Research output per year
Research output per year
- 1 - 50 out of 98 results
Search results
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2023
The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1 + precursors.
Pærregaard, S. I., Wulff, L., Schussek, S., Niss, K., Mörbe, U., Jendholm, J., Wendland, K., Andrusaite, A. T., Brulois, K. F., Nibbs, R. J. B., Sitnik, K., Mowat, A. M., Butcher, E. C., Brunak, S. & Agace, W. W., 2023 Apr 21, In: Nature Communications. 14, p. 1-16 2307.Research output: Contribution to journal › Article › peer-review
Open Access -
cDC1-derived IL-27 regulates small intestinal CD4+ T cell homeostasis in mice
Ahmadi, F., Junghus, F., Ashworth, C., Lappalainen, A., Mörbe, U., Kotarsky, K. & Agace, W. W., 2023, In: The Journal of experimental medicine. 220, 3Research output: Contribution to journal › Article › peer-review
Open Access -
Intragranuloma Accumulation and Inflammatory Differentiation of Neutrophils Underlie Mycobacterial ESX-1-Dependent Immunopathology
Lienard, J., Munke, K., Wulff, L., Da Silva, C., Vandamme, J., Laschanzky, K., Joeris, T., Agace, W. & Carlsson, F., 2023, In: mBio. 14, 2Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Identification and characterization of murine glycoprotein 2-expressing intestinal dendritic cells
Luda, K. M., Da Silva, C., Ahmadi, F., Mowat, A. M., Ohno, H., Kotarsky, K. & Agace, W. W., 2022 Nov, In: Scandinavian Journal of Immunology. 96, 5, p. 1-12 e13219.Research output: Contribution to journal › Article › peer-review
Open Access -
IRF8 deficiency induces the transcriptional, functional, and epigenetic reprogramming of cDC1 into the cDC2 lineage
Lança, T., Ungerbäck, J., Da Silva, C., Joeris, T., Ahmadi, F., Vandamme, J., Svensson-Frej, M., Mowat, A. M., Kotarsky, K., Sigvardsson, M. & Agace, W. W., 2022 Aug 9, In: Immunity. 55, 8, p. 1431-1447.e11Research output: Contribution to journal › Article › peer-review
Open Access -
ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection
Arabpour, M., Lebrero-Fernandez, C., Schön, K., Strömberg, A., Börjesson, V., Lahl, K., Ballegeer, M., Saelens, X., Angeletti, D., Agace, W. & Lycke, N., 2022, In: Mucosal Immunology. 15, 4 , p. 745-761Research output: Contribution to journal › Article › peer-review
Open Access -
A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut
Vergani, S., Muleta, K. G., Da Silva, C., Doyle, A., Kristiansen, T. A., Sodini, S., Krausse, N., Montano, G., Kotarsky, K., Nakawesi, J., Åkerstrand, H., Vanhee, S., Gupta, S. L., Bryder, D., Agace, W. W., Lahl, K. & Yuan, J., 2022, In: Immunity. 55, 10, p. 1829-1842.e6Research output: Contribution to journal › Article › peer-review
Open Access -
The porcine large intestine contains developmentally distinct submucosal lymphoid clusters and mucosal isolated lymphoid follicles
Jørgensen, P. B., Eriksen, L. L., Fenton, T. M., Bailey, M., Agace, W. W. & Mörbe, U. M., 2022, In: Developmental and Comparative Immunology. 131, 104375.Research output: Contribution to journal › Article › peer-review
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2021
Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3+CD8+ Tregs
Joeris, T., Gomez-Casado, C., Holmkvist, P., Tavernier, S. J., Silva-Sanchez, A., Klotz, L., Randall, T. D., Mowat, A. M., Kotarsky, K., Malissen, B. & Agace, W. W., 2021 Jun, In: Science Immunology. 6, 60, eabd3774.Research output: Contribution to journal › Article › peer-review
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Identification, isolation and analysis of human gut-associated lymphoid tissues
Jørgensen, P. B., Fenton, T. M., Mörbe, U. M., Riis, L. B., Jakobsen, H. L., Nielsen, O. H. & Agace, W. W., 2021 Apr 1, In: Nature Protocols. 16, 4, p. 2051–2067 17 p.Research output: Contribution to journal › Article › peer-review
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Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism
Jensen, B. A. H., Holm, J. B., Larsen, I. S., von Burg, N., Derer, S., Sonne, S. B., Pærregaard, S. I., Damgaard, M. V., Indrelid, S. A., Rivollier, A., Agrinier, A.-L., Sulek, K., Arnoldussen, Y. J., Fjære, E., Marette, A., Angell, I. L., Rudi, K., Treebak, J. T., Madsen, L. & Åkesson, C. P. & 5 others, , 2021 Feb 17, In: Nature Communications. 12, 1, 1093.Research output: Contribution to journal › Article › peer-review
Open Access -
Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut
Laursen, M. F., Sakanaka, M., von Burg, N., Mörbe, U., Andersen, D., Moll, J. M., Pekmez, C. T., Rivollier, A., Michaelsen, K. F., Mølgaard, C., Lind, M. V., Dragsted, L. O., Katayama, T., Frandsen, H. L., Vinggaard, A. M., Bahl, M. I., Brix, S., Agace, W., Licht, T. R. & Roager, H. M., 2021, In: Nature Microbiology. 6, p. 1367-1382 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Migration of murine intestinal dendritic cell subsets upon intrinsic and extrinsic TLR3 stimulation
López, A. G., Bekiaris, V., Luda, K. M., Hütter, J., Ulmert, I., Getachew Muleta, K., Nakawesi, J., Kotarsky, K., Malissen, B., O'Keeffe, M., Holzmann, B., Agace, W. & Lahl, K., 2020 Oct, In: European Journal of Immunology. 50, 10, p. 1525-1536 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Complete Topological Mapping of a Cellular Protein Interactome Reveals Bow-Tie Motifs as Ubiquitous Connectors of Protein Complexes
Niss, K., Gomez-Casado, C., Hjaltelin, J. X., Joeris, T., Agace, W. W., Belling, K. G. & Brunak, S., 2020 Jun 16, In: Cell Reports. 31, 11, 107763.Research output: Contribution to journal › Article › peer-review
Open Access -
Immune Profiling of Human Gut-Associated Lymphoid Tissue Identifies a Role for Isolated Lymphoid Follicles in Priming of Region-Specific Immunity
Fenton, T. M., Jørgensen, P. B., Niss, K., Rubin, S. J. S., Mörbe, U. M., Riis, L. B., Da Silva, C., Plumb, A., Vandamme, J., Jakobsen, H. L., Brunak, S., Habtezion, A., Nielsen, O. H., Johansson-Lindbom, B. & Agace, W. W., 2020 Mar 17, In: Immunity. 52, 3, p. 557-570 21 p.Research output: Contribution to journal › Article › peer-review
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Deletion of IRF4 in Dendritic Cells Leads to Delayed Onset of T Cell-Dependent Colitis
Pool, L., Rivollier, A. & Agace, W. W., 2020 Feb 15, In: Journal of immunology. 204, 4, p. 1047-1055 9 p.Research output: Contribution to journal › Article › peer-review
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2019
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
et al., 2019, In: European Journal of Immunology. 49, 10, p. 1457-1973 517 p.Research output: Contribution to journal › Article › peer-review
Open Access -
SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation
Rizk, J., Kaplinsky, J., Agerholm, R., Kadekar, D., Ivars, F., Agace, W. W., Wei-Lynn Wong, W., Szucs, M. J., Myers, S. A., Carr, S. A., Waisman, A. & Bekiaris, V., 2019, In: Science Signaling. 12, 596, aaw3469.Research output: Contribution to journal › Article › peer-review
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2018
Intestinal CD103+CD11b+ cDC2 conventional dendritic cells are required for primary CD4+ T and B cell responses to soluble flagellin
Flores-Langarica, A., Cook, C., Luda, K. M., Persson, E. K., Marshall, J. L., Beristain-Covarrubias, N., Yam-Puc, J. C., Dahlgren, M., Persson, J. J., Uematsu, S., Akira, S., Henderson, I. R., Lindbom, B. J., Agace, W. & Cunningham, A. F., 2018 Oct 17, In: Frontiers in Immunology. 9, OCT, 2409.Research output: Contribution to journal › Article › peer-review
Open Access -
Retinoic acid signaling in thymic epithelial cells regulates thymopoiesis
Wendland, K., Niss, K., Kotarsky, K., Wu, N. Y. H., White, A. J., Jendholm, J., Rivollier, A., Izarzugaza, J. M. G., Brunak, S., Holländer, G. A., Anderson, G., Sitnik, K. M. & Agace, W. W., 2018 Jul 15, In: Journal of Immunology. 201, 2, p. 524-532 9 p.Research output: Contribution to journal › Article › peer-review
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CD103 + CD11b + mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin
Flores-Langarica, A., Müller Luda, K., Persson, E. K., Cook, C. N., Bobat, S., Marshall, J. L., Dahlgren, M. W., Hägerbrand, K., Toellner, K. M., Goodall, M. D., Withers, D. R., Henderson, I. R., Johansson Lindbom, B., Cunningham, A. F. & Agace, W. W., 2018 May 1, In: Mucosal Immunology. 11, 3, p. 681-692 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Distinct DC subsets regulate adaptive Th1 and 2 responses during Trichuris muris infection
Demiri, M., Müller-Luda, K., Agace, W. W. & Svensson-Frej, M., 2017 Oct 1, In: Parasite Immunology. 39, 10, e12458.Research output: Contribution to journal › Article › peer-review
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Different populations of CD11b + dendritic cells drive Th2 responses in the small intestine and colon
Mayer, J. U., Demiri, M., Agace, W. W., MacDonald, A. S., Svensson-Frej, M. & Milling, S. W., 2017 Jun 9, In: Nature Communications. 8, 15820.Research output: Contribution to journal › Article › peer-review
Open Access -
Eosinophils are key regulators of perivascular adipose tissue and vascular functionality
Withers, S. B., Forman, R., Meza-Perez, S., Sorobetea, D., Sitnik, K., Hopwood, T., Lawrence, C. B., Agace, W. W., Else, K. J., Heagerty, A. M., Svensson-Frej, M. & Cruickshank, S. M., 2017 Mar 17, In: Scientific Reports. 7, 44571.Research output: Contribution to journal › Article › peer-review
Open Access -
Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus
Pohl, J. M., Gutweiler, S., Thiebes, S., Volke, J. K., Klein-Hitpass, L., Zwanziger, D., Gunzer, M., Jung, S., Agace, W. W., Kurts, C. & Engel, D. R., 2017, In: Gut. 66, 12, p. 2110-2120Research output: Contribution to journal › Article › peer-review
Open Access -
2016
Long-Term persistence of human donor alveolar macrophages in lung transplant recipients
Eguíluz-Gracia, I., Schultz, H. H. L., Sikkeland, L. I. B., Danilova, E., Holm, A. M., Pronk, C. J. H., Agace, W. W., Iversen, M., Andersen, C., Jahnsen, F. L. & Baekkevold, E. S., 2016 Nov 1, In: Thorax. 71, 11, p. 1006-1011 6 p.Research output: Contribution to journal › Article › peer-review
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IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively
Sichien, D., Scott, C. L., Martens, L., Vanderkerken, M., Van Gassen, S., Plantinga, M., Joeris, T., De Prijck, S., Vanhoutte, L., Vanheerswynghels, M., Van Isterdael, G., Toussaint, W., Madeira, F. B., Vergote, K., Agace, W. W., Clausen, B. E., Hammad, H., Dalod, M., Saeys, Y. & Lambrecht, B. N. & 1 others, , 2016 Sept 20, In: Immunity. 45, 3, p. 626-640 15 p.Research output: Contribution to journal › Article › peer-review
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A reduced population of CD103+CD11b+ dendritic cells has a limited impact on oral Salmonella infection
Fernández-Santoscoy, M., Wenzel, U. A., Persson, E., Yrlid, U., Agace, W. & Wick, M. J., 2016 Aug 1, In: Immunology Letters. 176, p. 72-80 9 p.Research output: Contribution to journal › Article › peer-review
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IL-18Rα-deficient CD4+ T cells induce intestinal inflammation in the CD45RBhi transfer model of colitis despite impaired innate responsiveness
Holmkvist, P., Pool, L., Hägerbrand, K., Agace, W. W. & Rivollier, A., 2016 Jun 1, In: European Journal of Immunology. 46, 6, p. 1371-1382 12 p.Research output: Contribution to journal › Article › peer-review
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IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis
Luda, K. M., Joeris, T., Persson, E. K., Rivollier, A., Demiri, M., Sitnik, K. M., Pool, L., Holm, J. B., Melo-Gonzalez, F., Richter, L., Lambrecht, B. N., Kristiansen, K., Travis, M. A., Svensson-Frej, M., Kotarsky, K. & Agace, W. W., 2016 Apr 19, In: Immunity. 44, 4, p. 860-874 15 p.Research output: Contribution to journal › Article › peer-review
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Macrophage and dendritic cell subsets in IBD: ALDH(+) cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation.
Magnusson, M. K., Brynjólfsson, S. F., Dige, A., Uronen-Hansson, H., Börjesson, L. G., Bengtsson, J. L., Gudjonsson, S., Öhman, L., Agnholt, J., Sjövall, H., Agace, W. & Wick, M. J., 2016, In: Mucosal Immunology. 9, 1, p. 171-182Research output: Contribution to journal › Article › peer-review
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2015
A major population of mucosal memory CD4(+) T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality.
Holmkvist, P., Roepstorff, K., Uronen-Hansson, H., Sandén, C., Gudjonsson, S., Hultman Patschan, O., Grip, O., Marsal, J., Schmidtchen, A., Hornum, L., Erjefält, J., Håkansson, K. & Agace, W., 2015, In: Mucosal Immunology. 8, 3, p. 545-558Research output: Contribution to journal › Article › peer-review
File200 Downloads (Pure) -
CCR2(+)CD103(-) intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells.
Scott, C. L., Bain, C. C., Wright, P. B., Sichien, D., Kotarsky, K., Persson, E., Luda, K., Guilliams, M., Lambrecht, B. N., Agace, W., Milling, S. W. & Mowat, A., 2015, In: Mucosal Immunology. 8, 2, p. 327-339Research output: Contribution to journal › Article › peer-review
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CCRL1/ACKR4 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice
Lucas, B., White, A. J., Ulvmar, M. H., Nibbs, R. J. B., Sitnik, K., Agace, W., Jenkinson, W. E., Anderson, G. & Rot, A., 2015, In: European Journal of Immunology. 45, 2, p. 574-583Research output: Contribution to journal › Article › peer-review
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Lymph-borne CD8α(+) dendritic cells are uniquely able to cross-prime CD8(+) T cells with antigen acquired from intestinal epithelial cells.
Cerovic, V., Houston, S. A., Westlund, J., Utriainen, L., Davison, E. S., Scott, C. L., Bain, C. C., Joeris, T., Agace, W., Kroczek, R. A., Mowat, A. M., Yrlid, U. & Milling, S. W., 2015, In: Mucosal Immunology. 8, 1, p. 38-48Research output: Contribution to journal › Article › peer-review
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MyD88 Signaling Regulates Steady-State Migration of Intestinal CD103+ Dendritic Cells Independently of TNF-α and the Gut Microbiota.
Hägerbrand, K., Westlund, J., Yrlid, U., Agace, W. & Johansson Lindbom, B., 2015, In: Journal of Immunology. 195, 6, p. 2888-2899Research output: Contribution to journal › Article › peer-review
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2014
CD14(hi) HLA-DRdim macrophages, with a resemblance to classical blood monocytes, dominate inflamed mucosa in Crohn's disease
Thiesen, S., Janciauskiene, S., Uronen-Hansson, H., Agace, W., Hogerkorp, C.-M., Spee, P., Hakansson, K. & Grip, O., 2014, In: Journal of Leukocyte Biology. 95, 3, p. 531-541Research output: Contribution to journal › Article › peer-review
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Involvement of neurons and retinoic acid in lymphatic development: new insights in increased nuchal translucency
Burger, N. B., Stuurman, K. E., Kok, E., Konijn, T., Schooneman, D., Niederreither, K., Coles, M., Agace, W., Christoffels, V. M., Mebius, R. E., van de Pavert, S. A. & Bekker, M. N., 2014, In: Prenatal Diagnosis. 34, 13, p. 1312-1319Research output: Contribution to journal › Article › peer-review
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2013
Dendritic cell subsets in the intestinal lamina propria: Ontogeny and function.
Persson, E., Scott, C. L., Mowat, A. M. & Agace, W., 2013, In: European Journal of Immunology. 43, 12, p. 3098-3107Research output: Contribution to journal › Article › peer-review
Open Access -
IRF4 Transcription-Factor-Dependent CD103(+)CD11b(+) Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation.
Persson, E., Uronen-Hansson, H., Semmrich, M., Rivollier, A., Hägerbrand, K., Marsal, J., Gudjonsson, S., Håkansson, U., Reizis, B., Kotarsky, K. & Agace, W., 2013, In: Immunity. 38, 5, p. 958-969Research output: Contribution to journal › Article › peer-review
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2012
Directed antigen targeting in vivo identifies a role for CD103(+) dendritic cells in both tolerogenic and immunogenic T-cell responses.
Semmrich, M., Plantinga, M., Svensson Frej, M., Uronen-Hansson, H., Gustafsson, T., Mowat, A., Yrlid, U., Lambrecht, B. N. & Agace, W., 2012, In: Mucosal Immunology. 5, 2, p. 150-160Research output: Contribution to journal › Article › peer-review
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DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues
Poulin, L. F., Reyal, Y., Uronen-Hansson, H., Schraml, B. U., Sancho, D., Murphy, K. M., Håkansson, U., Moita, L. F., Agace, W., Bonnet, D. & Reis e Sousa, C., 2012, In: Blood. 119, 25, p. 6052-6062Research output: Contribution to journal › Article › peer-review
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How vitamin A metabolizing dendritic cells are generated in the gut mucosa.
Agace, W. & Persson, E., 2012, In: Trends in Immunology. 33, p. 42-48Research output: Contribution to journal › Article › peer-review
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Mesenchymal Cells Regulate Retinoic Acid Receptor-Dependent Cortical Thymic Epithelial Cell Homeostasis.
Sitnik, K. M., Kotarsky, K., White, A. J., Jenkinson, W. E., Anderson, G. & Agace, W., 2012, In: Journal of immunology. 188, 10, p. 4801-4809Research output: Contribution to journal › Article › peer-review
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2011
Bile retinoids imprint intestinal CD103(+) dendritic cells with the ability to generate gut-tropic T cells.
Jaensson Gyllenbäck, E., Kotarsky, K., Zapata, F., Persson, E. K., Gundersen, T. E., Blomhoff, R. & Agace, W., 2011, In: Mucosal Immunology. 4, p. 438-447Research output: Contribution to journal › Article › peer-review
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2010
A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.
Kotarsky, K., Sitnik, K., Stenstad, H., Kotarsky, H., Schmidtchen, A., Koslowski, M., Wehkamp, J. & Agace, W., 2010, In: Mucosal Immunology. 3, p. 40-48Research output: Contribution to journal › Article › peer-review
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Generation of gut-homing T cells and their localization to the small intestinal mucosa.
Agace, W., 2010, In: Immunology Letters. 128, p. 21-23Research output: Contribution to journal › Article › peer-review
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The diverse ontogeny and function of murine small intestinal dendritic cell/macrophage subsets.
Persson, E., Jaensson Gyllenbäck, E. & Agace, W., 2010, In: Immunobiology. Jul 1, p. 692-697Research output: Contribution to journal › Article › peer-review
File195 Downloads (Pure) -
The Sensing of Environmental Stimuli by Follicular Dendritic Cells Promotes Immunoglobulin A Generation in the Gut
Suzuki, K., Maruya, M., Kawamoto, S., Sitnik, K., Kitamura, H., Agace, W. & Fagarasan, S., 2010, In: Immunity. 33, 1, p. 71-83Research output: Contribution to journal › Article › peer-review
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2009
Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
van de Pavert, S. A., Olivier, B. J., Goverse, G., Vondenhoff, M. F., Greuter, M., Beke, P., Kusser, K., Hoepken, U. E., Lipp, M., Niederreither, K., Blomhoff, R., Sitnik, K., Agace, W., Randall, T. D., de Jonge, W. J. & Mebius, R. E., 2009, In: Nature Immunology. 10, 11, p. 1193-U78Research output: Contribution to journal › Article › peer-review