Research output per year
Research output per year
Affiliated with the university
My research background is in Soft Matter Physics and both Neutron and X-ray small angle scattering techniques.
I have been working at the Virus Biophysics Group at the Faculty of Medicine LU, to study the structural organisation of viral genome inside capsids by using scattering techniques, as well as, performing data analysis. It includes the physico-chemistry, thermodynamics and biophysical mechanisms that give rise to viral genome release. Also, we have been researching on the derivation of a semi-empirical equation (EOS) of state that accounts for both viral DNA-DNA interaction and bending stress to the total viral internal pressure. This EOS accurately predicts the relationship between the capsid pressure and the packaged DNA density, which is intimately linked to the interxial distance.
Our research, also, have been focused on account for the effectivity of capsid attachment to cell nuclei prior to genome ejection, which initiates the viral infection and replication processes into the lytic life cycle of a virus. On other side, another challenge that our lab has, is the time-tracking of growing of viral genome inside cell's nucleus in order to follow up how the DNA is replicating at certain time points post infection.
The Virus Biophysics Lab currently is moving on to be involved into research of gene therapy through Adeno-Associated-Virus (AAV) in order to help with treatment of some diseases. Please, stay tuned to heard progress on this regard.
Update:
Recently I started a temporary position as intern on Pulmonary Tuberculosis research. Specifically, I am working with mycobacteria and a set of drugs to test the antibiotic stress. It gives rise to the secretion of extracellular vesicles which carry some proteins and lipids that are analysed with bioinformatic tools.
From a broader perspective, I have a lot of interest on the usage of nanocarriers to deliver a cargo for biomedical applications and development of pharmaceutical technology.
About me:
I got my PhD in Physics (on Soft Condensed Matter) by the University of Guanajuato, México. I have been Guest Researcher at the NIST Center for Neutron Research, Gaithersburg MD, USA, where I learnt all basics behind small angle neutron scattering (SANS) focused to soft matter.
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review