Personal profile
Research
Research topics: Structural, mechanical, and chemical characterization of soft biological and biomedical tissues - relation mechanical stimuli-microstructure in tendons, articular cartilage and meniscus; - embryonic bone formation: growth plates and soft tissue-bone interfaces; - pathological heterotopic calcifications in soft tissues.
In particular: The aim of my research is to use phase contrast enhanced synchrotron X-ray tomography to answer some still open questions regarding Achilles tendon structure and tendon structural response to mechanical load during healing. Furthermore, I use high-resolution characterization techniques to investigate structural and mechanical changes in articular cartilage and meniscus associated with osteoarthritis progression. Other research topics that I currently working on range from embryonic bone formation in relation to mechanical stimuli to tissue mineralization and pathological calcification in soft tissues.
https://scholar.google.com/citations?hl=en&user=mkfvJ9QAAAAJ
Subject classification (UKÄ)
- Medical Engineering
- Natural Sciences
- Medical Imaging
Free keywords
- biomechanics
- phase contrast tomography
- tendons
- articular cartilage
- Meniscus
- growth plate
- heterotopic ossification
- biomineralization
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations the last five years
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Synchrotron phase-contrast microtomography reveals the impact of degeneration on the 3D structure of human articular cartilage
Wrammerfors, E. T. B., Pierantoni, M., Dejea, H., Sjögren, A., Orozco, G. A., Das Gupta, S., Gstöhl, S. J., Schlepütz, C. M., Nygård, K., Englund, M. & Isaksson, H., 2026 Apr 22, (E-pub ahead of print) In: Osteoarthritis and Cartilage.Research output: Contribution to journal › Article › peer-review
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Fibrillar deformation mechanisms in rat Achilles tendons are governed by strain rate
Sharma, K., Silva Barreto, I., Dejea, H., Mota-Santiago, P., Eliasson, P., Pierantoni, M. & Isaksson, H., 2025 Sept, In: Acta Biomaterialia. 204, p. 404-412 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Investigating Achilles tendon adaptation to mechanical load: a computational model integrating collagen fibre orientation heterogeneity
Janssen, R., Gustafsson, A., Jönsson, V., Grassi, L., Pierantoni, M. & Isaksson, H., 2025, In: Biomechanics and Modeling in Mechanobiology. 24, 6, p. 1959-1972Research output: Contribution to journal › Article › peer-review
Open Access -
Quantification of 3D micro-reorientations in Achilles tendons during in situ loading reveals anisotropic fiber response
Pierantoni, M., Sharma, K., Kok, J., Novak, V., Eliasson, P. & Isaksson, H., 2025, In: Acta Biomaterialia. 194, p. 246–257 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Deprivation of loading during rat Achilles tendon healing affects extracellular matrix composition and structure, and reduces cell density and alignment
Hammerman, M., Pierantoni, M., Isaksson, H. & Eliasson, P., 2024 Dec, In: Scientific Reports. 14, 1, 23380.Research output: Contribution to journal › Article › peer-review
Open Access
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PhD Project - Characterization of knee joint tissues via novel neutron and synchrotron imaging techniques
Bokvist Wrammerfors, E. T. (Research student), Isaksson, H. (Supervisor), Pierantoni, M. (Assistant supervisor) & Englund, M. (Assistant supervisor)
2021/03/15 → …
Project: Dissertation
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PhD project: Multi-modal characterization of (non-) mineralized collagen in Achilles tendons
Sharma, K. (Researcher), Isaksson, H. (Supervisor) & Pierantoni, M. (Assistant supervisor)
2021/06/01 → 2025/12/31
Project: Dissertation
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TENDON_MECHBIO: A multimodal approach to tendon mechanobiology
Isaksson, H. (Researcher), Pierantoni, M. (Researcher), Silva Barreto, I. (Researcher), Sharma, K. (Researcher) & Axelsson, R. (Researcher)
European Commission - Horizon 2020
2021/05/01 → 2026/04/30
Project: Research