Malin Lindstedt

2024

In vivo dendritic cell reprogramming for cancer immunotherapy

Ascic, E., Åkerström, F., Sreekumar Nair, M., Rosa, A., Kurochkin, I., Zimmermannova, O., Catena, X., Rotankova, N., Veser, C., Rudnik, M., Ballocci, T., Schärer, T., Huang, X., de Rosa Torres, M., Renaud, E., Velasco Santiago, M., Met, Ö., Askmyr, D., Lindstedt, M. & Greiff, L. & 6 others, Ligeon, L.-A., Agarkova, I., Svane, I. M., Pires, C. F., Rosa, F. F. & Pereira, C.-F., 2024 Sept 5, (E-pub ahead of print) In: Science (New York, N.Y.).

Research output: Contribution to journal › Article › peer-review

Fine tuning of the innate and adaptive immune responses by Interleukin-2

Sakellariou, C., Roser, L. A., Schiffmann, S. & Lindstedt, M., 2024, In: Journal of Immunotoxicology. 21, 1, 2332175.

Research output: Contribution to journal › Article › peer-review

Open Access

IL-2-mediated hepatotoxicity: knowledge gap identification based on the irAOP concept

Roser, L. A., Sakellariou, C., Lindstedt, M., Neuhaus, V., Dehmel, S., Sommer, C., Raasch, M., Flandre, T., Roesener, S., Hewitt, P., Parnham, M. J., Sewald, K. & Schiffmann, S., 2024, In: Journal of Immunotoxicology. 21, 1, 2332177.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Early Pharmacodynamic Changes Measured Using RNA Sequencing of Peripheral Blood from Patients in a Phase I Study with Mitazalimab, a Potent CD40 Agonistic Monoclonal Antibody

Andersson, H., Sobti, A., Jimenez, D. G., de Coaña, Y. P., Ambarkhane, S. V., Hägerbrand, K., Smith, K. E., Lindstedt, M. & Ellmark, P., 2023 Oct, In: Cells. 12, 19, 2365.

Research output: Contribution to journal › Article › peer-review

Open Access

Restoring tumor immunogenicity with dendritic cell reprogramming

Zimmermannova, O., Ferreira, A. G., Ascic, E., Velasco Santiago, M., Kurochkin, I., Hansen, M., Met, Ö., Caiado, I., Shapiro, I. E., Michaux, J., Humbert, M., Soto-Cabrera, D., Benonisson, H., Silvério-Alves, R., Gomez-Jimenez, D., Bernardo, C., Bauden, M., Andersson, R., Höglund, M. & Miharada, K. & 9 others, Nakamura, Y., Hugues, S., Greiff, L., Lindstedt, M., Rosa, F. F., Pires, C. F., Bassani-Sternberg, M., Svane, I. M. & Pereira, C.-F., 2023 Jul 7, In: Science Immunology. 8, 85, eadd4817.

Research output: Contribution to journal › Article › peer-review

Exploring Spatial Heterogeneity of Immune Cells in Nasopharyngeal Cancer

Sobti, A., Sakellariou, C., Nilsson, J. S., Askmyr, D., Greiff, L. & Lindstedt, M., 2023 Apr, In: Cancers. 15, 7, 2165.

Research output: Contribution to journal › Article › peer-review

Open Access

Single-cell analysis of myeloid cells in HPV⁺ tonsillar cancer

Jimenez, D. G., Altunbulakli, C., Swoboda, S., Sobti, A., Askmyr, D., Ali, A., Greiff, L. & Lindstedt, M., 2023 Jan 19, In: Frontiers in Immunology. 13, 1087843.

Research output: Contribution to journal › Article › peer-review

Open Access

A proteomics dataset capturing myeloid cell responses upon cellular exposure to fungicides, adjuvants and fungicide formulations

de Ávila, R. I., Carreira Santos, S., Siino, V., Levander, F., Lindstedt, M. & Zeller, K. S., 2023 Jan 4, In: Data in Brief. 46, 108878.

Research output: Contribution to journal › Article › peer-review

Open Access

Human papillomavirus-associated head and neck squamous cell carcinoma cells rely on glycolysis and display reduced oxidative phosphorylation

Li, N., Chamkha, I., Verma, G., Swoboda, S., Lindstedt, M., Greiff, L., Elmér, E. & Ehinger, J., 2023, In: Frontiers in Oncology. 13, 1304106.

Research output: Contribution to journal › Article › peer-review

Open Access

Targeted spatial proteomic analysis of CD8⁺ T- and myeloid cells in tonsillar cancer

Altunbulakli, C., Jimenez, D. G., Askmyr, D., Sobti, A., Swoboda, S., Greiff, L. & Lindstedt, M., 2023, In: Frontiers in Oncology. 13, 1253418.

Research output: Contribution to journal › Article › peer-review

Open Access

Upper airway microbiome transplantation for patients with chronic rhinosinusitis

Mårtensson, A., Cervin-Hoberg, C., Huygens, F., Lindstedt, M., Sakellariou, C., Greiff, L. & Cervin, A., 2023, In: International Forum of Allergy and Rhinology. 13, 6, p. 979-988

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Bispecific antibodies targeting CD40 and tumor-associated antigens promote cross-priming of T cells resulting in an antitumor response superior to monospecific antibodies

Hägerbrand, K., Varas, L., Deronic, A., Nyesiga, B., Sundstedt, A., Ljung, L., Sakellariou, C., Werchau, D., Thagesson, M., Gomez Jimenez, D., Greiff, L., Celander, M., Smedenfors, K., Rosén, A., Bölükbas, D., Carlsson, F., Levin, M., Säll, A., Von Schantz, L. & Lindstedt, M. & 1 others, Ellmark, P., 2022 Nov 2, In: Journal for ImmunoTherapy of Cancer. 10, 11, e005018.

Research output: Contribution to journal › Article › peer-review

Open Access

Adjuvants in fungicide formulations can be skin sensitizers and cause different types of cell stress responses

de Ávila, R. I., Carreira Santos, S., Siino, V., Levander, F., Lindstedt, M. & Zeller, K. S., 2022 Jan, In: Toxicology Reports. 9, p. 2030-2041 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Nasal administration of a probiotic assemblage in allergic rhinitis: A randomised placebo-controlled crossover trial

Mårtensson, A., Nordström, F. U., Cervin-Hoberg, C., Lindstedt, M., Sakellariou, C., Cervin, A. & Greiff, L., 2022, In: Clinical and Experimental Allergy. 52, 6, p. 774-783

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Pattern recognition receptor expression and maturation profile of dendritic cell subtypes in human tonsils and lymph nodes

Askmyr, D., Abolhalaj, M., Gomez Jimenez, D., Greiff, L., Lindstedt, M. & Lundberg, K., 2021, In: Human Immunology. 82, 12, p. 976-981

Research output: Contribution to journal › Article › peer-review

Open Access

Tonsillar cancer with high cd8⁺ t‐cell infiltration features increased levels of dendritic cells and transcriptional regulation associated with an inflamed tumor microenvironment

Jimenez, D. G., Sobti, A., Askmyr, D., Sakellariou, C., Santos, S. C., Swoboda, S., Forslund, O., Greiff, L. & Lindstedt, M., 2021, In: Cancers. 13, 21, 5341.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Immune phenotypes of nasopharyngeal cancer

Nilsson, J. S., Sobti, A., Swoboda, S., Erjefält, J. S., Forslund, O., Lindstedt, M. & Greiff, L., 2020 Nov, In: Cancers. 12, 11, p. 1-17 17 p., 3428.

Research output: Contribution to journal › Article › peer-review

Open Access

Subpopulations of organoid-forming cells have different motility

Jimenez, D. G., Santos, S. C., Greiff, L., Alm, K. & Lindstedt, M., 2020 Jul 1, In: Applied Sciences (Switzerland). 10, 13, 4673.

Research output: Contribution to journal › Article › peer-review

Open Access

An integrated transcriptomic- and proteomic-based approach to evaluate the human skin sensitization potential of glyphosate and its commercial agrochemical formulations

Lindberg, T., de Ávila, R. I., Zeller, K. S., Levander, F., Eriksson, D., Chawade, A. & Lindstedt, M., 2020 Apr 15, In: Journal of Proteomics. 217, 103647.

Research output: Contribution to journal › Article › peer-review

Open Access

Changes in Intestinal Permeability Ex Vivo and Immune Cell Activation by Three Commonly Used Emulsifiers

Oscarsson, E., Lindberg, T., Zeller, K. S., Lindstedt, M., Agardh, D., Håkansson, Å. & Östbring, K., 2020, In: Molecules (Basel, Switzerland). 25, 24, 5943.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Intralesional EBV-DNA load as marker of prognosis for nasopharyngeal cancer

Nilsson, J. S., Forslund, O., Andersson, F. C., Lindstedt, M. & Greiff, L., 2019 Oct, In: Scientific Reports. 9, 15432.

Research output: Contribution to journal › Article › peer-review

Open Access

Batch adjustment by reference alignment (BARA): Improved prediction performance in biological test sets with batch effects

Gradin, R., Lindstedt, M. & Johansson, H., 2019 Feb 22, In: PLoS ONE. 14, 2, e0212669.

Research output: Contribution to journal › Article › peer-review

Open Access

Dendritic cell subpopulations in nasopharyngeal cancer

Nilsson, J. S., Abolhalaj, M., Lundberg, K., Lindstedt, M. & Greiff, L., 2019, In: Oncology Letters. 17, 2, p. 2557-2561 5 p.

Research output: Contribution to journal › Article › peer-review

Evaluation of in vitro testing strategies for hazard assessment of the skin sensitization potential of “real-life” mixtures: The case of henna-based hair-colouring products containing p-phenylenediamine

de Ávila, R. I., Veloso, D. F. M. C., Teixeira, G. C., Rodrigues, T. L., Lindberg, T., Lindstedt, M., Fonseca, S. G., Lima, E. M. & Valadares, M. C., 2019, In: Contact Dermatitis. 81, 3, p. 194-209

Research output: Contribution to journal › Article › peer-review

In vitro assessment of mechanistic events induced by structurally related chemical rubber sensitizers

Lindberg, T., Forreryd, A., Bergendorff, O., Lindstedt, M. & Zeller, K. S., 2019, In: Toxicology in Vitro. 60, p. 144-153 10 p.

Research output: Contribution to journal › Article › peer-review

2018

Human bone marrow-derived myeloid dendritic cells show an immature transcriptional and functional profile compared to their peripheral blood counterparts and separate from slan+ non-classical monocytes

van Leeuwen-Kerkhoff, N., Lundberg, K., Westers, T. M., Kordasti, S., Bontkes, H. J., Lindstedt, M., de Gruijl, T. D. & van de Loosdrecht, A. A., 2018 Jul 16, In: Frontiers in Immunology. 9, JUL, 1619.

Research output: Contribution to journal › Article › peer-review

Open Access

Profiling dendritic cell subsets in head and neck squamous cell tonsillar cancer and benign tonsils.

Abolhalaj, M., Askmyr, D., Sakellariou, C., Lundberg, K., Greiff, L. & Lindstedt, M., 2018 May 23, In: Scientific Reports. 8, 8030, 8030.

Research output: Contribution to journal › Article › peer-review

Open Access

Predicting skin sensitizers with confidence — Using conformal prediction to determine applicability domain of GARD

Forreryd, A., Norinder, U., Lindberg, T. & Lindstedt, M., 2018 Apr 1, In: Toxicology in Vitro. 48, p. 179-187 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

An alternative biomarker-based approach for the prediction of proteins known to sensitize the respiratory tract

Zeller, K. S., Johansson, H., Lund, T. Ø., Kristensen, N. N., Roggen, E. L. & Lindstedt, M., 2018 Feb 1, In: Toxicology in Vitro. 46, p. 155-162 8 p.

Research output: Contribution to journal › Article › peer-review

2017

Clinical efficacy of a topical lactic acid bacterial microbiome in chronic rhinosinusitis: A randomized controlled trial

Mårtensson, A., Abolhalaj, M., Lindstedt, M., Mårtensson, A., Olofsson, T., Vasquez, A., Greiff, L. & Cervin, A., 2017 Dec 26, In: Laryngoscope Investigative Otolaryngology. 2, 6, p. 410-416

Research output: Contribution to journal › Article › peer-review

Open Access

Transcriptional profiling reveals functional dichotomy between human slan+ non-classical monocytes and myeloid dendritic cells

van Leeuwen-Kerkhoff, N., Lundberg, K., Westers, T. M., Kordasti, S., Bontkes, H. J., Gruijl, T. D., Lindstedt, M. & van de Loosdrecht, A. A., 2017 Oct, In: Journal of Leukocyte Biology. 102, 4, p. 1055-1068

Research output: Contribution to journal › Article › peer-review

Evaluation of the GARD assay in a blind cosmetics Europe study

Johansson, H., Gradin, R., Forreryd, A., Agemark, M., Zeller, K., Johansson, A., Larne, O., Van Vliet, E., Borrebaeck, C. & Lindstedt, M., 2017, In: ALTEX Alternatives To Animal Experimentation. 34, 4, p. 515-523 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The GARD platform for potency assessment of skin sensitizing chemicals

Zeller, K. S., Forreryd, A., Lindberg, T., Gradin, R., Chawade, A. & Lindstedt, M., 2017, In: ALTEX Alternatives To Animal Experimentation. 34, 4, p. 539-559 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

From genome-wide arrays to tailor-made biomarker readout – Progress towards routine analysis of skin sensitizing chemicals with GARD

Forreryd, A., Zeller, K. S., Lindberg, T., Johansson, H. & Lindstedt, M., 2016 Dec 1, In: Toxicology in Vitro. 37, p. 178-188 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

C-type Lectin Receptor Expression on Human Basophils and Effects of Allergen-Specific Immunotherapy

Lundberg, K., Rydnert, F., Broos, S., Andersson, M., Greiff, L. & Lindstedt, M., 2016 Sept 1, In: Scandinavian Journal of Immunology. 84, 3, p. 150-157 8 p.

Research output: Contribution to journal › Article › peer-review

Effects of a honeybee lactic acid bacterial microbiome on human nasal symptoms, commensals, and biomarkers

Mårtensson, A., Greiff, L., Lamei, S. S., Lindstedt, M., Olofsson, T. C., Vasquez, A. & Cervin, A., 2016 Apr 15, In: International Forum of Allergy & Rhinology. 6, 9, p. 956–963

Research output: Contribution to journal › Article › peer-review

Allergen-Specific Immunotherapy Alters the Frequency, as well as the FcR and CLR Expression Profiles of Human Dendritic Cell Subsets.

Lundberg, K., Rydnert, F., Broos, S., Andersson, M., Greiff, L. & Lindstedt, M., 2016, In: PLoS ONE. 11, 2, e0148838.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Prediction of Chemical Respiratory Sensitizers Using GARD, a Novel In Vitro Assay Based on a Genomic Biomarker Signature.

Forreryd, A., Johansson, H., Albrekt, A.-S., Borrebaeck, C. & Lindstedt, M., 2015, In: PLoS ONE. 10, 3, e0118808.

Research output: Contribution to journal › Article › peer-review

Open Access

Systematic evaluation of non-animal test methods for skin sensitisation safety assessment.

Reisinger, K., Hoffmann, S., Alépée, N., Ashikaga, T., Barroso, J., Elcombe, C., Gellatly, N., Galbiati, V., Gibbs, S., Groux, H., Hibatallah, J., Keller, D., Kern, P., Klaric, M., Kolle, S., Kuehnl, J., Lambrechts, N., Lindstedt, M., Millet, M. & Martinozzi-Teissier, S. & 9 others, Natsch, A., Petersohn, D., Pike, I., Sakaguchi, H., Schepky, A., Tailhardat, M., Templier, M., van Vliet, E. & Maxwell, G., 2015, In: Toxicology in Vitro. 29, 1, p. 259-270

Research output: Contribution to journal › Article › peer-review

2014

Evaluation of high throughput gene expression platforms using a genomic biomarker signature for prediction of skin sensitization.

Forreryd, A., Johansson, H., Albrekt, A.-S. & Lindstedt, M., 2014, In: BMC Genomics. 15, 379.

Research output: Contribution to journal › Article › peer-review

Open Access

Genomic Allergen Rapid Detection In-House Validation—A Proof of Concept

Johansson, H., Rydnert, F., Kühnl, J., Schepky, A. G., Borrebaeck, C. & Lindstedt, M., 2014, In: Toxicological Sciences. 139, 2, p. 362-370

Research output: Contribution to journal › Article › peer-review

Human blood dendritic cell subsets exhibit discriminative pattern recognition receptor profiles.

Lundberg, K., Rydnert, F., Greiff, L. & Lindstedt, M., 2014, In: Immunology. 142, 2, p. 279-288

Research output: Contribution to journal › Article › peer-review

Skin sensitizers differentially regulate signaling pathways in MUTZ-3 cells in relation to their individual potency.

Albrekt, A.-S., Johansson, H., Börjesson, A., Borrebaeck, C. & Lindstedt, M., 2014, In: BMC Pharmacology. 15, 1, 5.

Research output: Contribution to journal › Article › peer-review

Open Access

2013

Intradermal Delivery of TLR Agonists in a Human Explant Skin Model: Preferential Activation of Migratory Dendritic Cells by Polyribosinic-Polyribocytidylic Acid and Peptidoglycans

Oosterhoff, D., Heusinkveld, M., Lougheed, S. M., Kosten, I., Lindstedt, M., Bruijns, S. C. M., van Es, T., van Kooyk, Y., van der Burg, S. H. & de Gruijl, T. D., 2013, In: Journal of Immunology. 190, 7, p. 3338-3345

Research output: Contribution to journal › Article › peer-review

Phl p 1–Specific Human Monoclonal IgE and Design of a Hypoallergenic Group 1 Grass Pollen Allergen Fragment

Levin, M., Rydnert, F., Källström, E., Tan, L. W., Wormald, P. J., Lindstedt, M., Greiff, L. & Ohlin, M., 2013, In: Journal of Immunology. 191, 2, p. 551-560

Research output: Contribution to journal › Article › peer-review