Research output per year
Research output per year
- 1 - 50 out of 79 results
Search results
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2023
TGF-β Promotes the Postselection Thymic Development and Peripheral Function of IFN-γ-Producing Invariant NKT cells
Morgan, R. C., Frank, C., Greger, M., Attaway, M., Sigvardsson, M., Bartom, E. T. & Kee, B. L., 2023 Nov 1, In: Journal of Immunology. 211, 9, p. 1376-1384 9 p.Research output: Contribution to journal › Article › peer-review
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B-lineage acute lymphoblastic leukemia causes cell-autonomous defects in long-term hematopoietic stem cell function
Jensen, C. T., Åhsberg, J., Tingvall-Gustafsson, J., Somasundaram, R., Lang, S., Ungerbäck, J., Porwit, A., Soneji, S. & Sigvardsson, M., 2023 Nov, In: Haematologica. 108, 11, p. 3175-3180 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option
Dolinska, M., Cai, H., Månsson, A., Shen, J., Xiao, P., Bouderlique, T., Li, X., Leonard, E., Chang, M., Gao, Y., Medina, J. P., Kondo, M., Sandhow, L., Johansson, A. S., Deneberg, S., Söderlund, S., Jädersten, M., Ungerstedt, J., Tobiasson, M. & Östman, A. & 9 others, , 2023, In: Blood. 142, 1, p. 73-89 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
IRF8 deficiency induces the transcriptional, functional, and epigenetic reprogramming of cDC1 into the cDC2 lineage
Lança, T., Ungerbäck, J., Da Silva, C., Joeris, T., Ahmadi, F., Vandamme, J., Svensson-Frej, M., Mowat, A. M., Kotarsky, K., Sigvardsson, M. & Agace, W. W., 2022 Aug 9, In: Immunity. 55, 8, p. 1431-1447.e11Research output: Contribution to journal › Article › peer-review
Open Access -
Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in E2a-/- T Acute Lymphoblastic Leukemia
Carr, T., McGregor, S., Dias, S., Verykokakis, M., Le Beau, M. M., Xue, H. H., Sigvardsson, M., Bartom, E. T. & Kee, B. L., 2022 Mar, In: Frontiers in Immunology. 13, 845488.Research output: Contribution to journal › Article › peer-review
Open Access -
Developmental cues license megakaryocyte priming in murine hematopoietic stem cells
Kristiansen, T. A., Zhang, Q., Vergani, S., Boldrin, E., Krausse, N., André, O., Nordenfelt, P., Sigvardsson, M., Bryder, D., Ungerbäck, J. & Yuan, J., 2022, In: Blood Advances. 6, 24 , p. 6228-6241 27 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene
Somasundaram, R., Jensen, C. T., Tingvall-Gustafsson, J., Åhsberg, J., Okuyama, K., Prasad, M., Hagman, J. R., Wang, X., Soneji, S., Strid, T., Ungerbäck, J. & Sigvardsson, M., 2021 Jun 3, In: Blood. 137, 22, p. 3037-3049 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
B lymphocyte specification is preceded by extensive epigenetic priming in multipotent progenitors
Strid, T., Okuyama, K., Tingvall-Gustafsson, J., Kuruvilla, J., Jensen, C. T., Lang, S., Prasad, M., Somasundaram, R., Åhsberg, J., Cristobal, S., Soneji, S., Ungerback, J. & Sigvardsson, M., 2021 Jun, In: Journal of Immunology. 206, 11, p. 2700-2713 14 p.Research output: Contribution to journal › Article › peer-review
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The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude
Li, Z. Y., Morman, R. E., Hegermiller, E., Sun, M., Bartom, E. T., Maienschein-Cline, M., Sigvardsson, M. & Kee, B. L., 2021, In: Journal of Experimental Medicine. 218, 6, e20202032.Research output: Contribution to journal › Article › peer-review
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2020
13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking
Yang, M., Safavi, S., Woodward, E. L., Duployez, N., Olsson-arvidsson, L., Ungerbäck, J., Sigvardsson, M., Zaliova, M., Zuna, J., Fioretos, T., Johansson, B., Nord, K. H. & Paulsson, K., 2020 Aug 20, In: Blood. 136, 8, p. 946-956 11 p.Research output: Contribution to journal › Article › peer-review
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ARID1a Associates with Lymphoid-Restricted Transcription Factors and Has an Essential Role in T Cell Development
Astori, A., Tingvall-Gustafsson, J., Kuruvilla, J., Coyaud, E., Laurent, E. M. N., Sunnerhagen, M., Åhsberg, J., Ungerbäck, J., Strid, T., Sigvardsson, M., Raught, B. & Somasundaram, R., 2020, In: Journal of immunology. 205, 5, p. 1419-1432 14 p.Research output: Contribution to journal › Article › peer-review
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Ezh2 Represses Transcription of Innate Lymphoid Genes in B Lymphocyte Progenitors and Maintains the B-2 Cell Fate
Jacobsen, J. A., Bartom, E. T., Sigvardsson, M. & Kee, B. L., 2020, In: Journal of immunology. 204, 7, p. 1760-1769 10 p.Research output: Contribution to journal › Article › peer-review
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Prospective isolation of radiation induced erythroid stress progenitors reveals unique transcriptomic and epigenetic signatures enabling increased erythroid output
Singbrant, S., Mattebo, A., Sigvardsson, M., Strid, T. & Flygare, J., 2020, In: Haematologica. 105, 11, p. 2561-2571 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia
Okuyama, K., Strid, T., Kuruvilla, J., Somasundaram, R., Cristobal, S., Smith, E., Prasad, M., Fioretos, T., Lilljebjörn, H., Soneji, S., Lang, S., Ungerbäck, J. & Sigvardsson, M., 2019 Aug 1, In: PLoS Genetics. 15, 8, e1008280.Research output: Contribution to journal › Article › peer-review
Open Access -
Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1
de Pooter, R. F., Dias, S., Chowdhury, M., Bartom, E. T., Okoreeh, M. K., Sigvardsson, M. & Kee, B. L., 2019, In: Journal of immunology. 202, 10, p. 2837-2842 6 p.Research output: Contribution to journal › Article › peer-review
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Lin28b controls a neonatal to adult switch in B cell positive selection
Vanhee, S., Åkerstrand, H., Kristiansen, T. A., Datta, S., Montano, G., Vergani, S., Lang, S., Ungerbäck, J., Doyle, A., Olsson, K., Beneventi, G., Jensen, C. T., Bellodi, C., Soneji, S., Sigvardsson, M., Gyllenbäck, E. J. & Yuan, J., 2019, In: Science Immunology. 4, 39, eaax4453.Research output: Contribution to journal › Article › peer-review
Open AccessFile175 Downloads (Pure) -
2018
Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis
Jensen, C. T., Åhsberg, J., Sommarin, M. N. E., Strid, T., Somasundaram, R., Okuyama, K., Ungerbäck, J., Kupari, J., Airaksinen, M. S., Lang, S., Bryder, D., Soneji, S., Karlsson, G. & Sigvardsson, M., 2018 Jul 2, In: Journal of Experimental Medicine. 215, 7, p. 1947-1963 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1)
Ungerbäck, J., Hosokawa, H., Wang, X., Strid, T., Williams, B. A., Sigvardsson, M. & Rothenberg, E. V., 2018, In: Genome Research. 28, 10, p. 1508-1519 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells
Guzzi, N., Cieśla, M., Ngoc, P. C. T., Lang, S., Arora, S., Dimitriou, M., Pimková, K., Sommarin, M. N. E., Munita, R., Lubas, M., Lim, Y., Okuyama, K., Soneji, S., Karlsson, G., Hansson, J., Jönsson, G., Lund, A. H., Sigvardsson, M., Hellström-Lindberg, E. & Hsieh, A. C. & 1 others, , 2018, In: Cell. 173, 5, p. 1204-1216.e26Research output: Contribution to journal › Article › peer-review
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2017
Don't judge a cell by its cover: heterogeneity within early lymphoid progenitors
Karlsson, G., Sigvardsson, M. & Böiers, C., 2017 Dec 15, In: EMBO Journal. 36, 24, p. 3552-3554 3 p.Research output: Contribution to journal › Article
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EZH2 regulates the developmental timing of effectors of the pre-Antigen receptor checkpoints
Jacobsen, J. A., Woodard, J., Mandal, M., Clark, M. R., Bartom, E. T., Sigvardsson, M. & Kee, B. L., 2017 Jun 15, In: Journal of Immunology. 198, 12, p. 4682-4691 10 p.Research output: Contribution to journal › Article › peer-review
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2016
Clonal conversion of B lymphoid leukemia reveals cross-lineage transfer of malignant states
Somasundaram, R., Åhsberg, J., Okuyama, K., Ungerbäck, J., Lilljebjörn, H., Fioretos, T., Strid, T. & Sigvardsson, M., 2016 Nov 15, In: Genes and Development. 30, 22, p. 2486-2499 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Identification of stage-specific surface markers in early B cell development provides novel tools for identification of progenitor populations
Jensen, C. T., Lang, S., Somasundaram, R., Soneji, S. & Sigvardsson, M., 2016 Sept 1, In: Journal of Immunology. 197, 5, p. 1937-1944 8 p.Research output: Contribution to journal › Article › peer-review
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2015
A novel Lin-CD34+CD38-integrin α2- bipotential megakaryocyte-erythrocyte progenitor population in human bone marrow.
Wong, W. M., Dolinska, M., Sigvardsson, M., Ekblom, M. & Qian, H., 2015, In: Leukemia. 30, p. 1399-1402Research output: Contribution to journal › Article › peer-review
Open AccessFile212 Downloads (Pure) -
Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency.
Prasad, M. A. J., Ungerbäck, J., Åhsberg, J., Somasundaram, R., Strid, T., Larsson, M., Månsson, R., De Paepe, A., Lilljebjörn, H., Fioretos, T., Hagman, J. & Sigvardsson, M., 2015, In: Blood. 125, 26, p. 4052-4059Research output: Contribution to journal › Article › peer-review
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2013
An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.
Wahlestedt, M., Norddahl, G., Sten, G., Ugale, A., Micha Frisk, M.-A., Mattsson, R., Deierborg, T., Sigvardsson, M. & Bryder, D., 2013, In: Blood. 121, 21, p. 4257-4264Research output: Contribution to journal › Article › peer-review
File414 Downloads (Pure) -
Expression of Integrin A2 Receptor in Human Cord Blood Cd34+Cd38-Cd90+ Stem Cells Engrafting Long-Term in Nod/Scid-Il2rγ(C) Null Mice.
Wong, W. M., Sigvardsson, M., Åstrand-Grundström, I., Hogge, D., Larsson, J., Qian, H. & Ekblom, M., 2013, In: Stem Cells. 31, 2, p. 360-371Research output: Contribution to journal › Article › peer-review
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2012
Reduced repression of cytokine signaling ameliorates age-induced decline in hematopoietic stem cell function.
Norddahl, G., Wahlestedt, M., Gisler, S., Sigvardsson, M. & Bryder, D., 2012, In: Aging Cell.Research output: Contribution to journal › Article › peer-review
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2011
Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.
Norddahl, G., Pronk, K.-J., Wahlestedt, M., Sten, G., Nygren, J., Ugale, A., Sigvardsson, M. & Bryder, D., 2011, In: Cell Stem Cell. 8, 5, p. 499-510Research output: Contribution to journal › Article › peer-review
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A dose-dependent role for EBF1 in repressing non-B-cell-specific genes
Lukin, K., Fields, S., Guerrettaz, L., Straign, D., Rodriguez, V., Zandi, S., Månsson, R., Cambier, J. C., Sigvardsson, M. & Hagman, J., 2011, In: European Journal of Immunology. 41, 6, p. 1787-1793Research output: Contribution to journal › Article › peer-review
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B-lymphocyte commitment: Identifying the point of no return.
Welinder, E., Ahsberg, J. & Sigvardsson, M., 2011, In: Seminars in Immunology. 23, p. 335-340Research output: Contribution to journal › Article › peer-review
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2010
Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells.
Weishaupt, H., Sigvardsson, M. & Attema, J., 2010, In: Blood. 115, p. 247-256Research output: Contribution to journal › Article › peer-review
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Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication
Zetterblad, J., Qian, H., Zandi, S., Månsson, R., Lagergren, A., Hansson, F., Bryder, D., Paulsson, N. & Sigvardsson, M., 2010, In: BMC Genomics. 11, 108.Research output: Contribution to journal › Article › peer-review
Open Access -
Load and lock: the molecular mechanisms of B-lymphocyte commitment.
Zandi, S., Bryder, D. & Sigvardsson, M., 2010, In: Immunological Reviews. 238, 1, p. 47-62Research output: Contribution to journal › Article › peer-review
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Nuclear Factor of Activated T Cells Regulates Osteopontin Expression in Arterial Smooth Muscle in Response to Diabetes-Induced Hyperglycemia.
Berglund, L., Zetterqvist, A., Öhman, J., Sigvardsson, M., González Bosc, L. V., Smith, M.-L., Salehi, S. A., Agardh, E., Nordin Fredrikson, G., Agardh, C.-D., Nilsson, J., Wamhoff, B. R., Hultgårdh, A. & Gomez, M., 2010, In: Arteriosclerosis, Thrombosis and Vascular Biology. 30, p. 218-U154Research output: Contribution to journal › Article › peer-review
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Shaping up a lineage-lessons from B lymphopoesis.
Bryder, D. & Sigvardsson, M., 2010, In: Current Opinion in Immunology. Apr 7, p. 148-153Research output: Contribution to journal › Article › peer-review
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Single cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity.
Månsson, R., Zandi, S., Welinder, E., Tsapogas, P., Sakaguchi, N., Bryder, D. & Sigvardsson, M., 2010, In: Blood. 115, 13, p. 2601-2609Research output: Contribution to journal › Article › peer-review
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2008
B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells
Månsson, R., Zandi, S., Anderson, K., Martensson, I.-L., Jacobsen, S. E. W., Bryder, D. & Sigvardsson, M., 2008, In: Blood. 112, 4, p. 1048-1055Research output: Contribution to journal › Article › peer-review
Open Access -
Deciphering developmental stages of adult myelopoiesis.
Pronk, C. J., Attema, J., Rossi, D. J., Sigvardsson, M. & Bryder, D., 2008, In: Cell Cycle. 7, 6, p. 706-713Research output: Contribution to journal › Article › peer-review
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EBF1 is essential for B-Lineage priming and establishment of a transcription factor network in common lymphoid progenitors
Zandi, S., Månsson, R., Tsapogas, P., Zetterblad, J., Bryder, D. & Sigvardsson, M., 2008, In: Journal of Immunology. 181, 5, p. 3364-3372Research output: Contribution to journal › Article › peer-review
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Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression.
Hansson, F., Toporski, J., Månsson, R., Johansson, B., Norén-Nyström, U., Jacobsen, S. E. W., Wiebe, T., Larsson, M., Sigvardsson, M. & Castor, A., 2008, In: Molecular Cancer. 7, 67.Research output: Contribution to journal › Article › peer-review
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Molecular profiling reveals distinct functional attributes of CD1d-restricted natural killer (NK) T cell subsets
Rolf, J., Berntman, E., Stenström, M., Smith, E., Månsson, R., Stenstad, H., Yamagata, T., Agace, W., Sigvardsson, M. & Cardell, S., 2008, In: Molecular Immunology. 45, 9, p. 2607-2620Research output: Contribution to journal › Article › peer-review
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Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T cell development
Jensen, C., Böiers, C., Kharazi, S., Lübking, A., Rydén, T., Sigvardsson, M., Sitnicka Quinn, E. & Jacobsen, S. E. W., 2008, In: Blood. 111, 4, p. 2083-2090Research output: Contribution to journal › Article › peer-review
Open Access -
2007
A critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade.
Jimenez, M. A., Akerblad, P., Sigvardsson, M. & Rosen, E. D., 2007, In: Molecular and Cellular Biology. 27, Oct 23, p. 743-757Research output: Contribution to journal › Article › peer-review
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Critical role of FLT3 ligand in IL-7 receptor-independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors
Sitnicka Quinn, E., Buza-Vidas, N., Ahlenius, H., Cilio, C., Gekas, C., Nygren, J., Månsson, R., Cheng, M., Jensen, C., Svensson Frej, M., Leandersson, K., Agace, W., Sigvardsson, M. & Jacobsen, S. E. W., 2007, In: Blood. 110, 8, p. 2955-2964Research output: Contribution to journal › Article › peer-review
Open Access -
Ectopic expression of PAX5 promotes self renewal of bi-phenotypic myeloid progenitors co-expressing myeloid and B-cell lineage associated genes.
Anderson, K., Rusterholz, C., Månsson, R., Jensen, C., Bacos, K., Zandi, S., Sasaki, Y., Nerlov, C., Sigvardsson, M. & Jacobsen, S. E. W., 2007, In: Blood. 109, Jan 11, p. 3697-3705Research output: Contribution to journal › Article › peer-review
Open Access -
Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy
Pronk, C. J. H., Rossi, D. J., Månsson, R., Attema, J., Norddahl, G., Chan, C. K. F., Sigvardsson, M., Weissman, I. L. & Bryder, D., 2007, In: Cell Stem Cell. 1, 4, p. 428-442Research output: Contribution to journal › Article › peer-review
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HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development.
Magnusson, M., Brun, A., Miyake, N., Larsson, J., Ehinger, M., Björnsson, J. M., Wutz, A., Sigvardsson, M. & Karlsson, S., 2007, In: Blood. 109, 9, p. 3687-3696Research output: Contribution to journal › Article › peer-review
Open Access -
Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis
Lietz, A., Janz, M., Sigvardsson, M., Jundt, F., Doerken, B. & Mathas, S., 2007, In: British Journal of Haematology. 137, 4, p. 342-348Research output: Contribution to journal › Article › peer-review
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Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors.
Månsson, R., Hultquist, A., Luc, S., Yang, L., Anderson, K., Kharazi, S., Al-Hashmi, S., Liuba, K., Thorén, L., Adolfsson, J., Buza-Vidas, N., Qian, H., Soneji, S., Enver, T., Sigvardsson, M. & Jacobsen, S. E. W., 2007, In: Immunity. 26, 4, p. 407-419Research output: Contribution to journal › Article › peer-review