Project Details
Description
RBCs are an important target in the life cycle of all human Plasmodium parasites, and blood group polymorphism distribution between different populations in endemic and non–endemic regions is often an indicator that a glycoprotein is a potential ligand on the RBC surface. This research will focus on blood group polymorphism in less well–studied regions in South East Asia, where malaria is endemic. We will investigate what RBC surface molecules are used by P.vivax and P. knowlesi other than those which have already been described (Duffy and Glycophorin A).
Aim 1: To investigate the blood group antigen polymorphism in individuals in Thailand.
Aim 2: To culture P. vivax and P. knowlesi and to test RBCs of different blood group phenotypes for their invasion susceptibility.
Aim 3: To investigate the RBC specificity of autoantibodies made in patients with, or recovering from, malaria.
Aim 1: To investigate the blood group antigen polymorphism in individuals in Thailand.
Aim 2: To culture P. vivax and P. knowlesi and to test RBCs of different blood group phenotypes for their invasion susceptibility.
Aim 3: To investigate the RBC specificity of autoantibodies made in patients with, or recovering from, malaria.
| Status | Finished |
|---|---|
| Effective start/end date | 2016/05/01 → 2020/05/20 |
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Subject classification (UKÄ)
- Hematology
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Characterization of GYP*Mur and novel GYP*Bun-like hybrids in Thai blood donors reveals a qualitatively altered s antigen
Jongruamklang, P., Grimsley, S., Thornton, N., Robb, J., Olsson, M. L. & Storry, J. R., 2020 Jul, In: Vox Sanguinis. 115, 5, p. 472-477 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Studies of Thai blood group and platelet polymorphism. Implications for malaria susceptibility.
Jongruamklang, P., 2020, Lund: Lund University, Faculty of Medicine. 97 p.Research output: Thesis › Doctoral Thesis (compilation)
Open AccessFile373 Downloads (Pure) -
Multiple miscarriages in two sisters of Thai origin with the rare Pk phenotype caused by a novel nonsense mutation at the B3GALNT1 locus
Ricci Hagman, J., Hult, A. K., Westman, J. S., Hosseini-Maaf, B., Jongruamklang, P., Saipin, J., Bejrachandra, S. & Olsson, M. L., 2019, In: Transfusion Medicine. 29, 3, p. 202-208 7 p.Research output: Contribution to journal › Article › peer-review