Simon Ekström

2025

Dissecting the properties of circulating IgG against streptococcal pathogens through a combined systems antigenomics-serology workflow

Gomez Toledo, A., Chowdhury, S., Hjortswang, E., Sorrentino, J. T., Lewis, N. E., Bläckberg, A., Ekström, S., Kjellström, S., Izadi, A., Olofsson, B., Nordenfelt, P., Malmström, L., Rasmussen, M. & Malmström, J., 2025 Feb 24, In: Nature Communications. 16, p. 1-16 1942.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

Streptolysin O accelerates the conversion of plasminogen to plasmin

Tang, D., Khakzad, H., Hjortswang, E., Malmström, L., Ekström, S., Happonen, L. & Malmström, J., 2024 Nov 25, In: Nature Communications. 15, p. 1-15 15 p., 10212.

Research output: Contribution to journal › Article › peer-review

Open Access

Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding

Bimai, O., Banerjee, I., Grinberg, I. R., Huang, P., Hultgren, L., Ekström, S., Lundin, D., Sjöberg, B.-M. & Logan, D. T., 2024 Jul 5, In: eLife. 12, 35 p., RP89292.

Research output: Contribution to journal › Article › peer-review

Open Access

Multimodal Mass Spectrometry Identifies a Conserved Protective Epitope in S. pyogenes Streptolysin O

Tang, D., Gueto-Tettay, C., Hjortswang, E., Ströbaek, J., Ekström, S., Happonen, L., Malmström, L. & Malmström, J., 2024 Jun 4, In: Analytical Chemistry. 96, 22, p. 9060–9068

Research output: Contribution to journal › Article › peer-review

Open Access

New insights into complex formation by SARS-CoV-2 nsp10 and nsp14

Sele, C., Krupinska, E., Andersson Rasmussen, A., Ekström, S., Hultgren, L., Lou, J., Kozielski, F., Fisher, S. Z. & Knecht, W., 2024, In: Nucleosides, Nucleotides & Nucleic Acids. 43, 8, p. 798-812 15 p.

Research output: Contribution to journal › Article › peer-review

2023

Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs

Petruk, G., Puthia, M., Samsudin, F., Petrlova, J., Olm, F., Mittendorfer, M., Hyllén, S., Edström, D., Strömdahl, A.-C., Diehl, C., Ekström, S., Walse, B., Kjellström, S., Bond, P. J., Lindstedt, S. & Schmidtchen, A., 2023 Sept 29, In: Nature Communications. 14, p. 1-20 6097.

Research output: Contribution to journal › Article › peer-review

Open Access

Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies

Pushparaj, P., Nicoletto, A., Sheward, D. J., Das, H., Castro Dopico, X., Perez Vidakovics, L., Hanke, L., Chernyshev, M., Narang, S., Kim, S., Fischbach, J., Ekström, S., McInerney, G., Hällberg, B. M., Murrell, B., Corcoran, M. & Karlsson Hedestam, G. B., 2023 Jan 10, In: Immunity. 56, 1, p. 193-206.e7

Research output: Contribution to journal › Article › peer-review

Open Access

Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses

Pushparaj, P., Nicoletto, A., Castro Dopico, X., Sheward, D. J., Kim, S., Ekström, S., Murrell, B., Corcoran, M. & Karlsson Hedestam, G. B., 2023, In: Frontiers in Virology. 3, 1128253.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies

Hanke, L., Sheward, D. J., Pankow, A., Vidakovics, L. P., Karl, V., Kim, C., Urgard, E., Smith, N. L., Astorga-Wells, J., Ekström, S., Coquet, J. M., McInerney, G. M. & Murrell, B., 2022 Mar, In: Science Advances. 8, 12, eabm0220.

Research output: Contribution to journal › Article › peer-review

Open Access

Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome

Guzzi, N., Muthukumar, S., Cieśla, M., Todisco, G., Ngoc, P. C. T., Madej, M., Munita, R., Fazio, S., Ekström, S., Mortera-Blanco, T., Jansson, M., Nannya, Y., Cazzola, M., Ogawa, S., Malcovati, L., Hellström-Lindberg, E., Dimitriou, M. & Bellodi, C., 2022 Mar, In: Nature Cell Biology. 24, 3, p. 299-306

Research output: Contribution to journal › Article › peer-review

Open Access

2021

(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains

Roghanian, M., Van Nerom, K., Takada, H., Caballero-Montes, J., Tamman, H., Kudrin, P., Talavera, A., Dzhygyr, I., Ekström, S., Atkinson, G. C., Garcia-Pino, A. & Hauryliuk, V., 2021, In: Molecular Cell. 81, 16, p. 3310-3322.e6

Research output: Contribution to journal › Article › peer-review

Open Access

Binding of the human antioxidation protein α₁-microglobulin (A1M) to heparin and heparan sulfate. Mapping of binding site, molecular and functional characterization, and co-localization in vivo and in vitro

Bergwik, J., Kristiansson, A., Larsson, J., Ekström, S., Åkerström, B. & Allhorn, M., 2021, In: Redox Biology. 41, 101892.

Research output: Contribution to journal › Article › peer-review

Open Access

Streptococcus pyogenes Forms Serotype- and Local Environment-Dependent Interspecies Protein Complexes

Chowdhury, S., Khakzad, H., Bergdahl, G. E., Lood, R., Ekstrom, S., Linke, D., Malmström, L., Happonen, L. & Malmström, J., 2021, In: mSystems. 6, 5, p. 1-19 e0027121.

Research output: Contribution to journal › Article › peer-review

Open Access

Structure dynamics of ApoA-I amyloidogenic variants in small HDL increase their ability to mediate cholesterol efflux

Nilsson, O., Lindvall, M., Obici, L., Ekström, S., Lagerstedt, J. O. & Del Giudice, R., 2021, In: Journal of Lipid Research. 62, 100004.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Cold Atmospheric Plasma Disarms M1 Protein, an Important Streptococcal Virulence Factor

Persson, S. T., Ekström, S., Papareddy, P. & Herwald, H., 2020 Jul, In: Journal of Innate Immunity. 12, 4, p. 277-290 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Structural Basis for YjbH Adaptor-Mediated Recognition of Transcription Factor Spx

Awad, W., Al-Eryani, Y., Ekström, S., Logan, D. T. & von Wachenfeldt, C., 2019, In: Structure. 27, 6, p. 923-936.e6

Research output: Contribution to journal › Article › peer-review

2018

Molecularly imprinted polymers synthesized via template immobilization on fumed silica nanoparticles for the enrichment of phosphopeptides

Nogueira Duarte, M., Subedi, P., Yilmaz, E., Marcus, K., Laurell, T. & Ekström, S., 2018 Mar, In: Journal of Molecular Recognition. 31, 3, p. e2677

Research output: Contribution to journal › Article › peer-review

2017

Filter Plate–Based Screening of MIP SPE Materials for Capture of the Biomarker Pro-Gastrin-Releasing Peptide

Jagadeesan, K., Rossetti, C., Abdel Qader, A., Reubsaet, L., Sellergren, B., Laurell, T. & Ekström, S., 2017 Dec 1, In: SLAS Discovery. 22, 10, p. 1253-1261

Research output: Contribution to journal › Article › peer-review

MALDIViz: A Comprehensive Informatics Tool for MALDI-MS Data Visualization and Analysis

Jagadeesan, K. K. & Ekström, S., 2017 Dec 1, In: SLAS Discovery. 22, 10, p. 1246-1252 7 p.

Research output: Contribution to journal › Article › peer-review

Solid-phase extraction of the alcohol abuse biomarker phosphatidylethanol using newly synthesized polymeric sorbent materials containing quaternary heterocyclic groups

Nogueira Duarte, M., Jagadeesan, K. K., Billing, J., Yilmaz, E., Laurell, T. & Ekström, S., 2017 Oct 13, In: Journal of Chromatography A. 1519, p. 1-8 8 p.

Research output: Contribution to journal › Article › peer-review

2016

Catalytic Formation of Disulfide Bonds in Peptides by Molecularly Imprinted Microgels at Oil/Water Interfaces

Shen, X., Huang, C., Shinde, S., Jagadeesan, K., Ekström, S., Fritz, E. & Sellergren, B., 2016 Oct 17, In: ACS Applied Materials and Interfaces. 8, 44, p. 30484–30491 8 p.

Research output: Contribution to journal › Article › peer-review

Multiplexed MALDI-MS arrays for screening of MIP solid phase extraction materials.

Jagadeesan, K., Wierzbicka, C., Laurell, T., Sellergren, B., Shinde, S. & Ekström, S., 2016, In: Journal of Chromatography. B. 1021, p. 213-220

Research output: Contribution to journal › Article › peer-review

2015

Mass-Tag Enhanced Immuno-Laser Desorption/Ionization Mass Spectrometry for Sensitive Detection of Intact Protein Antigens

Lorey, M., Adler, B., Yan, H., Soliymani, R., Ekström, S., Yli-Kauhaluoma, J., Laurell, T. & Baumann, M., 2015, In: Analytical Chemistry. 87, 10, p. 5255-5262

Research output: Contribution to journal › Article › peer-review

2014

Aptamer/ISET-MS: A New Affinity-Based MALDI Technique for Improved Detection of Biomarkers

Lee, S., Adler, B., Ekström, S., Rezeli, M., Végvári, Á., Park, J., Malm, J. & Laurell, T., 2014, In: Analytical Chemistry. 86, 15, p. 7627-7634

Research output: Contribution to journal › Article › peer-review

MALDI-target integrated platform for affinity-captured protein digestion.

Ahmad Tajudin, A., Adler, B., Ekström, S., Marko-Varga, G., Malm, J., Lilja, H. & Laurell, T., 2014, In: Analytica Chimica Acta. 807, Jan 7, p. 1-8

Research output: Contribution to journal › Article › peer-review

2013

Efficient sample preparation in immuno-matrix-assisted laser desorption/ionization mass spectrometry using acoustic trapping

Hammarström, B., Yan, H., Nilsson, J. & Ekström, S., 2013, In: Biomicrofluidics. 7, 2, 024107.

Research output: Contribution to journal › Article › peer-review

2012

Acoustic trapping with seed-particles for submicron particle enrichment.

Hammarström, B., Ekström, S., Laurell, T. & Nilsson, J., 2012, In: Journal of the Acoustical Society of America. 132, 3, 1954.

Research output: Contribution to journal › Article › peer-review

Acoustophoretic microfluidic chip for sequential elution of surface bound molecules from beads or cells

Augustsson, P., Malm, J. & Ekström, S., 2012, In: Biomicrofluidics. 6, 3, 034115.

Research output: Contribution to journal › Article › peer-review

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Miniaturized and Automated High-Throughput Verification of Proteins in the ISET Platform with MALDI MS.

Adler, B., Boström, T., Ekström, S., Hober, S. & Laurell, T., 2012, In: Analytical Chemistry. 84, 20, p. 8663-8669

Research output: Contribution to journal › Article › peer-review

Optimizing nanovial outlet designs for improved solid-phase extraction in the integrated selective enrichment target-ISET.

Adler, B., Laurell, T. & Ekström, S., 2012, In: Electrophoresis. 33, 21, p. 3143-3150

Research output: Contribution to journal › Article › peer-review

2011

Noncovalent antibody immobilization on porous silicon combined with miniaturized Solid-Phase Extraction (SPE) for array based immunoMALDI assays

Yan, H., Ahmad Tajudin, A., Bengtsson, M., Xiao, S., Laurell, T. & Ekström, S., 2011, In: Analytical Chemistry. 83, p. 4942-4948

Research output: Contribution to journal › Article › peer-review

2009

Decomplexing biofluids using microchip based acoustophoresis

Augustsson, P., Persson, J., Ekström, S., Ohlin, M. & Laurell, T., 2009, In: Lab on a Chip. 9, 6, p. 810-818

Research output: Contribution to journal › Article › peer-review

2008

Implementation of a protein profiling platform developed as an academic-pharmaceutical industry collaborative effort

Végvári, A., Magnusson, M., Wallman, L., Ekström, S., Bolmsjö, G., Nilsson, J., Miliotis, T., Ostling, J., Kjellström, S., Ottervald, J., Franzén, B., Hultberg, H., Marko-Varga, G. & Laurell, T., 2008 Jun, In: Electrophoresis. 29, 12, p. 2696-705 10 p.

Research output: Contribution to journal › Article › peer-review

Implementation of a Protein Profiling Platform Developed as an Academic-Pharmaceutical Industry Collaborative Effort

Végvári, Á., Magnusson, M., Wallman, L., Ekström, S., Bolmsjö, G., Nilsson, J., Milliotis, T., Östrling, J., Kjällström, S., Ottervald, J., Franzén, B., Hultberg, H., Marko-Varga, G. & Laurell, T., 2008, In: Electrophoresis. 29, 12, p. 2696-2705

Research output: Contribution to journal › Article › peer-review