Pontus Dunér

2024

Dysregulation of MMP2-dependent TGF-ß2 activation impairs fibrous cap formation in type 2 diabetes-associated atherosclerosis

Singh, P., Sun, J., Cavalera, M., Al-Sharify, D., Matthes, F., Barghouth, M., Tengryd, C., Dunér, P., Persson, A., Sundius, L., Nitulescu, M., Bengtsson, E., Rattik, S., Engelbertsen, D., Orho-Melander, M., Nilsson, J., Monaco, C., Goncalves, I. & Edsfeldt, A., 2024 Dec, In: Nature Communications. 15, p. 1-18 10464.

Research output: Contribution to journal › Article › peer-review

Open Access

A New IL-6-Inducing Mechanism in Cancer with New Therapeutic Possibilities

Håkansson, L., Dunér, P., Broströmer, E., Gustavsson, B., Wettergren, Y., Ghafouri, B., Håkansson, A. & Clinchy, B., 2024 Nov, In: Cancers. 16, 21, 3588.

Research output: Contribution to journal › Article › peer-review

Open Access

Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis

Chen, Y., Gialeli, C., Shen, J., Dunér, P., Walse, B., Duelli, A., Caing-Carlsson, R., Blom, A. M., Zibert, J. R., Nilsson, A. H., Alenfall, J., Liang, C. & Nilsson, J., 2024 Jun 11, In: Pharmacological Research. 205, 18 p., 107259.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Transforming growth factor-β2 is associated with atherosclerotic plaque stability and lower risk for cardiovascular events

Edsfeldt, A., Singh, P., Matthes, F., Tengryd, C., Cavalera, M., Bengtsson, E., Dunér, P., Volkov, P., Karadimou, G., Gisterå, A., Orho-Melander, M., Nilsson, J., Sun, J. & Gonçalves, I., 2023 Aug, In: Cardiovascular Research. 119, 11, p. 2061-2073

Research output: Contribution to journal › Article › peer-review

Open Access

Ablation of GPR56 Causes β-Cell Dysfunction by ATP Loss through Mistargeting of Mitochondrial VDAC1 to the Plasma Membrane

Mohammad Al-Amily, I., Sjögren, M., Duner, P., Tariq, M., Wollheim, C. B. & Salehi, A., 2023, In: Biomolecules. 13, 3, 557.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Antibodies against apoB100 peptide 210 inhibit atherosclerosis in apoE^-/- mice

Dunér, P., Mattisson, I. Y., Fogelstrand, P., Glise, L., Ruiz, S., Farina, C., Borén, J., Nilsson, J. & Bengtsson, E., 2021 Dec 1, In: Scientific Reports. 11, 1, 9022.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

The proteoglycan mimecan is associated with carotid plaque vulnerability and increased risk of future cardiovascular death

Tengryd, C., Nielsen, S. H., Cavalera, M., Bengtsson, E., Genovese, F., Karsdal, M., Dunér, P., Orho-Melander, M., Nilsson, J., Edsfeldt, A. & Gonçalves, I., 2020 Nov, In: Atherosclerosis. 313, p. 88-95 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

An osteopontin-derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor-7 production in outer root sheath keratinocytes

Alam, M., Bertolini, M., Gherardini, J., Keren, A., Ponce, L., Chéret, J., Alenfall, J., Dunér, P., Hultgårdh, A., Gilhar, A. & Paus, R., 2020 Jun, In: British Journal of Dermatology. 182, 6, p. 1404-1414 11 p.

Research output: Contribution to journal › Article › peer-review

Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin

Herum, K. M., Romaine, A., Wang, A., Melleby, A. O., Strand, M. E., Pacheco, J., Braathen, B., Dunér, P., Tønnessen, T., Lunde, I. G., Sjaastad, I., Brakebusch, C., McCulloch, A. D., Gomez, M. F., Carlson, C. R. & Christensen, G., 2020 Feb 4, In: Journal of the American Heart Association. 9, 3, p. e013518

Research output: Contribution to journal › Article › peer-review

Open Access

Inhibitory effect of UDP-glucose on cAMP generation and insulin secretion

Parandeh, F., Amisten, S., Verma, G., Mohammed Al-Amily, I., Dunér, P. & Salehi, A., 2020, In: The Journal of biological chemistry. 295, 45, p. 15245-15252 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Orphan G-protein coupled receptor 183 (GPR183) potentiates insulin secretion and prevents glucotoxicity-induced β-cell dysfunction

Taneera, J., Mohammed, I., Mohammed, A. K., Hachim, M., Dhaiban, S., Malek, A., Dunér, P., Elemam, N. M., Sulaiman, N., Hamad, M. & Salehi, A., 2020, In: Molecular and Cellular Endocrinology. 499, 110592.

Research output: Contribution to journal › Article › peer-review

2019

ILC2 transfers to apolipoprotein E deficient mice reduce the lipid content of atherosclerotic lesions

Mantani, P. T., Dunér, P., Ljungcrantz, I., Nilsson, J., Björkbacka, H. & Fredrikson, G. N., 2019 Dec 10, In: BMC Immunology. 20, 47.

Research output: Contribution to journal › Article › peer-review

Open Access

Activation of immune responses against the basement membrane component collagen type IV does not affect the development of atherosclerosis in ApoE-deficient mice

Vallejo, J., Dunér, P., To, F., Engelbertsen, D., Gonçalves, I., Nilsson, J. & Bengtsson, E., 2019 Apr 12, In: Scientific Reports. 9, 1, 5964.

Research output: Contribution to journal › Article › peer-review

Open Access

Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

Knutsson, A., Björkbacka, H., Dunér, P., Engström, G., Binder, C. J., Nilsson, A. H. & Nilsson, J., 2019, In: JACC: Basic to Translational Science. 4, 8, p. 891-902 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Cartilage Oligomeric Matrix Protein Associates With a Vulnerable Plaque Phenotype in Human Atherosclerotic Plaques

Hultman, K., Edsfeldt, A., Björkbacka, H., Dunér, P., Sundius, L., Nitulescu, M., Persson, A., Boyle, J. J., Nilsson, J., Hultgårdh-Nilsson, A., Bengtsson, E. & Gonçalves, I., 2019, In: Stroke. 50, 11, p. 3289-3292 4 p.

Research output: Contribution to journal › Article › peer-review

The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent

Al-Amily, I. M., Dunér, P., Groop, L. & Salehi, A., 2019, In: Pflügers Archiv. 471, 4, p. 633-645

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Hyperglycemia does not affect tissue repair responses in shear stress-induced atherosclerotic plaques in ApoE-/-mice

Hsiung, S., Knutsson, A., Vallejo, J., Dunér, P., Heinonen, S. E., Jönsson-Rylander, A. C., Bengtsson, E., Nilsson, J. & Hultgårdh-Nilsson, A., 2018 Dec 1, In: Scientific Reports. 8, 1, 7530.

Research output: Contribution to journal › Article › peer-review

Open Access

Activation of imidazoline receptor I₂, and improved pancreatic β-cell function in human islets

Amisten, S., Duner, P., Asplund, O., Mohammed Al-Amily, I., Groop, L. & Salehi, A., 2018 Sept, In: Journal of Diabetes and its Complications. 32, 9, p. 813-818

Research output: Contribution to journal › Article › peer-review

Interleukin-25 (IL-25) has a protective role in atherosclerosis development in the aortic arch in mice

Mantani, P. T., Dunér, P., Bengtsson, E., Ljungcrantz, I., Sundius, L., To, F., Nilsson, J., Björkbacka, H. & Fredrikson, G. N., 2018 Jan 1, In: Journal of Biological Chemistry. 293, 18, p. 6791-6801 11 p.

Research output: Contribution to journal › Article › peer-review

2017

ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis

Bengtsson, E., Hultman, K., Dunér, P., Asciutto, G., Almgren, P., Orho-Melander, M., Melander, O., Nilsson, J., Hultgårdh, A. & Gonçalves, I., 2017 Dec 1, In: Scientific Reports. 7, 1, 3753.

Research output: Contribution to journal › Article › peer-review

Open Access

Autoantibodies against aldehyde-modified collagen type IV are associated with risk of development of myocardial infarction

Vallejo, J., Dunér, P., Fredrikson, G. N., Nilsson, J. & Bengtsson, E., 2017 Dec, In: Journal of Internal Medicine. 282, 6, p. 496-507

Research output: Contribution to journal › Article › peer-review

β-Sarcoglycan Deficiency Reduces Atherosclerotic Plaque Development in ApoE-Null Mice

Murugesan, V., Degerman, E., Knutsson, A., Dunér, P., Holmén-Pålbrink, A.-K., Hultgårdh, A. & Rauch, U., 2017 Jul 29, In: Journal of Vascular Research. 54, p. 235-245

Research output: Contribution to journal › Article › peer-review

2016

Adhesion G protein-coupled receptor G1 (ADGRG1/GPR56) and pancreatic β-cell function

Dunér, P., Mohammed, I., Soni, A., Asplund, O., Safi, F., Storm, P., Groop, L., Amisten, S. & Salehi, S. A., 2016 Dec 1, In: Journal of Clinical Endocrinology and Metabolism. 101, 12, p. 4637-4645 9 p.

Research output: Contribution to journal › Article › peer-review

Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

Berglund, L., Lyssenko, V., Ladenvall, C., Kotova, O., Edsfeldt, A., Pilgaard, K., Alkayyali, S., Brøns, C., Forsblom, C., Jonsson, A., Zetterqvist, A., Nitulescu, M., Ruiz McDavitt, C., Dunér, P., Stancáková, A., Kuusisto, J., Ahlqvist, E., Lajer, M., Tarnow, L. & Madsbad, S. & 13 others, Rossing, P., Kieffer, T. J., Melander, O., Orho-Melander, M., Nilsson, P., Groop, P.-H., Vaag, A., Lindblad, B., Gottsäter, A., Laakso, M., Goncalves, I., Groop, L. & Gomez, M., 2016, In: Diabetes. 65, 1, p. 239-254

Research output: Contribution to journal › Article › peer-review

File

354 Downloads (Pure)

High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.

Goncalves, I., Hultman, K., Dunér, P., Edsfeldt, A., Hedblad, B., Nordin Fredrikson, G., Björkbacka, H., Nilsson, J. & Bengtsson, E., 2016, In: Open Heart. 3, 1, p. e000353

Research output: Contribution to journal › Article › peer-review

High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid Endarterectomy.

Edsfeldt, A., Bengtsson, E., Asciutto, G., Dunér, P., Björkbacka, H., Nordin Fredrikson, G., Nilsson, J. & Goncalves, I., 2016, In: Cerebrovascular Diseases. 41, 3-4, p. 199-203

Research output: Contribution to journal › Article › peer-review

Proinflammatory Role of Sphingolipids and Glycosphingolipids in the Human Atherosclerotic Plaque

Edsfeldt, A., Dunér, P., Ståhlman, M., Mollet, I. G., Asciutto, G., GRUFMAN, A. H. M., Nitulescu, M., Persson, A. F., Fisher, R. M., Melander, O., Orho-Melander, M., Borén, J., Nilsson, J. & Gonçalves, I., 2016, In: Arteriosclerosis, Thrombosis and Vascular Biology. 36, 6, p. 1132-1140

Research output: Contribution to journal › Article › peer-review

2015

Autoantibodies against basement membrane collagen type IV are associated with myocardial infarction

McLeod, O., Dunér, P., Samnegård, A., Tornvall, P., Nilsson, J., Hamsten, A. & Bengtsson, E., 2015 Mar 1, In: IJC Heart and Vasculature. 6, p. 42-47 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Dystrophin deficiency reduces atherosclerotic plaque development in ApoE-null mice.

Shami, A., Knutsson, A., Dunér, P., Rauch, U., Bengtsson, E., Tengryd, C., Murugesan, V., Durbeej-Hjalt, M., Goncalves, I., Nilsson, J. & Hultgårdh, A., 2015, In: Scientific Reports. 5, 13904.

Research output: Contribution to journal › Article › peer-review

Open Access

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

Goncalves, I., Bengtsson, E., Colhoun, H. M., Shore, A. C., Palombo, C., Natali, A., Edsfeldt, A., Dunér, P., Nordin Fredrikson, G., Björkbacka, H., Östling, G., Aizawa, K., Casanova, F., Persson, M., Gooding, K., Strain, D., Kahn, F., Looker, H. C., Adams, F. & Belch, J. & 6 others, Pinnoli, S., Venturi, E., Kozakova, M., Gan, L.-M., Schnecke, V. & Nilsson, J., 2015, In: Arteriosclerosis, Thrombosis and Vascular Biology. 35, 7, p. 1723-1731

Research output: Contribution to journal › Article › peer-review

High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events.

Rattik, S., Wigren, M., Björkbacka, H., Nordin Fredrikson, G., Hedblad, B., Siegbahn, A., Bengtsson, E., Schiopu, A., Edsfeldt, A., Dunér, P., Grufman, H., Goncalves, I. & Nilsson, J., 2015, In: Arteriosclerosis, Thrombosis and Vascular Biology. 35, 1, p. 222-228

Research output: Contribution to journal › Article › peer-review

IL-25 Inhibits Atherosclerosis Development in Apolipoprotein E Deficient Mice.

Mantani, P., Dunér, P., Bengtsson, E., Alm, R., Ljungcrantz, I., Söderberg, I., Sundius, L., To, F., Nilsson, J., Björkbacka, H. & Nordin Fredrikson, G., 2015, In: PLoS ONE. 10, 1, e0117255.

Research output: Contribution to journal › Article › peer-review

Open Access

File

292 Downloads (Pure)

Increased aldehyde-modification of collagen type IV in symptomatic plaques - A possible cause of endothelial dysfunction.

Dunér, P., Goncalves, I., Grufman, H., Edsfeldt, A., To, F., Nitulescu, M., Nilsson, J. & Bengtsson, E., 2015, In: Atherosclerosis. 240, 1, p. 26-32

Research output: Contribution to journal › Article › peer-review

File

245 Downloads (Pure)

Low elastin content of carotid plaques is associated with increased risk of ipsilateral stroke.

Asciutto, G., Dias, N., Edsfeldt, A., Nitulescu, M., Persson, A., Nilsson, M. M., Dunér, P., Nilsson, J. & Goncalves, I., 2015, In: PLoS ONE. 10, 3, e0121086.

Research output: Contribution to journal › Article › peer-review

Open Access

File

177 Downloads (Pure)

2014

Impaired Fibrous Repair: A Possible Contributor to Atherosclerotic Plaque Vulnerability in Patients With Type II Diabetes.

Edsfeldt, A., Goncalves, I., Grufman, H., Nitulescu, M., Dunér, P., Bengtsson, E., Mollet, I., Persson, A., Nilsson, M. M., Orho-Melander, M., Melander, O., Björkbacka, H. & Nilsson, J., 2014, In: Arteriosclerosis, Thrombosis and Vascular Biology. 34, 9, p. 2143-2150

Research output: Contribution to journal › Article › peer-review

Plasma S100A8/A9 Correlates With Blood Neutrophil Counts, Traditional Risk Factors, and Cardiovascular Disease in Middle-Aged Healthy Individuals.

Cotoi, O., Dunér, P., Ko, N., Hedblad, B., Nilsson, J., Björkbacka, H. & Schiopu, A., 2014, In: Arteriosclerosis, Thrombosis and Vascular Biology. 34, 1, p. 202

Research output: Contribution to journal › Article › peer-review

File

304 Downloads (Pure)

2013

Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice.

Zetterqvist, A., Berglund, L., Blanco, F., Garcia Vaz, E., Wigren, M., Dunér, P., Dutius Andersson, A.-M., To, F., Spégel, P., Nilsson, J., Bengtsson, E. & Gomez, M., 2013, In: PLoS ONE. 8, 6, e65020.

Research output: Contribution to journal › Article › peer-review

Open Access

File

448 Downloads (Pure)

2012

Increased Inflammation in Atherosclerotic Lesions of Diabetic Akita-LDLr(-/-) Mice Compared to Nondiabetic LDLr(-/-) Mice.

Engelbertsen, D., To, F., Dunér, P., Kotova, O., Söderberg, I., Alm, R., Gomez, M., Nilsson, J. & Bengtsson, E., 2012, In: Experimental Diabetes Research. 2012, Nov.,28, 176162.

Research output: Contribution to journal › Article › peer-review

Open Access

File

199 Downloads (Pure)

Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation

Rohwedder, I., Montanez, E., Beckmann, K., Bengtsson, E., Dunér, P., Nilsson, J., Soehnlein, O. & Faessler, R., 2012, In: EMBO Molecular Medicine. 4, 7, p. 564-576

Research output: Contribution to journal › Article › peer-review

2011

Evidence for a role of regulatory T cells in mediating the atheroprotective effect of apolipoprotein B peptide vaccine.

Wigren, M., Kolbus, D., Dunér, P., Ljungcrantz, I., Söderberg, I., Björkbacka, H., Nordin Fredrikson, G. & Nilsson, J., 2011, In: Journal of Internal Medicine. 269, p. 546-556

Research output: Contribution to journal › Article › peer-review

Immunization of apoE-/- mice with aldehyde-modified fibronectin inhibits the development of atherosclerosis.

Dunér, P., To, F., Beckmann, K., Björkbacka, H., Nordin Fredrikson, G., Nilsson, J. & Bengtsson, E., 2011, In: Cardiovascular Research. 91, 3, p. 528-536

Research output: Contribution to journal › Article › peer-review

File

197 Downloads (Pure)

Pleiotropic Effects of GIP on Islet Function Involve Osteopontin

Lyssenko, V., Eliasson, L., Kotova, O., Pilgaard, K., Wierup, N., Salehi, S. A., Wendt, A., Jonsson, A., De Marinis, Y. Z., Berglund, L., Taneera, J., Balhuizen, A., Hansson, O., Osmark, P., Dunér, P., Brons, C., Stancakova, A., Kuusisto, J., Bugliani, M. & Saxena, R. & 19 others, Ahlqvist, E., Kieffer, T. J., Tuomi, T., Isomaa, B., Melander, O., Sonestedt, E., Orho-Melander, M., Nilsson, P., Bonetti, S., Bonadonna, R., Miccoli, R., DelPrato, S., Marchetti, P., Madsbad, S., Poulsen, P., Vaag, A., Laakso, M., Gomez, M. & Groop, L., 2011, In: Diabetes. 60, 9, p. 2424-2433

Research output: Contribution to journal › Article › peer-review

2010

Fc{gamma}RIIB Inhibits the Development of Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice.

Zhao, M., Wigren, M., Dunér, P., Kolbus, D., Berg, K., Björkbacka, H., Nilsson, J. & Nordin Fredrikson, G., 2010, In: Journal of Immunology. 184, 5, p. 2253-2260

Research output: Contribution to journal › Article › peer-review

Immune responses against aldehyde-modified laminin accelerate atherosclerosis in Apoe(-/-) mice.

Dunér, P., To, F., Berg, K., Alm, R., Björkbacka, H., Engelbertsen, D., Nordin Fredrikson, G., Nilsson, J. & Bengtsson, E., 2010, In: Atherosclerosis. 212, 2, p. 457-465

Research output: Contribution to journal › Article › peer-review

File

190 Downloads (Pure)

2009

Atheroprotective Effects of Alum Are Associated With Capture of Oxidized LDL Antigens and Activation of Regulatory T Cells.

Wigren, M., Kolbus, D., Dunér, P., Berg, K., Björkbacka, H., Bengtsson, E., Nordin Fredrikson, G. & Nilsson, J., 2009, In: Circulation Research. 104, p. E62-E70

Research output: Contribution to journal › Article › peer-review

Open Access

Evidence Of A Role Of T Regulatory Cells Mediating Atheroprotection By APO B 100 Peptide Immunization

Wigren, M., Kolbus, D., Dunér, P., Björkbacka, H., Nordin Fredrikson, G. & Nilsson, J., 2009, In: Atherosclerosis Supplements. 10, 2, p. e885-e885

Research output: Contribution to journal › Published meeting abstract › peer-review

Immune responses against fibronectin modified by lipoprotein oxidation and their association with cardiovascular disease.

Dunér, P., To, F., Alm, R., Goncalves, I., Nordin Fredrikson, G., Hedblad, B., Berglund, G., Nilsson, J. & Bengtsson, E., 2009, In: Journal of Internal Medicine. Feb 14., p. 593-603

Research output: Contribution to journal › Article › peer-review

Immune Responses Aginst Aldehyde Modified Extracellular Matrix in Atherosclerosis

Dunér, P., 2009, Department of Clinical Sciences, Lund University. 113 p.

Research output: Thesis › Doctoral Thesis (compilation)

File

382 Downloads (Pure)

2007

A constitutive endogenous osteopontin production is important for macrophage function and differentiation.

Nyström, T., Dunér, P. & Hultgårdh, A., 2007, In: Experimental Cell Research. 313, 6, p. 1149-1160

Research output: Contribution to journal › Article › peer-review

Pontus Dunér

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