Peter Ellmark

2023

The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies

Nelson, M. H., Fritzell, S., Miller, R., Werchau, D., Van Citters, D., Nilsson, A., Misher, L., Ljung, L., Bader, R., Deronic, A., Chunyk, A. G., Schultz, L., Varas, L. A., Rose, N., Håkansson, M., Gross, J., Furebring, C., Pavlik, P., Sundstedt, A., Veitonmäki, N., & 9 othersRamos, H. J., Säll, A., Dahlman, A., Bienvenue, D., von Schantz, L., McMahan, C. J., Askmyr, M., Hernandez-Hoyos, G. & Ellmark, P., 2023 Jan 3, In: Molecular Cancer Therapeutics. 22, 1, p. 89-101 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Bispecific antibodies targeting CD40 and tumor-associated antigens promote cross-priming of T cells resulting in an antitumor response superior to monospecific antibodies

Hägerbrand, K., Varas, L., Deronic, A., Nyesiga, B., Sundstedt, A., Ljung, L., Sakellariou, C., Werchau, D., Thagesson, M., Gomez Jimenez, D., Greiff, L., Celander, M., Smedenfors, K., Rosén, A., Bölükbas, D., Carlsson, F., Levin, M., Säll, A., Von Schantz, L., Lindstedt, M., & 1 othersEllmark, P., 2022 Nov 2, In: Journal for ImmunoTherapy of Cancer. 10, 11, e005018.

Research output: Contribution to journal › Article › peer-review

Open Access

Transcriptional profiling demonstrates altered characteristics of CD8 + cytotoxic T-cells and regulatory T-cells in TP53-mutated acute myeloid leukemia

Abolhalaj, M., Sincic, V., Lilljebjörn, H., Sandén, C., Aab, A., Hägerbrand, K., Ellmark, P., Borrebaeck, C., Fioretos, T. & Lundberg, K., 2022, In: Cancer Medicine. 11, 15 , p. 3023-3032

Research output: Contribution to journal › Article › peer-review

Open Access

2021

CD137 (4-1BB) costimulation of CD8⁺ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

Otano, I., Azpilikueta, A., Glez-Vaz, J., Alvarez, M., Medina-Echeverz, J., Cortés-Domínguez, I., Ortiz-de-Solorzano, C., Ellmark, P., Fritzell, S., Hernandez-Hoyos, G., Nelson, M. H., Ochoa, M. C., Bolaños, E., Cuculescu, D., Jaúregui, P., Sanchez-Gregorio, S., Etxeberria, I., Rodriguez-Ruiz, M. E., Sanmamed, M. F., Teijeira, Á., & 2 othersBerraondo, P. & Melero, I., 2021 Dec 1, In: Nature Communications. 12, 1, 7296.

Research output: Contribution to journal › Article › peer-review

Open Access

Rationale and clinical development of CD40 agonistic antibodies for cancer immunotherapy

Enell Smith, K., Deronic, A., Hägerbrand, K., Norlén, P. & Ellmark, P., 2021, In: Expert Opinion on Biological Therapy. 21, 12, p. 1635-1646

Research output: Contribution to journal › Review article › peer-review

Open Access

The human anti-CD40 agonist antibody mitazalimab (ADC-1013; JNJ-64457107) activates antigen-presenting cells, improves expansion of antigen-specific T cells, and enhances anti-tumor efficacy of a model cancer vaccine in vivo

Deronic, A., Nilsson, A., Thagesson, M., Werchau, D., Enell Smith, K. & Ellmark, P., 2021, In: Cancer Immunology, Immunotherapy. 70, 12, p. 3629-3642

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer.

Sincic, V., Abolhalaj, M., Lilljebjörn, H., Aab, A., Hägerbrand, K., Ellmark, P., Fioretos, T., Borrebaeck, C., Liedberg, F. & Lundberg, K., 2020, In: Journal for ImmunoTherapy of Cancer. 8, Suppl. 3

Research output: Contribution to journal › Published meeting abstract › peer-review

Open Access

2018

Administration of low-dose combination anti-CTLA4, anti-CD137, and anti-OX40 into murine tumor or proximal to the tumor draining lymph node induces systemic tumor regression

Hebb, J. P. O., Mosley, A. R., Vences-Catalán, F., Rajasekaran, N., Rosén, A., Ellmark, P. & Felsher, D. W., 2018 Jan, In: Cancer Immunology, Immunotherapy. 67, 1, p. 47-60

Research output: Contribution to journal › Article › peer-review

2017

Local checkpoint inhibition of CTLA-4 as a monotherapy or in combination with anti-PD1 prevents the growth of murine bladder cancer

van Hooren, L., Sandin, L. C., Moskalev, I., Ellmark, P., Dimberg, A., Black, P., Tötterman, T. H. & Mangsbo, S. M., 2017 Feb, In: European Journal of Immunology. 47, 2, p. 385-393

Research output: Contribution to journal › Article › peer-review

Tumor-directed immunotherapy can generate tumor-specific T cell responses through localized co-stimulation

Ellmark, P., Mangsbo, S. M., Furebring, C., Norlén, P. & Tötterman, T. H., 2017 Jan, In: Cancer Immunology and Immunotherapy. 66, 1, p. 1-7 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Selective FcγR engagement by human agonistic anti-CD40 antibodies

Ellmark, P., Mangsbo, S. M. & Lindstedt, M., 2016, In: Translational Cancer Research. 5, p. S839-S841

Research output: Contribution to journal › Debate/Note/Editorial › peer-review

2015

Kick-starting the cancer-immunity cycle by targeting CD40

Ellmark, P., Mangsbo, S. M., Furebring, C., Totterman, T. H. & Norlen, P., 2015, In: OncoImmunology. 4, 7, p. e1011484

Research output: Contribution to journal › Debate/Note/Editorial

2014

Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo.

Sandin, L. C., Eriksson, F., Ellmark, P., Loskog, A. S., Tötterman, T. H. & Mangsbo, S. M., 2014, In: OncoImmunology. 3, 1, p. e27614

Research output: Contribution to journal › Article › peer-review

Locally Delivered CD40 Agonist Antibody Accumulates in Secondary Lymphoid Organs and Eradicates Experimental Disseminated Bladder Cancer.

Sandin, L. C., Orlova, A., Gustafsson, E., Ellmark, P., Tolmachev, V., Tötterman, T. H. & Mangsbo, S. M., 2014, In: Cancer immunology research. 2, 1, p. 80-90

Research output: Contribution to journal › Article › peer-review

2009

Attovial-based antibody nanoarrays.

Ellmark, P., Ghatnekar-Nilsson, S., Meister, A., Heinzelmann, H., Montelius, L., Wingren, C. & Borrebaeck, C., 2009, In: Proteomics. 9, 24, p. 5406-5413

Research output: Contribution to journal › Article › peer-review

2008

Detection of pancreatic cancer using antibody microarray-based serum protein profiling

Ingvarsson, J., Wingren, C., Carlsson, A., Ellmark, P., Wahren, B., Engström, G., Harmenberg, U., Krogh, M., Peterson, C. & Borrebaeck, C., 2008, In: Proteomics. 8, 11, p. 2211-2219

Research output: Contribution to journal › Article › peer-review

Identification of a strongly activating human anti-CD40 antibody that suppresses HIV-1 infection

Ellmark, P., Andersson, H., Abayneh, S., Fenyö, E. M. & Borrebaeck, C., 2008, In: AIDS Research and Human Retroviruses. 24, 3, p. 367-373

Research output: Contribution to journal › Article › peer-review

Multiplexed Lipid Dip-Pen Nanolithography on Subcellular Scales for the Templating of Functional Proteins and Cell Culture

Sekula, S., Fuchs, J., Weg-Remers, S., Nagel, P., Schuppler, S., Fragala, J., Theilacker, N., Franueb, M., Wingren, C., Ellmark, P., Borrebaeck, C., Mirkin, C. A., Fuchs, H. & Lenhert, S., 2008, In: Small. 4, 10, p. 1785-1793

Research output: Contribution to journal › Article › peer-review

2007

Recombinant antibdy microarray based oncoproteomics detects cancer and defines a predictor of survival for pancreatic carcinoma

Ingvarsson, J., Wingren, C., Carlsson, A., Ellmark, P., Wahren, B., Engström, G., Harmenberg, U., Krogh, M., Peterson, C. & Borrebaeck, C., 2007, In: Molecular & Cellular Proteomics. p. S311

Research output: Contribution to journal › Published meeting abstract › peer-review

Serum protein profiling of metastatic breast cancer

Carlsson, A., Wingren, C., Ingvarsson, J., Ellmark, P., Baldetorp, B., Fernö, M., Olsson, H. & Borrebaeck, C., 2007, In: Molecular & Cellular Proteomics. October, p. S311

Research output: Contribution to journal › Published meeting abstract › peer-review

2006

Antibody microarray based oncoproteomics - analysis of breast cancer proteomes

Carlsson, A., Wingren, C., Ingvarsson, J., Ellmark, P., Baldetorp, B., Fernö, M., Olsson, H. & Borrebaeck, C., 2006, In: Proceedings of the 29th annual San Antonio breast cancer symposium.

Research output: Contribution to journal › Published meeting abstract › peer-review

High-throughput membrane proteomics using recombinant antibody microarrays

Dexlin Mellby, L., Ingvarsson, J., Karlsson, J., Ellmark, P., Frendeus, B., Borrebaeck, C. & Wingren, C., 2006, In: Molecular & Cellular Proteomics. 5, 10, p. S70

Research output: Contribution to journal › Published meeting abstract › peer-review

Identification of protein expression signatures associated with Helicobacter pylori infection and gastric adenocarcinoma using recombinant antibody microarrays

Ellmark, P., Ingvarsson, J., Carlsson, A., Lundin, B. S., Wingren, C. & Borrebaeck, C., 2006, In: Molecular & Cellular Proteomics. 5, 9, p. 1638-1646

Research output: Contribution to journal › Article › peer-review

2005

Protein expression profiling in normal and malignant stomach tissue using recombinant antibody microarrays

Ellmark, P., Ingvarsson, J., Carlsson, A., Lundin, S., Svennerholm, A-M., Wingren, C. & Borrebaeck, C., 2005.

Research output: Contribution to conference › Abstract › peer-review

2004

A novel mammalian display system for the selection of protein-protein interactions by decoy receptor engagement

Ellmark, P., Ohlin, M., Borrebaeck, C. & Furebring, C., 2004, In: Journal of Molecular Recognition. 17, 4, p. 316-322

Research output: Contribution to journal › Article › peer-review

Profiling of internalizing tumor-associated antigens on breast and pancreatic cancer cells by reversed genomics

Fransson, J., Ek, S., Ellmark, P., Söderlind, E., Borrebaeck, C. & Furebring, C., 2004, In: Cancer Letters. 208, 2, p. 235-242

Research output: Contribution to journal › Article › peer-review

2003

Affinity and Epitope Profiling of Mouse Anti-CD40 Monoclonal Antibodies

Malmborg Hager, A-C., Ellmark, P., Borrebaeck, C. & Furebring, C., 2003, In: Scandinavian Journal of Immunology. 57, 6, p. 517-524

Research output: Contribution to journal › Article › peer-review

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Pre-assembly of the extracellular domains of CD40 is not necessary for rescue of mouse B cells from anti-immunoglobulin M-induced apoptosis

Ellmark, P., Furebring, C. & Borrebaeck, C., 2003, In: Immunology. 108, 4, p. 452-457

Research output: Contribution to journal › Article › peer-review

File

229 Downloads (Pure)

Pre-assembly of the extracellular domains of CD40 is not necessary for rescue of naïve B-cells from anti-IgM induced apoptosis

Ellmark, P., Borrebaeck, C. & Furebring, C., 2003, (Unpublished) p. W14.01.

Research output: Contribution to conference › Paper, not in proceeding

2002

In vitro molecular evolution of antibody genes mimicking receptor revision

Ellmark, P., Esteban, O., Furebring, C., Malmborg Hager, A-C. & Ohlin, M., 2002, In: Molecular Immunology. 39, 5-6, p. 349-356

Research output: Contribution to journal › Article › peer-review

Modulation of the CD40-CD40 ligand interaction using human anti-CD40 single-chain antibody fragments obtained from the n-CoDeR phage display library

Ellmark, P., Ottosson, C., Borrebaeck, C., Malmborg Hager, A-C. & Furebring, C., 2002, In: Immunology. 106, 4, p. 456-463

Research output: Contribution to journal › Article › peer-review

The CD40 Receptor - Target,Tool and Technology

Ellmark, P., 2002, 150 p.

Research output: Thesis › Doctoral Thesis (compilation)

Peter Ellmark

Research output

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