Research output per year
Research output per year
Personal profile
Research
Bone as an Organ system
Bone is a complex Organ offering structural and mechanical support of our body, but also consisting in our principal hematopoietic center. The formation of Bone involves distinct stages, including cartilage, vasculature, bone and bone marrow establishment. Our lab aims at compiling human-specific knowledge on these processes, toward the development of innovative Regenerative Therapies. Precisely, three main research axes are being explored:
(i) Deciphering the cellular/molecularmechanisms involved in Bone formation
(ii) In vitro developmentof 3D Bone models
(iii) Design of 3D biological grafts for skeletal tissue regeneration
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
UKÄ subject classification
- Medical and Health Sciences
- Engineering and Technology
Free keywords
- Bone
- Hematopoiesis
- Mesenchymal stem cells
- Developmental engineering
- Regenerative medicine
- Hematopoietic stem cells
- bone marrow niche
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Customizable 3D printed perfusion bioreactor for the engineering of stem cell microenvironments
Dupard, S. J., Garcia, A. G. & Bourgine, P. E., 2023 Jan, In: Frontiers in Bioengineering and Biotechnology. 10, 1081145.Research output: Contribution to journal › Article › peer-review
Open Access -
Sustained delivery of a heterodimer bone morphogenetic protein-2/7 via a collagen hydroxyapatite scaffold accelerates and improves critical femoral defect healing
Liu, Y., Puthia, M., Sheehy, E. J., Ambite, I., Petrlova, J., Prithviraj, S., Oxborg, M. W., Sebastian, S., Vater, C., Zwingenberger, S., Struglics, A., Bourgine, P. E., O'Brien, F. J. & Raina, D. B., 2023 May, In: Acta Biomaterialia. 162, p. 164-181Research output: Contribution to journal › Article › peer-review
Open Access -
Engineering human mini-bones for the standardized modeling of healthy hematopoiesis, leukemia, and solid tumor metastasis
Grigoryan, A., Zacharaki, D., Balhuizen, A., Côme, C. R., Garcia, A. G., Hidalgo Gil, D., Frank, A-K., Aaltonen, K., Mañas, A., Esfandyari, J., Kjellman, P., Englund, E., Rodriguez, C., Sime, W., Massoumi, R., Kalantari, N., Prithiviraj, S., Li, Y., Dupard, S. J., Isaksson, H., & 4 others, 2022 Oct 12, In: Science Translational Medicine. 14, 666, p. 1-15 eabm6391.Research output: Contribution to journal › Article › peer-review
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3D Engineering of Human Hematopoietic Niches in Perfusion Bioreactor
Dupard, S. J. & Bourgine, P. E., 2021, Methods in Molecular Biology. Humana Press, p. 253-262 10 p. (Methods in Molecular Biology; vol. 2308).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Culturing patient-derived malignant hematopoietic stem cells in engineered and fully humanized 3D niches
García-García, A., Klein, T., Born, G., Hilpert, M., Scherberich, A., Lengerke, C., Skoda, R. C., Bourgine, P. E. & Martin, I., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 40, e2114227118.Research output: Contribution to journal › Article › peer-review
Projects
- 3 Active
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Biomaterials@LU
Hajizadeh, S., Larsson, M., Orlov, D., Dicko, C., Aits, S., Bourgine, P., Käll, J., Svensson Bonde, J., Raina, D., Antfolk, M. & Elowsson, L.
2023/09/01 → …
Project: Network
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Roadmap of Biomaterials 4.0 - Theme, Pufendorf IAS
Dicko, C., Hajizadeh, S., Larsson, M., Orlov, D., Aits, S., Bourgine, P. & Käll, J.
2023/09/01 → 2024/06/30
Project: Research
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hOssicle: Bioengineering of human ossicles as advanced in vivo hematopoietic model
European Commission - Horizon 2020, Crafoord Foundation
2020/08/15 → 2026/04/30
Project: Research
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Lund University Cancer Centre (LUCC) meeting
Pia Berntsson (Member of programme committee), Sophia Zackrisson (Member of programme committee), Mef Nilbert (Member of programme committee), Vinay Swaminathan (Member of programme committee), Anna Martling (Invited speaker), Ron M.A. Heeren (Invited speaker), David Gisselsson Nord (Speaker), Cristian Bellodi (Speaker), Sergio Mosquim Junior (Speaker), Natalie Andersson (Speaker), Kelin Gonçalves de Oliveira (Speaker), Selamawit Mekuria (Speaker), Teo Helkkula (Speaker), Christopher Godina (Speaker), Lars E Olsson (Speaker), Kristina Lång (Speaker), Helena Ågerstam (Speaker), Axel Hyrenius Wittsten (Speaker), Paul Bourgine (Speaker), Maria Alvarado Kristensson (Speaker), Ana Carneiro (Speaker), Helena Jernström (Speaker), Annika Malmborg Kisch (Speaker), Marlene Malmström (Speaker), Anna-Maria Larsson (Speaker), Sophia Zackrisson (Session chair), Kajsa Paulsson (Session chair), Kees-Jan Pronk (Session chair), Vinay Swaminathan (Session chair), Ingrid Hedenfalk (Session chair), Ramin Massoumi (Session chair), Ida Dalene Skarping (Session chair), Karin Leandersson (Session chair), Anna Sandström Gerdtsson (Session chair), Marcus Järås (Session chair), Ana Carneiro (Session chair), Tanja Stocks (Session chair), Annika Malmborg Kisch (Session chair) & Marlene Malmström (Session chair)
2023 May 4Activity: Participating in or organising an event › Organisation of conference
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Steven Dupard
Paul Bourgine (Role not specified)
2019 Mar 1Activity: Examination and supervision › Supervision of PhD students
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Co-supervision of PhD student: Sujeethkumar Prithiviraj
Paul Bourgine (First/primary/lead supervisor) & Carlos-Filipe Pereira (Second supervisor)
2018 → 2022Activity: Examination and supervision › Supervision of PhD students