Sophie Lehn

Search results

• 2018

  Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling

  Roswall, P., Bocci, M., Bartoschek, M., Li, H., Kristiansen, G., Jansson, S., Lehn, S., Sjölund, J., Reid, S., Larsson, C., Eriksson, P., Anderberg, C., Cortez, E., Saal, L. H., Orsmark-Pietras, C., Cordero, E., Haller, B. K., Häkkinen, J., Burvenich, I. J. G., Lim, E., & 7 othersOrimo, A., Höglund, M., Rydén, L., Moch, H., Scott, A. M., Eriksson, U. & Pietras, K., 2018 Mar 12, In: Nature Medicine. 24, p. 463–473

  Research output: Contribution to journal › Article › peer-review

  • Platelet-Derived Growth Factor 100%
  • Hormone 86%
  • Cancer-Associated Fibroblasts 72%
  • Breast Neoplasms 55%
  • Hormones 24%
• 2016

  Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.

  Michaut, M., Chin, S-F., Majewski, I., Severson, T. M., Bismeijer, T., de Koning, L., Peeters, J. K., Schouten, P. C., Rueda, O. M., Bosma, A. J., Tarrant, F., Fan, Y., He, B., Xue, Z., Mittempergher, L., Kluin, R. J. C., Heijmans, J., Snel, M., Pereira, B., Schlicker, A., & 26 othersProvenzano, E., Ali, H. R., Gaber, A., O'Hurley, G., Lehn, S., Muris, J. J. F., Wesseling, J., Kay, E., Sammut, S. J., Bardwell, H. A., Barbet, A. S., Bard, F., Lecerf, C., O'Connor, D. P., Vis, D. J., Benes, C. H., McDermott, U., Garnett, M. J., Simon, I. M., Jirström, K., Dubois, T., Linn, S. C., Gallagher, W. M., Wessels, L. F. A., Caldas, C. & Bernards, R., 2016, In: Scientific Reports. 6, 18517.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lobular Carcinoma 100%
  • Proteomics 67%
  • Breast Neoplasms 46%
  • eIF-4B 18%
  • Chromosomes 16%

• Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.

  Welinder, C., Jirström, K., Lehn, S., Nodin, B., Marko-Varga, G., Blixt, O., Danielsson, L. & Jansson, B., 2016, In: Heliyon. 2, 8, e00143.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Urinary Bladder Neoplasms 100%
  • Immunoglobulin A 97%
  • Neoplasms 33%
  • Breast Neoplasms 19%
  • Testicular Neoplasms 16%

• Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer

  Larsson, A. H., Lehn, S., Wangefjord, S., Karnevi, E., Kuteeva, E., Sundström, M., Nodin, B., Uhlén, M., Eberhard, J., Birgisson, H. & Jirström, K., 2016 May 10, In: Journal of Translational Medicine. 14, 1, 128.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • podocalyxin 100%
  • ErbB Receptors 58%
  • Colorectal Neoplasms 48%
  • Protein 25%
  • Proteins 22%
• 2015

  Therapeutic Targeting of Nuclear Gamma-Tubulin in RB1-negative Tumors.

  Lindström, L., Villoutreix, B. O., Lehn, S., Hellsten, R., Nilsson, E., Crneta, E., Olsson, R. & Alvarado-Kristensson, M., 2015, In: Molecular Cancer Research. 13, 7, p. 1073-1082

  Research output: Contribution to journal › Article › peer-review

  • Tubulin 100%
  • citral dimethyl acetal 90%
  • citral 30%
  • Tubulin Modulators 30%
  • Neoplasms 30%
• 2014

  Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response.

  Lehn, S., Tobin, N. P., Sims, A. H., Stål, O., Jirström, K., Axelson, H. & Landberg, G., 2014, In: BMC Cancer. 14, 1, 119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tamoxifen 100%
  • Breast Neoplasms 60%
  • Proteins 34%
  • Neoplasm Genes 33%
  • Oncogenes 29%
  215 Downloads (Pure)
• 2013

  Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance

  Lehn, S., 2013, Department of Laboratory Medicine, Lund University. 93 p.

  Research output: Thesis › Doctoral Thesis (compilation)

  File

  • Tamoxifen 100%
  • Estrogen Receptors 88%
  • Cell Cycle 74%
  • Breast Neoplasms 60%
  • Stem Cells 18%
  202 Downloads (Pure)

• Cell cycle regulators cyclin D1 and CDK4/6 have estrogen receptor-dependent divergent functions in breast cancer migration and stem cell-like activity

  Lamb, R., Lehn, S., Rogerson, L., Clarke, R. B. & Landberg, G., 2013, In: Cell Cycle. 12, 15, p. 2384-2394

  Research output: Contribution to journal › Article › peer-review

  • Cyclin D1 100%
  • Neoplastic Stem Cells 98%
  • Estrogen Receptors 86%
  • Cell Cycle 72%
  • Breast Neoplasms 59%
• 2011

  A non-functional retinoblastoma tumor suppressor (RB) pathway in premenopausal breast cancer is associated with resistance to tamoxifen.

  Lehn, S., Fernö, M., Jirström, K., Rydén, L. & Landberg, G., 2011, In: Cell Cycle. 10, 6, p. 956-962

  Research output: Contribution to journal › Article › peer-review

  • Retinoblastoma 100%
  • Tamoxifen 89%
  • Breast Neoplasms 53%
  • Neoplasms 27%
  • Phosphorylation 16%

• Cyclin D1, Id1 and EMT in breast cancer

  Tobin, N. P., Sims, A. H., Lundgren, K. L., Lehn, S. & Landberg, G., 2011, In: BMC Cancer. 11

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cyclin D1 100%
  • Epithelial-Mesenchymal Transition 95%
  • Breast Neoplasms 59%
  • Cell Movement 25%
  • Gene Expression 24%
  162 Downloads (Pure)

• Stromal Expression of β-Arrestin-1 Predicts Clinical Outcome and Tamoxifen Response in Breast Cancer.

  Lundgren, K., Tobin, N. P., Lehn, S., Stål, O., Rydén, L., Jirström, K. & Landberg, G., 2011, In: The Journal Of Molecular Diagnostics. 13, 3, p. 340-351

  Research output: Contribution to journal › Article › peer-review

  • Arrestin 100%
  • Tamoxifen 73%
  • Breast Neoplasms 44%
  • Genes 9%
  • Cell Line 9%
• 2010

  Down-Regulation of the Oncogene Cyclin D1 Increases Migratory Capacity in Breast Cancer and Is Linked to Unfavorable Prognostic Features.

  Lehn, S., Tobin, N. P., Berglund, P., Nilsson, K., Sims, A. H., Jirström, K., Härkönen, P., Lamb, R. & Landberg, G., 2010, In: American Journal of Pathology. 177, p. 2886-2897

  Research output: Contribution to journal › Article › peer-review

  • Cyclin D1 100%
  • Oncogenes 87%
  • Down-Regulation 64%
  • Breast Neoplasms 59%
  • Small Interfering RNA 12%
• 2009

  Inactivation of the retinoblastoma tumour suppressor pathway in premenopausal breast cancer is associated with resistance to tamoxifen

  Lehn, S. & Landberg, G., 2009, In: Breast Cancer Research. 11, p. S13-S13

  Research output: Contribution to journal › Published meeting abstract › peer-review