Kristina Drott

Affiliated with the university

Personal profile

Research

Many B-cell lymphomas are characterised by mutations in epigenetic regulators, either at primary diagnosis or at disease relapse. Therefore, both development and treatment resitance of B-cell lymphomas, are probably dependent on correct epigenetic regulation of chromatin conformation and gene expression. Starting from the overall hypothesis that a deranged epigenetic regulation can be restored by treatment with epigenetic modulators like histone deacetylase inhibitors (HDACis) and DNA methyltransferase inhibitors, the research in our group focuses on epigenetic regulation of gene expression in B-cell lymphomas,We aim to increase sensitivity to treatment with chemo- and immuno-therapy by epigenetic manipulation. We are presently evaluating the response of the HDACi Valproate in diffuse large Bcell lymphoma patients (the VALFRID trial) and in patients with chronic lymphocytic leukemia (the PREVAIL trial). Simultaneously, we are elaborating our findings in lymphoma cell lines and primary cells, where we have the opportunity to study the function of individual epigenetic regulators in detail. We utilize techniques like chromatin immunoprecipitation (ChIP), flow cytometry, gene knockdown by lentiviral transduction of shRNA, qPCR and Western blot. Since a range of HDACis and DNA methyltransferase inhibitors are presently clinically utilised, we hope that our findings will soon be of patient benefit.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

UKÄ subject classification

  • Cancer and Oncology

Free keywords

  • B-cell lymphoma
  • Epigenetics
  • HDAC inhibitor

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