Delineating the cellular taxonomy of the cancer microenvironment

Describe the complexity of cancer associated fibroblasts (CAFs) by ascribing functional roles to observed subgroups of CAFs through the use of state-of-the-art analyses at single cell resolution. This will lead to the development and presentation of an improved cellular, molecular and functional taxonomy of CAFs, opening up the possibility for development of novel targeted drugs and biomarkers of clinical significance with improved precision.