Research output per year
Research output per year
Personal profile
Research
Aneuploidy in malignancies
Aberrant chromosome numbers – i.e. aneuploidy – is one of the most common characteristics of malignant cells. The overall aim of my research is to understand how aneuploidy arises in somatic cells, how it affects tumorigenesis, and how it correlates with prognosis and treatment response. In particular, my studies are focused on high hyperdiploid and hypodiploid childhood acute lymphoblastic leukemia. Ultimately, the goal is to use the new knowledge that we gain from these studies of the basis of tumorigenesis to improve the survival of cancer patients.
Professional work
Dr Paulsson is Professor of Medical Genetics and runs the Aneuploidy in Cancer research group at the Division of Clinical Genetics. She is an expert in cancer genomics and is experienced in classic genetic techniques such as chromosome analysis and fluorescence in situ hybridization as well as state-of-the-art SNP array analysis and next generation sequencing (NGS).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Subject classification (UKÄ)
- Cancer and Oncology
- Basic Cancer Research
Free keywords
- aneuploidy
- hyperdiploidy
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia
Woodward, E. L., Yang, M., Moura-Castro, L. H., van den Bos, H., Gunnarsson, R., Olsson-Arvidsson, L., Spierings, D. C. J., Castor, A., Duployez, N., Zaliova, M., Zuna, J., Johansson, B., Foijer, F. & Paulsson, K., 2023 Mar 25, In: Nature Communications. 14, 1658.Research output: Contribution to journal › Article › peer-review
Open Access -
13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking
Yang, M., Safavi, S., Woodward, E. L., Duployez, N., Olsson-arvidsson, L., Ungerbäck, J., Sigvardsson, M., Zaliova, M., Zuna, J., Fioretos, T., Johansson, B., Nord, K. H. & Paulsson, K., 2020 Aug 20, In: Blood. 136, 8, p. 946-956 11 p.Research output: Contribution to journal › Article › peer-review
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Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia
Yang, M., Vesterlund, M., Siavelis, I., Moura-Castro, L. H., Castor, A., Fioretos, T., Jafari, R., Lilljebjörn, H., Odom, D. T., Olsson, L., Ravi, N., Woodward, E. L., Harewood, L., Lehtiö, J. & Paulsson, K., 2019 Apr 3, In: Nature Communications. 10, 1, 1519.Research output: Contribution to journal › Article › peer-review
Open Access -
Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Retrospective Multinational Study
Paulsson, K. & Ponte di Legno Childhood ALL Working Group, 2019 Apr 1, In: Journal of Clinical Oncology. 37, 10, p. 770-779 10 p.Research output: Contribution to journal › Article › peer-review
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The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia.
Paulsson, K., Lilljebjörn, H., Biloglav, A., Olsson, L., Rissler, M., Castor, A., Barbany, G., Fogelstrand, L., Nordgren, A., Sjögren, H., Fioretos, T. & Johansson, B., 2015, In: Nature Genetics. 47, 6, p. 672-676Research output: Contribution to journal › Article › peer-review
File612 Downloads (Pure)
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Non-coding mutations in pediatric acute lymphoblastic leukemia
Aydin, E. (Research student), Paulsson, K. (Supervisor) & Yang, M. (Assistant supervisor)
2021/10/01 → 2025/10/01
Project: Dissertation
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Epigenetics - Theme, Pufendorf IAS
Forsén, S. (Project coordinator), Castor, A. (Researcher), Bengtsson, T. (Researcher), Brosberg, K. (Researcher), Hedlund, M. (Researcher), Höglund, M. (Researcher), Lindvall, M. (Researcher), Ling, C. (Researcher), Minssen, T. (Researcher), Paulsson, K. (Researcher), Psouni, E. (Researcher), Ringnér, M. (Researcher), Bommenel, E. (Researcher) & Lundin, S. (Researcher)
2009/08/09 → 2010/08/10
Project: Network
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LUCC - Seminar
Hansén Nord, K. (Chair), Pillay, N. (Invited speaker), Paulsson, K. (Speaker), Sjödahl, G. (Speaker) & Staaf, J. (Speaker)
2024 May 17Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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LUCC - Blood, lymphoma & myeloma: Experimental highlight series: "The 3D genome architecture in BCP ALL"
Paulsson, K. (Speaker), Hagström-Andersson, A. (Organiser) & Scheding, S. (Organiser)
2024 Feb 8Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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6th Swedish Cancer Research Meeting
Jönsson, G. B. (Keynote/plenary speaker), Fioretos, T. (Keynote/plenary speaker), Zackrisson, S. (Chair), Ceder, Y. (Chair), Sereti, E. (Session chair), Paulsson, K. (Speaker), Sandström Gerdtsson, A. (Speaker), Pietras, A. (Speaker), Lehn, S. (Session chair), Ascic, E. (Speaker), de Bono, J. (Keynote/plenary speaker), Öhlund, D. (Keynote/plenary speaker), diaz, L. (Keynote/plenary speaker), Martner, A. (Keynote/plenary speaker), Enblad, G. (Keynote/plenary speaker), Esserman, L. J. (Keynote/plenary speaker), Kallioniemi, O. (Keynote/plenary speaker) & Beets-Tan, R. (Keynote/plenary speaker)
2023 May 16 → 2023 May 17Activity: Participating in or organising an event › Organisation of conference
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Lund University Cancer Centre (LUCC) meeting
Berntsson, P. (Member of programme committee), Zackrisson, S. (Member of programme committee), Nilbert, M. (Member of programme committee), Swaminathan, V. (Member of programme committee), Martling, A. (Invited speaker), Heeren, R. M. A. (Invited speaker), Gisselsson Nord, D. (Speaker), Bellodi, C. (Speaker), Mosquim Junior, S. (Speaker), Andersson, N. (Speaker), Gonçalves de Oliveira, K. (Speaker), Mekuria, S. (Speaker), Helkkula, T. (Speaker), Godina, C. (Speaker), Olsson, L. E. (Speaker), Lång, K. (Speaker), Ågerstam, H. (Speaker), Hyrenius Wittsten, A. (Speaker), Bourgine, P. (Speaker), Alvarado Kristensson, M. (Speaker), Carneiro, A. (Speaker), Jernström, H. (Speaker), Malmborg Kisch, A. (Speaker), Malmström, M. (Speaker), Larsson, A.-M. (Speaker), Zackrisson, S. (Session chair), Paulsson, K. (Session chair), Pronk, K.-J. (Session chair), Swaminathan, V. (Session chair), Hedenfalk, I. (Session chair), Massoumi, R. (Session chair), Dalene Skarping, I. (Session chair), Leandersson, K. (Session chair), Sandström Gerdtsson, A. (Session chair), Järås, M. (Session chair), Carneiro, A. (Session chair), Stocks, T. (Session chair), Malmborg Kisch, A. (Session chair) & Malmström, M. (Session chair)
2023 May 4Activity: Participating in or organising an event › Organisation of conference
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LUCC - Child: Acute Lymphoblastic Leukemia (ALL) - Seminar
Bexell, D. (Organiser), Pronk, K.-J. (Organiser), Castor, A. (Speaker) & Paulsson, K. (Speaker)
2021 Apr 29Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
Prizes and Distinction
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Samfundet Folkhälsan Albert de la Chapelle Prize in Medical Genetics
Paulsson, K. (Recipient), 2022
Prize: Prize (including medals and awards)
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Senior Investigator Award, Cancerfonden
Paulsson, K. (Recipient), 2015
Prize: Prize (including medals and awards)