Research output per year
Research output per year
Personal profile
Research
Targeting innate immune checkpoints in acute myeloid leukemia
The major goals of my research are to identify how acute myeloid leukemia (AML) cells suppress the innate immune system and use this knowledge to develop new immunotherapies. I will accomplish this by identifying and mechanistically characterize cell surface proteins that protect leukemia cells against the innate immune system. I will also provide in vivo proof of concept for a therapeutic effect by inhibiting the identified cell surface proteins in mouse models of leukemia. The work focuses on three specific aims:
- To identify cell surface proteins on leukemia cells that inhibit Natural killer cells (Aim 1a) or macrophages (Aim 1b) using CRISPR screens.
- To characterize the function and expression patterns of the identified cell surface proteins in acute myeloid leukemia cells from patients.
- To demonstrate proof of concept for a therapeutic effect by inhibiting the identified cell surface proteins in patient-derived xenograft models of leukemia.
Successful completion of these projects will identify new therapeutic targets in AML and expand our knowledge regarding how AML cells escape the immune system, findings that might be translated into new therapeutic opportunities in AML and possibly other cancer types.
UKÄ subject classification
- Cancer and Oncology
Free keywords
- Leukemia stem cells
- Antibodies
- CRISPR/Cas9
Fingerprint
Dive into the research topics where Marcus Järås is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia
Ramakrishnan, R., Peña-Martínez, P., Agarwal, P., Rodriguez-Zabala, M., Chapellier, M., Högberg, C., Eriksson, M., Yudovich, D., Shah, M., Ehinger, M., Nilsson, B., Larsson, J., Hagström-Andersson, A., Ebert, B. L., Bhatia, R. & Järås, M., 2020 May 26, In: Cell Reports. 31, 8, 107684.Research output: Contribution to journal › Article › peer-review
Open Access -
Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells
Chapellier, M., Peña-Martínez, P., Ramakrishnan, R., Eriksson, M., Safaee-Talkhoncheh, M., Orsmark-Pietras, C., Lilljebjörn, H., Högberg, C., Hagström-Andersson, A., Fioretos, T., Larsson, J. & Järås, M., 2019, In: Haematologica. 104, 10, p. 2006-2016Research output: Contribution to journal › Article › peer-review
Open Access -
Interleukin 4 induces apoptosis of acute myeloid leukemia cells in a Stat6 dependent manner
Peña, P., Eriksson, M., Ramakrishnan, R., Chapellier, M., Högberg, C., Orsmark-Pietras, C., Richter, J., Andersson, A., Fioretos, T. & Järås, M., 2018, In: Leukemia. 32, 3, p. 588-596Research output: Contribution to journal › Article › peer-review
Open Access -
IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models
Ågerstam, H., Hansen, N., von Palffy, S., Sandén, C., Reckzeh, K., Karlsson, C., Lilljebjörn, H., Landberg, N., Askmyr, M., Högberg, C., Rissler, M., Porkka, K., Wadenvik, H., Mustjoki, S., Richter, J., Järås, M. & Fioretos, T., 2016 Dec 8, In: Blood. 128, 23, p. 2683-2693Research output: Contribution to journal › Article › peer-review
-
Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.
Ågerstam, H., Karlsson, C., Hansen, N., Sandén, C., Askmyr, M., von Palffy, S., Högberg, C., Rissler, M., Wunderlich, M., Juliusson, G., Richter, J., Sjöström, K., Bhatia, R., Mulloy, J. C., Järås, M. & Fioretos, T., 2015, In: Proceedings of the National Academy of Sciences. 112, 34, p. 10786-10791Research output: Contribution to journal › Article › peer-review
Open AccessFile300 Downloads (Pure)
-
Defining Regulators of Human Hematopoietic Stem Cells using CRISPR/Cas9 Gene Targeting
Bäckström, A., Larsson, J. & Järås, M.
2018/05/01 → …
Project: Dissertation
-
CRISPRideas: Debating CRISPR – Comparative analysis of the discourses on medical and agricultural applications of new genome editing technologies
Broberg, K., Tunlid, A., Järås, M., Vareman, N., Nordberg, A., Jakobsson, J., Hansson, M., Hansson, K., Wahlberg, K. E., Kristoffersson, U. & Dunér, I.
2019/10/01 → 2020/06/30
Project: Network
-
Identification and characterization of candidate therapeutic targets in acute myeloid leukemia
Eriksson, M., Järås, M. & Fioretos, T.
2014/03/03 → 2018/03/08
Project: Dissertation
-
Lund University Cancer Centre (LUCC) meeting
Pia Berntsson (Member of programme committee), Sophia Zackrisson (Member of programme committee), Mef Nilbert (Member of programme committee), Vinay Swaminathan (Member of programme committee), Anna Martling (Invited speaker), Ron M.A. Heeren (Invited speaker), David Gisselsson Nord (Speaker), Cristian Bellodi (Speaker), Sergio Mosquim Junior (Speaker), Natalie Andersson (Speaker), Kelin Gonçalves de Oliveira (Speaker), Selamawit Mekuria (Speaker), Teo Helkkula (Speaker), Christopher Godina (Speaker), Lars E Olsson (Speaker), Kristina Lång (Speaker), Helena Ågerstam (Speaker), Axel Hyrenius Wittsten (Speaker), Paul Bourgine (Speaker), Maria Alvarado Kristensson (Speaker), Ana Carneiro (Speaker), Helena Jernström (Speaker), Annika Malmborg Kisch (Speaker), Marlene Malmström (Speaker), Anna-Maria Larsson (Speaker), Sophia Zackrisson (Session chair), Kajsa Paulsson (Session chair), Kees-Jan Pronk (Session chair), Vinay Swaminathan (Session chair), Ingrid Hedenfalk (Session chair), Ramin Massoumi (Session chair), Ida Dalene Skarping (Session chair), Karin Leandersson (Session chair), Anna Sandström Gerdtsson (Session chair), Marcus Järås (Session chair), Ana Carneiro (Session chair), Tanja Stocks (Session chair), Annika Malmborg Kisch (Session chair) & Marlene Malmström (Session chair)
2023 May 4Activity: Participating in or organising an event › Organisation of conference
File -
World Cancer Day 2023
Pia Berntsson (Organiser), Mats Jerkeman (Chair), Marcus Järås (Chair), Elin Trägårdh (Speaker), Anna Hagström-Andersson (Speaker), Axel Hyrenius Wittsten (Speaker) & Martin Nilsson (Speaker)
2023 Feb 4Activity: Participating in or organising an event › Organisation of conference
-
Focus on Cancer collaboration
Cecilia Jädert (Organiser), Anna-Karin Wihlborg (Invited speaker), Carina Bernardo (Organiser), Corinna Richter (Organiser), Chris Madsen (Organiser), Douglas Hanahan (Invited speaker), Åsa Dahm (Invited speaker), Göran Ahlgren (Invited speaker), Trine Grönlund (Invited speaker), Anders Bjartell (Invited speaker), Bjorn Walse (Invited speaker), Kajsa Paulsson (Session chair), Emma Niméus (Session chair), Pamela Buchwald (Session chair), Roland Andersson (Session chair), Marcus Järås (Session chair), Ana Carneiro (Session chair), Håkan Axelson (Session chair), Gottfrid Sjödahl (Session chair) & Pia Berntsson (Advisor)
2021 Feb 4Activity: Participating in or organising an event › Organisation of conference
File -
Supervision of PhD student: Fábio Fiúza Rosa
Carlos-Filipe Pereira (First/primary/lead supervisor), William Agace (Second supervisor), João Ramalho-Santos (Second supervisor), Thomas Graf (Commissioned member of Examining committee), Henrik Ahlenius (Commissioned member of Examining committee), Marcus Järås (Commissioned member of Examining committee), Luis Almeida (Commissioned member of Examining committee), Miguel Mano (Commissioned member of Examining committee) & Martin Roelsgaard Jakobsen (Commissioned member of Examining committee)
2018 → 2021Activity: Examination and supervision › Supervision of PhD students