Research output per year
Research output per year
Personal profile
Research
Bone as an Organ system
Bone is a complex Organ offering structural and mechanical support of our body, but also consisting in our principal hematopoietic center. The formation of Bone involves distinct stages, including cartilage, vasculature, bone and bone marrow establishment. Our lab aims at compiling human-specific knowledge on these processes, toward the development of innovative Regenerative Therapies. Precisely, three main research axes are being explored:
(i) Deciphering the cellular/molecularmechanisms involved in Bone formation
(ii) In vitro developmentof 3D Bone models
(iii) Design of 3D biological grafts for skeletal tissue regeneration
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Subject classification (UKÄ)
- Medical and Health Sciences
- Engineering and Technology
Free keywords
- Bone
- Hematopoiesis
- Mesenchymal stem cells
- Developmental engineering
- Regenerative medicine
- Hematopoietic stem cells
- bone marrow niche
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines
Prithiviraj, S., Garcia Garcia, A., Linderfalk, K., Yiguang, B., Ferveur, S., Falck, L. N., Subramaniam, A., Mohlin, S., Hidalgo Gil, D., Dupard, S. J., Zacharaki, D., Raina, D. B. & Bourgine, P. E., 2025 Mar 28, In: eLife. 13, RP96941.Research output: Contribution to journal › Article › peer-review
Open Access -
Sustained delivery of a heterodimer bone morphogenetic protein-2/7 via a collagen hydroxyapatite scaffold accelerates and improves critical femoral defect healing
Liu, Y., Puthia, M., Sheehy, E. J., Ambite, I., Petrlova, J., Prithviraj, S., Oxborg, M. W., Sebastian, S., Vater, C., Zwingenberger, S., Struglics, A., Bourgine, P. E., O'Brien, F. J. & Raina, D. B., 2023 May, In: Acta Biomaterialia. 162, p. 164-181Research output: Contribution to journal › Article › peer-review
Open Access -
Customizable 3D printed perfusion bioreactor for the engineering of stem cell microenvironments
Dupard, S. J., Garcia, A. G. & Bourgine, P. E., 2023 Jan, In: Frontiers in Bioengineering and Biotechnology. 10, 1081145.Research output: Contribution to journal › Article › peer-review
Open Access -
Engineering human mini-bones for the standardized modeling of healthy hematopoiesis, leukemia, and solid tumor metastasis
Grigoryan, A., Zacharaki, D., Balhuizen, A., Côme, C. R., Garcia, A. G., Hidalgo Gil, D., Frank, A.-K., Aaltonen, K., Mañas, A., Esfandyari, J., Kjellman, P., Englund, E., Rodriguez, C., Sime, W., Massoumi, R., Kalantari, N., Prithiviraj, S., Li, Y., Dupard, S. J. & Isaksson, H. & 4 others, , 2022 Oct 12, In: Science Translational Medicine. 14, 666, p. 1-15 eabm6391.Research output: Contribution to journal › Article › peer-review
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3D Engineering of Human Hematopoietic Niches in Perfusion Bioreactor
Dupard, S. J. & Bourgine, P. E., 2021, Methods in Molecular Biology. Humana Press, p. 253-262 10 p. (Methods in Molecular Biology; vol. 2308).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Human bone marrow niche regulation of dendritic cells in health, disease and upon therapy
Rabanal Cajal, L. (Researcher) & Bourgine, P. (PI)
2025/03/03 → …
Project: Dissertation
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Modelling and characterizing neuroblastoma metastasis
Adamic, D. (Research student), Bexell, D. (Supervisor), Aaltonen, K. (Assistant supervisor) & Bourgine, P. (Assistant supervisor)
2025/02/01 → …
Project: Dissertation
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BuonMarrow: Bone Marrow-on-Chip as smart sensor of lung cancer relapse
Bourgine, P. (PI)
European Commission - Horizon Europe
2024/03/01 → 2027/02/28
Project: Research
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Personalized modeling of AML disorders by engineering of patient-derived mini-bone organs
Bourgine, P. (PI)
2024/01/01 → 2027/12/31
Project: Research
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Biomaterials@LU
Hajizadeh, S. (PI), Larsson, M. (PI), Orlov, D. (PI), Dicko, C. (PI), Aits, S. (PI), Bourgine, P. (PI), Käll, J. (PI), Svensson Bonde, J. (PI), Raina, D. (PI), Nordin, M. (PI), Elowsson, L. (PI), Ibáñez-Fonseca, A. (PI), Wagner, D. (PI), Parvaneh, S. (Researcher), Wendi, I. P. (Researcher), Alsafadi, H. (Researcher) & Gvazava, N. (Researcher)
2023/09/01 → …
Project: Network
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LUCC - Breast and Imaging & nuclear/radiology: Retreat
Saal, L. (Organiser), Skarping, I. (Organiser), Massoumi, R. (Organiser), Skarping, I. (Session chair), Zackrisson, S. (Speaker), Ryden, L. (Speaker), van Brakel, J. (Speaker), Alkner, S. (Speaker), Saal, L. (Session chair), Rantalainen, M. (Keynote/plenary speaker), Lehn, S. (Session chair), Jessica, P. (Speaker), Olsson, L. E. (Speaker), Massoumi, R. (Session chair), Sydoff, M. (Speaker), Barrientos Baeza, S. (Speaker), Rolny, C. (Speaker), Ahlin Gullers, A. (Speaker), Olsson, J. (Speaker), Wiklund, H. (Speaker), Loman, N. (Speaker), Kimbung, S. (Session chair), Heiberg, E. (Speaker), Swaminathan, V. (Speaker), Bourgine, P. (Speaker), Saal, L. (Speaker), Vallon-Christersson, J. (Speaker) & Staaf, J. (Speaker)
2025 Mar 20 → 2025 Mar 21Activity: Participating in or organising an event › Organisation of conference
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Future Biomaterials: Data-Driven Insight to Cell-Biomaterial Interaction
Aits, S. (Organiser), Dicko, C. (Organiser), De Boer, J. (Organiser), Bourgine, P. (Organiser), Käll, J. (Organiser), Larsson, M. (Organiser), Orlov, D. (Role not specified) & Hajizadeh, S. (Organiser)
2024 May 29 → 2024 May 31Activity: Participating in or organising an event › Organisation of conference
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Lund University Cancer Centre (LUCC) meeting
Berntsson, P. (Member of programme committee), Zackrisson, S. (Member of programme committee), Nilbert, M. (Member of programme committee), Swaminathan, V. (Member of programme committee), Martling, A. (Invited speaker), Heeren, R. M. A. (Invited speaker), Gisselsson Nord, D. (Speaker), Bellodi, C. (Speaker), Mosquim Junior, S. (Speaker), Andersson, N. (Speaker), Gonçalves de Oliveira, K. (Speaker), Mekuria, S. (Speaker), Helkkula, T. (Speaker), Godina, C. (Speaker), Olsson, L. E. (Speaker), Lång, K. (Speaker), Ågerstam, H. (Speaker), Hyrenius Wittsten, A. (Speaker), Bourgine, P. (Speaker), Alvarado Kristensson, M. (Speaker), Carneiro, A. (Speaker), Jernström, H. (Speaker), Malmborg Kisch, A. (Speaker), Malmström, M. (Speaker), Larsson, A.-M. (Speaker), Zackrisson, S. (Session chair), Paulsson, K. (Session chair), Pronk, K.-J. (Session chair), Swaminathan, V. (Session chair), Hedenfalk, I. (Session chair), Massoumi, R. (Session chair), Dalene Skarping, I. (Session chair), Leandersson, K. (Session chair), Sandström Gerdtsson, A. (Session chair), Järås, M. (Session chair), Carneiro, A. (Session chair), Stocks, T. (Session chair), Malmborg Kisch, A. (Session chair) & Malmström, M. (Session chair)
2023 May 4Activity: Participating in or organising an event › Organisation of conference
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Steven Dupard
Bourgine, P. (Role not specified)
2019 Mar 1Activity: Examination and supervision › Supervision of PhD students
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Co-supervision of PhD student: Sujeethkumar Prithiviraj
Bourgine, P. (First/primary/lead supervisor) & Pereira, C.-F. (Second supervisor)
2018 → 2022Activity: Examination and supervision › Supervision of PhD students