Aneuploidy in malignancies

Aberrant chromosome numbers – i.e. aneuploidy – is one of the most common characteristics of malignant cells. The overall aim of my research is to understand how aneuploidy arises in somatic cells, how it affects tumorigenesis, and how it correlates with prognosis and treatment response. In particular, my studies are focused on high hyperdiploid and hypodiploid childhood acute lymphoblastic leukemia. Ultimately, the goal is to use the new knowledge that we gain from these studies of the basis of tumorigenesis to improve the survival of cancer patients.

Dr Paulsson is Professor of Medical Genetics and runs the Aneuploidy in Cancer research group at the Division of Clinical Genetics. She is an expert in cancer genomics and is experienced in classic genetic techniques such as chromosome analysis and fluorescence in situ hybridization as well as state-of-the-art SNP array analysis and next generation sequencing (NGS).