Mats Lindström

Mats Lindström

Timlärare, associate professor

If you made any changes in Pure these will be visible here soon.

Personal profile


The aim of the project is to evaluate the NMDA-receptor-antagonist ketamine as a novel antidepressant drug for patients with major depression and to compare its effectiveness with the established antidepressant treatment electroconvulsive therapy (ECT).

Primary outcome is the proportion of patients in respective treatment arm that reach remission. 200 patients will be randomized to sub-anaesthetic iv infusions of ketamine or standard ECT. Treatment will be given three times weekly up to a maximum of 4 weeks (12 treatments). The sample size was calculated to be sufficient to statistically demonstrate non-inferiority of ketamine compared to ECT.

The antidepressive effect is evaluated with the Montgomery Åsberg Depression Rating Scale (MADRS). Neuropsychological testing, using a touchscreen-based system, is performed at baseline (prior to treatment), after the 6th treatment, within one week after treatment cession (remission) and at 2, 6 and 12 months after the last treatment. Blood samples are collected before the first treatment and 2-3 months after it ends.

The extensive cognitive testing and frequent use of rating scales in this study is important for monitoring side effects and to acquire a high resolution of the temporal characteristics of symptomatic relief for respective treatment.

Project-group members: Pouya Movahed (head of study), Joakim Ekstrand, Anders Tingström, Aki Johanson, Mikael Johansson, Lund; Mats Lindström, Jonas Åkeson, Malmö; Axel Nordenskjöld, Örebro.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 4 - Quality Education

UKÄ subject classification

  • Psychiatry

Free keywords

  • ketamine
  • ECT
  • major depressive disorder


Dive into the research topics where Mats Lindström is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or