Personal profile
Research
I am a consultant physician at Skåne University Hospital, Department of Neurological Rehabilitation and Docent in Neurology at Lund University. I divide my time between clinical work within rehabilitation medicine and research at the Lund University Center for Cardiac Arrest focusing on brain injury in patients who had a cardiac arrest. I study biomarkers of brain injury, neuroimaging and neurophysiology to individualize patient care. My goal is to establish which prognostic methods are reliable for early prediction of a patients long-term neurological outcome and to improve outcome in cardiac arrest survivors.
Our research group has performed the TTM- and TTM2-trials which found no benefit of targeted temperature management compared to fever treatment only for survival or functional outcome in patients with an out-of-hospital cardiac arrest.
We are currently recruiting patietents in the STEPCARE trial (www.stepcare.org), in which we evaluate whether sedation, treatment of fever and blood pressure targets can improve patient outcomes. I am principal investigator of the EARLY-NEURO substudy in which we examine whether blood biomarkers, neuroimaging (CT) and electrophysiology (EEG) safely predict patient outcomes at 24 hours after cardiac arrest.
I further collaborate with the CARTA trial group (ass. Prof. Igor Zindovic, Skåne University Hospital) on the risk of ischaemic stroke during surgical repair of type A aortic dissection, and the ORCA expert panel on neuroprognostication after cardiac arrest (Prof. Jonathan Elmer and Prof. Clifton Callaway, Pittsburgh University).
Subject classification (UKÄ)
- Medical and Health Sciences
- Neurology
Free keywords
- Cardiac Arrest, Prognostication, Computed Tomography, Multimodal Prognostication
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations the last five years
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Blood biomarkers for the prediction of outcome after cardiac arrest: an international prospective observational study within the Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial
Moseby-Knappe, M., Levin, H., Ullén, S., Zetterberg, H., Blennow, K., Lagebrant, A., Dankiewicz, J., Jakobsen, J. C., Lilja, G., Nichol, A. D., Eastwood, G., Ainscough, K., Thomas, M. J. C., Grejs, A. M., Keeble, T. R., Rylander, C., Düring, J., Wise, M. P., Hovdenes, J. & Storm, C. & 28 others, , 2026, In: The Lancet Respiratory Medicine. 14, 3, p. 215-224 10 p.Research output: Contribution to journal › Article › peer-review
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Long-Term Outcomes and Recovery Trajectories in Out-of-Hospital Cardiac Arrest: A 2-Year Follow-Up of the Randomized Clinical TTM2 Trial
Hultgren, M., Blennow Nordström, E., Ullén, S., Nielsen, N., Dankiewicz, J., Jakobsen, J. C., Heimburg, K., Moseby-Knappe, M., Bělohlávek, J., Bohm, M., Cariou, A., Eastwood, G., Friberg, H., Grejs, A. M., Hammond, N., Hänggi, M., Hrečko, J., Iten, M., Keeble, T. R. & Leithner, C. & 9 others, , 2026, (E-pub ahead of print) In: JAMA Neurology. p. E1-E10Research output: Contribution to journal › Article › peer-review
Open Access -
Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial
Ceric, A., Dankiewicz, J., Cronberg, T., Düring, J., Moseby-Knappe, M., Annborn, M., May, T. L., Thomas, M., Grejs, A. M., Rylander, C., Belohlavek, J., Wendel-Garcia, P., Haenggi, M., Schrag, C., Hilty, M. P., Keeble, T. R., Wise, M. P., Young, P., Taccone, F. S. & Robba, C. & 8 others, , 2025 Dec, In: Critical Care. 29, 1, 247.Research output: Contribution to journal › Article › peer-review
Open Access -
The semi-quantitative cardiac arrest brain ischemia (CABI) score for magnetic resonance imaging predicts functional outcome after cardiac arrest
Arctaedius, I., Wassélius, J., Lang, M., Drake, M., Johnsson, M., Friberg, H., Leithner, C., Kenda, M., Lybeck, A. & Moseby-Knappe, M., 2025 Dec, In: Critical Care. 29, 1, 373.Research output: Contribution to journal › Article › peer-review
Open Access -
Accuracy of EEG Slow Wave Activity in Predicting Favorable Outcome in Patients With Hypoxic Brain Injury—A Protocol for a Substudy of the STEPCARE Trial
Hästbacka, J., Westhall, E., Moseby-Knappe, M., Tiainen, M., Lybeck, A., Reinikainen, M., Levin, H., Skrifvars, M. B., Tirkkonen, J., Jakobsen, J. C., Nielsen, N., Toppila, J., Admiraal, M. M. & Kortelainen, J., 2025 Oct, In: Acta Anaesthesiologica Scandinavica. 69, 9, e70126.Research output: Contribution to journal › Article › peer-review
Open Access
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Proteomics in out-of-hospital cardiac arrest
Lileikyte, G. (Researcher), Nielsen, N. (Supervisor), Bakochi, A. (Assistant supervisor) & Moseby Knappe, M. (Assistant supervisor)
2023/01/01 → …
Project: Dissertation
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CARbon dioxide flooding to reduce postoperative neurological injury following surgery for acute Type A aortic dissection. A prospective, randomized, blinded, controlled clinical trial
Zindovic, I. (PI), Ede, J. (Researcher), Teurneau-Hermansson, K. (Researcher), Moseby Knappe, M. (Researcher), Ramgren, B. (Researcher), Bjursten, H. (Researcher), Ederoth, P. (Researcher), Larsson, M. (Researcher), Mattsson-Carlgren, N. (Researcher), Sjögren, J. (Researcher), Wierup, P. (Researcher) & Nozohoor, S. (Researcher)
The Swedish Heart Lung Foundation, Thorsten Westerströms stiftelse
2022/01/01 → …
Project: Research
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Assessing Neurological Outcome After Cardiac Arrest
Lagebrant, A. (Research student), Cronberg, T. (Supervisor), Moseby Knappe, M. (Assistant supervisor) & Nielsen, N. (Assistant supervisor)
2021/10/01 → …
Project: Dissertation
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Neurological prognostication after cardiac arrest
Moseby Knappe, M. (PI), Cronberg, T. (Supervisor), Dragancea, I. (Assistant supervisor) & Nielsen, N. (Assistant supervisor)
Project: Dissertation