Personal profile
Research
Ongoing Project
Colorectal peritoneal carcinomatosis (PC) presents a significant clinical challenge, marked by high rates of mortality, and recurrence. In the tumor microenvironment (TME) the interaction between macrophages and cancer cells plays a vital role in disease progression and resistance to therapies. Our approach integrates both mouse models and human tissue samples, using cutting-edge techniques such as single-cell RNA sequencing and spatial RNA sequencing. The project aims to understand how PC manipulates the TME and evade current therapies with a particular focus on macrophage plasticity.
Funded by Swedish Research Council-Vetenskapsrådet (VR)
Available degree project: Master's and Bachelor's projects are available in the following subproject: “Investigating the Role of Extracellular Vesicles (EVs) in Macrophage-Cancer Cell Communication.”
Biography
Dr. Rahman began his academic journey in Bangladesh, earning a bachelor’s degree in Biotechnology and Genetic Engineering from Khulna University. He pursued advanced studies at Lund University in Sweden, where he obtained his Master of Science in Biotechnology in 2007 from the Faculty of Engineering.
Continuing at Lund University’s Faculty of Medicine, Dr. Rahman completed his PhD in 2012 in Clinical Medicine-Experimental Surgery, followed by his first postdoctoral fellowship (2012-2014) in the same field. His strong interest in vascular biology and immunology then led him to the United States, where he undertook a second postdoctoral fellowship at Stanford University (2015-2016), supported by the prestigious Swedish Research Council-International Postdoctoral Grant. His overarching goal is to establish an innovative translational research program focused on advancing studies in colorectal cancer and peritoneal metastasis, aiming to make meaningful contributions to the field.
Membership
EACR- European Association for Cancer Research
Major Awards
2025- Allmänna Sjukhusets i Malmö stiftelse
2024- Vetenskapsrådet (VR)/Swedish Research Council
2021- Maggie Stephens Foundation
2019- Einar and Inga Nilssons Foundation
2018- Einar and Inga Nilssons Foundation
2014- Vetenskapsrådet (VR)-international postdoc grant
Subject classification (UKÄ)
- Cancer and Oncology
- Immunology in the Medical Area (including Cell and Immunotherapy)
Free keywords
- Colorectal cancer
- Peritoneal Metastasis
- tumor-associated macrophages
- Immune evasion
- Exosome-mediated communication
- microRNA
- Neutrophils
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations the last five years
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The role of extracellular vesicle fusion with target cells in triggering systemic inflammation
Papareddy, P., Tapken, I., Kroh, K., Varma Bhongir, R. K., Rahman, M., Baumgarten, M., Cim, E. I., Györffy, L., Smeds, E., Neumann, A., Veerla, S., Olinder, J., Thorlacus, H., Ryden, C., Bartakova, E., Holub, M. & Herwald, H., 2024 Feb 7, In: Nature Communications. 15, 1150.Research output: Contribution to journal › Article › peer-review
Open Access -
CT is unreliable in locoregional staging of early colon cancer: A nationwide registry-based study
Wetterholm, E., Rosén, R., Rahman, M. & Rönnow, C.-F., 2023, In: Scandinavian Journal of Surgery. 112, 1, p. 33-40 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
E3 Ubiquitin Ligase Midline 1 Regulates Endothelial Cell ICAM-1 Expression and Neutrophil Adhesion in Abdominal Sepsis
Du, F., Hawez, A., Ding, Z., Wang, Y., Rönnow, C. F., Rahman, M. & Thorlacius, H., 2023, In: International Journal of Molecular Sciences. 24, 1, 705.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting miRNA by CRISPR/Cas in cancer: advantages and challenges
Hussen, B. M., Rasul, M. F., Abdullah, S. R., Hidayat, H. J., Faraj, G. S. H., Ali, F. A., Salihi, A., Baniahmad, A., Ghafouri-Fard, S., Rahman, M., Glassy, M. C., Branicki, W. & Taheri, M., 2023, In: Military Medical Research. 10, 1, 32.Research output: Contribution to journal › Review article › peer-review
Open Access -
S100A9 induces reactive oxygen species-dependent formation of neutrophil extracellular traps in abdominal sepsis
Du, F., Ding, Z., Rönnow, C.-F., Rahman, M., Schiopu, A. & Thorlacius, H., 2022 Dec 15, In: Experimental Cell Research. 421, 2, 113405.Research output: Contribution to journal › Article › peer-review
Projects
- 1 Active
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Deciphering Tumor Microenvironment and Macrophage Polarization in Colorectal Peritoneal Metastasis
Rahman, M. (PI)
2025/01/01 → 2028/12/31
Project: Research
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Exploring the impact of DNase I on the myeloid cells in Colorectal Peritoneal Carcinomatosis
Rahman, M. (Presenter)
2025 Jun 18Activity: Talk or presentation › Presentation
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LUCC - Gastrolintestinal - Colorectal: "A research seminar presentation bridging clinical and preclinical studies"
Buchwald, P. (Organiser), Lydrup, M.-L. (Organiser) & Rahman, M. (Organiser)
2025 Apr 4Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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LUCC - Malmö cancer seminars: “Use of AI-Based Predictive Modelling in Colorectal Cancer Surgery: Methodological Considerations and Experiences”
Buchwald, P. (Host), Lydrup, M.-L. (Host), Rahman, M. (Host) & Gögenur, I. (Invited speaker)
2025 Mar 12Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
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Inaccuracy of MRI imaging in early rectal cancer
Rosén, R. C. A. (Speaker), Nilsson, E. (Role not specified), Rahman, M. (Role not specified) & Rønnow, C.-F. (Role not specified)
2022 May 5Activity: Talk or presentation › Presentation