Marion Moseby Knappe

Marion Moseby Knappe

Affiliated with the university

Personal profile

Research

I am a clinical neurologist employed at Skåne University Hospital, Department of Neurological Rehabilitation. I divide my time between clinical work and research at the Lund University Center for Cardiac Arrest focusing on brain injury in patients who had a cardiac arrest. I study biomarkers of brain injury, neuroimaging and neurophysiology to individualize patient care. My goal is to establish which prognostic methods are reliable for early prediction of a patients long-term neurological outcome and to improve outcome in cardiac arrest survivors. 

Our research group has performed the TTM- and TTM2-trials which found no benefit of targeted temperature management compared to fever treatment only for survival or functional outcome in patients with an out-of-hospital cardiac arrest. 

We are currently recruiting patietents in the STEPCARE trial (www.stepcare.org), in which we evaluate whether sedation, treatment of fever and blood pressure targets can improve patient outcomes. I am principal investigator of the EARLY-NEURO substudy in which we examine whether blood biomarkers, neuroimaging (CT) and electrophysiology (EEG) safely predict patient outcomes at 24 hours after cardiac arrest. 

 

I further collaborate with the CARTA trial group (ass. Prof. Igor Zindovic, Skåne University Hospital) on the risk of ischaemic stroke during surgical repair of type A aortic dissection, the CABO trial group on biomarkers for prediction of outcome within the ICECAP trials/SIREN Network (Dr. Frederick Korley and Dr. Ericka Finck) and the ORCA expert panel on neuroprognostication after cardiac arrest (Prof. Jonathan Elmer and Prof. Clifton Callaway, Pittsburgh University). 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

UKÄ subject classification

  • Medical and Health Sciences
  • Neurology

Free keywords

  • Cardiac Arrest, Prognostication, Computed Tomography, Multimodal Prognostication

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Collaborations the last five years

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