Mårten Segelmark

Search results

• 2011

  Genes That Link Nephritis to Autoantibodies and Innate Immunity.

  Segelmark, M., 2011, In: New England Journal of Medicine. 364, 7, p. 679-680

  Research output: Contribution to journal › Debate/Note/Editorial

• Pseudomonas aeruginosa in cystic fibrosis: Pyocyanin negative strains are associated with BPI-ANCA and progressive lung disease.

  Carlsson, M., Shukla, S., Petersson, A. C., Segelmark, M. & Hellmark, T., 2011, In: Journal of Cystic Fibrosis. 10, p. 265-271

  Research output: Contribution to journal › Article › peer-review

  • Pyocyanine 100%
  • Antineutrophil Cytoplasmic Antibodies 80%
  • Cystic Fibrosis 62%
  • Pseudomonas aeruginosa 59%
  • Lung Diseases 57%
• 2010

  Autoimmune kidney diseases.

  Segelmark, M. & Hellmark, T., 2010, In: Autoimmunity Reviews. 9, p. A366-A371

  Research output: Contribution to journal › Article › peer-review

  • Membranous Glomerulonephritis 100%
  • Glomerulonephritis 83%
  • Kidney Diseases 82%
  • Anti-Glomerular Basement Membrane Disease 78%
  • Immunoglobulin A 73%

• Elevated neutrophil membrane expression of proteinase 3 is dependent upon CD177 expression.

  AbdGawad, M., Gunnarsson, L., Bengtsson, A., Geborek, P., Nilsson, L., Segelmark, M. & Hellmark, T., 2010, In: Clinical and Experimental Immunology. 161, p. 89-97

  Research output: Contribution to journal › Article › peer-review

  • Myeloblastin 100%
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 63%
  • Systemic Vasculitis 56%
  • Neutrophils 54%
  • Membranes 41%

• Epitope shift of proteinase-3 anti-neutrophil cytoplasmic antibodies in patients with small vessel vasculitis.

  Selga, D., Segelmark, M., Gunnarsson, L. & Hellmark, T., 2010, In: Clinical and Experimental Immunology. 160, p. 318-324

  Research output: Contribution to journal › Article › peer-review

  • Myeloblastin 100%
  • Antineutrophil Cytoplasmic Antibodies 87%
  • Vasculitis 71%
  • Epitopes 59%
  • Recurrence 15%

• EULAR points to consider in the development of classification and diagnostic criteria in systemic vasculitis

  Basu, N., Watts, R., Bajema, I., Baslund, B., Bley, T., Boers, M., Brogan, P., Calabrese, L., Cid, M. C., Cohen-Tervaert, J. W., Flores-Suarez, L. F., Fujimoto, S., de Groot, K., Guillevin, L., Hatemi, G., Hauser, T., Jayne, D., Jennette, C., Kallenberg, C. G. M., Kobayashi, S., & 19 othersLittle, M. A., Mahr, A., McLaren, J., Merkel, P. A., Ozen, S., Puechal, X., Rasmussen, N., Salama, A., Salvarani, C., Savage, C., Scott, D. G. I., Segelmark, M., Specks, U., Sunderkoeetter, C., Suzuki, K., Tesar, V., Wiik, A., Yazici, H. & Luqmani, R., 2010, In: Annals of the Rheumatic Diseases. 69, 10, p. 1744-1750

  Research output: Contribution to journal › Article › peer-review

  • Systemic Vasculitis 100%
  • Rheumatic Diseases 83%
  • Vasculitis 80%
  • Terminology 78%
  • Marker 68%

• Natural autoantibodies to myeloperoxidase, proteinase 3, and the glomerular basement membrane are present in normal individuals

  Cui, Z., Zhao, M., Segelmark, M. & Hellmark, T., 2010, In: Kidney International. 78, 6, p. 590-597

  Research output: Contribution to journal › Article › peer-review

  • Myeloblastin 100%
  • Glomerular Basement Membrane 87%
  • Peroxidase 66%
  • Autoantibodies 64%
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 25%

• Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis.

  Jones, R. B., Tervaert, J. W. C., Hauser, T., Luqmani, R., Morgan, M. D., Peh, C. A., Savage, C. O., Segelmark, M., Tesar, V., van Paassen, P., Walsh, D., Walsh, M., Westman, K. & Jayne, D. R. W., 2010, In: New England Journal of Medicine. 363, 3, p. 211-220

  Research output: Contribution to journal › Article › peer-review

  • Antineutrophil Cytoplasmic Antibodies 100%
  • Rituximab 86%
  • Vasculitis 81%
  • Cyclophosphamide 74%
  • Kidney 42%

• Successful treatment of experimental glomerulonephritis with IdeS and EndoS, IgG-degrading streptococcal enzymes

  Yang, R., Otten, M. A., Hellmark, T., Collin, M., Björck, L., Zhao, M-H., Daha, M. R. & Segelmark, M., 2010, In: Nephrology Dialysis Transplantation. 25, 8, p. 2479-2486

  Research output: Contribution to journal › Article › peer-review

  • Glycoside Hydrolases 100%
  • Glomerulonephritis 84%
  • Immunoglobulin G 59%
  • Enzymes 43%
  • Anti-Glomerular Basement Membrane Disease 39%
• 2009

  A comparison between biopsy-proven Lupus and ANCA-associated nephritis within a defined geographical area in southern Sweden

  Mohammad, A., Ståhl Hallengren, C., Nived, O., Sturfelt, G., Bengtsson, A. & Segelmark, M., 2009, In: APMIS. 117, p. 159-159

  Research output: Contribution to journal › Published meeting abstract › peer-review

• BPI-ANCA and long-term prognosis among adult CF patients: a prospective 10-year follow-up study

  Lindberg, U., Mared, L., Carlsson, M. & Segelmark, M., 2009, In: APMIS. 117, p. 172-172

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Capture ELISA for PR3-ANCA is superior to detect and predict relapses of systemic vasculitis compared with direct ELISA

  Selga, D. & Segelmark, M., 2009, In: APMIS. 117, p. 177-177

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Incidence and survival rates in Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and polyarteritis nodosa.

  Mohammad, A., Jacobsson, L., Westman, K., Sturfelt, G. & Segelmark, M., 2009, In: Rheumatology (Oxford, England). 48, p. 1560-1565

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microscopic Polyangiitis 100%
  • Churg-Strauss Syndrome 96%
  • Polyarteritis Nodosa 91%
  • Granulomatosis with Polyangiitis 84%
  • Survival Rate 50%

• Levels of epitope-specific autoantibodies correlate with renal damage in anti-GBM disease

  Yang, R., Hellmark, T., Zhao, J., Cui, Z., Segelmark, M., Zhao, M. & Wang, H., 2009, In: Nephrology Dialysis Transplantation. 24, 6, p. 1838-1844

  Research output: Contribution to journal › Article › peer-review

  • Anti-Glomerular Basement Membrane Disease 100%
  • Autoantibodies 61%
  • Epitopes 57%
  • Glomerular Basement Membrane 55%
  • Antibodies 36%

• Monocyte chemoattractant protein 1 is a prognostic marker in ANCA-associated small vessel vasculitis.

  Ohlsson, S., Bakoush, O., Tencer, J., Torffvit, O. & Segelmark, M., 2009, In: Mediators of Inflammation. 2009, Jul 5, 584916.

  Research output: Contribution to journal › Article › peer-review

  • Antineutrophil Cytoplasmic Antibodies 100%
  • Chemokine CCL2 88%
  • Vasculitis 81%
  • Interleukin-8 75%
  • Immunoglobulin M 70%

• Natural autoantibodies against myeloperoxidase, protease 3 and glomerular basement membrane in normal healthy individuals

  Cui, Z., Zhao, M-H., Segelmark, M. & Hellmark, T., 2009, In: APMIS. 117, p. 171-171

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Randomized trial of rituximab vs cyclophosphamide for ANCA-associated renal vasculitis: RITUXVAS

  Jones, R., Tervaert, J. W. C., Hauser, T., Luqmani, R., Peh, C. A. U., Savage, C., Segelmark, M., Tesar, V., Van Paassen, P., Walsh, M., Walsh, D., Westman, K. & Jayne, D., 2009, In: APMIS. 117, p. 78-78

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Severe alpha 1-antitrypsin deficiency and primary systemic vasculitis revisited

  Segelmark, M. & Mohammad, A., 2009, In: APMIS. 117, p. 163-163

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Studies of mechanisms underlying the prolonged neutrophil survival in ANCA-associated systemic vasculitis

  AbdGawad, M., Gunnarsson, L., Bengtsson, A., Geborek, P., Segelmark, M. & Hellmark, T., 2009, In: APMIS. 117, p. 125-125

  Research output: Contribution to journal › Published meeting abstract › peer-review

• The clinical significance of a positive test for direct MPO-ANCA ELISA or capture MPO-ANCA ELISA when using international units

  Segelmark, M., Baslund, B. & Wieslander, J., 2009, In: APMIS. 117, p. 176-176

  Research output: Contribution to journal › Published meeting abstract › peer-review

• The extent and pattern of organ damage in small vessel vasculitis measured by the Vasculitis Damage Index (VDI)

  Mohammad, A. J., Bakoush, O., Sturfelt, G. & Segelmark, M., 2009, In: Scandinavian Journal of Rheumatology. 38, 4, p. 268-275

  Research output: Contribution to journal › Article › peer-review

  • Vasculitis 100%
  • Microscopic Polyangiitis 43%
  • Churg-Strauss Syndrome 41%
  • Pharynx 39%
  • Polyarteritis Nodosa 39%

• Two cases of Wegener's granulomatosis with unusual localization of granulomatous vasculitis

  Mohammad, A., Selga, D. & Segelmark, M., 2009, In: APMIS. 117, p. 109-109

  Research output: Contribution to journal › Published meeting abstract › peer-review
• 2008

  Irreversible Kidney Damage due to Multicentric Castleman's Disease

  Kahn, F., Fagerström, A., Segelmark, M. & Bakoush, O., 2008 Jun 1, In: Libyan Journal of Medicine. 3, 2, p. 101-3 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Multi-centric Castleman's Disease 100%
  • Castleman Disease 93%
  • Kidney 35%
  • Amyloidosis 29%
  • Hyalin 16%

• Modulation of disease in an experimental complement-dependent murine model of renal inflammation

  Groeneveld, T., Otten, M., Flierman, R., Yang, R., Rastaldi, M-P., Trouw, L., Faber-Krol, M., Essers, M., Verbeek, S., Segelmark, M., Daha, M. & Roos, A., 2008, In: Molecular Immunology. 45, 16, p. P158

  Research output: Contribution to journal › Published meeting abstract › peer-review

• The incidence of renal vasculitis in southern Sweden

  Mohammad, A., Jacobsson, L., Westman, K., Sturfelt, G. & Segelmark, M., 2008, In: Arthritis and Rheumatism. 58, 9, p. S848-S848

  Research output: Contribution to journal › Published meeting abstract › peer-review
• 2007

  Antigen and epitope specificity of anti-glomerular basement membrane antibodies in patients with Goodpasture disease with or without anti-neutrophil cytoplasmic antibodies

  Yang, R., Hellmark, T., Zhao, J., Cui, Z., Segelmark, M., Zhao, M. & Wang, H., 2007, In: Journal of the American Society of Nephrology. 18, 4, p. 1338-1343

  Research output: Contribution to journal › Article › peer-review

  • Glomerular Basement Membrane 100%
  • Antineutrophil Cytoplasmic Antibodies 99%
  • Epitopes 68%
  • Antigens 50%
  • Antibodies 43%

• Autoantibody response to BPI predict disease severity and outcome in cystic fibrosis.

  Carlsson, M., Eriksson, L., Pressler, T., Kornfält, R., Mared, L., Meyer, P., Wiik, A., Wieslander, J. & Segelmark, M., 2007, In: Journal of Cystic Fibrosis. 6, p. 228-233

  Research output: Contribution to journal › Article › peer-review

• Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies

  Watts, R., Lane, S., Hanslik, T., Hauser, T., Hellmich, B., Koldingsnes, W., Mahr, A., Segelmark, M., Cohen-Tervaert, J. W. & Scott, D., 2007, In: Annals of the Rheumatic Diseases. 66, 2, p. 222-227

  Research output: Contribution to journal › Article › peer-review

  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 100%
  • Polyarteritis Nodosa 93%
  • Granulomatosis with Polyangiitis 69%
  • Microscopic Polyangiitis 61%
  • Marker 60%

• Glomerular basement membrane autoantibodies

  Hellmark, T. & Segelmark, M., 2007 Dec 1, Autoantibodies. Shoenfeld, Y., Gershwin, M. E. & Meroni, P. L. (eds.). Elsevier, p. 553-559

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  • Glomerular Basement Membrane 100%
  • Autoantibodies 73%
  • Indirect Fluorescent Antibody Technique 50%
  • Anti-Glomerular Basement Membrane Disease 47%
  • Antibodies 43%

• På väg mot evidensbaserad terapi vid primär systemisk vaskulit. De senaste decenniernas framsteg har gett dagens patienter bättre läge

  Segelmark, M. & Westman, K., 2007, In: Läkartidningen. 104, 12, p. 954-957

  Research output: Contribution to journal › Article › peer-review

  • Vasculitis 100%
  • Antineutrophil Cytoplasmic Antibodies 40%
  • Cyclophosphamide 30%
  • Multicenter Studies 28%
  • Patient Care 25%

• PR3 and CD177 are co-expressed on neutrophil plasma membranes in patients with ANCA associated systemic vasculitis

  AbdGawad, M., Gunnarsson, L., Segelmark, M. & Hellmark, T., 2007, In: Clinical and Experimental Rheumatology. 25, 1 Suppl. 44, p. S82-S82

  Research output: Contribution to journal › Published meeting abstract › peer-review

• Prevalence of Wegener's granulomatosis, microscopic polyangiitis, polyarteritis nodosa and Churg-Strauss syndrome within a defined population in southern Sweden

  Mohammad, A., Jacobsson, L. T. H., Mahr, A. D., Sturfelt, G. & Segelmark, M., 2007, In: Rheumatology. 46, 8, p. 1329-1337

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microscopic Polyangiitis 100%
  • Churg-Strauss Syndrome 96%
  • Polyarteritis Nodosa 91%
  • Granulomatosis with Polyangiitis 84%
  • Sweden 66%

• Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils.

  Bauer, S., AbdGawad, M., Gunnarsson, L., Segelmark, M., Tapper, H. & Hellmark, T., 2007, In: Journal of Leukocyte Biology. 81, p. 458-464

  Research output: Contribution to journal › Article › peer-review

  • Myeloblastin 100%
  • Neutrophils 54%
  • Cell Membrane 50%
  • Polycythemia Vera 22%
  • Granulomatosis with Polyangiitis 21%

• The challenge of managing patients with polyarteritis nodosa.

  Segelmark, M. & Selga, D., 2007, In: Current Opinion in Rheumatology. 19, 1, p. 33-38

  Research output: Contribution to journal › Review article › peer-review

  • Polyarteritis Nodosa 100%
  • Microscopic Polyangiitis 18%
  • Systemic Vasculitis 15%
  • Vasculitis 12%
  • Natural History 12%

• Thirty-five years of hemodialysis: two case reports as a tribute to Nils Alwall.

  Kurkus, J., Nykvist, M., Lindergård, B. & Segelmark, M., 2007, In: American Journal of Kidney Diseases. 49, 3, p. 471-476

  Research output: Contribution to journal › Article › peer-review

  • Renal Dialysis 100%
  • Renal Replacement Therapy 26%
  • Survival 25%
  • Kidney Transplantation 21%
  • Survivors 20%
• 2006

  Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism.

  AbdGawad, M., Hellmark, T., Gunnarsson, L., Westman, K. & Segelmark, M., 2006, In: Clinical and Experimental Immunology. 145, 1, p. 63-70

  Research output: Contribution to journal › Article › peer-review

  File

  • Myeloblastin 100%
  • Systemic Vasculitis 89%
  • Neutrophils 54%
  • Cell Membrane 50%
  • Vasculitis 21%
  162 Downloads (Pure)

• Polyarteritis nodosa when applying the Chapel Hill nomenclature--a descriptive study on ten patients.

  Selga, D., Mohammad, A., Sturfelt, G. & Segelmark, M., 2006, In: Rheumatology. 45, 10, p. 1276-1281

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Polyarteritis Nodosa 100%
  • Terminology 74%
  • Recurrence 21%
  • Kidney 19%
  • Microscopic Polyangiitis 18%

• Urine IgM excretion predicts outcome in ANCA-associated renal vasculitis.

  Bakoush, O., Segelmark, M., Torffvit, O., Ohlsson, S. & Tencer, J., 2006, In: Nephrology Dialysis Transplantation. 21, 5, p. 1263-1269

  Research output: Contribution to journal › Article › peer-review
• 2005

  Alport syndrome caused by inversion of a 21 Mb fragment of the long arm of the X-chromosome comprising exon 9 through 51 of the COL4A5 gene

  Hertz, J. M., Persson, U., Juncker, I. & Segelmark, M., 2005, In: Human Genetics. 118, 1, p. 23-28

  Research output: Contribution to journal › Article › peer-review

  • Hereditary Nephritis 100%
  • Single-Stranded Conformational Polymorphism 77%
  • X Chromosome 77%
  • Exons 57%
  • Mutation 38%

• Alport syndrome in southern Sweden.

  Persson, U., Hertz, J. M., Wieslander, J. & Segelmark, M., 2005, In: Clinical Nephrology. 64, 2, p. 85-90

  Research output: Contribution to journal › Article › peer-review

• Deficiency of the mannan-binding lectin pathway of complement and poor outcome in cystic fibrosis: bacterial colonization may be decisive for a relationship.

  Carlsson, M., Sjöholm, A., Eriksson, L., Thiel, S., Jensenius, J. C., Segelmark, M. & Truedsson, L., 2005, In: Clinical and Experimental Immunology. 139, 2, p. 306-313

  Research output: Contribution to journal › Article › peer-review

  File
  163 Downloads (Pure)

• Increased monocyte transcription of the proteinase 3 gene in small vessel vasculitis.

  Ohlsson, S., Hellmark, T., Pieters, K., Sturfelt, G., Wieslander, J. & Segelmark, M., 2005, In: Clinical and Experimental Immunology. 141, 1, p. 174-182

  Research output: Contribution to journal › Article › peer-review

  File
  172 Downloads (Pure)

• Rapid resolution of EPO-induced pure red cell aplasia after a course of immunoadsorption therapy using protein a columns

  Westerlund, P., Kurkus, J. & Segelmark, M., 2005, In: American Journal of Kidney Diseases. 45, 6, p. E97-E99

  Research output: Contribution to journal › Article › peer-review

  • Pure Red-Cell Aplasia 100%
  • Erythropoietin 70%
  • Proteins 24%
  • Reticulocyte Count 22%
  • Staphylococcal Protein A 19%
• 2004

  Circulating cytokine profile in anti-neutrophilic cytoplasmatic autoantibody-associated vasculitis: prediction of outcome?

  Ohlsson, S., Wieslander, J. & Segelmark, M., 2004, In: Mediators of Inflammation. 13, 4, p. 275-283

  Research output: Contribution to journal › Article › peer-review

  • Vasculitis 100%
  • Autoantibodies 89%
  • Interleukin-8 69%
  • Interleukin-10 64%
  • Cytokines 60%

• Epitope mapping of anti-PR3 antibodies using chimeric human/mouse PR3 recombinant proteins.

  Selga, D., Segelmark, M., Wieslander, J., Gunnarsson, L. & Hellmark, T., 2004, In: Clinical and Experimental Immunology. 135, 1, p. 164-172

  Research output: Contribution to journal › Article › peer-review

  File
  227 Downloads (Pure)

• Patients with Goodpasture's disease have two normal COL4A3 alleles encoding the NC1 domain of the type IV collagen {alpha}3 chain.

  Persson, U., Michael Hertz, J., Carlsson, M., Hellmark, T., Juncker, I., Wieslander, J. & Segelmark, M., 2004, In: Nephrology Dialysis Transplantation. 19, 8, p. 2030-2035

  Research output: Contribution to journal › Article › peer-review

  • Collagen Type IV 100%
  • Alleles 61%
  • Major Histocompatibility Complex 42%
  • HLA-DRB1 Chains 41%
  • type IV collagen alpha3 chain 36%
• 2003

  Increased circulating levels of proteinase 3 in patients with anti-neutrophilic cytoplasmic autoantibodies-associated systemic vasculitis in remission.

  Ohlsson, S., Wieslander, J. & Segelmark, M., 2003, In: Clinical and Experimental Immunology. 131, 3, p. 528-535

  Research output: Contribution to journal › Article › peer-review

  File
  191 Downloads (Pure)

• Monitoring proteinase 3 antineutrophil cytoplasmic antibodies for detection of relapses in small vessel vasculitis.

  Segelmark, M., Phillips, B. D., Hogan, S. L., Falk, R. J. & Jennette, J. C., 2003, In: Clinical and Diagnostic Laboratory Immunology. 10, 5, p. 769-774

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  112 Downloads (Pure)

• Pseudomonas-induced lung damage in cystic fibrosis correlates to bactericidal-permeability increasing protein (BPI)-autoantibodies

  Carlsson, A., Eriksson, L., Erwander, I., Wieslander, J. & Segelmark, M., 2003, In: Clinical and Experimental Rheumatology. 21, Suppl. 32, p. S95-S100

  Research output: Contribution to journal › Article › peer-review

  • bactericidal permeability increasing protein 100%
  • Antineutrophil Cytoplasmic Antibodies 78%
  • Pseudomonas 69%
  • Cystic Fibrosis 60%
  • Autoantibodies 57%

• The prognostic significance in Goodpasture's disease of specificity, titre and affinity of anti-glomerular-basement-membrane antibodies.

  Segelmark, M., Hellmark, T. & Wieslander, J., 2003, In: Nephron Clinical Practice. 94, 3, p. C59-C68

  Research output: Contribution to journal › Article › peer-review

  • Glomerular Basement Membrane 100%
  • Antibodies 43%
  • Kidney 42%
  • Dialysis 19%
  • Anti-Glomerular Basement Membrane Disease 17%