Karin Leandersson

Karin Leandersson

Professor

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Research

Cancer immunosurveillance is a process where the immune system scans and eradicates tumor cells continuously. From recent research it has become clear that established tumors produce soluble factors that actually sculpts the immune system towards an anti-inflammatory, or “tolerogenic”, faith. In this state the immune response is suppressed by the tumor and even induces a wound healing processes stimulating stromal growth and angiogenesis. The local presence of suppressive myeloid cell populations in the primary tumor of breast cancer patients strongly correlates with a decreased survival. The parallel systemic immune response in breast cancer patients is less well characterized. Aim: In my group we study how metastatic processes depend on suppression of the immune response and how the immune system actually instead promotes breast cancer metastasis.

Results and Planned work: This is done using human material and mouse models of breast cancer metastasis. My research has a strong translational character with clinical collaborations and primary material as base in all projects. The focus is on immunosuppressive cell populations and metastatic processes in breast cancer.

Relevance: Understanding the immune suppression in breast cancer patients may lead to insights into treatment responses, resistance mechanisms and novel treatment modalities aimed to hinder this phenomenon which would eventually encumber the devastating progression of breast cancer metastasis. 

Research

Background:  Cancer immunosurveillance is a process where the immune system scans and eradicates tumor cells continuously. From recent research it has become clear that established tumors produce soluble factors that actually sculpts the immune system towards an anti-inflammatory, or “tolerogenic”, faith. In this state the immune response is suppressed by the tumor and even induces a wound healing processes stimulating stromal growth and angiogenesis. The local presence of suppressive myeloid cell populations in the primary tumor of breast cancer patients strongly correlates with a decreased survival. The parallel systemic immune response in breast cancer patients is less well characterized. Aim: In my group we study how metastatic processes depend on suppression of the immune response and how the immune system actually instead promotes breast cancer metastasis. Results and Planned work: This is done using human material and mouse models of breast cancer metastasis. My research has a strong translational character with clinical collaborations and primary material as base in all projects. The focus is on immunosuppressive cell populations and metastatic processes in breast cancer. Relevance: Understanding the immune suppression in breast cancer patients may lead to insights into treatment responses, resistance mechanisms and novel treatment modalities aimed to hinder this phenomenon which would eventually encumber the devastating progression of breast cancer metastasis.

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Tumor immunology
  • Immune suppression
  • Breast cancer

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