Research output per year
Research output per year
Personal profile
Research
The Nordenfelt Lab is interested in the interplay between human cells and their environment and the cell biology that controls the outcome of the interactions. This could be immune cells trying to find their way to invading bacteria and viruses or cancer cells migrating out of a tumor. Surface molecules, morphology, and biomechanical forces govern these interactions. Antibodies, the complement system, and the cellular receptors regulating signaling, such as Fc receptors and integrins, are natural components to study. As these are complex systems to study, the lab is continuously developing new technology to improve the range and quality of the research. The results from the research aim to improve our understanding as well as introduce new diagnostic and treatment options for infections and cancer.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Subject classification (UKÄ)
- Infectious Medicine
- Immunology in the Medical Area (including Cell and Immunotherapy)
- Cell and Molecular Biology
- Microbiology in the Medical Area
- Computer graphics and computer vision
- Cell Biology
- Biophysics
- Bioinformatics and Computational Biology
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Collaborations the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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Dissecting the properties of circulating IgG against streptococcal pathogens through a combined systems antigenomics-serology workflow
Gomez Toledo, A., Chowdhury, S., Hjortswang, E., Sorrentino, J. T., Lewis, N. E., Bläckberg, A., Ekström, S., Kjellström, S., Izadi, A., Olofsson, B., Nordenfelt, P., Malmström, L., Rasmussen, M. & Malmström, J., 2025 Feb 24, In: Nature Communications. 16, p. 1-16 1942.Research output: Contribution to journal › Article › peer-review
Open Access -
ECM-dependent regulation of septin 7 in focal adhesions promotes mechanosensing and functional response in fibroblasts
Sturgess, W., Packirisamy, S., Geneidy, R., Nordenfelt, P. & Swaminathan, V., 2024 Dec 20, In: iScience. 27, 12, 111355.Research output: Contribution to journal › Article › peer-review
Open Access -
Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted
Governa, V., de Oliveira, K. G., Bång-Rudenstam, A., Offer, S., Cerezo-Magaña, M., Li, J., Beyer, S., Johansson, M. C., Månsson, A. S., Edvardsson, C., Durmo, F., Gustafsson, E., Boukredine, A., Jeannot, P., Schmidt, K., Gezelius, E., Menard, J. A., Garza, R., Jakobsson, J. & de Neergaard, T. & 11 others, , 2024 Oct 30, In: Science Translational Medicine. 16, 771, p. eadk1168Research output: Contribution to journal › Article › peer-review
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Protective non-neutralizing SARS-CoV-2 monoclonal antibodies
Izadi, A. & Nordenfelt, P., 2024 Aug, In: Trends in Immunology. 45, 8, p. 609-624Research output: Contribution to journal › Review article › peer-review
Open Access -
Protective Non-neutralizing anti-N-terminal Domain mAb Maintains Fc-mediated Function against SARS-COV-2 Variants up to BA.2.86-JN.1 with Superfluous In Vivo Protection against JN.1 Due to Attenuated Virulence
Izadi, A., Godzwon, M., Söderlund Strand, A., Schmidt, T., Kumlien Georén, S., Drosten, C., Ohlin, M. & Nordenfelt, P., 2024 Jul 17, In: Journal of immunology. 213, 5, p. 678-689Research output: Contribution to journal › Article › peer-review
Open Access
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Exploring the role of antibody engineering in HER2-targeted cancer immunotherapy
Popovic, S. (Researcher), Nordenfelt, P. (Supervisor), Järås, M. (Assistant supervisor) & Swaminathan, V. (Assistant supervisor)
2025/02/01 → …
Project: Dissertation
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Spatiotemporal multiplexed imaging of migrating cancer cells at high fidelity using correlative datadriven microscopy
Nordenfelt, P. (PI)
Mrs. Berta Kamprad's Cancer Foundation
2025/01/01 → 2028/02/29
Project: Research
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Effective antibody function against bacterial pathogens
Nordenfelt, P. (PI)
2023/12/01 → 2029/12/31
Project: Research
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Broad antibody-based protection against SARS-CoV-2 through Fc-mediated opsonization
Nordenfelt, P. (PI)
2023/12/01 → 2027/12/31
Project: Research
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New Effective antibodies against Pseudomonas aeruginosa
Nordenfelt, P. (PI)
The Foundation to Prevent Antibiotic Resistance (PAR Foundation)
2023/09/01 → 2026/01/31
Project: Research
Activities
- 1 Participation in workshop/ seminar/ course
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SFO recruitment workshop
Lundberg, T. (Participant), Tufvesson, F. (Invited speaker), Mickwitz, P. (Invited speaker), Pietras, K. (Invited speaker), Rönnmar, M. (Invited speaker), Nordenfelt, P. (Invited speaker), Naurin, S. (Invited speaker), Trono, D. (Invited speaker), Ämmälahti, E. (Invited speaker), Söderbergh Widding, A. (Invited speaker) & Albinsson, B. (Invited speaker)
2021 Sept 23Activity: Participating in or organising an event › Participation in workshop/ seminar/ course