Research output per year
Research output per year
Personal profile
Research
Functional genomics - Gene-Environment interactions on obesity and type 2 diabetes. In the post-GWAS era, to understand how the DNA variations affect metabolic disease development is crucial for precision medicine. My research interests are using CRISPR technology in adipose cell models and in combination in silicon functional annotation to revel the causal DNA variants in obesity and further understanding the biological mechanisms behind gene and environment interaction in weight loss and regain.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Subject classification (UKÄ)
- Cell and Molecular Biology
- Endocrinology and Diabetes
Free keywords
- CRISPR/Cas9
- GWAS
- Obesity, Type 2 Diabetes, polyphenols, berries
- alleles
- Gene-environment interaction
- brown adipocytes
- white adipocytes
- genome editing
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Synthesis of gem-Difluorinated 2,3-Dihydrobenzofurans Using Freon-22 via [4 + 1] Annulation of Difluorocarbene and Antitumor Activity Evaluation
Zhou, Q., Huang, M., Shen, Y., Chen, Z., Xu, L. & Yang, Z., 2024 Feb, In: Organic Letters. 26, 6, p. 1212-1217 6 p.Research output: Contribution to journal › Article › peer-review
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Human Genetic Variation at rs10071329 Correlates with Adiposity-related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function
Huang, M., Prasad, R. B., Coral, D. E., Hjort, L., Minja, D. T. R., Mulder, H., Franks, P. W. & Kalamajski, S., 2024, In: Diabetes. 73, 4, p. 637-645Research output: Contribution to journal › Article › peer-review
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Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes
Gheibi, S., Cataldo, L. R., Hamilton, A., Huang, M., Kalamajski, S., Fex, M. & Mulder, H., 2023 Apr 1, In: Diabetes. 72, 4, p. 455-466 12 p.Research output: Contribution to journal › Article › peer-review
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Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function
Huang, M., Coral, D., Ardalani, H., Spégel, P., Saadat, A., Claussnitzer, M., Mulder, H., Franks, P. W. & Kalamajski, S., 2023 Mar 6, In: eLife. 12:e84168.Research output: Contribution to journal › Article › peer-review
Open Access -
Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover
Huang, M., Claussnitzer, M., Saadat, A., Coral, D., Kalamajski, S. & Franks, P., 2023, In: Diabetologia. 66, 7, p. 1289-1305 17 p.Research output: Contribution to journal › Article › peer-review
Open Access
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56th Annual Meeting of the Scandinavian Society for the Study of Diabetes
Huang, M. (Presenter)
2022 May 12 → 2022 May 13Activity: Participating in or organising an event › Participation in conference
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CRISPR-Cas9 editing of the PPARGC1A Gly482Ser shows allele-dependent causal effects on cold-induced UCP-1 expression
Huang, M. (Presenter)
2022 May 12Activity: Talk or presentation › Presentation
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Fat cells directly sense temperature to activate thermogenesis
Huang, M. (Presenter)
2022 Apr 5Activity: Talk or presentation › Presentation
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European Association for the Study of Diabetes (EASD) 57th Annual meeting
Huang, M. (Presenter)
2021 SeptActivity: Participating in or organising an event › Participation in conference
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