Praveen Papareddy

Search results

• 2020

  Cold Atmospheric Plasma Disarms M1 Protein, an Important Streptococcal Virulence Factor

  Persson, S. T., Ekström, S., Papareddy, P. & Herwald, H., 2020 Jul, In: Journal of Innate Immunity. 12, 4, p. 277-290 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Plasma Gases 100%
  • Virulence Factors 69%
  • Proteins 24%
  • Streptococcus pyogenes 23%
  • Local Anti-Infective Agents 11%
• 2019

  A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infection

  Papareddy, P., Rossnagel, M., Doreen Hollwedel, F., Kilic, G., Veerla, S., Naudin, C., Smeds, E., Westman, J., Martinez-Martinez, I., Egesten, A., de la Morena-Barrio, M. E., Corral, J., Linder, A., Artoni, A., Abbattista, M., Novembrino, C., Herbert Brakebusch, C., Martinelli, I., Kasetty, G. & Herwald, H., 2019, In: Nature Microbiology. 4, 12, p. 2442-2455

  Research output: Contribution to journal › Article › peer-review

  • Antithrombins 100%
  • Bacterial Infections 76%
  • Protein Isoforms 65%
  • Lipopolysaccharides 15%
  • Antithrombin Proteins 13%

• Osteopontin protects against lung injury caused by extracellular histones

  Kasetty, G., Papareddy, P., Bhongir, R. K. V., Ali, M. N., Mori, M., Wygrecka, M., Erjefält, J. S., Hultgårdh-Nilsson, A., Palmberg, L., Herwald, H. & Egesten, A., 2019 Jan, In: Mucosal Immunology. 12, 1, p. 39-50

  Research output: Contribution to journal › Article › peer-review

  • Osteopontin 100%
  • Lung Injury 88%
  • Histones 79%
  • Inflammation 33%
  • Acute Lung Injury 21%

• Osteopontin protects against pneumococcal infection in a murine model of allergic airway inflammation

  Kasetty, G., Bhongir, R. K. V., Papareddy, P., Tufvesson, E., Stenberg, H., Bjermer, L., Hultgårdh-Nilsson, A., Herwald, H. & Egesten, A., 2019, In: Allergy: European Journal of Allergy and Clinical Immunology. 74, 4, p. 663-674

  Research output: Contribution to journal › Article › peer-review

  • Pneumococcal Infections 100%
  • Osteopontin 96%
  • Inflammation 47%
  • Asthma 47%
  • Bronchoalveolar Lavage Fluid 32%
• 2018

  A fibrin biofilm covers blood clots and protects from microbial invasion

  Macrae, F. L., Duval, C., Papareddy, P., Baker, S. R., Yuldasheva, N., Kearney, K. J., McPherson, H. R., Asquith, N., Konings, J., Casini, A., Degen, J. L., Connell, S. D., Philippou, H., Wolberg, A. S., Herwald, H. & Ariëns, R. A. S., 2018 Aug 1, In: Journal of Clinical Investigation. 128, 8, p. 3356-3368 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fibrin 100%
  • Biofilms 95%
  • Thrombosis 75%
  • Blood Cells 26%
  • Fibrinolysin 19%

• An ecoimmunological approach to study evolutionary and ancient links between coagulation, complement and Innate immunity

  Papareddy, P., Kasetty, G., Alyafei, S., Smeds, E., Salo-Ahen, O. M. H., Hansson, S. R., Egesten, A. & Herwald, H., 2018 Dec 31, In: Virulence. 9, 1, p. 724-737 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • coagulation 100%
  • innate immunity 95%
  • Innate Immunity 86%
  • complement 79%
  • peptides 64%

• Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor)

  Neumann, A., Papareddy, P., Westman, J., Hyldegaard, O., Snäll, J., Norrby-Teglund, A. & Herwald, H., 2018, In: Journal of Innate Immunity. 10, 1, p. 30-43

  Research output: Contribution to journal › Article › peer-review

  • Alarmins 100%
  • Extracellular Traps 93%
  • Peroxidase 63%
  • Streptococcus pyogenes 40%
  • Bacteria 22%

• TFPI-2 protects against gram-negative bacterial infection

  Ali, M. N., Kasetty, G., Elvén, M., Alyafei, S., Jovic, S., Egesten, A., Herwald, H., Schmidtchen, A. & Papareddy, P., 2018 Sept 11, In: Frontiers in Immunology. 9, SEP, 2072.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • tissue-factor-pathway inhibitor 2 100%
  • Gram-Negative Bacterial Infections 92%
  • Bacterial Infections 16%
  • EDC34 peptide 15%
  • Immunoglobulins 10%
• 2017

  DNA-fragmentation is a source of bactericidal activity against Pseudomonas aeruginosa

  Bhongir, R. K. V., Kasetty, G., Papareddy, P., Mörgelin, M., Herwald, H. & Egesten, A., 2017 Jan 20, In: Biochemical Journal. 474, 3, p. 411-425

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Fragmentation 100%
  • Monoatomic Dication 96%
  • Pseudomonas aeruginosa 86%
  • DNA 52%
  • Pseudomonas Infections 51%

• The nonantibiotic macrolide em703 improves survival in a model of quinolone-treated pseudomonas aeruginosa airway infection

  Kasetty, G., Bhongir, R. K. V., Papareddy, P., Herwald, H. & Egesten, A., 2017 Sept 1, In: Antimicrobial Agents and Chemotherapy. 61, 9, e02761-16.

  Research output: Contribution to journal › Article › peer-review

  • EM703 100%
  • Pseudomonas Infections 54%
  • Quinolones 50%
  • Macrolides 50%
  • Anti-Bacterial Agents 24%
• 2016

  NLF20: an antimicrobial peptide with therapeutic potential against invasive Pseudomonas aeruginosa infection.

  Papareddy, P., Kasetty, G., Kalle, M., Bhongir, R., Mörgelin, M., Schmidtchen, A. & Malmsten, M., 2016, In: Journal of Antimicrobial Chemotherapy. 71, 1, p. 170-180

  Research output: Contribution to journal › Article › peer-review

  File

  • Pseudomonas Infections 100%
  • Heparin Cofactor II 64%
  • Peptides 51%
  • Microbial Drug Resistance 40%
  • Blood Proteins 35%
  263 Downloads (Pure)

• Roflumilast increases bacterial load and dissemination in a model of Pseudomononas aeruginosa airway infection

  Kasetty, G., Papareddy, P., Bhongir, R. & Egesten, A., 2016, In: Journal of Pharmacology and Experimental Therapeutics. 357, 1, p. 66-72

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Roflumilast 100%
  • Bacterial Load 71%
  • Pseudomonas aeruginosa 35%
  • Infections 28%
  • Chronic Obstructive Pulmonary Disease 20%

• Vertebrate TFPI-2 C-terminal peptides exert therapeutic applications against Gram-negative infections

  Kasetty, G., Smeds, E., Holmberg, E., Wrange, L., Adikesavan, S. & Papareddy, P., 2016 Jun 27, In: BMC Microbiology. 16, 1, 129.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • tissue-factor-pathway inhibitor 2 100%
  • Vertebrates 54%
  • Peptides 38%
  • Infections 28%
  • Antimicrobial Cationic Peptides 12%
• 2015

  Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.

  Westman, J., Papareddy, P., Dahlgren, M., Chakrakodi, B., Norrby-Teglund, A., Smeds, E., Linder, A., Mörgelin, M., Johansson Lindbom, B., Egesten, A. & Herwald, H., 2015, In: PLoS Pathogens. 11, 12, e1005319.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • chemokines 100%
  • histones 72%
  • Chemokines 71%
  • Histones 70%
  • leukocytes 67%
• 2014

  An antimicrobial helix A-derived peptide of heparin cofactor II blocks endotoxin responses in vivo.

  Papareddy, P., Kalle, M., Singh, S., Mörgelin, M., Schmidtchen, A. & Malmsten, M., 2014, In: Biochimica et Biophysica Acta. 1838, 5, p. 1225-1234

  Research output: Contribution to journal › Article › peer-review

  File

  • Heparin Cofactor II 100%
  • Endotoxins 61%
  • Membrane Lipids 45%
  • Septic Shock 42%
  • Peptides 39%
  220 Downloads (Pure)

• Antimicrobial effects of helix D-derived peptides of human antithrombin III.

  Papareddy, P., Kalle, M., Bhongir, R., Mörgelin, M., Malmsten, M. & Schmidtchen, A., 2014, In: Journal of Biological Chemistry. 289, 43, p. 29790-29800

  Research output: Contribution to journal › Article › peer-review

  File

  • Antithrombin 100%
  • Antithrombin III 99%
  • Antimicrobial Agent 55%
  • Peptides 50%
  • Peptide 45%
  190 Downloads (Pure)

• A Peptide of Heparin Cofactor II Inhibits Endotoxin-Mediated Shock and Invasive Pseudomonas aeruginosa Infection.

  Kalle, M., Papareddy, P., Kasetty, G., van der Plas, M., Mörgelin, M., Malmsten, M. & Schmidtchen, A., 2014, In: PLoS ONE. 9, 7, e102577.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heparin Cofactor II 100%
  • Pseudomonas Infections 76%
  • Endotoxins 61%
  • Shock 54%
  • Sepsis 49%
  171 Downloads (Pure)

• Effects of linear amphiphilicity on membrane interactions of C-terminal thrombin peptides

  Singh, S., Papareddy, P., Kalle, M., Schmidtchen, A. & Malmsten, M., 2014, In: RSC Advances. 4, 71, p. 37582-37591

  Research output: Contribution to journal › Article › peer-review

  File

  • Peptides 100%
  • Thrombin 81%
  • Membranes 63%
  • Peptide 44%
  • Amino acids 22%
  216 Downloads (Pure)

• Effects of PEGylation on Membrane and Lipopolysaccharide Interactions of Host Defense Peptides

  Singh, S., Papareddy, P., Mörgelin, M., Schmidtchen, A. & Malmsten, M., 2014, In: Biomacromolecules. 15, 4, p. 1337-1345

  Research output: Contribution to journal › Article › peer-review

  • Peptides 100%
  • Polyethylene glycols 98%
  • Lipopolysaccharide 83%
  • Membranes 63%
  • Antiinflammatory 58%
• 2013

  Importance of lipopolysaccharide aggregate disruption for the anti-endotoxic effects of heparin cofactor II peptides

  Singh, S., Papareddy, P., Kalle, M., Schmidtchen, A. & Malmsten, M., 2013, In: Biochimica et Biophysica Acta - Biomembranes. 1828, 11, p. 2709-2719

  Research output: Contribution to journal › Article › peer-review

  • Antiendotoxic 100%
  • Heparin Cofactor II 82%
  • Lipopolysaccharide 56%
  • Heparin 52%
  • Cofactor 46%

• Lipopolysaccharide Interactions of C-Terminal Peptides from Human Thrombin

  Singh, S., Kalle, M., Papareddy, P., Schmidtchen, A. & Malmsten, M., 2013, In: Biomacromolecules. 14, 5, p. 1482-1492

  Research output: Contribution to journal › Article › peer-review

  • Peptides 100%
  • Lipopolysaccharide 83%
  • Thrombin 81%
  • Antiendotoxic 59%
  • Peptide 44%

• Proteolytic Activation Transforms Heparin Cofactor II into a Host Defense Molecule.

  Kalle, M., Papareddy, P., Kasetty, G., Tollefsen, D. M., Malmsten, M., Mörgelin, M. & Schmidtchen, A., 2013, In: Journal of Immunology. 190, 12, p. 6303-6310

  Research output: Contribution to journal › Article › peer-review

  • Heparin Cofactor II 100%
  • Endotoxins 17%
  • Epitopes 15%
  • Bacteria 11%
  • Serine Proteinase Inhibitors 11%

• The TFPI-2 Derived Peptide EDC34 Improves Outcome of Gram-Negative Sepsis.

  Papareddy, P., Kalle, M., Sørensen, O. E., Malmsten, M., Mörgelin, M. & Schmidtchen, A., 2013, In: PLoS Pathogens. 9, 12, e1003803.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • EDC34 peptide 100%
  • tissue-factor-pathway inhibitor 2 66%
  • Sepsis 32%
  • peptides 27%
  • therapeutics 23%
• 2012

  Antimicrobial activity of peptides derived from human ß-amyloid precursor protein.

  Papareddy, P., Mörgelin, M., Walse, B., Schmidtchen, A. & Malmsten, M., 2012, In: Journal of Peptide Science. 18, 3, p. 183-191

  Research output: Contribution to journal › Article › peer-review

  • Amyloid beta-Protein Precursor 100%
  • Antimicrobial Agent 60%
  • Peptides 55%
  • Peptide 49%
  • Protein 35%

• Host Defense Peptides of Thrombin Modulate Inflammation and Coagulation in Endotoxin-Mediated Shock and Pseudomonas aeruginosa Sepsis.

  Kalle, M., Papareddy, P., Kasetty, G., Mörgelin, M., van der Plas, M., Rydengård, V., Malmsten, M., Albiger, B. & Schmidtchen, A., 2012, In: PLoS ONE. 7, 12, e51313.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Antimicrobial Cationic Peptides 100%
  • Endotoxins 68%
  • Thrombin 68%
  • Pseudomonas aeruginosa 64%
  • Shock 60%
  194 Downloads (Pure)

• Novel Aspects of the Coagulation System in Host Defence

  Papareddy, P., 2012, Lund University. 184 p.

  Research output: Thesis › Doctoral Thesis (compilation)

  • Antimicrobial Cationic Peptides 100%
  • Sepsis 55%
  • tissue-factor-pathway inhibitor 2 32%
  • Heparin Cofactor II 31%
  • Thrombin 19%

• Tissue factor pathway inhibitor 2 is found in skin and its C-terminal region encodes for antibacterial activity.

  Papareddy, P., Kalle, M., Sørensen, O. E., Lundqvist, K., Mörgelin, M., Malmsten, M. & Schmidtchen, A., 2012, In: PLoS ONE. 7, 12, e52772.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • tissue-factor-pathway inhibitor 2 100%
  • Skin 33%
  • Fibrin 20%
  • Wounds and Injuries 9%
  146 Downloads (Pure)
• 2011

  Structure-Activity Studies and Therapeutic Potential of Host Defense Peptides of Human Thrombin

  Kasetty, G., Papareddy, P., Kalle, M., Rydengård, V., Mörgelin, M., Albiger, B., Malmsten, M. & Schmidtchen, A., 2011, In: Antimicrobial Agents and Chemotherapy. 55, 6, p. 2880-2890

  Research output: Contribution to journal › Article › peer-review

  File

  • Antimicrobial Cationic Peptides 100%
  • Thrombin 68%
  • Peptides 44%
  • GKY25 peptide 28%
  • Amino Acids 24%
  229 Downloads (Pure)

• The C-Terminal Sequence of Several Human Serine Proteases Encodes Host Defense Functions.

  Kasetty, G., Papareddy, P., Kalle, M., Rydengård, V., Walse, B., Svensson, B., Mörgelin, M., Malmsten, M. & Schmidtchen, A., 2011, In: Journal of Innate Immunity. 3, 5, p. 471-482

  Research output: Contribution to journal › Article › peer-review

  • Serine Proteases 100%
  • Lipopolysaccharides 57%
  • Peptides 56%
  • Antimicrobial Cationic Peptides 32%
  • Kallikreins 28%
• 2010

  C-terminal peptides of tissue-factor pathway inhibitor are novel host defense molecules.

  Papareddy, P., Kalle, M., Kasetty, G., Mörgelin, M., Rydengård, V., Albiger, B., Lundqvist, K., Malmsten, M. & Schmidtchen, A., 2010, In: Journal of Biological Chemistry. 285, 36, p. 28387-28398

  Research output: Contribution to journal › Article › peer-review

  • Pathway Inhibitor 100%
  • lipoprotein-associated coagulation inhibitor 85%
  • Peptides 38%
  • Peptide 34%
  • Leg Ulcer 30%

• Proteolysis of human thrombin generates novel host defense peptides.

  Papareddy, P., Rydengård, V., Pasupuleti, M., Walse, B., Mörgelin, M., Chalupka, A., Malmsten, M. & Schmidtchen, A., 2010, In: PLoS Pathogens. 6, 4, e1000857.

  Research output: Contribution to journal › Article › peer-review

  File

  • Antimicrobial Cationic Peptides 100%
  • thrombin 78%
  • Thrombin 68%
  • proteolysis 66%
  • Proteolysis 64%
  158 Downloads (Pure)