Sven Kjellström

2024

Peptide clustering enhances large-scale analyses and reveals proteolytic signatures in mass spectrometry data

Hartman, E., Forsberg, F., Kjellström, S., Petrlova, J., Luo, C., Scott, A., Puthia, M., Malmström, J. & Schmidtchen, A., 2024 Aug 20, In: Nature Communications. 15, 1, 7128.

Research output: Contribution to journal › Article › peer-review

Open Access

Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling

De Marchi, T., Lai, C-F., Simmons, G. M., Goldsbrough, I., Harrod, A., Lam, T., Buluwela, L., Kjellström, S., Brueffer, C., Saal, L. H., Malmström, J., Ali, S. & Niméus, E., 2024 Mar 22, In: Scientific Reports. 14, p. 1-16 6873.

Research output: Contribution to journal › Article › peer-review

Open Access

Proteomic Analysis of Primary Graft Dysfunction in Porcine Lung Transplantation Reveals Alveolar-Capillary Barrier Changes Underlying the High Particle Flow Rate in Exhaled Breath

Niroomand, A., Hirdman, G., Bèchet, N., Ghaidan, H., Stenlo, M., Kjellström, S., Isaksson, M., Broberg, E., Pierre, L., Hyllén, S., Olm, F. & Lindstedt, S., 2024, In: Transplant International. 37, 12298.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Selective protein aggregation confines and inhibits endotoxins in wounds: Linking host defense to amyloid formation

Petrlova, J., Hartman, E., Petruk, G., Lim, J. C. H., Adav, S. S., Kjellström, S., Puthia, M. & Schmidtchen, A., 2023 Oct 20, In: iScience. 26, 10, 107951.

Research output: Contribution to journal › Article › peer-review

Open Access

Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs

Petruk, G., Puthia, M., Samsudin, F., Petrlova, J., Olm, F., Mittendorfer, M., Hyllén, S., Edström, D., Strömdahl, A-C., Diehl, C., Ekström, S., Walse, B., Kjellström, S., Bond, P. J., Lindstedt, S. & Schmidtchen, A., 2023 Sept 29, In: Nature Communications. 14, p. 1-20 6097.

Research output: Contribution to journal › Article › peer-review

Open Access

Serum proteome profiles in patients treated with targeted temperature management after out-of-hospital cardiac arrest

Lileikyte, G., Bakochi, A., Ali, A., Moseby-Knappe, M., Cronberg, T., Friberg, H., Lilja, G., Levin, H., Årman, F., Kjellström, S., Dankiewicz, J., Hassager, C., Malmström, J. & Nielsen, N., 2023 Jul 17, In: Intensive Care Medicine Experimental. 11, 1, 43.

Research output: Contribution to journal › Article › peer-review

Open Access

Bioactive Suture with Added Innate Defense Functionality for the Reduction of Bacterial Infection and Inflammation

Puthia, M., Petrlova, J., Petruk, G., Butrym, M., Samsudin, F., Andersson, M. Å., Strömdahl, A-C., Wasserstrom, S., Hartman, E., Kjellström, S., Caselli, L., Klementieva, O., Bond, P. J., Malmsten, M., Raina, D. & Schmidtchen, A., 2023, In: Advanced healthcare materials. 12, 31

Research output: Contribution to journal › Article › peer-review

Open Access

Proteomic changes to immune and inflammatory processes underlie lung preservation using ex vivo cytokine adsorption.

Niroomand, A., Hirdman, G., Pierre, L., Ghaidan, H., Kjellström, S., Stenlo, M., Hyllén, S., Olm, F. & Lindstedt, S., 2023, In: Frontiers in Cardiovascular Medicine. 10, 1274444.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

A bacterial protease depletes c-MYC and increases survival in mouse models of bladder and colon cancer

Butler, D. S. C., Cafaro, C., Putze, J., Wan, M. L. Y., Tran, T. H., Ambite, I., Ahmadi, S., Kjellström, S., Welinder, C., Chao, S. M., Dobrindt, U. & Svanborg, C., 2021 Jun 1, In: Nature Biotechnology. 39, 6, p. 754–764 11 p.

Research output: Contribution to journal › Article › peer-review

Bioinformatic Analysis of the Wound Peptidome Reveals Potential Biomarkers and Antimicrobial Peptides

Hartman, E., Wallblom, K., van der Plas, M. J. A., Petrlova, J., Cai, J., Saleh, K., Kjellström, S. & Schmidtchen, A., 2021 Feb 3, In: Frontiers in Immunology. 11, 620707.

Research output: Contribution to journal › Article › peer-review

Open Access

Method development and characterisation of the low-molecular-weight peptidome of human wound fluids

van der Plas, M. J. A., Cai, J., Petrlova, J., Saleh, K., Kjellström, S. & Schmidtchen, A., 2021, In: eLife. 10, e66876.

Research output: Contribution to journal › Article › peer-review

Open Access

Peptimetric: Quantifying and Visualizing Differences in Peptidomic Data

Hartman, E., Mahdavi, S., Kjellström, S. & Schmidtchen, A., 2021, In: Frontiers in Bioinformatics. 1, 722466.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

A dual-action peptide-containing hydrogel targets wound infection and inflammation

Puthia, M., Butrym, M., Petrlova, J., Strömdahl, A. C., Andersson, M., Kjellström, S. & Schmidtchen, A., 2020 Jan 1, In: Science Translational Medicine. 12, 524, eaax6601.

Research output: Contribution to journal › Article › peer-review

SARS-CoV-2 Spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity

Petruk, G., Puthia, M., Petrlova, J., Samsudin, F., Strömdahl, A-C., Cerps, S., Uller, L., Kjellström, S., Bond, P. J. & Schmidtchen, A., 2020, In: Journal of Molecular Cell Biology. 12, 12, p. 916–932

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Adsorption of unfolded Cu/Zn superoxide dismutase onto hydrophobic surfaces catalyzes its formation of amyloid fibrils

Khan, A., Weininger, U., Kjellström, S., Deep, S. & Akke, M., 2019, In: Protein Engineering Design & Selection. 32, 2, p. 77–85

Research output: Contribution to journal › Article › peer-review

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2018

Genetic Elucidation of Xg, the last unresolved blood group system

Möller, M., Lee, Y. Q., Vidovic, K., Darlison, M., Björkman, L., Kjellström, S., Storry, J. & Olsson, M. L., 2018 Sept 13, p. 41-42. 2 p.

Research output: Contribution to conference › Abstract

Disruption of a GATA1-binding motif upstream of XG/PBDX abolishes Xg^a expression and resolves the Xg blood group system

Möller, M., Lee, Y. Q., Vidovic, K., Kjellström, S., Björkman, L., Storry, J. R. & Olsson, M. L., 2018 Jul 19, In: Blood. 132, 3, p. 334-338 5 p.

Research output: Contribution to journal › Article › peer-review

Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides

Saravanan, R., Holdbrook, D. A., Petrlova, J., Singh, S., Berglund, N. A., Choong, Y. K., Kjellström, S., Bond, P. J., Malmsten, M. & Schmidtchen, A., 2018 Jul 17, In: Nature Communications. 9, 1, 2762.

Research output: Contribution to journal › Article › peer-review

Open Access

Allele-selective RUNX1 binding regulates P1 blood group status by transcriptional control of A4GALT

Westman, J. S., Stenfelt, L., Vidovic, K., Möller, M., Hellberg, Å., Kjellström, S. & Olsson, M. L., 2018 Apr 5, In: Blood. 131, 14, p. 1611-1616

Research output: Contribution to journal › Article › peer-review

Structural and Biophysical Characterization of Human EXTL3: Domain Organization, Glycosylation, and Solution Structure

Awad, W., Kjellström, S., Svensson Birkedal, G., Mani, K. & Logan, D. T., 2018 Feb 20, In: Biochemistry. 57, 7, p. 1166-1177 12 p.

Research output: Contribution to journal › Article › peer-review

BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma article

Sime, W., Niu, Q., Abassi, Y., Masoumi, K. C., Zarrizi, R., Køhler, J. B., Kjellström, S., Lasorsa, V. A., Capasso, M., Fu, H. & Massoumi, R., 2018 Jan 1, In: Cell Death and Disease. 9, 5, 458.

Research output: Contribution to journal › Article › peer-review

Open Access

A molecular mechanism underlying the P₁/P₂ phenotypes: allele-selective RUNX1 binding regulates P1 blood group status by transcriptional control of A4GALT

Stenfelt, L., Westman, J. S., Vidovic, K., Möller, M., Hellberg, Å., Kjellström, S. & Olsson, M. L., 2018, In: Vox Sanguinis. 113, S1, p. 251-252

Research output: Contribution to journal › Published meeting abstract

Open Access

2017

Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis

Sonesson, A., Przybyszewska, K., Eriksson, S., Mörgelin, M., Kjellström, S., Davies, J., Potempa, J. & Schmidtchen, A., 2017 Dec 1, In: Scientific Reports. 7, 1, 8689.

Research output: Contribution to journal › Article › peer-review

Open Access

Proteolytic signatures define unique thrombin-derived peptides present in human wound fluid in vivo

Saravanan, R., Adav, S. S., Choong, Y. K., Van Der Plas, M. J. A., Petrlova, J., Kjellström, S., Sze, S. K. & Schmidtchen, A., 2017 Dec 1, In: Scientific Reports. 7, 1, 13136.

Research output: Contribution to journal › Article › peer-review

Open Access

Cu/Zn Superoxide Dismutase Forms Amyloid Fibrils under Near-Physiological Quiescent Conditions: The Roles of Disulfide Bonds and Effects of Denaturant

Khan, A., Respondek, M., Kjellström, S., Deep, S., Linse, S. & Akke, M., 2017 Sept 20, In: ACS Chemical Neuroscience. 8, 9, p. 2019-2026 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Three-dimensional structures and functional studies of two GH43 arabinofuranosidases from Weissella sp. strain 142 and Lactobacillus brevis

Linares-Pastén, J. A., Falck, P., Albasri, K., Kjellström, S., Adlercreutz, P., Logan, D. T. & Karlsson, E. N., 2017 Jul 1, In: The FEBS Journal. 284, 13, p. 2019-2036 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Exploring structure and interactions of the bacterial adaptor protein YjbH by crosslinking mass spectrometry

Al-Eryani, Y., Ib Rasmussen, M., Kjellström, S., Højrup, P., Emanuelsson, C. & von Wachenfeldt, C., 2016 Sept 1, In: Proteins: Structure, Function and Genetics. 84, 9, p. 1234-1245 12 p.

Research output: Contribution to journal › Article › peer-review

The aquaporin splice variant NbXIP1;1α is permeable to boric acid and is Phosphorylated in the N-terminal domain

Ampah-Korsah, H., Anderberg, H. I., Engfors, A., Kirscht, A., Nordén, K., Kjellström, S., Kjellbom, P. & Johanson, U., 2016 Jun 16, In: Frontiers in Plant Science. 7, JUNE2016, 862.

Research output: Contribution to journal › Article › peer-review

Open Access

Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses

van Der Plas, M., Bhongir, R., Kjellström, S., Siller, H., Kasetty, G., Mörgelin, M. & Schmidtchen, A., 2016 May 16, In: Nature Communications. 7, 13 p., 11567.

Research output: Contribution to journal › Article › peer-review

Open Access

Elucidating the Molecular Composition of Cartilage by Proteomics

Hsueh, M. F., Khabut, A., Kjellström, S., Önnerfjord, P. & Kraus, V. B., 2016 Feb 5, In: Journal of Proteome Research. 15, 2, p. 374-388 15 p.

Research output: Contribution to journal › Article › peer-review

2014

Galiellalactone is a Direct Inhibitor of STAT3 in Prostate Cancer Cells.

Don-Doncow, N., Escobar Gabriel, Z., Johansson, M. H., Kjellström, S., Garcia, V., Munoz, E., Sterner, O., Bjartell, A. & Hellsten, R., 2014, In: Journal of Biological Chemistry. 289, 23, p. 15969-15978

Research output: Contribution to journal › Article › peer-review

2013

Fast Surface Acoustic Wave-Matrix-Assisted Laser Desorption Ionization Mass Spectrometry of Cell Response from Islets of Langerhans.

Bllaci, L., Kjellström, S., Eliasson, L., Friend, J. R., Yeo, L. Y. & Nilsson, S., 2013, In: Analytical Chemistry. 85, 5, p. 2623-2629

Research output: Contribution to journal › Article › peer-review

Further Insights into the Catalytical Properties of Deglycosylated Pyranose Dehydrogenase from Agaricus meleagris Recombinantly Expressed in Pichia pastoris

Yakovleva, M., Killyeni, A., Seubert, O., Conghaile, P. O., MacAodha, D., Leech, D., Gonaus, C., Popescu, I. C., Peterbauer, C. K., Kjellström, S. & Gorton, L., 2013, In: Analytical Chemistry. 85, 20, p. 9852-9858

Research output: Contribution to journal › Article › peer-review

Liquid chromatography-tandem mass spectrometry approach for quantification of mucins from sputum using C-13,N-15-labeled peptides as internal standards

Lindberg, C., van Geest, M., Lindberg, H. & Kjellström, S., 2013, In: Analytical Biochemistry. 434, 1, p. 84-92

Research output: Contribution to journal › Article › peer-review

Quantitative high-performance liquid chromatography-tandem mass spectrometry method for the analysis of free desmosines in plasma and urine

Miliotis, T., Lindberg, C., Semb, K. F., van Geest, M. & Kjellström, S., 2013, In: Journal of Chromatography A. 1308, p. 73-78

Research output: Contribution to journal › Article › peer-review

2012

Detection of Crosslinks within and between Proteins by LC-MALDI-TOFTOF and the Software FINDX to Reduce the MSMS-Data to Acquire for Validation.

Söderberg, C., Lambert, W., Kjellström, S., Wiegandt, A., Peterson Wulff, R., Månsson, C., Rutsdottir, G. & Emanuelsson, C., 2012, In: PLoS ONE. 7, 6, e38927.

Research output: Contribution to journal › Article › peer-review

Open Access

Probing the transient interaction between the small heat-shock protein Hsp21 and a model substrate protein using crosslinking mass spectrometry.

Lambert, W., Rutsdottir, G., Hussein, R., Bernfur, K., Kjellström, S. & Emanuelsson, C., 2012, In: Cell Stress & Chaperones.

Research output: Contribution to journal › Article › peer-review

2004

Phosphoric acid as a matrix additive for MALDI MS analysis of phosphopeptides and phosphoproteins

Kjellström, S. & Jensen, O. N., 2004, In: Analytical Chemistry. 76, 17, p. 5109–5117

Research output: Contribution to journal › Article › peer-review

2003

Mass spectrometry and site-directed mutagenesis identify several autophosphorylated residues required for the activity of PrkC, a Ser/Thr kinase from Bacillus subtilis

Madec, E., Stensballe, A., Kjellström, S., Cladière, L., Obuchowski, M., Jensen, O. N. & Séror, S. J., 2003 Jul 11, In: Journal of Molecular Biology. 330, 3, p. 459-72 14 p.

Research output: Contribution to journal › Article › peer-review

2002

Ready-made matrix-assisted laser desorption/ionization target plates coated with thin matrix layer for automated sample deposition in high-density array format.

Miliotis, T., Kjellström, S., Nilsson, J., Laurell, T., Edholm, L-E. & Marko-Varga, G., 2002, In: Rapid Communications in Mass Spectrometry. 16, 2, p. 117-126

Research output: Contribution to journal › Article › peer-review

2000

Protein identification platform utilizing micro dispensing technology interfaced to matrix-assisted laser desorption ionization time-of-flight mass spectrometry

Miliotis, T., Kjellström, S., Önnerfjord, P., Nilsson, J., Laurell, T., Edholm, L. E. & Marko-Varga, G., 2000 Jul 21, In: Journal of Chromatography A. 886, 1-2, p. 99-110 12 p.

Research output: Contribution to journal › Article › peer-review

Sven Kjellström

Research output

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