My research is focused on the development of biosensors based on the optical properties of semiconductor nanowires for the detection of biomolecules. These devices could be applied for diagnostics by the detection of biomarkers of disease at early stages and for performing sensitive biological measurements.

In particular, we work with III-V group semiconductor nanowires, such as GaP. Due to their lightguiding properties, they behave like nano-optical fibers and are able to collect and guide the light from close-bound fluorescent molecules. Our aim is to explore and take advantage of these optical properties to build sensitive sensors that enhance the performance and surpass the limit of detection of conventional flat sensing surfaces.

In combination with model membrane systems such as supported lipid bilayers (SLB), it is also possible to create biomimetic systems to study relevant cellular interactions with the enhanced sensitivity offered by nanowires. In order to improve the efficiency of drug-delivery nanocarriers, we emulate and study the interactions between cell membranes and lipid nanoparticles designed for the delivery of mRNA-based drugs. We expect to get a better understanding on the mechanisms responsible of mRNA endosomal escape and thus, improve the efficacy of the treatment.