Personal profile
Research
My research activities involve building subject-specific numerical models of the hip to improve the diagnosis and treatment of several hip-related diseases.
We have been focusing for many years on improving osteoporosis diagnosis and fracture risk assessment. This can be accomplished by combining DXA imaging, a pre-developed shape template, statistical shape modeling, and finite element analysis (FEA). The project develops a method to estimate the 3D geometry of the hip bone based on a 2D image and a shape template. This method can describe both the external geometry and the internal bone mineral density distribution. Thereafter, the shape template and the 2D image of the patient, is used together with finite element analyses to assess the bone strength and the individuals' fracture risk.
Starting from January 2023, we are looking at using similar 2D-to-3D reconstruction techniques to predict hip-related pathologies in kids during their development. This requires to build more robust methods that encompass the large variability of hip anatomy during growth, and the development of quantitative methods that can support the doctors in their clinical decision-making for each patient.
Teaching
I am course responsible for the following courses:
- Biomechanics (BMEN05), 7.5 HP
- Bachelor Project in Clinical Innovation (EEML05), 15 HP
Subject classification (UKÄ)
- Medical Imaging
- Other Mechanical Engineering
Free keywords
- biomechanics
- finite element analysis
- Bone
- hip fractures
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations the last five years
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Open and reproducible research in musculoskeletal imaging: why it matters and how to implement it with the guidelines of the Open and Reproducible Musculoskeletal Imaging Research (ORMIR) community
Bonaretti, S., Barzegari, M., Bevers, M., Boyd, S., Burghardt, A. J., Cameron, D., Chiumento, F., Crimi, G., Degenhart, G., Durongbhan, P., Espinosa Hernandez, M. A., Fraterrigo, G., Ghasem-Zadeh, A., Grassi, L., Hirvasniemi, J., Hosseinitabatabaei, S., Iori, G., Kok, J., Kuczynski, M. & Lee, Y. & 24 others, , 2026 Apr, In: JBMR Plus. 10, 4, 10 p., ziag025.Research output: Contribution to journal › Article › peer-review
Open Access -
DXA-derived three-dimensional finite element models of the femur: validation against CT-based models
Aldieri, A., Bhattacharya, P., Paggiosi, M., Eastell, R. & Grassi, L., 2026 Feb 9, (E-pub ahead of print) In: Bone. p. 117830Research output: Contribution to journal › Article › peer-review
Open Access -
Variations over time in proximal femoral strength in young adult men are not explained by areal bone mineral density alone
Attar, S., Isaksson, H., Jehpsson, L., Rosengren, B. E., Karlsson, M. K. & Grassi, L., 2025 Oct, In: JBMR Plus. 9, 10, 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
DXA-based 3D finite element models predict hip fractures better than areal BMD in elderly women
Grassi, L., Väänänen, S. P., Voss, A., Nissinen, T., Sund, R., Kröger, H. & Isaksson, H., 2025 Jun, In: Bone. 195, 7 p., 117457.Research output: Contribution to journal › Article › peer-review
Open Access -
Investigating Achilles tendon adaptation to mechanical load: a computational model integrating collagen fibre orientation heterogeneity
Janssen, R., Gustafsson, A., Jönsson, V., Grassi, L., Pierantoni, M. & Isaksson, H., 2025, In: Biomechanics and Modeling in Mechanobiology. 24, 6, p. 1959-1972Research output: Contribution to journal › Article › peer-review
Open Access
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In silico models to detect developmental hip dysplasia and prevent osteoarthritis
Grassi, L. (PI)
2025/01/01 → 2027/03/31
Project: Research
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PhD Project: Investigation of the link between hip pathologies during growth and osteoarthritis
Attar, S. (Researcher), Grassi, L. (Assistant supervisor) & Isaksson, H. (Supervisor)
2024/02/01 → 2028/02/29
Project: Dissertation
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Early quantification of hip-related abnormalities in children using statistical shape models
Grassi, L. (PI)
2023/01/01 → 2027/12/31
Project: Research
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Phd project: Characterization of articular cartilage at different knee osteoarthritis stages
Jönsson, V. (Researcher), Isaksson, H. (Researcher), Gustafsson, A. (Researcher) & Grassi, L. (Researcher)
2022/06/01 → 2026/10/01
Project: Dissertation
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eSSENCE@LU 8:4 - Diving deeper than ever into dolphin echolocation
Starkhammar, J. (PI), Grassi, L. (Researcher) & Sandsten, M. (Researcher)
2022/01/01 → 2023/12/31
Project: Research
Activities
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Swedish Society of Biomechanics annual meeting
Grassi, L. (Organiser)
2024 May 27 → 2024 May 28Activity: Participating in or organising an event › Participation in conference
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External examiner
Grassi, L. (Role not specified)
2023 Nov 29Activity: Examination and supervision › External Reviewer of PhD thesis
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The COMSOL Conference 2023
Starkhammar, J. (Speaker), Grassi, L. (Contributor), Finneran, J. (Contributor), Mulsow, J. (Contributor) & Houser, D. S. (Contributor)
2023 Oct 25 → 2023 Oct 27Activity: Participating in or organising an event › Participation in conference
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External examiner
Grassi, L. (Role not specified)
2022 Nov 4Activity: Examination and supervision › External Reviewer of PhD thesis
Prizes and Distinction
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ESB Best Doctoral Thesis Award
Grassi, L. (Recipient), 2017 May 4
Prize: Prize (including medals and awards)
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