Research output per year
Research output per year
Personal profile
Research
Bone as an Organ system
Bone is a complex Organ offering structural and mechanical support of our body, but also consisting in our principal hematopoietic center. The formation of Bone involves distinct stages, including cartilage, vasculature, bone and bone marrow establishment. Our lab aims at compiling human-specific knowledge on these processes, toward the development of innovative Regenerative Therapies. Precisely, three main research axes are being explored:
(i) Deciphering the cellular/molecularmechanisms involved in Bone formation
(ii) In vitro developmentof 3D Bone models
(iii) Design of 3D biological grafts for skeletal tissue regeneration
UKÄ subject classification
- Medical and Health Sciences
- Engineering and Technology
Keywords
- Bone
- Hematopoiesis
- Mesenchymal stem cells
- Developmental engineering
- Regenerative medicine
- Hematopoietic stem cells
- bone marrow niche
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3D Engineering of Human Hematopoietic Niches in Perfusion Bioreactor
Dupard, S. J. & Bourgine, P. E., 2021, Methods in Molecular Biology. Humana Press, p. 253-262 10 p. (Methods in Molecular Biology; vol. 2308).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › peer-review
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Culturing patient-derived malignant hematopoietic stem cells in engineered and fully humanized 3D niches
García-García, A., Klein, T., Born, G., Hilpert, M., Scherberich, A., Lengerke, C., Skoda, R. C., Bourgine, P. E. & Martin, I., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 40, e2114227118.Research output: Contribution to journal › Article › peer-review
3 Citations (SciVal) -
Engineering human hematopoietic environments through ossicle and bioreactor technologies exploitation
Sommerkamp, P., Mercier, F. E., Wilkinson, A. C., Bonnet, D. & Bourgine, P. E., 2021, In: Experimental Hematology. 94Research output: Contribution to journal › Review article › peer-review
7 Citations (SciVal) -
Extracellular-Matrix-Reinforced Bioinks for 3D Bioprinting Human Tissue
De Santis, M. M., Alsafadi, H. N., Tas, S., Bölükbas, D. A., Prithiviraj, S., Da Silva, I. A., Mittendorfer, M., Ota, C., Stegmayr, J., Daoud, F., Königshoff, M., Swärd, K., Wood, J. A., Tassieri, M., Bourgine, P. E., Lindstedt, S., Mohlin, S. & Wagner, D. E., 2021, In: Advanced Materials. 33, 3, 2005476.Research output: Contribution to journal › Article › peer-review
Open Access34 Citations (SciVal) -
Manufacturing of Human Tissues as off-the-Shelf Grafts Programmed to Induce Regeneration
Pigeot, S., Klein, T., Gullotta, F., Dupard, S. J., Garcia Garcia, A., García-García, A., Prithiviraj, S., Lorenzo, P., Filippi, M., Jaquiery, C., Kouba, L., Asnaghi, M. A., Raina, D. B., Dasen, B., Isaksson, H., Önnerfjord, P., Tägil, M., Bondanza, A., Martin, I. & Bourgine, P. E., 2021, In: Advanced Materials. 33, 43, 2103737.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (SciVal)