We aim to molecularly map the support functions performed by the various cell types comprising the tumor microenvironment. We believe that decisive treatment benefit can only be achieved by targeting distinct cell types and pathways that collectively sustain tumor
growth.

Specifically, molecular interactions between cancer-associated fibroblasts, pericytes and endothelial cells are explored with a special focus on novel anti-cancer strategies. Importantly, the cellular networks within tumors cannot be studied in isolation. Thus, our work ranges over many different topics, with methodology, technology and purpose as the common denominators.

We currently pursue three main avenues of research:

1. Basic Biology
Identification of new cellular subsets of the tumor stroma and their influence on
cancer progression

2. Pre-clinical studies Investigation of the therapeutic utility of the tumor stroma

3. Translational studies
Exploration of the tumor stroma as biomarkers of prognosis or response to
therapy in human cancer

Taken together, the overall aim of our work is to generate basic knowledge about the interdependent way cells within a tumor relate to each other, as well as produce information that will be immediately useful for the design and modification of clinical practice.