Research output per year
Research output per year
Personal profile
Research
Targeting innate immune checkpoints in acute myeloid leukemia
The major goals of my research are to identify how acute myeloid leukemia (AML) cells suppress the innate immune system and use this knowledge to develop new immunotherapies. I will accomplish this by identifying and mechanistically characterize cell surface proteins that protect leukemia cells against the innate immune system. I will also provide in vivo proof of concept for a therapeutic effect by inhibiting the identified cell surface proteins in mouse models of leukemia. The work focuses on three specific aims:
- To identify cell surface proteins on leukemia cells that inhibit Natural killer cells (Aim 1a) or macrophages (Aim 1b) using CRISPR screens.
- To characterize the function and expression patterns of the identified cell surface proteins in acute myeloid leukemia cells from patients.
- To demonstrate proof of concept for a therapeutic effect by inhibiting the identified cell surface proteins in patient-derived xenograft models of leukemia.
Successful completion of these projects will identify new therapeutic targets in AML and expand our knowledge regarding how AML cells escape the immune system, findings that might be translated into new therapeutic opportunities in AML and possibly other cancer types.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
UKÄ subject classification
- Cancer and Oncology
Free keywords
- Leukemia stem cells
- Antibodies
- CRISPR/Cas9
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia
Ramakrishnan, R., Peña-Martínez, P., Agarwal, P., Rodriguez-Zabala, M., Chapellier, M., Högberg, C., Eriksson, M., Yudovich, D., Shah, M., Ehinger, M., Nilsson, B., Larsson, J., Hagström-Andersson, A., Ebert, B. L., Bhatia, R. & Järås, M., 2020 May 26, In: Cell Reports. 31, 8, 107684.Research output: Contribution to journal › Article › peer-review
Open Access -
Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells
Chapellier, M., Peña-Martínez, P., Ramakrishnan, R., Eriksson, M., Safaee-Talkhoncheh, M., Orsmark-Pietras, C., Lilljebjörn, H., Högberg, C., Hagström-Andersson, A., Fioretos, T., Larsson, J. & Järås, M., 2019, In: Haematologica. 104, 10, p. 2006-2016Research output: Contribution to journal › Article › peer-review
Open Access -
Interleukin 4 induces apoptosis of acute myeloid leukemia cells in a Stat6 dependent manner
Peña, P., Eriksson, M., Ramakrishnan, R., Chapellier, M., Högberg, C., Orsmark-Pietras, C., Richter, J., Andersson, A., Fioretos, T. & Järås, M., 2018, In: Leukemia. 32, 3, p. 588-596Research output: Contribution to journal › Article › peer-review
Open Access -
IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models
Ågerstam, H., Hansen, N., von Palffy, S., Sandén, C., Reckzeh, K., Karlsson, C., Lilljebjörn, H., Landberg, N., Askmyr, M., Högberg, C., Rissler, M., Porkka, K., Wadenvik, H., Mustjoki, S., Richter, J., Järås, M. & Fioretos, T., 2016 Dec 8, In: Blood. 128, 23, p. 2683-2693Research output: Contribution to journal › Article › peer-review
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Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.
Ågerstam, H., Karlsson, C., Hansen, N., Sandén, C., Askmyr, M., von Palffy, S., Högberg, C., Rissler, M., Wunderlich, M., Juliusson, G., Richter, J., Sjöström, K., Bhatia, R., Mulloy, J. C., Järås, M. & Fioretos, T., 2015, In: Proceedings of the National Academy of Sciences. 112, 34, p. 10786-10791Research output: Contribution to journal › Article › peer-review
Open AccessFile340 Downloads (Pure)
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Targeting new innate immune evasion mechanisms in acute myeloid leukemia
Järås, M. (PI)
2024/01/01 → 2028/12/31
Project: Research
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Defining Regulators of Human Hematopoietic Stem Cells using CRISPR/Cas9 Gene Targeting
Bäckström, A. (Researcher), Larsson, J. (Supervisor) & Järås, M. (Assistant supervisor)
2018/05/01 → …
Project: Dissertation
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CRISPRideas: Debating CRISPR – Comparative analysis of the discourses on medical and agricultural applications of new genome editing technologies
Broberg, K. (PI), Tunlid, A. (CoI), Järås, M. (Researcher), Vareman, N. (Researcher), Nordberg, A. (Researcher), Jakobsson, J. (Researcher), Hansson, M. (Researcher), Hansson, K. (Researcher), Wahlberg, K. E. (Researcher), Kristoffersson, U. (Researcher) & Dunér, I. (Researcher)
2019/10/01 → 2020/06/30
Project: Network
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Identification and characterization of candidate therapeutic targets in acute myeloid leukemia
Eriksson, M. (Research student), Järås, M. (Supervisor) & Fioretos, T. (Supervisor)
2014/03/03 → 2018/03/08
Project: Dissertation
Activities
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LUCC - Retreat executive group & network leaders
Berntsson, P. (Organiser), Hagman, J. (Organiser), Zackrisson, S. (Organiser), Zackrisson, S. (Presenter), Jerkeman, M. (Presenter), Nilbert, M. (Speaker), Swaminathan, V. (Presenter), Järås, M. (Presenter), Jädert, C. (Presenter), Hedenfalk, I. (Participant), Bocci, M. (Participant), Skarping, I. (Participant), Jerkeman, M. (Organiser), Malmborg Kisch, A. (Participant), Jernström, H. (Participant), Axelson, H. (Participant), Liedberg, F. (Participant), Böiers, C. (Participant), Pietras, A. (Participant), Sandström Gerdtsson, A. (Participant), Leandersson, K. (Participant), Stocks, T. (Participant), Saal, L. (Participant), Staaf, J. (Participant), Alkner, S. (Participant), Hagström-Andersson, A. (Participant), Isaksson, K. (Participant), Jönsson, G. B. (Participant), Scheding, S. (Participant), Larsson, A.-M. (Participant), Andersson, R. (Participant), Lindstedt, M. (Participant) & Greiff, L. (Participant)
2024 Feb 1 → 2024 Feb 2Activity: Participating in or organising an event › Organisation of conference
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Lund University Cancer Centre (LUCC) meeting
Berntsson, P. (Member of programme committee), Zackrisson, S. (Member of programme committee), Nilbert, M. (Member of programme committee), Swaminathan, V. (Member of programme committee), Martling, A. (Invited speaker), Heeren, R. M. A. (Invited speaker), Gisselsson Nord, D. (Speaker), Bellodi, C. (Speaker), Mosquim Junior, S. (Speaker), Andersson, N. (Speaker), Gonçalves de Oliveira, K. (Speaker), Mekuria, S. (Speaker), Helkkula, T. (Speaker), Godina, C. (Speaker), Olsson, L. E. (Speaker), Lång, K. (Speaker), Ågerstam, H. (Speaker), Hyrenius Wittsten, A. (Speaker), Bourgine, P. (Speaker), Alvarado Kristensson, M. (Speaker), Carneiro, A. (Speaker), Jernström, H. (Speaker), Malmborg Kisch, A. (Speaker), Malmström, M. (Speaker), Larsson, A.-M. (Speaker), Zackrisson, S. (Session chair), Paulsson, K. (Session chair), Pronk, K.-J. (Session chair), Swaminathan, V. (Session chair), Hedenfalk, I. (Session chair), Massoumi, R. (Session chair), Dalene Skarping, I. (Session chair), Leandersson, K. (Session chair), Sandström Gerdtsson, A. (Session chair), Järås, M. (Session chair), Carneiro, A. (Session chair), Stocks, T. (Session chair), Malmborg Kisch, A. (Session chair) & Malmström, M. (Session chair)
2023 May 4Activity: Participating in or organising an event › Organisation of conference
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World Cancer Day 2023
Berntsson, P. (Organiser), Jerkeman, M. (Chair), Järås, M. (Chair), Trägårdh, E. (Speaker), Hagström-Andersson, A. (Speaker), Hyrenius Wittsten, A. (Speaker) & Nilsson, M. (Speaker)
2023 Feb 4Activity: Participating in or organising an event › Organisation of conference
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World Cancer Day 4 February 2021 / Världscancerdagen 4 februari 2021
Nyman, J. (Director), Berntsson, P. (Contributor), Hagerling, C. (Presenter), Bocci, M. (Presenter), Dahlblom, V. (Presenter), Saal, L. (Presenter), Lindgren Belal, S. (Presenter), Falkman, T. (Presenter), Järås, M. (Contributor), Carneiro, A. (Presenter), Jönsson, G. B. (Presenter), Hjorth, L. (Presenter), Sällfors Holmqvist, A. (Presenter), Tonning Olsson, I. (Presenter) & Broberg, O. (Presenter)
2021 May 3 → 2021 May 11Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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Focus on Cancer collaboration
Jädert, C. (Organiser), Wihlborg, A.-K. (Invited speaker), Bernardo, C. (Organiser), Richter, C. (Organiser), Madsen, C. (Organiser), Hanahan, D. (Invited speaker), Dahm, Å. (Invited speaker), Ahlgren, G. (Invited speaker), Grönlund, T. (Invited speaker), Bjartell, A. (Invited speaker), Walse, B. (Invited speaker), Paulsson, K. (Session chair), Niméus, E. (Session chair), Buchwald, P. (Session chair), Andersson, R. (Session chair), Järås, M. (Session chair), Carneiro, A. (Session chair), Axelson, H. (Session chair), Sjödahl, G. (Session chair) & Berntsson, P. (Advisor)
2021 Feb 4Activity: Participating in or organising an event › Organisation of conference
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