152, 1, p. 107-116.e4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mast Cell 100%
  • Asthma 100%
  • Respiratory Tract Allergy 100%
  • Corticosteroid 100%
  • Exhaled Nitric Oxide 70%

• Distribution of type 2 biomarkers and association with severity, clinical characteristics and comorbidities in the BREATHE real-life asthma population

  Frøssing, L., Klein, D. K., Hvidtfeldt, M., Obling, N., Telg, G., Erjefält, J. S., Bodtger, U. & Porsbjerg, C., 2023, In: ERJ open research. 9, 2, 00483-2022.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Asthma 100%
  • Severe Asthma 62%
  • Sputum 37%
  • Immunoglobulin E 12%
  • Exhaled Nitric Oxide 12%

• Neutrophil phenotypes in bronchial airways differentiate single from dual responding allergic asthmatics

  van der Burg, N., Stenberg, H., Ekstedt, S., Diamant, Z., Bornesund, D., Ankerst, J., Kumlien Georén, S., Cardell, L. O., Bjermer, L., Erjefält, J. & Tufvesson, E., 2023, In: Clinical and Experimental Allergy. 53, 1, p. 65-77

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Asthma 100%
  • Neutrophil 100%
  • Allergen 37%
  • Blood Plasma 25%
  • Hypersensitive Response 25%
• 2022

  Tartrate resistant acid phosphatase 5 (TRAP5) mediates immune cell recruitment in a murine model of pulmonary bacterial infection

  Tanner, L., Bergwik, J., Bhongir, R. K. V., Puthia, M., Lång, P., Ali, M. N., Welinder, C., Önnerfjord, P., Erjefält, J., Palmberg, L., Andersson, G. & Egesten, A., 2022 Dec 8, In: Frontiers in Immunology. 13, 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pulmonary Bacterial Infection 100%
  • Mouse 100%
  • Inflammation 50%
  • Disease 33%
  • Lung 33%

• Diffuse alveolar damage patterns reflect the immunological and molecular heterogeneity in fatal COVID-19

  Erjefält, J. S., de Souza Xavier Costa, N., Jönsson, J., Cozzolino, O., Dantas, K. C., Clausson, C. M., Siddhuraj, P., Lindö, C., Alyamani, M., Lombardi, S. C. F. S., Mendroni Júnior, A., Antonangelo, L., Faria, C. S., Duarte-Neto, A. N., de Almeida Monteiro, R. A., Rebello Pinho, J. R., Gomes-Gouvêa, M. S., Verciano Pereira, R., Monteiro, J. S. & Setubal, J. C. & 9 others, de Oliveira, E. P., Theodoro Filho, J., Sanden, C., Orengo, J. M., Sleeman, M. A., da Silva, L. F. F., Saldiva, P. H. N., Dolhnikoff, M. & Mauad, T., 2022 Sept, In: EBioMedicine. 83, 104229.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • COVID-19 100%
  • CD8 Antigen 66%
  • Angiogenesis 50%
  • Gene Expression Profiling 50%
  • Length 50%

• Zoledronic Acid Targeting of the Mevalonate Pathway Causes Reduced Cell Recruitment and Attenuates Pulmonary Fibrosis

  Tanner, L., Bergwik, J., Single, A., Bhongir, R. K. V., Erjefält, J. & Egesten, A., 2022 Jun 2, In: Frontiers in Pharmacology. 13, 899469.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lung Fibrosis 100%
  • Mevalonic Acid 100%
  • Fibrosing Alveolitis 50%
  • Bleomycin 16%
  • Pathogenesis 8%

• Dynamically upregulated mast cell CPA3 patterns in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis

  Siddhuraj, P., Jönsson, J., Alyamani, M., Prabhala, P., Magnusson, M., Lindstedt, S. & Erjefält, J. S., 2022, In: Frontiers in Immunology. 13, 924244.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lung 100%
  • Chronic Obstructive Pulmonary Disease 100%
  • Idiopathic Pulmonary Fibrosis 100%
  • Chronic Obstructive Lung Disease 100%
  • Fibrosing Alveolitis 100%

• Histology-based blood leukocyte profiling reveals parallel Th2 and Th17 signatures in seasonal allergic rhinitis

  Siddhuraj, P., Nordström, F. U., Jogdand, P., Elangovan, G., Mori, M., Bjermer, L., Greiff, L. & Erjefält, J. S., 2022, In: Acta Oto-Laryngologica. 142, 9-12, p. 696-704

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transcription Factor GATA 2 100%
  • GATA2 100%
  • Inflammation 50%
  • Monocyte 50%
  • Th1 Cell 50%

• Mucosal cryobiopsies: a new method for studying airway pathology in asthma

  Hvidtfeldt, M., Sverrild, A., Pulga, A., Frøssing, L., Silberbrandt, A., Sanden, C., Clausson, C. M., Bornesund, D., Erjefält, J. & Porsbjerg, C., 2022, In: ERJ open research. 8, 1, 00666-2021.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biopsy 100%
  • Pathology 100%
  • Asthma 100%
  • Patient with Asthma 50%
  • Epithelium 40%

• The effect of tezepelumab on airway hyperresponsiveness to mannitol in asthma (UPSTREAM)

  Sverrild, A., Hansen, S., Hvidtfeldt, M., Clausson, C.-M., Cozzolino, O., Cerps, S., Uller, L., Backer, V., Erjefält, J. & Porsbjerg, C., 2022, In: The European respiratory journal. 59, 1, 2101296.

  Research output: Contribution to journal › Article › peer-review

  • Mannitol 100%
  • Patient 50%
  • Thymic Stromal Lymphopoietin 37%
  • Inflammation 37%
  • Cytokine 25%
• 2021

  RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma

  Lamb, D., De Sousa, D., Quast, K., Fundel-Clemens, K., Erjefält, J. S., Sandén, C., Hoffmann, H. J., Kästle, M., Schmid, R., Menden, K. & Delic, D., 2021 Dec 1, In: Respiratory Research. 22, 1, 158.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Asthma 100%
  • Interleukin 17 100%
  • Mouse 35%
  • Proinflammatory Cytokine 23%
  • Respiratory Tract Allergy 17%

• Basophil sensitivity reflects long-term clinical outcome of subcutaneous immunotherapy in grass pollen-allergic patients

  Schmid, J. M., Würtzen, P. A., Siddhuraj, P., Jogdand, P., Petersen, C. G., Dahl, R., Erjefält, J. S. & Hoffmann, H. J., 2021 May 1, In: Allergy: European Journal of Allergy and Clinical Immunology. 76, 5, p. 1528-1538 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Grass Pollen 100%
  • Basophil 100%
  • Allergen 40%
  • Allergen Immunotherapy 40%
  • Immunoglobulin E 20%

• Heparin fragments induce cervical inflammation by recruiting immune cells through Toll-like receptor 4 in nonpregnant mice

  Åkerud, A., Axelsson, J., Yadav, M., Erjefält, J., Ekman-Ordeberg, G., Malmström, A. & Fischer, H., 2021, In: Molecular Human Reproduction. 27, 3, gaab004.

  Research output: Contribution to journal › Article › peer-review

  • Inflammation 100%
  • Toll Like Receptor 4 100%
  • Mouse 100%
  • Cervix 80%
  • Antithrombotic 40%

• Lung Mast Cells Have a High Constitutive Expression of Carboxypeptidase A3 mRNA That Is Independent from Granule-Stored CPA3

  Siddhuraj, P., Clausson, C. M., Sanden, C., Alyamani, M., Kadivar, M., Marsal, J., Wallengren, J., Bjermer, L. & Erjefält, J. S., 2021, In: Cells. 10, 2

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein 100%
  • Messenger RNA 100%
  • Cells 60%
  • Skin 40%
  • Cell Population 25%
• 2020

  Immune phenotypes of nasopharyngeal cancer

  Nilsson, J. S., Sobti, A., Swoboda, S., Erjefält, J. S., Forslund, O., Lindstedt, M. & Greiff, L., 2020 Nov, In: Cancers. 12, 11, p. 1-17 17 p., 3428.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dendritic Cell 100%
  • Nasopharynx Cancer 100%
  • Cytotoxic T-Cell 60%
  • Cancer Cell 40%
  • Epstein Barr Virus 40%

• Clinical characteristics of the BREATHE cohort–a real-life study on patients with asthma and COPD

  Backer, V., Klein, D. K., Bodtger, U., Romberg, K., Porsbjerg, C., Erjefält, J. S., Kristiansen, K., Xu, R., Silberbrandt, A., Frøssing, L., Hvidtfeldt, M., Obling, N., Jarenbäck, L., Nasr, A., Tufvesson, E., Mori, M., Winther-Jensen, M., Karlsson, L., Nihlén, U. & Veje Flintegaard, T. & 1 others, Bjermer, L., 2020 Mar 17, In: European clinical respiratory journal. 7, 1, 1736934.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Life 100%
  • Chronic Obstructive Pulmonary Disease 100%
  • Patient with Asthma 100%
  • Asthma 100%
  • Patient 46%

• Eosinophils, basophils, and type 2 immune microenvironments in COPD-affected lung tissue

  Jogdand, P., Siddhuraj, P., Mori, M., Sanden, C., Jönsson, J., Walls, A. F., Kearley, J., Humbles, A. A., Kolbeck, R., Bjermer, L., Newbold, P. & Erjefält, J. S., 2020, In: European Respiratory Journal. 55, 4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Eosinophil Granulocyte 100%
  • Eosinophil 60%
  • Mouse 40%
  • Eotaxin 40%
  • CCL24 40%

• Microbial Regulation of Enteric Eosinophils and Its Impact on Tissue Remodeling and Th2 Immunity

  Jiménez-Saiz, R., Anipindi, V. C., Galipeau, H., Ellenbogen, Y., Chaudhary, R., Koenig, J. F., Gordon, M. E., Walker, T. D., Mandur, T. S., Abed, S., Humbles, A., Chu, D. K., Erjefält, J., Ask, K., Verdú, E. F. & Jordana, M., 2020, In: Frontiers in Immunology. 11, 155.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Immunity 100%
  • Eosinophil Granulocyte 100%
  • Eosinophil 60%
  • Infectious Agent 40%
  • Mouse 20%
• 2019

  IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation

  Allinne, J., Scott, G., Lim, W. K., Birchard, D., Erjefält, J. S., Sandén, C., Ben, L. H., Agrawal, A., Kaur, N., Kim, J. H., Kamat, V., Fury, W., Huang, T., Stahl, N., Yancopoulos, G. D., Murphy, A. J., Sleeman, M. A. & Orengo, J. M., 2019 Dec, In: Journal of Allergy and Clinical Immunology. 144, 6, p. 1624-1637 24 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Inflammation 100%
  • Respiratory Tract Inflammation 100%
  • Interleukin-33 100%
  • Respiratory Tract Disease 40%
  • Mouse Model 20%

• Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells

  Ali, M. N., Mori, M., Mertens, T. C. J., Siddhuraj, P., Erjefält, J. S., Önnerfjord, P., Hiemstra, P. S. & Egesten, A., 2019 Oct, In: Scientific Reports. 9, 15566.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Differentiation 100%
  • Epithelium 100%
  • Osteopontin 100%
  • Goblet Cell 100%
  • Basal Cell 18%

• Expression, activity and localization of lysosomal sulfatases in Chronic Obstructive Pulmonary Disease

  Weidner, J., Jogdand, P., Jarenbäck, L., Åberg, I., Helihel, D., Ankerst, J., Westergren-Thorsson, G., Bjermer, L., Erjefält, J. S. & Tufvesson, E., 2019 Jan 13, In: Scientific Reports. 9, 1, 1991.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sulfatase 100%
  • Fibroblast 75%
  • DNA Polymorphism 25%
  • Lung Fibroblast 25%
  • Messenger RNA 16%

• Bronchoscopic mucosal cryobiopsies as a method for studying airway disease

  Hvidtfeldt, M., Pulga, A., Hostrup, M., Sanden, C., Mori, M., Bornesund, D., Larsen, K. R., Erjefält, J. S. & Porsbjerg, C., 2019 Jan, In: Clinical and Experimental Allergy. 49, 1, p. 27-34

  Research output: Contribution to journal › Article › peer-review

  • Biopsy 100%
  • Respiratory Disease 100%
  • Mucosa 50%
  • Antigen 50%
  • Epithelium 50%

• Osteopontin protects against lung injury caused by extracellular histones

  Kasetty, G., Papareddy, P., Bhongir, R. K. V., Ali, M. N., Mori, M., Wygrecka, M., Erjefält, J. S., Hultgårdh-Nilsson, A., Palmberg, L., Herwald, H. & Egesten, A., 2019 Jan, In: Mucosal Immunology. 12, 1, p. 39-50

  Research output: Contribution to journal › Article › peer-review

  • Inflammation 100%
  • Mouse 33%
  • Wild Type Mouse 33%
  • Neutrophil Extracellular Traps 16%
  • Patient 16%

• Comparison of Normal and Metaplastic Epithelium in Patients with Stable versus Persistently Symptomatic Severe Asthma Using Laser-Capture Microdissection and Data-Independent Acquisition–Mass Spectrometry

  Weitoft, M., Müller, C., Åhrman, E., Bjermer, L., Hoffmann, H. J., Erjefält, J. & Westergren-Thorsson, G., 2019, In: American Journal of Pathology. 189, 12, p. 2358-2365 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein 100%
  • Laser Capture Microdissection 100%
  • Epithelium 100%
  • Severe Asthma 100%
  • Proteome 28%

• IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity

  Ravanetti, L., Dijkhuis, A., Dekker, T., Sabogal Pineros, Y. S., Ravi, A., Dierdorp, B. S., Erjefält, J. S., Mori, M., Pavlidis, S., Adcock, I. M., Rao, N. L. & Lutter, R., 2019, In: Journal of Allergy and Clinical Immunology. 143, 4, p. 1355-1370.e16

  Research output: Contribution to journal › Article › peer-review

  • Asthma Exacerbation 100%
  • Influenza 100%
  • Interleukin-33 100%
  • Antiviral Immunity 100%
  • Mouse 30%

• Severe asthma: Entering an era of new concepts and emerging therapies: Highlights of the 4th international severe asthma forum, Madrid, 2018

  Seys, S. F., Bjermer, L., Erjefält, J., Diamant, Z. & et al., 2019, In: Allergy: European Journal of Allergy and Clinical Immunology. 74, 11, p. 2244-2248

  Research output: Contribution to journal › Article › peer-review

• Unravelling the complexity of tissue inflammation in uncontrolled and severe asthma

  Erjefält, J. S., 2019, In: Current Opinion in Pulmonary Medicine. 25, 1, p. 79-86 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Asthma 100%
  • Inflammation 100%
  • Severe Asthma 100%
• 2018

  Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage

  Scott, I. C., Majithiya, J. B., Sanden, C., Thornton, P., Sanders, P. N., Moore, T., Guscott, M., Corkill, D. J., Erjefält, J. S. & Cohen, E. S., 2018 Dec 1, In: Scientific Reports. 8, 1, 3363.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Allergen 100%
  • Protein Degradation 100%
  • Mast Cell 11%
  • Mouse 11%
  • Immunocompetent Cell 11%

• Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells

  Andersson, C. K., Shikhagaie, M., Mori, M., Al-Garawi, A., Reed, J. L., Humbles, A. A., Welliver, R., Mauad, T., Bjermer, L., Jordana, M. & Erjefält, J. S., 2018 Oct, In: ERJ Open Research. 4, 4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mast Cell 100%
  • Viral Disease 100%
  • Influenza A Virus (H1N1) 33%
  • Lower Respiratory Tract 33%
  • Mouse 13%

• The Pulmonary Extracellular Matrix Is a Bactericidal Barrier Against Haemophilus influenzae in Chronic Obstructive Pulmonary Disease (COPD): Implications for an in vivo Innate Host Defense Function of Collagen VI

  Abdillahi, S. M., Tati, R., Nordin, S. L., Baumgarten, M., Hallgren, O., Bjermer, L., Erjefält, J., Westergren-Thorsson, G., Singh, B., Riesbeck, K. & Mörgelin, M., 2018 Aug 31, In: Frontiers in Immunology. 9, 1988.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Host Resistance 100%
  • Haemophilus influenzae 100%
  • Bacterium 50%
  • Infectious Agent 33%
  • Host 33%

• Uncontrolled asthmatics have increased FceRI⁺ and TGF-β–positive MC_TC mast cells and collagen VI in the alveolar parenchyma

  Andersson, C. K., Weitoft, M., Rydell-Törmänen, K., Bjermer, L., Westergren-Thorsson, G. & Erjefält, J. S., 2018 Mar 1, In: Clinical and Experimental Allergy. 48, 3, p. 266-277 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Collagen 100%
  • Collagen VI 100%
  • Parenchyma 100%
  • Phenotype 37%
  • Immunoreactivity 37%

• Intratumoural leukocyte infiltration is a prognostic indicator among pancreatic cancer patients with type 2 diabetes

  Karnevi, E., Sasor, A., Hilmersson, K. S., Ansari, D., Erjefält, J. S., Rosendahl, A. H. & Andersson, R., 2018, In: Pancreatology. 18, 1, p. 85-93

  Research output: Contribution to journal › Article › peer-review

  • Indicator 100%
  • Pancreas Cancer 100%
  • Patient with Type 2 Diabetes 100%
  • Leukocyte 100%
  • Macrophage 100%
• 2017

  IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD

  Briend, E., Ferguson, G. J., Mori, M., Damera, G., Stephenson, K., Karp, N. A., Sethi, S., Ward, C. K., Sleeman, M. A., Erjefält, J. S. & Finch, D. K., 2017 Aug 22, In: Respiratory Research. 18, 1, 159.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chronic Obstructive Pulmonary Disease 100%
  • Gamma Interferon 100%
  • Interleukin 18 100%
  • Interferon Gamma 100%
  • Disease 36%

• Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

  Shikhagaie, M. M., Björklund, Å. K., Mjösberg, J., Erjefält, J. S., Cornelissen, A. S., Ros, X. R., Bal, S. M., Koning, J. J., Mebius, R. E., Mori, M., Bruchard, M., Blom, B. & Spits, H., 2017 Feb 14, In: Cell Reports. 18, 7, p. 1761-1773 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lymphoid Cell 100%
  • Innate Lymphoid Cell 100%
  • Lymphoid Tissue 100%
  • Cells 57%
  • High Endothelial Venules 28%

• Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis

  Sanden, C., Mori, M., Jogdand, P., Jönsson, J., Krishnan, R., Wang, X. & Erjefält, J. S., 2017, In: Immunity, Inflammation and Disease. 5, 3, p. 300-309

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Antiinflammatory Activity 100%
  • Neutralization 100%
  • Anti-Inflammatory Drug 100%
  • Allergic Asthma 50%

• Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers

  Forkel, M., Berglin, L., Kekäläinen, E., Carlsson, A., Svedin, E., Michaëlsson, J., Nagasawa, M., Erjefält, J. S., Mori, M., Flodström-Tullberg, M., Bergquist, A., Ljunggren, H.-G., Westgren, M., Lindforss, U., Friberg, D., Jorns, C., Ellis, E., Björkström, N. K. & Mjösberg, J., 2017, In: European Journal of Immunology. 47, 8, p. 1280-1294 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Liver 100%
  • Lymphoid Cell 100%
  • Cell Compartment 100%
  • Innate Lymphoid Cell 100%
  • Disease 40%

• Effectiveness of bronchial thermoplasty in patients with severe refractory asthma: Clinical and histopathologic correlations

  Pretolani, M., Bergqvist, A., Thabut, G., Dombret, M. C., Knapp, D., Hamidi, F., Alavoine, L., Taillé, C., Chanez, P., Erjefält, J. S. & Aubier, M., 2017, In: Journal of Allergy and Clinical Immunology. 139, 4, p. 1176-1185

  Research output: Contribution to journal › Article › peer-review

  • Asthma 100%
  • Smooth Muscle 50%
  • Severe Asthma 12%

• Eosinophilic airway inflammation in asthmatic patients is associated with an altered airway microbiome

  Sverrild, A., Kiilerich, P., Brejnrod, A., Pedersen, R., Porsbjerg, C., Bergqvist, A., Erjefält, J. S., Kristiansen, K. & Backer, V., 2017, In: Journal of Allergy and Clinical Immunology. 140, 2, p. 407-417.e11

  Research output: Contribution to journal › Article › peer-review

  • Inflammation 100%
  • Eosinophil Granulocyte 83%
  • Asthma 50%
  • Sputum 16%
  • Bronchoalveolar Lavage Fluid 16%

• Inducible nitric oxide synthase expression is increased in the alveolar compartment of asthmatic patients

  Tufvesson, E., Andersson, C., Weidner, J., Erjefält, J. S. & Bjermer, L., 2017, In: Allergy: European Journal of Allergy and Clinical Immunology. 72, 4, p. 627-635

  Research output: Contribution to journal › Article › peer-review

  • Asthma 100%
  • Macrophage 42%
  • Exhaled Nitric Oxide 28%
• 2016

  Pulmonary and pleural lymphatic endothelial cells from pediatric, but not adult, patients with Gorham-Stout disease and generalized lymphatic anomaly, show a high proliferation rate

  Mori, M., Dictor, M., Brodszki, N., López-Gutiérrez, J. C., Beato, M., Erjefält, J. S. & Eklund, E. A., 2016 May 18, In: Orphanet Journal of Rare Diseases. 11, 1, 67.

  Research output: Contribution to journal › Article › peer-review

  • Patient 100%
  • Adult 100%
  • Pediatrics 100%
  • Endothelial Cell 100%
  • Lymph Duct 100%

• Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation.

  Sverrild, A., Bergqvist, A., Baines, K. J., Porsbjerg, C., Andersson, C., Thomsen, S. F., Hoffmann, H. J., Gibson, P., Erjefält, J. & Backer, V., 2016, In: Clinical and Experimental Allergy. 46, 2, p. 288-297

  Research output: Contribution to journal › Article › peer-review

  • Mast Cell 100%
  • Asthma 100%
  • Inflammation 100%
  • Respiratory Tract Allergy 50%
  • Eosinophil Granulocyte 16%

• IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

  Bal, S. M., Bernink, J. H., Nagasawa, M., Groot, J., Shikhagaie, M. M., Golebski, K., Van Drunen, C. M., Lutter, R., Jonkers, R. E., Hombrink, P., Bruchard, M., Villaudy, J., Munneke, J. M., Fokkens, W. J., Erjefält, J. S., Spits, H. & Ros, X. R., 2016, In: Nature Immunology. 17, 6, p. 636-645

  Research output: Contribution to journal › Article › peer-review

• IL-33 is related to innate immune activation and sensitization to HDM in mild steroid-free asthma.

  Porsbjerg, C., Baines, K., Gibson, P., Bergqvist, A., Erjefält, J., Sverrild, A. & Backer, V., 2016, In: Clinical and Experimental Allergy. 46, p. 564-574

  Research output: Contribution to journal › Article › peer-review

  • Asthma 100%
  • Interleukin-33 100%
  • Inflammation Response 33%
  • Epithelium 33%
  • Inflammation 33%

• Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs

  Silver, J. S., Kearley, J., Copenhaver, A. M., Sanden, C., Mori, M., Yu, L., Pritchard, G. H., Berlin, A. A., Hunter, C. A., Bowler, R., Erjefält, J., Kolbeck, R. & Humbles, A. A., 2016, In: Nature Immunology. 17, 6, p. 626-635

  Research output: Contribution to journal › Article › peer-review

  Open Access