Alpha1-Oleate (Alpha1H) is a protein-lipid complex derived from human breast milk called HAMLET (Human Alpha Lactalbumin made lethal to Tumor cells). A peptide screen based on the structural elements of the protein part of the complex (alpha-lactalbumin) has led to the discovery of an N-terminal peptide that reproduces essential tumoricidal features of the holo-protein. Alpha1H enters the cells and induces rapid cell death similar to what has been seen for the parent HAMLET complex. A more detailed mechanistic understanding of the mode of action of this complex in cancer cells is studied.
|Effective start/end date||2021/07/01 → …|