Peter Ellmark

Search results

• 2023

  The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies

  Nelson, M. H., Fritzell, S., Miller, R., Werchau, D., Van Citters, D., Nilsson, A., Misher, L., Ljung, L., Bader, R., Deronic, A., Chunyk, A. G., Schultz, L., Varas, L. A., Rose, N., Håkansson, M., Gross, J., Furebring, C., Pavlik, P., Sundstedt, A., Veitonmäki, N., & 9 othersRamos, H. J., Säll, A., Dahlman, A., Bienvenue, D., von Schantz, L., McMahan, C. J., Askmyr, M., Hernandez-Hoyos, G. & Ellmark, P., 2023 Jan 3, In: Molecular Cancer Therapeutics. 22, 1, p. 89-101 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasm Antigens 100%
  • T-Lymphocytes 58%
  • Neoplasms 30%
  • Bispecific Antibodies 22%
  • X Ray Crystallography 21%
• 2022

  Bispecific antibodies targeting CD40 and tumor-associated antigens promote cross-priming of T cells resulting in an antitumor response superior to monospecific antibodies

  Hägerbrand, K., Varas, L., Deronic, A., Nyesiga, B., Sundstedt, A., Ljung, L., Sakellariou, C., Werchau, D., Thagesson, M., Gomez Jimenez, D., Greiff, L., Celander, M., Smedenfors, K., Rosén, A., Bölükbas, D., Carlsson, F., Levin, M., Säll, A., Von Schantz, L., Lindstedt, M., & 1 othersEllmark, P., 2022 Nov 2, In: Journal for ImmunoTherapy of Cancer. 10, 11, e005018.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cross-Priming 100%
  • Bispecific Antibodies 99%
  • Neoplasm Antigens 75%
  • T-Lymphocytes 43%
  • Antibodies 39%

• Transcriptional profiling demonstrates altered characteristics of CD8 + cytotoxic T-cells and regulatory T-cells in TP53-mutated acute myeloid leukemia

  Abolhalaj, M., Sincic, V., Lilljebjörn, H., Sandén, C., Aab, A., Hägerbrand, K., Ellmark, P., Borrebaeck, C., Fioretos, T. & Lundberg, K., 2022, In: Cancer Medicine. 11, 15 , p. 3023-3032

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2021

  CD137 (4-1BB) costimulation of CD8⁺ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

  Otano, I., Azpilikueta, A., Glez-Vaz, J., Alvarez, M., Medina-Echeverz, J., Cortés-Domínguez, I., Ortiz-de-Solorzano, C., Ellmark, P., Fritzell, S., Hernandez-Hoyos, G., Nelson, M. H., Ochoa, M. C., Bolaños, E., Cuculescu, D., Jaúregui, P., Sanchez-Gregorio, S., Etxeberria, I., Rodriguez-Ruiz, M. E., Sanmamed, M. F., Teijeira, Á., & 2 othersBerraondo, P. & Melero, I., 2021 Dec 1, In: Nature Communications. 12, 1, 7296.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Effector 100%
  • stimulation 91%
  • Agonist 87%
  • Metabolic 74%
  • T-Lymphocytes 56%

• The human anti-CD40 agonist antibody mitazalimab (ADC-1013; JNJ-64457107) activates antigen-presenting cells, improves expansion of antigen-specific T cells, and enhances anti-tumor efficacy of a model cancer vaccine in vivo

  Deronic, A., Nilsson, A., Thagesson, M., Werchau, D., Enell Smith, K. & Ellmark, P., 2021, In: Cancer Immunology, Immunotherapy. 70, 12, p. 3629-3642

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ADC-1013 100%
  • Cancer Vaccines 48%
  • Antigen-Presenting Cells 42%
  • Ovalbumin 25%
  • Antigens 25%
• 2018

  Administration of low-dose combination anti-CTLA4, anti-CD137, and anti-OX40 into murine tumor or proximal to the tumor draining lymph node induces systemic tumor regression

  Hebb, J. P. O., Mosley, A. R., Vences-Catalán, F., Rajasekaran, N., Rosén, A., Ellmark, P. & Felsher, D. W., 2018 Jan, In: Cancer Immunology, Immunotherapy. 67, 1, p. 47-60

  Research output: Contribution to journal › Article › peer-review

  • Lymph Nodes 100%
  • Neoplasms 45%
  • Immunologic Factors 27%
  • Vaccines 19%
  • Neoplasm Antibodies 17%
• 2017

  Local checkpoint inhibition of CTLA-4 as a monotherapy or in combination with anti-PD1 prevents the growth of murine bladder cancer

  van Hooren, L., Sandin, L. C., Moskalev, I., Ellmark, P., Dimberg, A., Black, P., Tötterman, T. H. & Mangsbo, S. M., 2017 Feb, In: European Journal of Immunology. 47, 2, p. 385-393

  Research output: Contribution to journal › Article › peer-review

  • Urinary Bladder Neoplasms 100%
  • Growth 52%
  • Antibodies 28%
  • Urinary Bladder 25%
  • Therapeutics 17%

• Tumor-directed immunotherapy can generate tumor-specific T cell responses through localized co-stimulation

  Ellmark, P., Mangsbo, S. M., Furebring, C., Norlén, P. & Tötterman, T. H., 2017 Jan, In: Cancer Immunology and Immunotherapy. 66, 1, p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Immunotherapy 100%
  • T-Lymphocytes 70%
  • Neoplasms 36%
  • Bispecific Antibodies 22%
  • Immune System 12%
• 2014

  Local CTLA4 blockade effectively restrains experimental pancreatic adenocarcinoma growth in vivo.

  Sandin, L. C., Eriksson, F., Ellmark, P., Loskog, A. S., Tötterman, T. H. & Mangsbo, S. M., 2014, In: OncoImmunology. 3, 1, p. e27614

  Research output: Contribution to journal › Article › peer-review

  • Adenocarcinoma 100%
  • Growth 64%
  • Antibodies 47%
  • Regulatory T-Lymphocytes 42%
  • Neoplasms 41%

• Locally Delivered CD40 Agonist Antibody Accumulates in Secondary Lymphoid Organs and Eradicates Experimental Disseminated Bladder Cancer.

  Sandin, L. C., Orlova, A., Gustafsson, E., Ellmark, P., Tolmachev, V., Tötterman, T. H. & Mangsbo, S. M., 2014, In: Cancer immunology research. 2, 1, p. 80-90

  Research output: Contribution to journal › Article › peer-review

  • Urinary Bladder Neoplasms 100%
  • Anti-Idiotypic Antibodies 58%
  • Antibodies 57%
  • Neoplasms 33%
  • Cytokine Release Syndrome 27%
• 2009

  Attovial-based antibody nanoarrays.

  Ellmark, P., Ghatnekar-Nilsson, S., Meister, A., Heinzelmann, H., Montelius, L., Wingren, C. & Borrebaeck, C., 2009, In: Proteomics. 9, 24, p. 5406-5413

  Research output: Contribution to journal › Article › peer-review

  • Antibodies 100%
  • Complement C1q 91%
  • Proteome 62%
  • Proteomics 55%
  • Technology 39%
• 2008

  Detection of pancreatic cancer using antibody microarray-based serum protein profiling

  Ingvarsson, J., Wingren, C., Carlsson, A., Ellmark, P., Wahren, B., Engström, G., Harmenberg, U., Krogh, M., Peterson, C. & Borrebaeck, C., 2008, In: Proteomics. 8, 11, p. 2211-2219

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Neoplasms 100%
  • Blood Proteins 93%
  • Antibodies 58%
  • Microarrays 45%
  • Proteome 44%

• Identification of a strongly activating human anti-CD40 antibody that suppresses HIV-1 infection

  Ellmark, P., Andersson, H., Abayneh, S., Fenyö, E. M. & Borrebaeck, C., 2008, In: AIDS Research and Human Retroviruses. 24, 3, p. 367-373

  Research output: Contribution to journal › Article › peer-review

  • HIV Infections 100%
  • HIV-1 98%
  • Anti-Idiotypic Antibodies 95%
  • CD40 Ligand 56%
  • B-Lymphocytes 52%

• Multiplexed Lipid Dip-Pen Nanolithography on Subcellular Scales for the Templating of Functional Proteins and Cell Culture

  Sekula, S., Fuchs, J., Weg-Remers, S., Nagel, P., Schuppler, S., Fragala, J., Theilacker, N., Franueb, M., Wingren, C., Ellmark, P., Borrebaeck, C., Mirkin, C. A., Fuchs, H. & Lenhert, S., 2008, In: Small. 4, 10, p. 1785-1793

  Research output: Contribution to journal › Article › peer-review

  • Nitrilotriacetic Acid 100%
  • Nanolithography 99%
  • Ink 78%
  • Lipids 78%
  • Cell culture 75%

• Phenotypic protein profiling of different B cell sub-populations using antibody CD-microarrays

  Ellmark, P., Högerkorp, C-M., Ek, S., Beelov, L., Berglund, M., Rosenquist, R., Christopherson, R. & Borrebaeck, C., 2008, In: Cancer Letters. 265, p. 98-106

  Research output: Contribution to journal › Article › peer-review

  • B-Lymphocytes 100%
  • Antibodies 71%
  • Germinal Center 51%
  • Population 50%
  • Proteins 47%

• Sensitivity of HIV-1 primary isolates to human anti-CD40 antibody-mediated suppression is related to co-receptor use

  Abayneh, S. A., Ellmark, P., Karlsson, U., Andersson, H., Borrebaeck, C., Karlsson, I. & Fenyö, E. M., 2008, In: AIDS Research and Human Retroviruses. 24, 3, p. 447-452

  Research output: Contribution to journal › Article › peer-review

  • HIV-1 100%
  • CC Chemokines 97%
  • Anti-Idiotypic Antibodies 96%
  • CXCR4 Receptors 52%
  • Monoclonal Antibodies 42%

• Serum proteome profiling of metastatic breast cancer using recombinant antibody microarrays.

  Carlsson, A., Wingren, C., Ingvarsson, J., Ellmark, P., Baldetorp, B., Fernö, M., Olsson, H. & Borrebaeck, C., 2008, In: European Journal of Cancer. 44, 3, p. 472-480

  Research output: Contribution to journal › Article › peer-review

  • Proteome 100%
  • Biomarkers 62%
  • Breast Neoplasms 61%
  • Antibodies 53%
  • Serum 43%

• The Applicability of a Cluster of Differentiation Monoclonal Antibody Microarray to the Diagnosis of Human Disease

  Ellmark, P., Woolfson, A., Belov, L. & Christopherson, R. I., 2008, In: Methods in Molecular Biology. 439, p. 199-209

  Research output: Contribution to journal › Article › peer-review
• 2006

  Identification of protein expression signatures associated with Helicobacter pylori infection and gastric adenocarcinoma using recombinant antibody microarrays

  Ellmark, P., Ingvarsson, J., Carlsson, A., Lundin, B. S., Wingren, C. & Borrebaeck, C., 2006, In: Molecular & Cellular Proteomics. 5, 9, p. 1638-1646

  Research output: Contribution to journal › Article › peer-review

  • Microarrays 100%
  • Helicobacter Infections 98%
  • Helicobacter pylori 89%
  • Immunoglobulin Fragments 78%
  • Adenocarcinoma 72%

• Multiplex detection of surface molecules on colorectal cancers

  Ellmark, P., Belov, L., Huang, P., Lee, S., Solomon, M., Morgan, D. & Christopherson, R., 2006, In: Proteomics. 6, 6, p. 1791-1802

  Research output: Contribution to journal › Article › peer-review

  • Microarrays 100%
  • Colorectal Neoplasms 73%
  • Antigen 51%
  • Fluorescence 35%
  • Molecule 32%
• 2004

  A novel mammalian display system for the selection of protein-protein interactions by decoy receptor engagement

  Ellmark, P., Ohlin, M., Borrebaeck, C. & Furebring, C., 2004, In: Journal of Molecular Recognition. 17, 4, p. 316-322

  Research output: Contribution to journal › Article › peer-review

  • Proteins 100%
  • Peptides 43%
  • Peptide Receptors 42%
  • Proteomics 31%
  • B-Lymphocytes 26%

• Profiling of internalizing tumor-associated antigens on breast and pancreatic cancer cells by reversed genomics

  Fransson, J., Ek, S., Ellmark, P., Söderlind, E., Borrebaeck, C. & Furebring, C., 2004, In: Cancer Letters. 208, 2, p. 235-242

  Research output: Contribution to journal › Article › peer-review

  • Neoplasm Antigens 100%
  • Genomics 94%
  • Pancreatic Neoplasms 88%
  • Single-Chain Antibodies 60%
  • Breast Neoplasms 59%
• 2003

  Affinity and Epitope Profiling of Mouse Anti-CD40 Monoclonal Antibodies

  Malmborg Hager, A-C., Ellmark, P., Borrebaeck, C. & Furebring, C., 2003, In: Scandinavian Journal of Immunology. 57, 6, p. 517-524

  Research output: Contribution to journal › Article › peer-review

  File

  • CD40 Ligand 100%
  • Epitopes 69%
  • Monoclonal Antibodies 58%
  • Anti-Idiotypic Antibodies 33%
  • Humoral Immunity 20%
  253 Downloads (Pure)

• Pre-assembly of the extracellular domains of CD40 is not necessary for rescue of mouse B cells from anti-immunoglobulin M-induced apoptosis

  Ellmark, P., Furebring, C. & Borrebaeck, C., 2003, In: Immunology. 108, 4, p. 452-457

  Research output: Contribution to journal › Article › peer-review

  File

  • Immunoglobulin M 100%
  • B-Lymphocytes 86%
  • Peptides 71%
  • Apoptosis 68%
  • Tumor Necrosis Factor Receptors 64%
  229 Downloads (Pure)
• 2002

  In vitro molecular evolution of antibody genes mimicking receptor revision

  Ellmark, P., Esteban, O., Furebring, C., Malmborg Hager, A-C. & Ohlin, M., 2002, In: Molecular Immunology. 39, 5-6, p. 349-356

  Research output: Contribution to journal › Article › peer-review

  • Directed Molecular Evolution 100%
  • Immunoglobulin Fragments 33%
  • Antibodies 28%
  • Base Pairing 26%
  • Bacteriophages 25%

• Modulation of the CD40-CD40 ligand interaction using human anti-CD40 single-chain antibody fragments obtained from the n-CoDeR phage display library

  Ellmark, P., Ottosson, C., Borrebaeck, C., Malmborg Hager, A-C. & Furebring, C., 2002, In: Immunology. 106, 4, p. 456-463

  Research output: Contribution to journal › Article › peer-review

  • Single-Chain Antibodies 100%
  • Immunoglobulin Fragments 99%
  • CD40 Ligand 96%
  • Bacteriophages 76%
  • Libraries 68%