Magnus Gram

2024

Choroid plexus extracellular vesicle transport of blood-borne insulin-like growth factor 1 to the hippocampus of the immature brain

Ortenlöf, N., Vallius, S., Karlsson, H., Ekström, C., Kristiansson, A., Holmqvist, B., Pankratova, S., Barton, N., Ley, D. & Gram, M., 2024 Dec, In: PNAS Nexus. 3, 12, pgae496.

Research output: Contribution to journal › Article › peer-review

Open Access

Heme: A link between hemorrhage and retinopathy of prematurity progression

Gáll, T., Pethő, D., Erdélyi, K., Egri, V., Balla, J. G., Nagy, A., Póliska, S., Gram, M., Gábriel, R., Nagy, P., Balla, J. & Balla, G., 2024 Oct, In: Redox Biology. 76, 103316.

Research output: Contribution to journal › Article › peer-review

Open Access

Effects of Recombinant α₁-Microglobulin on Early Proteomic Response in Risk Organs after Exposure to ¹⁷⁷Lu-Octreotate

Ytterbrink, C., Shubbar, E., Parris, T. Z., Langen, B., Druid, M., Schüler, E., Strand, S. E., Åkerström, B., Gram, M., Helou, K. & Forssell-Aronsson, E., 2024 Jul, In: International Journal of Molecular Sciences. 25, 13, 7480.

Research output: Contribution to journal › Article › peer-review

Open Access

Therapeutic a-1-microglobulin ameliorates kidney ischemia-reperfusion injury

Burmakin, M., Gilmour, P. S., Gram, M., Shushakova, N., Sandoval, R. M., Molitoris, B. A. & Larsson, T. E., 2024 Jul, In: American Journal of Physiology - Renal Physiology. 327, 1, p. F103-F112

Research output: Contribution to journal › Article › peer-review

Red blood cell-derived arginase release in hemolytic uremic syndrome

Friberg, N., Arvidsson, I., Tontanahal, A., Kristoffersson, A.-C., Gram, M., Kaplan, B. S. & Karpman, D., 2024 Jan 4, In: Journal of Translational Medicine. 22, 1, 16 p., 17.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Characterization of choroid plexus in the preterm rabbit pup following subcutaneous administration of recombinant human IGF-1/IGFBP-3

Ortenlöf, N., Vallius, S., Karlsson, H., Ekström, C., Kristiansson, A., Holmqvist, B., Göransson, O., Vaváková, M., Rydén, M., Carey, G., Barton, N., Ley, D. & Gram, M., 2023 Dec, In: Fluids and Barriers of the CNS. 20, 1, 59.

Research output: Contribution to journal › Article › peer-review

Open Access

Recombinant α 1-Microglobulin (rA1M) Protects against Hematopoietic and Renal Toxicity, Alone and in Combination with Amino Acids, in a 177Lu-DOTATATE Mouse Radiation Model.

Alattar, A. G., Kristiansson, A., Karlsson, H., Vallius, S., Ahlstedt, J., Forssell-Aronsson, E., Åkerström, B., Strand, S.-E., Flygare, J. & Gram, M., 2023 Jun 1, In: Biomolecules. 13, 6, p. 1-13 923.

Research output: Contribution to journal › Article › peer-review

Open Access

Arginase release in hemolytic uremic syndrome affects the vasculature

Friberg Hed, N., Tontanahal, A., Kristoffersson, A.-C., Kaplan, B. S., Gram, M., Arvidsson, I. & Karpman, D., 2023 May 7.

Research output: Contribution to conference › Abstract

Accessing the exosome proteome in a minute blood plasma sample by rapid acoustic isolation of extracellular vesicles

Havers, M., Ortenlöf, N., Scott, A., Isaksson, M., Ekström, S., Welinder, C., Baasch, T., Evander, M., Lenshof, A., Gram, M. & Laurell, T., 2023, (Unpublished).

Research output: Contribution to conference › Poster

Co-administration with A1M does not influence apoptotic response of ¹⁷⁷Lu-octreotate in GOT1 neuroendocrine tumors

Rassol, N., Andersson, C., Pettersson, D., Al-Awar, A., Shubbar, E., Kovács, A., Åkerström, B., Gram, M., Helou, K. & Forssell-Aronsson, E., 2023, In: Scientific Reports. 13, 1, 6417.

Research output: Contribution to journal › Article › peer-review

Open Access

Evaluation of recombinant human IGF‑1/IGFBP‑3 on intraventricular hemorrhage prevention and survival in the preterm rabbit pup model

Ekström, C., Ortenlöf, N., Kristiansson, A., Holmqvist, B., Jungner, Å., Vallius, S., Wang, X., Hellström, A., Barton, N. W., Carey, G., Ley, D. & Gram, M., 2023, In: Scientific Reports. 13, p. 1-12 19847 .

Research output: Contribution to journal › Article › peer-review

Open Access

Free heme and hemopexin in acute kidney injury after cardiopulmonary bypass and transient renal ischemia

Greite, R., Schott, S., Wang, L., Gohlke, L., Kreimann, K., Derlin, K., Gutberlet, M., Schmidbauer, M., Leffler, A., Tudorache, I., Salman, J., Ius, F., Natanov, R., Fegbeutel, C., Haverich, A., Lichtinghagen, R., Hüsing, A. M., von Vietinghoff, S., Schmitt, R. & Shushakova, N. & 8 others, Rong, S., Haller, H., Schmidt-Ott, K. M., Gram, M., Vijayan, V., Scheffner, I., Gwinner, W. & Immenschuh, S., 2023, In: Clinical and Translational Science. 16, 12, p. 2729-2743

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Cell-Free Hemoglobin in Acute Kidney Injury after Lung Transplantation and Experimental Renal Ischemia/Reperfusion

Greite, R., Wang, L., Gohlke, L., Schott, S., Kreimann, K., Doricic, J., Leffler, A., Tudorache, I., Salman, J., Natanov, R., Ius, F., Fegbeutel, C., Haverich, A., Lichtinghagen, R., Chen, R., Rong, S., Haller, H., Vijayan, V., Gram, M. & Scheffner, I. & 3 others, Gueler, F., Gwinner, W. & Immenschuh, S., 2022 Nov, In: International Journal of Molecular Sciences. 23, 21, 13272.

Research output: Contribution to journal › Article › peer-review

Open Access

Cell-Free Hemoglobin Concentration in Blood Prime Solution Is a Major Determinant of Cell-Free Hemoglobin Exposure during Cardiopulmonary Bypass Circulation in the Newborn

Jungner, Å., Vallius, S., Gram, M. & Ley, D., 2022, In: Journal of Clinical Medicine. 11, 14, 4071.

Research output: Contribution to journal › Article › peer-review

Open Access

Targeting elevated heme levels to treat a mouse model for Diamond-Blackfan Anemia

Sjögren, S. E., Chen, J., Mattebo, A., Alattar, A. G., Karlsson, H., Siva, K., Soneji, S., Tedgård, U., Chen, J. J., Gram, M. & Flygare, J., 2022, In: Experimental Hematology. 105, 0, p. 50-61

Research output: Contribution to journal › Article › peer-review

2021

Insulin-Like Growth Factor 1 in the Preterm Rabbit Pup: Characterization of Cerebrovascular Maturation following Administration of Recombinant Human Insulin-Like Growth Factor 1/Insulin-Like Growth Factor 1-Binding Protein 3

Gram, M., Ekström, C., Holmqvist, B., Carey, G., Wang, X., Vallius, S., Hellström, W., Ortenlöf, N., Agyemang, A. A., Smith, L. E. H., Hellström, A., Mangili, A., Barton, N. & Ley, D., 2021 Sept 1, In: Developmental Neuroscience. 43, 5, p. 281-295 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Production of functional human fetal hemoglobin in Nicotiana benthamiana for development of hemoglobin-based oxygen carriers

Kanagarajan, S., Carlsson, M. L. R., Chakane, S., Kettisen, K., Smeds, E., Kumar, R., Ortenlöf, N., Gram, M., Åkerström, B., Bülow, L. & Zhu, L. H., 2021 Aug 1, In: International Journal of Biological Macromolecules. 184, p. 955-966 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Cell-free oxidized hemoglobin drives reactive oxygen species production and pro-inflammation in an immature primary rat mixed glial cell culture

Agyemang, A. A., Kvist, S. V., Brinkman, N., Gentinetta, T., Illa, M., Ortenlöf, N., Holmqvist, B., Ley, D. & Gram, M., 2021 Feb 11, In: Journal of Neuroinflammation. 18, 1, 42.

Research output: Contribution to journal › Article › peer-review

Open Access

177Lu-PSMA-617 Therapy in Mice, with or without the Antioxidant α1-Microglobulin (A1M), Including Kidney Damage Assessment Using 99mTc-MAG3 Imaging

Kristiansson, A., Örbom, A., Ahlstedt, J., Karlsson, H., Zedan, W., Gram, M., Åkerström, B., Strand, S.-E., Altai, M., Strand, J. & Vilhelmsson Timmermand, O., 2021 Feb 10, In: Biomolecules. 11, 2, 263.

Research output: Contribution to journal › Article › peer-review

Open Access

Ferryl hemoglobin and heme induce Α1‐microglobulin in hemorrhaged atherosclerotic lesions with inhibitory function against hemoglobin and lipid oxidation

Pethő, D., Gáll, T., Hendrik, Z., Nagy, A., Beke, L., Gergely, A. P., Méhes, G., Tóth, C., Gram, M., Åkerström, B., Balla, G. & Balla, J., 2021, In: International Journal of Molecular Sciences. 22, 13, 6668.

Research output: Contribution to journal › Article › peer-review

Open Access

Human radical scavenger α1-microglobulin protects against hemolysis in vitro and α1-microglobulin knockout mice exhibit a macrocytic anemia phenotype

Kristiansson, A., Bergwik, J., Alattar, A. G., Flygare, J., Gram, M., Hansson, S. R., Olsson, M. L., Storry, J. R., Allhorn, M. & Åkerström, B., 2021, In: Free Radical Biology & Medicine. 162

Research output: Contribution to journal › Article › peer-review

Knockout of the radical scavenger α₁-microglobulin in mice results in defective bikunin synthesis, endoplasmic reticulum stress and increased body weight

Bergwik, J., Kristiansson, A., Welinder, C., Göransson, O., Hansson, S. R., Gram, M., Erlandsson, L. & Åkerström, B., 2021, In: Free Radical Biology and Medicine. 162

Research output: Contribution to journal › Article › peer-review

Structure, Functions, and Physiological Roles of the Lipocalin α₁-Microglobulin (A1M)

Bergwik, J., Kristiansson, A., Allhorn, M., Gram, M. & Åkerström, B., 2021, In: Frontiers in Physiology. 12, 645650.

Research output: Contribution to journal › Review article › peer-review

Open Access

2020

Heme-induced oxidation of cysteine groups of myofilament proteins leads to contractile dysfunction of permeabilized human skeletal muscle fibres

Alvarado, G., Tóth, A., Csősz, É., Kalló, G., Dankó, K., Csernátony, Z., Smith, A., Gram, M., Akerström, B., Édes, I., Balla, G., Papp, Z. & Balla, J., 2020 Nov 1, In: International Journal of Molecular Sciences. 21, 21, 19 p., 8172.

Research output: Contribution to journal › Article › peer-review

Open Access

The Role of α1-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis-Therapeutic Opportunities in Hemolytic Conditions

Kristiansson, A., Gram, M., Flygare, J., Hansson, S. R., Åkerström, B. & Storry, J. R., 2020 Sept 30, In: International Journal of Molecular Sciences. 21, 19, p. 1-21 7234.

Research output: Contribution to journal › Review article › peer-review

Open Access

Enhancing mitochondrial function in vivo rescues MDS-like anemia induced by pRb deficiency

Sen, T., Jain, M., Gram, M., Mattebo, A., Soneji, S., Walkley, C. R. & Singbrant, S., 2020 Aug 1, In: Experimental Hematology. 88, p. 28-41 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Editorial: Biomarkers of Oxidative Stress

Gram, M. & Åkerström, B., 2020 Apr 22, In: Frontiers in Physiology. 11, 338.

Research output: Contribution to journal › Debate/Note/Editorial

Open Access

White Matter Brain Development after Exposure to Circulating Cell-Free Hemoglobin and Hyperoxia in a Rat Pup Model

Jungner, Å., Vallius Kvist, S., Romantsik, O., Bruschettini, M., Ekström, C., Bendix, I., Herz, J., Felderhoff-Mueser, U., Bibic, A., In'T Zandt, R., Gram, M. & Ley, D., 2020 Feb, In: Developmental Neuroscience. 41, 3-4, p. 234-246 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

α₁-Microglobulin (A1M) Protects Human Proximal Tubule Epithelial Cells from Heme-Induced Damage In Vitro

Kristiansson, A., Davidsson, S., Johansson, M. E., Piel, S., Elmér, E., Hansson, M. J., Åkerström, B. & Gram, M., 2020, In: International Journal of Molecular Sciences. 21, 16, 16 p., 5825.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

THE INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) SYSTEM IN THE PRETERM RABBIT PUP: A CHARACTERIZATION OF THE IGF-1 MRNA EXPRESSION IN LIVER, IGF-1 PROTEIN LEVELS IN SERUM AND BRAIN DISTRIBUTION OF IGF-1 RECEPTORS

Ekström, C., Holmqvist, B., Carey, G. (Editor), Wang, X. (Editor), Hellström, A. (Editor), Barton, N. W. (Editor), Gram, M. & Ley, D., 2019 Sept 18.

Research output: Contribution to conference › Abstract › peer-review

The heme and radical scavenger α₁-microglobulin (A1M) confers early protection of the immature brain following preterm intraventricular hemorrhage

Romantsik, O., Agyemang, A. A., Sveinsdóttir, S., Rutardóttir, S., Holmqvist, B., Cinthio, M., Mörgelin, M., Gumus, G., Karlsson, H., Hansson, S. R., Åkerström, B., Ley, D. & Gram, M., 2019 Jun 7, In: Journal of Neuroinflammation. 16, 1, 122.

Research output: Contribution to journal › Article › peer-review

Open Access

Non-invasive imaging methodologies for assessment of radiation damage to bone marrow and kidneys from peptide receptor radionuclide therapy. -

Ahlstedt, J., Johansson, E., Sydoff, M., Karlsson, H., Thordarson, E., Gram, M. & Eriksson, O., 2019 Apr 19, In: Neuroendocrinology. 110, 1-2, p. 130-138

Research output: Contribution to journal › Article › peer-review

Recombinant alpha-1-microglobulin is a potential kidney protector in 177Lu-octreotate treatment of neuroendocrine tumors

Andersson, C., Shubbar, E., Schuler, E., Åkerström, B., Gram, M. & Forssell-Aronsson, E., 2019 Mar 29, In: Journal of Nuclear Medicine. 60, 11, p. 1600-1604

Research output: Contribution to journal › Article › peer-review

rA1M-035, a Physicochemically Improved Human Recombinant α-Microglobulin, Has Therapeutic Effects in Rhabdomyolysis-Induced Acute Kidney Injury

Åkerström, B., Rosenlöf, L., Hägerwall, A., Rutardottir, S., Ahlstedt, J., Johansson, M. E., Erlandsson, L., Allhorn, M. & Gram, M., 2019 Feb, In: Antioxidants and Redox Signaling. 30, 4, p. 489-504

Research output: Contribution to journal › Article › peer-review

Open Access

Protection of Kidney Function with Human Antioxidation Protein α ₁ -Microglobulin in a Mouse ¹⁷⁷ Lu-DOTATATE Radiation Therapy Model

Kristiansson, A., Ahlstedt, J., Holmqvist, B., Brinte, A., Tran, T. A., Forssell-Aronsson, E., Strand, S. E., Gram, M. & Akerström, B., 2019, In: Antioxidants and Redox Signaling. 30, 14, p. 1746-1759 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Heme induces endoplasmic reticulum stress (Hier stress) in human aortic smooth muscle cells

Gáll, T., Pethő, D., Nagy, A., Hendrik, Z., Méhes, G., Potor, L., Gram, M., Åkerström, B., Smith, A., Nagy, P., Balla, G. & Balla, J., 2018 Nov 20, In: Frontiers in Physiology. 9, NOV, 1595.

Research output: Contribution to journal › Article › peer-review

Open Access

α₁-microglobulin protects against bleeding-induced oxidative damage in knee arthropathies

Larsson, S., Åkerström, B., Gram, M., Stefan Lohmander, L. & Struglics, A., 2018 Nov 16, In: Frontiers in Physiology. 9, NOV, 1596.

Research output: Contribution to journal › Article › peer-review

Open Access

Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity

Hellgren, G., Löfqvist, C., Hansen-Pupp, I., Gram, M., Smith, L. E., Ley, D. & Hellström, A., 2018 Apr, In: Growth Hormone and IGF Research. 39, p. 19-24

Research output: Contribution to journal › Article › peer-review

Open Access

Composite imprinted macroporous hydrogels for haemoglobin purification from cell homogenate

Hajizadeh, S., Kettisen, K., Gram, M., Bülow, L. & Ye, L., 2018 Jan, In: Journal of Chromatography A. 1534, p. 22-31

Research output: Contribution to journal › Article › peer-review

Behavioral testing and litter effects in the rabbit

Gümüş, H. G., Agyemang, A. A., Romantsik, O., Sandgren, R., Karlsson, H., Gram, M., Vallius, S., Ley, D., van den Hove, D. L. A. & Bruschettini, M., 2018, In: Behavioural Brain Research. 353, p. 236-241

Research output: Contribution to journal › Article › peer-review

Cell free hemoglobin in the fetoplacental circulation: A novel cause of fetal growth restriction?

Brook, A., Hoaksey, A., Gurung, R., Yoong, E. E. C., Sneyd, R., Baynes, G. C., Bischof, H., Jones, S., Higgins, L. E., Jones, C., Greenwood, S. L., Jones, R. L., Gram, M., Lang, I., Desoye, G., Myers, J., Schneider, H., Hansson, S. R., Crocker, I. P. & Brownbill, P., 2018, In: FASEB Journal. 32, 10, p. 5436-5446 11 p.

Research output: Contribution to journal › Article › peer-review

2017

Cerebellar Exposure to Cell-Free Hemoglobin Following Preterm Intraventricular Hemorrhage: Causal in Cerebellar Damage?

Agyemang, A. A., Sveinsdóttir, K., Vallius, S., SVEINSDOTTIR, S., Bruschettini, M., Romantsik, O., Hellström, A., Smith, L. E. H., Ohlsson, L., Holmqvist, B., Gram, M. & Ley, D., 2017 Jun 10, In: Translational Stroke Research. p. 1-13 13 p.

Research output: Contribution to journal › Article › peer-review

Cardiopulmonary bypass in the newborn: effects of circulatory cell-free hemoglobin and hyperoxia evaluated in a novel rat pup model

Jungner, Å., Vallius Kvist, S., Bruschettini, M., Romantsik, O., Gram, M. & Ley, D., 2017, In: Intensive Care Medicine Experimental. 5, 1, 45.

Research output: Contribution to journal › Article › peer-review

Open Access

Impaired Cerebellar Maturation, Growth Restriction, and Circulating Insulin-Like Growth Factor 1 in Preterm Rabbit Pups

Sveinsdóttir, K., Länsberg, J. K., Sveinsdóttir, S., Garwicz, M., Ohlsson, L., Hellström, A., Smith, L., Gram, M. & Ley, D., 2017, In: Developmental Neuroscience. 39, p. 487-497

Research output: Contribution to journal › Article › peer-review

Pathophysiology of extracellular haemoglobin: use of animal models to translate molecular mechanisms into clinical significance

Smeds, E., Romantsik, O., Jungner, Å., Erlandsson, L. & Gram, M., 2017, In: ISBT Science Series. 12, 1, p. 134-141 8 p.

Research output: Contribution to journal › Review article › peer-review

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Recombinant alpha-1-microglobulin: A potential treatment for preeclampsia

Gunnarsson, R., Åkerström, B., Hansson, S. R. & Gram, M., 2017, In: Drug Discovery Today. 22, 4, p. 736-743

Research output: Contribution to journal › Review article › peer-review

Open Access

2016

High presence of extracellular hemoglobin in the periventricular white matter following preterm intraventricular hemorrhage

Ley, D., Romantsik, O., Vallius, S., Sveinsdóttir, K., Sveinsdóttir, S., Agyemang, A. A., Baumgarten, M., Mörgelin, M., Lutay, N., Bruschettini, M., Holmqvist, B. & Gram, M., 2016 Aug 3, In: Frontiers in Physiology. 7, AUG, 330.

Research output: Contribution to journal › Article › peer-review

Open Access

Fetal hemoglobin, α₁-microglobulin and hemopexin are potential predictive first trimester biomarkers for preeclampsia

DOLBERG ANDERSON, U., Gram, M., Ranstam, J., Thilaganathan, B., Åkerström, B. & Hansson, S. R., 2016 Apr 1, In: Pregnancy Hypertension. 6, 2, p. 103-109 7 p.

Research output: Contribution to journal › Article › peer-review

Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.

Erlandsson, L., Nääv, Å., Hennessy, A., Vaiman, D., Gram, M., Åkerström, B. & Hansson, S., 2016, In: American Journal of Reproductive Immunology. 75, 3, p. 402-410

Research output: Contribution to journal › Review article › peer-review

Open Access

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337 Downloads (Pure)

Serum concentrations of vascular endothelial growth factor in relation to retinopathy of prematurity.

Hellgren, G., Löfqvist, C., Hård, A.-L., Pupp, I., Gram, M., Ley, D., Smith, L. E. & Hellström, A., 2016, In: Pediatric Research. 79, p. 70-75

Research output: Contribution to journal › Article › peer-review

Magnus Gram

Research output

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