Research output per year
Research output per year
Research output
- 21 Article
- 21 results
Search results
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2024
Impact of site-specific conjugation strategies on the pharmacokinetics of antibody conjugated radiotherapeutics
Nagy, Á., Ulmert, D., Zedan, W., Storey, C. M., Park, J., Geres, S., Lückerath, K., Sjöström, K., Westin, H., Peekhaus, N., Thorek, D. L., Karlström, A. E. & Altai, M., 2024 Dec 15, In: European Journal of Medicinal Chemistry. 280, 116927.Research output: Contribution to journal › Article › peer-review
Open Access -
Intratumoral Distribution of [177Lu]Lu-PSMA-617 Over Time and in Relation to Diagnostic Tracers in Animal Models of Prostate Cancer
Örbom, A., Strand, J., Altai, M., Zedan, W., Kristiansson, A., Ceder, J. & Timmermand, O. V., 2024 Nov 27, (E-pub ahead of print) In: Cancer Biotherapy and Radiopharmaceuticals.Research output: Contribution to journal › Article › peer-review
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Hematological and renal toxicity in mice after three cycles of high activity [177Lu]Lu-PSMA-617 with or without human α1-microglobulin
Kristiansson, A., Vilhelmsson Timmermand, O., Altai, M., Strand, S.-E., Åkerström, B. & Örbom, A., 2024 May 11, In: Scientific Reports. 14, 1, 10787.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Co-injection of anti-HER2 antibody Trastuzumab does not increase efficacy of [177Lu]Lu-PSMA-617 therapy in an animal model of prostate cancer
Abouzayed, A., Zedan, W., Altai, M., Strand, J. & Örbom, A., 2023 Jun 30, In: American journal of nuclear medicine and molecular imaging. 13, 3, p. 107-117Research output: Contribution to journal › Article › peer-review
Open Access -
Quantitative In Vivo Imaging of the Androgen Receptor Axis Reveals Degree of Prostate Cancer Radiotherapy Response
Storey, C. M., Altai, M., Bicak, M., Veach, D. R., Lueckerath, K., Adrian, G., McDevitt, M. R., Kalidindi, T., Park, J. E., Herrmann, K., Abou, D., Zedan, W., Peekhaus, N., Klein, R. J., Damoiseaux, R., Larson, S. M., Lilja, H., Thorek, D. & Ulmert, D., 2023 Apr 1, In: Molecular cancer research : MCR. 21, 4, p. OF1-OF9Research output: Contribution to journal › Article › peer-review
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2022
Hematological Toxicity in Mice after High Activity Injections of 177Lu-PSMA-617
Kristiansson, A., Vilhelmsson Timmermand, O., Altai, M., Strand, J., Strand, S.-E., Åkerström, B. & Örbom, A., 2022, In: Pharmaceutics. 14, 4, 731.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
A conjugation strategy to modulate antigen binding and FcRn interaction leads to improved tumor targeting and radioimmunotherapy efficacy with an antibody targeting prostate-specific antigen
Vilhelmsson Timmermand, O., Örbom, A., Altai, M., Zedan, W., Holmqvist, B., Safi, M., Tran, T. A., Strand, S. E. & Strand, J., 2021 Jul 2, In: Cancers. 13, 14, 3469.Research output: Contribution to journal › Article › peer-review
Open Access -
PSA-Targeted Alpha-, Beta-, and Positron-emitting immunotheranostics in murine prostate cancer models and nonhuman primates
Veach, D. R., Storey, C. M., Lückerath, K., Braun, K., Von Bodman, C., Lamminmäki, U., Kalidindi, T., Strand, S. E., Strand, J., Altai, M., Damoiseaux, R., Zanzonico, P., Benabdallah, N., Pankov, D., Scher, H. I., Scardino, P., Larson, S. M., Lilja, H., McDevitt, M. R. & Thorek, D. L. J. & 1 others, , 2021 Apr, In: Clinical Cancer Research. 27, 7, p. 2050-2060 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
177Lu-PSMA-617 Therapy in Mice, with or without the Antioxidant α1-Microglobulin (A1M), Including Kidney Damage Assessment Using 99mTc-MAG3 Imaging
Kristiansson, A., Örbom, A., Ahlstedt, J., Karlsson, H., Zedan, W., Gram, M., Åkerström, B., Strand, S.-E., Altai, M., Strand, J. & Vilhelmsson Timmermand, O., 2021 Feb 10, In: Biomolecules. 11, 2, 263.Research output: Contribution to journal › Article › peer-review
Open Access -
The influence of domain permutations of an albumin-binding domain-fused her2-targeting affibody-based drug conjugate on tumor cell proliferation and therapy efficacy
Yin, W., Xu, T., Altai, M., Oroujeni, M., Zhang, J., Vorobyeva, A., Vorontsova, O., Vtorushin, S. V., Tolmachev, V., Gräslund, T. & Orlova, A., 2021, In: Pharmaceutics. 13, 11, 1974.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Evaluating the therapeutic efficacy of mono-and bivalent affibody-based fusion proteins targeting HER3 in a pancreatic cancer xenograft model
Leitao, C. D., Rinne, S. S., Altai, M., Vorontsova, O., Dunås, F., Jonasson, P., Tolmachev, V., Löfblom, J., Ståhl, S. & Orlova, A., 2020, In: Pharmaceutics. 12, 6, 15 p., 551.Research output: Contribution to journal › Article › peer-review
Open Access -
Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting
Myrhammar, A., Vorobyeva, A., Westerlund, K., Yoneoka, S., Orlova, A., Tsukahara, T., Tolmachev, V., Karlström, A. E. & Altai, M., 2020, In: Scientific Reports. 10, 1, 20777.Research output: Contribution to journal › Article › peer-review
Open Access -
HER2-specific pseudomonas exotoxin a pe25 based fusions: Influence of targeting domain on target binding, toxicity, and in vivo biodistribution
Ding, H., Altai, M., Yin, W., Lindbo, S., Liu, H., Garousi, J., Xu, T., Orlova, A., Tolmachev, V., Hober, S. & Gräslund, T., 2020, In: Pharmaceutics. 12, 4, 391.Research output: Contribution to journal › Article › peer-review
Open Access -
Influence of Several Compounds and Drugs on the Renal Uptake of Radiolabeled Affibody Molecules
Garousi, J., Vorobyeva, A. & Altai, M., 2020, In: Molecules (Basel, Switzerland). 25, 11, 2673.Research output: Contribution to journal › Article › peer-review
Open Access -
2015
Site-Specific Radioiodination of HER2-Targeting Affibody Molecules using 4-Iodophenethylmaleimide Decreases Renal Uptake of Radioactivity
Strand, J., Nordeman, P., Honarvar, H., Altai, M., Orlova, A., Larhed, M. & Tolmachev, V., 2015, In: ChemistryOpen. 4, 2, p. 174-182Research output: Contribution to journal › Article › peer-review
Open Access -
2014
Selection of an optimal cysteine-containing peptide-based chelator for labeling of affibody molecules with (188)Re
Altai, M., Honarvar, H., Wållberg, H., Strand, J., Varasteh, Z., Rosestedt, M., Orlova, A., Dunås, F., Sandström, M., Löfblom, J., Tolmachev, V. & Ståhl, S., 2014 Nov 24, In: European Journal of Medicinal Chemistry. 87, p. 519-28Research output: Contribution to journal › Article › peer-review
Open Access -
188Re-ZHER2:V2, a promising affibody-based targeting agent against HER2-expressing tumors: preclinical assessment
Altai, M., Wållberg, H., Honarvar, H., Strand, J., Orlova, A., Varasteh, Z., Sandström, M., Löfblom, J., Larsson, E., Strand, S.-E., Lubberink, M., Ståhl, S. & Tolmachev, V., 2014 Nov, In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 55, 11, p. 1842-8Research output: Contribution to journal › Article › peer-review
Open Access -
Imaging of HER3-expressing xenografts in mice using a (99m)Tc(CO) 3-HEHEHE-Z HER3:08699 affibody molecule
Orlova, A., Malm, M., Rosestedt, M., Varasteh, Z., Andersson, K., Selvaraju, R. K., Altai, M., Honarvar, H., Strand, J., Ståhl, S., Tolmachev, V. & Löfblom, J., 2014 Jul, In: European Journal of Nuclear Medicine and Molecular Imaging. 41, 7, p. 1450-9Research output: Contribution to journal › Article › peer-review
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Incorporation of a triglutamyl spacer improves the biodistribution of synthetic affibody molecules radiofluorinated at the N-terminus via oxime formation with (18)F-4-fluorobenzaldehyde
Rosik, D., Thibblin, A., Antoni, G., Honarvar, H., Strand, J., Selvaraju, R. K., Altai, M., Orlova, A., Eriksson Karlström, A. & Tolmachev, V., 2014 Jan 15, In: Bioconjugate Chemistry. 25, 1, p. 82-92 11 p.Research output: Contribution to journal › Article › peer-review
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2013
HAHAHA, HEHEHE, HIHIHI, or HKHKHK: influence of position and composition of histidine containing tags on biodistribution of [(99m)Tc(CO)3](+)-labeled affibody molecules
Hofström, C., Altai, M., Honarvar, H., Strand, J., Malmberg, J., Hosseinimehr, S. J., Orlova, A., Gräslund, T. & Tolmachev, V., 2013 Jun 27, In: Journal of Medicinal Chemistry. 56, 12, p. 4966-74Research output: Contribution to journal › Article › peer-review
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Influence of nuclides and chelators on imaging using affibody molecules: comparative evaluation of recombinant affibody molecules site-specifically labeled with ⁶⁸Ga and ¹¹¹In via maleimido derivatives of DOTA and NODAGA
Altai, M., Strand, J., Rosik, D., Selvaraju, R. K., Eriksson Karlström, A., Orlova, A. & Tolmachev, V., 2013 Jun 19, In: Bioconjugate Chemistry. 24, 6, p. 1102-9Research output: Contribution to journal › Article › peer-review