Ranit Kumar Mondal

I aim to establish how dynamic and thermodynamics parameters in proteins change upon binding with ligand molecules. I primarily use Nuclear Magnetic Resonance (NMR) Spectroscopy to study the dynamics of binding. My goal is to map out the structure, dynamics, and energy landscape of conformational changes along the binding pathway. 

Often lowly-populated, transient states of proteins are found crucial for binding. I aim to characterize these states using Relaxation-based NMR experiments. Additionally, I am interested to develop novel NMR methods and interpret the results in combination with other biophysical techniques such as Isothermal Titration Calorimetry (ITC), Time Resolved X-ray Crystallography and Molecular simulations.