Personal profile
Research
Kajsa M Paulsson leads a research group at Experimental Medical Sciences, Lund University focusing on antigen presentation in relation to both immunotherapy and disease mechanisms. With a passion for strategic development as well as cross-border and cross-disciplinary cooperation she has successfully driven several local as well as international projects and initiatives to e.g., promote collaboration, competence and technology development in the life science sector. She is a dedicated management and board member including at e.g., Lund Institute of Advanced X-ray and Neutron Sciences (LINXS), the board of the Biomedical Centre, Lund University, director of Microscopy Community Lund University and as the project manager of Hanseatic League of Science (HALOS). She is frequently consulted as reviewer of grants and prioritizations of investments in the life science sector as well as for opinions on future directions.
The main projects in her present reserach portfolio are:
1) ‘Tapasin as a prognostic and diagnostic tool in glioblastoma multiforme’
2) ‘How to get an efficient immune response against zoonotic avian flu? Lessons to be learned from studies of multiple species’
3) ‘MHC-I molecules and their role in ankylosing spondylitis’
The work use different methods spanning from molecular biology techniques, cellular assays, tissues analysis, work with recombinant proteins, biochemistry, spectroscopy and scattering techniques.
Subject classification (UKÄ)
- Cell and Molecular Biology
- Immunology
Free keywords
- tapasin
- tumor
- HLA
- MHC
- peptide
- antigen presentation
- ankylosing spondylitis
- structural biology
- life science
- spectrocsopy
- diffraction
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations the last five years
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Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum
Paulsson, K. M., Kleijmeer, M. J., Griffith, J., Jevon, M., Chen, S., Anderson, P. O., Sjögren, H. O., Li, S.-L. & Wang, P., 2002 May 24, In: Journal of Biological Chemistry. 277, 21, p. 18266-18271 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma
Thuring, C., Follin, E., Geironson Ulfsson, L., Freyhult, E., Junghans, V., Harndahl, M., Buus, S. & Paulsson, K. M., 2015, In: British Journal of Cancer. 113, 6, p. 952-962Research output: Contribution to journal › Article › peer-review
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In silico peptide-binding predictions of passerine MHC class I reveal similarities across distantly related species, suggesting convergence on the level of protein function.
Follin, E., Karlsson, M., Lundegaard, C., Nielsen, M., Wallin, S., Paulsson, K. M. & Westerdahl, H., 2013, In: Immunogenetics. 65, 4, p. 299-311Research output: Contribution to journal › Article › peer-review
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Tapasin Facilitation of Natural HLA-A and -B Allomorphs Is Strongly Influenced by Peptide Length, Depends on Stability, and Separates Closely Related Allomorphs.
Geironson Ulfsson, L., Thuring, C., Harndahl, M., Rasmussen, M., Buus, S., Røder, G. & Paulsson, K. M., 2013, In: Journal of Immunology. 191, 7, p. 3939-3947Research output: Contribution to journal › Article › peer-review
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Tapasin discriminates peptide-human leukocyte antigen-A*02:01 complexes fromed with natural ligands
Roder, G., Geironson Ulfsson, L., Rasmussen, M., Harndahl Nord, M., Buus, S. & Paulsson, K. M., 2011, In: Journal of Biological Chemistry. 286, 23, p. 20547-20557Research output: Contribution to journal › Article › peer-review
Open AccessFile160 Downloads (Pure)
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HALRIC: Hanseatic Life Science Research Infrastructure Consortium
Paulsson, K. M. (Researcher)
Interreg Öresund-Kattegat-Skagerrak
2023/04/01 → 2026/03/31
Project: Network
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CIPA: Correlative Image Processing and Analysis
Sopasakis, A. (Researcher), Paulsson, K. M. (Researcher), Larsson, E. (Researcher), Troein, C. (Researcher) & Ahlstedt, J. (Researcher)
2020/08/22 → 2027/03/30
Project: Network
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HALOS preparations: HAnseatic League Of Science (seed fund)
Paulsson, K. M. (Researcher) & Pearson, A. (Researcher)
2018/06/01 → …
Project: Network
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EATRIS: European Advanced Translational Research InfraStructure ERIC
Paulsson, K. M. (Researcher) & Bäckman, U. (PI)
2018/05/01 → …
Project: Other
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Aberant confirmations of HLA-B27 in ankylosing spondylitis
Paulsson, K. M. (PI), Zackrisson, M. (CoI), Morin, M. (Research assistant) & Junghans, V. (Research student)
2014/07/01 → …
Project: Research
Activities
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SRA workshop series: Future-oriented methodologies with focus on artificial intelligence (AI) related to SDG´s
Wittbom, C. (Organiser), Avery, H. (Organiser), Smirnova, O. (Host), Berntsson, P. (Host), Aits, S. (Invited speaker), Paulsson, K. M. (Invited speaker) & Wihlborg, A.-K. (Session chair)
2021 May 31Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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MEDICON VALLEY ALLIANCE R&D NETWORK MEETING – FOCUS ON RESEARCH INFRASTRUCTURE
Paulsson, K. M. (Speaker)
2021 May 20Activity: Talk or presentation › Invited talk
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Remote Access to Research Infrastructures
Paulsson, K. M. (Invited speaker)
2021 Apr 26Activity: Talk or presentation › Invited talk
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LUCC - Imaging & nuclear medicine/radiology: Webinar
Zackrisson, S. (Organiser), Massoumi, R. (Organiser), Massoumi, R. (Session chair), Bakic, P. (Session chair), Paulsson, K. M. (Speaker), Sydoff, M. (Invited speaker), In 't Zandt, R. (Invited speaker), Sime, W. (Speaker), Kjellman, P. (Speaker), Ruscher, K. (Invited speaker), Zackrisson, S. (Speaker), Markenroth Bloch, K. (Invited speaker), Malmsjö, M. (Invited speaker) & Bakic, P. (Speaker)
2021 Apr 21Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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Jämställdhet inom högre utbildning och forskning
Paulsson, K. M. (Keynote/plenary speaker)
2020 Aug 14Activity: Talk or presentation › Invited talk
Prizes and Distinction
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Lund University EUGLOH-infra application coordinator
Paulsson, K. M. (Recipient), 2020 Jun
Prize: Appointment
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Chair of the Faculty of Medicine 'Active cooperation' action group
Paulsson, K. M. (Recipient), 2020
Prize: Appointment
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Project manager Hanseatic League of Science (HALOS)
Paulsson, K. M. (Recipient), 2019 Feb 1
Prize: Appointment
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Member of expert council for LU strategy regarding MAX IV, ESS and SVS
Paulsson, K. M. (Recipient), 2019
Prize: Election to learned society
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Infrastructure
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InfraVis - National infrastructure for data visualization
Paulsson, K. M. (Manager) & Larsson, E. (Coordinator)
Antigen PresentationInfrastructure