Yutaka Sugihara

2021

An observational study on the molecular profiling of primary melanomas reveals a progression dependence on mitochondrial activation

Gil, J., Rezeli, M., Lutz, E. G., Kim, Y., Sugihara, Y., Malm, J., Semenov, Y. R., Yu, K. H., Nguyen, N., Wan, G., Kemény, L. V., Kárpáti, S., Németh, I. B. & Marko‐varga, G., 2021 Dec, In: Cancers. 13, 23, 6066.

Research output: Contribution to journal › Article › peer-review

Open Access

Matrix-assisted laser desorption ionization - mass spectrometry imaging of erlotinib reveals a limited tumor tissue distribution in a non-small-cell lung cancer mouse xenograft model

Kim, T. Y., Lee, B., Kim, Y., Sugihara, Y., Rezeli, M., Szasz, A. M., Dome, B., Marko-Varga, G. & Kwon, H. J., 2021, In: Clinical and Translational Medicine. 11, 7, e481.

Research output: Contribution to journal › Letter › peer-review

Open Access

The Human Melanoma Proteome Atlas-Complementing the melanoma transcriptome

Betancourt, L. H., Gil, J., Sanchez, A., Kuras, M., Velasquez, E., Kim, Y., Sugihara, Y., Parada, I. P., Appelqvist, R., Wieslander, E., Welinder, C., de Almeida, N. P., Woldmar, N., Marko-Varga, M., Eriksson, J., Baldetorp, B., Ingvar, C., Olsson, H., Lundgren, L., Lindberg, H., & 15 othersOskolas, H., Lee, B., Berge, E., Sjögren, M., Eriksson, C., Kim, D., Kwon, H. J., Rezeli, M., Malm, J., Horvath, P., Horvatovich, P., Miliotis, T., Ekedahl, H., Marko-Varga, G. & et al., 2021, In: Clinical and Translational Medicine. 11, 7, p. 1-25 e451.

Research output: Contribution to journal › Article › peer-review

Open Access

The human melanoma proteome atlas-Defining the molecular pathology

Betancourt, L. H., Gil, J., Kim, Y., Doma, V., Çakır, U., Sanchez, A., Murillo, J. R., Kuras, M., Parada, I. P., Sugihara, Y., Appelqvist, R., Wieslander, E., Welinder, C., Velasquez, E., de Almeida, N. P., Woldmar, N., Marko-Varga, M., Pawłowski, K., Eriksson, J., Szeitz, B., & 37 othersBaldetorp, B., Ingvar, C., Olsson, H., Lundgren, L., Lindberg, H., Oskolas, H., Lee, B., Berge, E., Sjögren, M., Eriksson, C., Kim, D., Kwon, H. J., Knudsen, B., Rezeli, M., Hong, R., Horvatovich, P., Miliotis, T., Nishimura, T., Kato, H., Steinfelder, E., Oppermann, M., Miller, K., Florindi, F., Zhou, Q., Domont, G. B., Pizzatti, L., Nogueira, F. C. S., Horvath, P., Szadai, L., Timar, J., Karpati, S., Szasz, A. M., Malm, J., Fenyö, D., Ekedahl, H., Németh, I. B. & Marko-Varga, G., 2021, In: Clinical and Translational Medicine. 11, 7, p. 1-20 e473.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Novel functional proteins coded by the human genome discovered in metastases of melanoma patients

Sanchez, A., Kuras, M., Murillo, J. R., Pla, I., Pawlowski, K., Szasz, A. M., Gil, J., Nogueira, F. C. S., Perez-Riverol, Y., Eriksson, J., Appelqvist, R., Miliotis, T., Kim, Y., Baldetorp, B., Ingvar, C., Olsson, H., Lundgren, L., Ekedahl, H., Horvatovich, P., Sugihara, Y., & 8 othersWelinder, C., Wieslander, E., Kwon, H. J., Domont, G. B., Malm, J., Rezeli, M., Betancourt, L. H. & Marko-Varga, G., 2020 Jun, In: Cell Biology and Toxicology. 36, 3, p. 261-272 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Identification and validation of VEGFR2 kinase as a target of voacangine by a systematic combination of DARTS and MSI

Kim, Y., Sugihara, Y., Kim, T. Y., Cho, S. M., Kim, J. Y., Lee, J. Y., Yoo, J. S., Song, D., Han, G., Rezeli, M., Welinder, C., Appelqvist, R., Marko-Varga, G. & Kwon, H. J., 2020 Mar 27, In: Biomolecules. 10, 4, 508.

Research output: Contribution to journal › Article › peer-review

Open Access

Amyloid-specific extraction using organic solvents

Kamiie, J., Aihara, N., Uchida, Y., Kobayashi, D., Yoshida, Y., Kuroda, T., Sakaue, M., Sugihara, Y., Rezeli, M. & Marko-Varga, G., 2020, In: MethodsX. 7, 100770.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Improved survival prognostication of node-positive malignant melanoma patients utilizing shotgun proteomics guided by histopathological characterization and genomic data

Betancourt, L. H., Pawłowski, K., Eriksson, J., Szasz, A. M., Mitra, S., Pla, I., Welinder, C., Ekedahl, H., Broberg, P., Appelqvist, R., Yakovleva, M., Sugihara, Y., Miharada, K., Ingvar, C., Lundgren, L., Baldetorp, B., Olsson, H., Rezeli, M., Wieslander, E., Horvatovich, P., & 3 othersMalm, J., Jönsson, G. & Marko-Varga, G., 2019 Mar 26, In: Scientific Reports. 9, 1, 5154.

Research output: Contribution to journal › Article › peer-review

Open Access

Optimization of sample preparation for transporter protein quantification in tissues by LC–MS/MS

Jankovskaja, S., Kamiie, J., Rezeli, M., Gustavsson, L., Sugihara, Y., Miliotis, T., Ruzgas, T. & Marko-Varga, G., 2019 Feb 5, In: Journal of Pharmaceutical and Biomedical Analysis. 164, p. 9-15 7 p.

Research output: Contribution to journal › Article › peer-review

Challenging the heterogeneity of disease presentation in malignant melanoma—impact on patient treatment

Marcell Szasz, A., Malm, J., Rezeli, M., Sugihara, Y., Betancourt, L. H., Rivas, D., Gyorffy, B. & Marko-Varga, G., 2019, In: Cell Biology and Toxicology. 35, 1, p. 1-14

Research output: Contribution to journal › Article › peer-review

Open Access

Clinical protein science in translational medicine targeting malignant melanoma

Gil, J., Betancourt, L. H., Pla, I., Sanchez, A., Appelqvist, R., Miliotis, T., Kuras, M., Oskolas, H., Kim, Y., Horvath, Z., Eriksson, J., Berge, E., Burestedt, E., Jönsson, G., Baldetorp, B., Ingvar, C., Olsson, H., Lundgren, L., Horvatovich, P., Murillo, J. R., & 18 othersSugihara, Y., Welinder, C., Wieslander, E., Lee, B., Lindberg, H., Pawłowski, K., Kwon, H. J., Doma, V., Timar, J., Karpati, S., Szasz, A. M., Németh, I. B., Nishimura, T., Corthals, G., Rezeli, M., Knudsen, B., Malm, J. & Marko-Varga, G., 2019, In: Cell Biology and Toxicology. 35, 4, p. 293-332

Research output: Contribution to journal › Article › peer-review

Open Access

The hidden story of heterogeneous B-raf V600E mutation quantitative protein expression in metastatic melanoma—association with clinical outcome and tumor phenotypes

Betancourt, L. H., Szasz, A. M., Kuras, M., Murillo, J. R., Sugihara, Y., Pla, I., Horvath, Z., Pawłowski, K., Rezeli, M., Miharada, K., Gil, J., Eriksson, J., Appelqvist, R., Miliotis, T., Baldetorp, B., Ingvar, C., Olsson, H., Lundgren, L., Horvatovich, P., Welinder, C., & 8 othersWieslander, E., Kwon, H. J., Malm, J., Nemeth, I. B., Jönsson, G., Fenyö, D., Sanchez, A. & Marko-Varga, G., 2019, In: Cancers. 11, 12, 1981.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Evaluation of Drug Exposure and Metabolism in Locust and Zebrafish Brains Using Mass Spectrometry Imaging

Villacrez, M., Hellman, K., Ono, T., Sugihara, Y., Rezeli, M., Ek, F., Marko-Varga, G. & Olsson, R., 2018 Aug 15, In: ACS Chemical Neuroscience. 9, 8, p. 1994-2000 7 p.

Research output: Contribution to journal › Article › peer-review

Endogenous expression mapping of malignant melanoma by mass spectrometry imaging

Sugihara, Y., Rivas, D., Malm, J., Szasz, M., Kwon, H., Baldetorp, B., Olsson, H., Ingvar, C., Rezeli, M., Fehniger, T. E. & Marko-Varga, G., 2018 Aug 6, In: Clinical and Translational Medicine. 7, p. 1-9 22.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Correlation of histopathologic characteristics to protein expression and function in malignant melanoma

Welinder, C., Pawlowski, K., Szász, M., Yakovleva, M., Sugihara, Y., Malm, J., Jönsson, G. B., Ingvar, C., Lundgren, L., Baldetorp, B., Olsson, H., Rezeli, M., Laurell, T., Wieslander, E. & Marko-Varga, G., 2017 Apr 1, In: PLoS ONE. 12, 4, e0176167.

Research output: Contribution to journal › Article › peer-review

Open Access

Limited tumor tissue drug penetration contributes to primary resistance against angiogenesis inhibitors

Torok, S., Rezeli, M., Kelemen, O., Vegvari, A., Watanabe, K., Sugihara, Y., Tisza, A., Marton, T., Kovacs, I., Tovari, J., Laszlo, V., Helbich, T. H., Hegedus, B., Klikovits, T., Hoda, M. A., Klepetko, W., Paku, S., Marko-Varga, G. & Dome, B., 2017, In: Theranostics. 7, 2, p. 400-412 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Novel insights in drug metabolism by MS imaging.

Sugihara, Y., Watanabe, K. & Végvári, Á., 2016, In: Bioanalysis. 8, 6, p. 575-588

Research output: Contribution to journal › Review article › peer-review

2015

A protein deep sequencing evaluation of metastatic melanoma tissues.

Welinder, C., Pawlowski, K., Sugihara, Y., Yakovleva, M., Jönsson, G. B., Ingvar, C., Lundgren, L., Baldetorp, B., Olsson, H., Rezeli, M., Jansson, B., Laurell, T., Fehniger, T., Döme, B., Malm, J., Wieslander, E., Nishimura, T. & Marko-Varga, G., 2015, In: PLoS ONE. 10, 4, e0123661.

Research output: Contribution to journal › Article › peer-review

Open Access

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Drug Compound Characterization by Mass Spectrometry Imaging in Cancer Tissue

Kwon, H. J., Kim, Y., Sugihara, Y., Baldetorp, B., Welinder, C., Watanabe, K., Nishimura, T., Malm, J., Török, S., Döme, B., Végvári, Á., Gustavsson, L., Fehniger, T. & Marko-Varga, G., 2015, In: Archives of Pharmacal Research. 38, 9, p. 1718-1727

Research output: Contribution to journal › Review article › peer-review

Open Access

Localization of Sunitinib in in vivo Animal and in vitro Experimental Models by MALDI Mass Spectrometry Imaging

James, C., Sugihara, Y., Török, S., Döme, B., Fehniger, T., Marko-Varga, G. & Végvári, Á., 2015, In: Analytical and Bioanalytical Chemistry. 407, 8, p. 2245-2253

Research output: Contribution to journal › Article › peer-review

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265 Downloads (Pure)

2014

A New Look at Drugs Targeting Malignant Melanoma – An Application for Mass Spectrometry Imaging

Sugihara, Y., Végvári, Á., Welinder, C., Jönsson, G. B., Ingvar, C., Lundgren, L., Olsson, H., Breslin, T., Wieslander, E., Laurell, T., Rezeli, M., Jansson, B., Fehniger, T., Baldetorp, B. & Marko-Varga, G., 2014, In: Proteomics. 14, 17-18, p. 1963-1970

Research output: Contribution to journal › Review article › peer-review

Open Access

Clinical initiatives linking Japanese and Swedish healthcare resources on cancer studies utilizing Biobank Repositories.

Nishimura, T., Kawamura, T., Sugihara, Y., Bando, Y., Sakamoto, S., Nomura, M., Ikeda, N., Ohira, T., Fujimoto, J., Tojo, H., Hamakubo, T., Kodama, T., Andersson, R., Fehniger, T. E., Kato, H. & Marko-Varga, G., 2014, In: Clinical and Translational Medicine. 3, 1, 61.

Research output: Contribution to journal › Article › peer-review

Open Access

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Yutaka Sugihara

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