Research output per year
Research output per year
Professor
We develop novel lab-on-a-chip technology for separation, enrichment and manipulation of cells and biological microparticles. A central area of our research is to use acousticforces (acoustophresis) in micrscale to manipulate biological mater. Acoustophoresis hich is a separation technology that enables non contact handling of cells and particles in microfluidic systems. It involves the establishment of an acoustic standing wave field in well-defined microchannels by means of an ultrasonic actuator. Particles/cells that have a density higher than the carrier medium will migrate to the acoustic pressure node in a microchannel under the influence of the acoustic standing wave force. This way cells can be concentrated into the center fraction of a flow channel and thereby be extracted as an enriched population at a multi-port outlet at the end of the channel. Since the migration of cells in an acoustic field is dependent of their acoustophysicla propeties different cell types can be separated from oneanother. We develop this label-free non-invasive method to enrich rare cells from complex biofluids such as circulating tumor cells (CTCs) from blood for subsequent detailed functional and molecular characterization (detailed genetic rearrangements, molecular profiling, and nuclear receptor signalling). A novel high-resolution adaptation allows us to isolate microvesicles/exosomes from biofluids for the study of cancer biomarkers such as miRNA. We also link the exosome studies to disease biomarker profiling using mass spectrometry and proteomic analyses.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Laurell, T. (PI)
2025/01/01 → 2027/12/31
Project: Research
Edthofer, A. (Researcher), Baasch, T. (Supervisor), Laurell, T. (Supervisor) & Lenshof, A. (Supervisor)
2023/04/01 → 2027/07/01
Project: Dissertation
Ohlsson, P. (Researcher), Gerlt, M. (Researcher), Laurell, T. (Researcher), Bruus, H. (Researcher), Evander, M. (Researcher) & Pryds, N. (Researcher)
2023/01/01 → 2025/12/31
Project: Research
Havers, M. (Researcher), Laurell, T. (Supervisor), Lenshof, A. (Assistant supervisor), Evander, M. (Assistant supervisor) & Baasch, T. (Assistant supervisor)
2020/09/01 → 2025/05/09
Project: Dissertation
Baasch, T. (Invited speaker), Qiu, W. (Contributor), Lenshof, A. (Contributor), Laurell, T. (Contributor), Edthofer, A. (Contributor), Péroux, L. (Contributor), Silversand, L. (Contributor) & Rengbrand, O. (Contributor)
Activity: Talk or presentation › Invited talk
Laurell, T. (Organiser)
Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
Laurell, T. (Organiser)
Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
Laurell, T. (Organiser) & Bengtsson, M. (Presenter)
Activity: Participating in or organising an event › Organisation of workshop/ seminar/ course
Laurell, T. (Organiser), Bengtsson, M. (Speaker) & Wallman, L. (Speaker)
Activity: Participating in or organising an event › Participation in workshop/ seminar/ course
Havers, M. (Recipient), Ortenlöf, N. (Recipient), Scott, A. (Recipient), Isaksson, M. (Recipient), Ekström, S. (Recipient), Welinder, C. (Recipient), Baasch, T. (Recipient), Evander, M. (Recipient), Lenshof, A. (Recipient), Gram, M. (Recipient) & Laurell, T. (Recipient), 2023 Nov 17
Prize: Prize (including medals and awards)
Laurell, T. (Recipient), 2022 Oct 27
Prize: Prize (including medals and awards)
Laurell, T. (Recipient), 2016 Feb
Prize: Election to learned society
Laurell, T. (Recipient), 2010
Prize: Election to learned society
Wallman, L. (Manager), Laurell, T. (Coordinator) & Meissner, A. (Coordinator)
Division for Biomedical EngineeringInfrastructure